A Five- to Fifteen-Year Follow-up Study of Infantile Psychosis

1969 ◽  
Vol 115 (525) ◽  
pp. 865-882 ◽  
Author(s):  
Linda Lockyer ◽  
Michael Rutter

Surprisingly little is known about the course of intellectual development in children with infantile psychosis. Kanner (1943; Kanner and Lesser, 1958) has stated explicitly in several papers that “even though most of these children are initially considered feeble-minded, they are all unquestionably endowed with good cognitive potentialities, which are masked by the basic disorder” (original italics—Kanner and Lesser, 1958). The expectation would seem to be that the child's IQ, should fluctuate with the course of the psychosis, particularly the autistic aspects, but this has not been tested. It has been suggested (Anthony, 1958) that an intelligence test result in a young child with infantile psychosis is most unreliable and virtually meaningless if the child is without speech. Perhaps because most investigators have shared this view, neither of the two major follow-up studies of children with infantile psychosis, that of Kanner's cases (Eisenberg, 1956; Eisenberg and Kanner, 1956; Kanner, 1943 and 1949; Kanner and Eisenberg, 1955; Kanner and Lesser, 1958) and that of psychotic children seen by Creak (1962, 1963a and b) has included information on IQ changes.

2014 ◽  
Vol 1 (4) ◽  
Author(s):  
Atsushi Kaida ◽  
Hideyuki Kubo ◽  
Nobuhiro Iritani ◽  
Seiji P. Yamamoto ◽  
Atsushi Hase ◽  
...  

2020 ◽  
Vol 41 (1_suppl) ◽  
pp. S23-S30
Author(s):  
Jere D. Haas ◽  
Juan Rivera-Dommarco

The first follow-up study of the original Institute of Nutrition of Central America and Panama Longitudinal Study was conducted in 1988 to 1989 when participants were between the ages of 11 and 27 years. The longer term effects of the original supplementation in early life of either high protein and energy, Atole, or no protein and low energy, Fresco, were seen in anthropometry, skeletal maturation, physical work capacity, and intellectual development, with maximum benefit seen in those participants who had maximum exposure to the supplementation during prenatal and early postnatal years. No effects were observed in bone mineralization and menarche. The long-term positive effects are consistent with the promotion of improved nutrition during the first 1000 days and established the foundation for further follow-up studies as the participants move into adulthood and further develop their human capital.


1988 ◽  
Vol 13 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Richard S. Neel ◽  
Nancy Meadows ◽  
Phyllis Levine ◽  
Eugene B. Edgar

Recently there have been several follow-up studies of students who have exited special education programs (Hasazi, Gordon, & Roe, 1985; Mithaug, Horiuchi, & Fanning, 1985). These studies raise an interesting question: How well have special education programs prepared the youth they were designed to serve? This study reviews findings concerning the postschool adjustment of 160 students who were labeled behaviorally disordered at graduation from public school in the state of Washington between 1978 and 1986.


1976 ◽  
Vol 25 (1) ◽  
pp. 198-212
Author(s):  
W. De Coster ◽  
J. Lerou ◽  
C. Dutoit ◽  
M. De Zutter ◽  
R. Derom ◽  
...  

Classical psychological twin studies have yielded in part equivocal and sometimes contradictory results. Besides the complexity of the problem, the delicate character of the diagnosis, and the rudimentary tools which were used, several other factors are underlying this situation: (1) insufficient systematization of the set-up and the careless design of the investigations; (2) lack of follow-up studies; (3) uncertain diagnosis of zygosity; in MZ twins no attention to the age of the ovum at the time of cleavage; (4) lack of consideration for antenatal and perinatal influences; (5) no attention to the typical circumstances linked to the twin situation. All this makes it difficult to balance nature against nurture on the basis of comparison between MZ twins, DZ twins, and singletons. Interactions may also appear between the effect of twinning and other factors such as the socioeconomic circumstances. A new investigation was therefore started where, besides the twins, a group of matched control singletons was constituted. The follow-up study is now completed up to the age of 5 years in 13 MZ and 20 DZ twin pairs (+ controls, that is to say, 99 children).The children were observed and subjected to psychological tests at the age of 6 months and of 1, 2, 3, 4, and 5 years.


2003 ◽  
Vol 21 (20) ◽  
pp. 3867-3874 ◽  
Author(s):  
Iris van Oostrom ◽  
Hanne Meijers-Heijboer ◽  
Litanja N. Lodder ◽  
Hugo J. Duivenvoorden ◽  
Arthur R. van Gool ◽  
...  

Purpose: To explore long-term psychosocial consequences of carrying a BRCA1/2 mutation and to identify possible risk factors for long-term psychological distress. Patients and Methods: Five years after genetic test disclosure, 65 female participants (23 carriers, 42 noncarriers) of our psychological follow-up study completed a questionnaire and 51 participants were interviewed. We assessed general and hereditary cancer-related distress, risk perception, openness to discuss the test result with relatives, body image and sexual functioning. Results: Carriers did not differ from noncarriers on several distress measures and both groups showed a significant increase in anxiety and depression from 1 to 5 years follow-up. Carriers having undergone prophylactic surgery (21 of 23 carriers) had a less favorable body image than noncarriers and 70% reported changes in the sexual relationship. A major psychological benefit of prophylactic surgery was a reduction in the fear of developing cancer. Predictors of long-term distress were hereditary cancer-related distress at blood sampling, having young children, and having lost a relative to breast/ovarian cancer. Long-term distress was also associated with less open communication about the test result within the family, changes in relationships with relatives, doubting about the validity of the test result, and higher risk perception. Conclusion: Our findings support the emerging consensus that genetic predisposition testing for BRCA1/2 does not pose major mental health risks, but our findings also show that the impact of prophylactic surgery on aspects such as body image and sexuality should not be underestimated, and that some women are at risk for high distress, and as a result, need more attentive care.


2020 ◽  
Author(s):  
shu li ◽  
li haoyu ◽  
xiao neng ◽  
lin yixiang ◽  
yu wenxian ◽  
...  

Abstract Background:There was a lacking of clinical diagnostic evidence in follow-up studies for reporting of secondary variants in 59 genes in American College of Medical Genetics and Genomics recommendations for reporting secondary findings and various strategies were applied to interpret the secondary variants. Results: Out of 1330 participants performed whole-exome sequencing, we identified 15 families with convincing clinical evidence. After Sanger validation and a comprehensive clinical follow-up, 10 families with both convincing clinical evidence and convincing genetic evidence of hereditary variants were found. Detailed clinical presentations and related clinical evidence were collected. Conclusions: Our research is a comprehensive follow-up study to identify secondary variants with convincing genetic and clinical evidence and it could help improve the strategy of screening actionable secondary variants and contribute to translation of genetic findings into medical practice.


2011 ◽  
Vol 194-196 ◽  
pp. 981-984
Author(s):  
Yong Tao Gao ◽  
Xiao Hu

With the unilateral extending test on 4 teams*12 aluminum alloy round pipes, compressing test on 4 teams*4 pipes and repeating extending/compressing test on 4 teams*4 pipes, get the stress-strain relationship of the aluminum alloy round pipe, and get the elastic modulus f0.1 and f0.2. At the same time, get the conclusion that the damaging type is brittleness. The test result is the foundation for follow-up studies on the loading capacity of the aluminum alloys.


2014 ◽  
Vol 11 (6) ◽  
pp. 635-647 ◽  
Author(s):  
Lea T Drye ◽  
Anne S Casper ◽  
Alice L Sternberg ◽  
Janet T Holbrook ◽  
Gabrielle Jenkins ◽  
...  

Background: Investigators may elect to extend follow-up of participants enrolled in a randomized clinical trial after the trial comes to its planned end. The additional follow-up may be initiated to learn about longer term effects of treatments, including adverse events, costs related to treatment, or for reasons unrelated to treatment such as to observe the natural course of the disease using the established cohort from the trial. Purpose: We examine transitioning from trials to extended follow-up studies when the goal of additional follow-up is to observe longer term treatment effects. Methods: We conducted a literature search in selected journals from 2000 to 2012 to identify trials that extended follow-up for the purpose of studying longer term treatment effects and extracted information on the operational and logistical issues in the transition. We also draw experience from three trials coordinated by the Johns Hopkins Coordinating Centers that made transitions to extended follow-up: the Alzheimer’s Disease Anti-inflammatory Prevention Trial, Multicenter Uveitis Steroid Treatment trial, and Childhood Asthma Management Program. Results: Transitions are not uncommon in multicenter clinical trials, even in trials that continued to the planned end of the trial. Transitioning usually necessitates new participant consents. If study infrastructure is not maintained during the transition, participants will be lost and re-establishing the staff and facilities will be costly. Merging data from the trial and follow-up study can be complicated by changes in data collection measures and schedules. Limitations: Our discussion and recommendations are limited to issues that we have experienced in transitions from trials to follow-up studies. Discussion: We discuss issues such as maintaining funding, institutional review board and consent requirements, contacting participants, and combining data from the trial and follow-up phases. We conclude with a list of recommendations to facilitate transitions from a trial to an extended follow-up study.


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