‘Pick's Disease’–101 Years on Still There, But in Need of Reform

1993 ◽  
Vol 163 (1) ◽  
pp. 100-104 ◽  
Author(s):  
Bob Baldwin ◽  
Hans Förstl
Keyword(s):  
Temporal Lobe ◽  
Cerebral Atrophy ◽  
Frontal Lobes ◽  
Cortical Atrophy ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Post Mortem ◽  
Left Temporal Lobe ◽  
History Of ◽  
Specific Symptoms

On 23 April 1892, Arnold Pick reported the case of AH, who died aged 71 years following a two-year history of progressive ‘feeble-mindedness', outbursts of rage, fits and, in the later stages, severe aphasia (Pick, 1892). The post-mortem showed cerebral atrophy, particularly affecting the left temporal lobe. Pick went on to describe further cases of circumscribed atrophy affecting the temporal lobe (Pick, 1901, 1904), and parietal and frontal lobes (Pick, 1906). Although he believed the focal pathology represented a local emphasis of ‘senile cortical atrophy’, he wanted to show that a localised form of cerebral atrophy could nevertheless cause specific symptoms:“… thereby bringing neuropathology and psychiatry into closer union … so that the latter may be brought nearer to medical understanding.”

Defective production and recognition of actions in Pick's disease with temporal lobe atrophy (semantic dementia)

2009 ◽  
Vol 29 (2) ◽  
pp. 268-276 ◽  
Author(s):  
Masaki Kondo ◽  
Satoshi Mochizuki ◽  
Mutsutaka Kobayakawa ◽  
Natsuko Tsuruya ◽  
Mitsuru Kawamura
Keyword(s):  
Temporal Lobe ◽  
Semantic Dementia ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Lobe Atrophy

Sporadic Pick's Disease in a 28-Year-Old Woman

1993 ◽  
Vol 162 (2) ◽  
pp. 259-262 ◽  
Author(s):  
H. Rana Mowadat ◽  
E. E. Kerr ◽  
D. Stclair
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Neurodegenerative Disorders ◽  
Young Patients ◽  
Initial Diagnosis ◽  
Cognitive Testing ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Functional Psychosis ◽  
History Of

Pick's disease was diagnosed in a 28-year-old woman without a family history of dementia (or other psychiatric disorder), after an initial diagnosis of functional psychosis and management with ECT and neuroleptics. The case illustrates the need for detailed neurological and cognitive testing and consideration of neurodegenerative disorders even in young patients.

A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease

1983 ◽  
Vol 62 (1-3) ◽  
pp. 211-217 ◽  
Author(s):  
P.L. Wood ◽  
P. Etienne ◽  
S. Lal ◽  
N.P.V. Nair ◽  
M.H. Finlayson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinergic System ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Post Mortem

scholarly journals Clinicopathological Studies of Some Non-Alzheimer Dementing Diseases

1986 ◽  
Vol 13 (S4) ◽  
pp. 483-489 ◽  
Author(s):  
David Munoz-Garcia ◽  
Samuel K. Ludwin
Keyword(s):  
Morphological Changes ◽  
Cerebral Atrophy ◽  
Paired Helical Filaments ◽  
Pick's Disease ◽  
Neuronal Dysfunction ◽  
Pick’S Disease ◽  
Cytoplasmic Localization ◽  
Adult Onset ◽  
Cytoplasmic Inclusions ◽  
Neuronal Cytoplasmic Inclusions

Abstract:The brains of most demented patients show at autopsy the lesions of Alzheimer's disease (AD). However, the brains of other demented patients show either no morphological changes or lesions distinct from those of AD. We report clinicopathological studies on two diseases in this latter group. The study of these diseases can improve our understanding of AD.Pick's disease is characterized by dementia, lobar cerebral atrophy, and neuronal cytoplasmic inclusions. Most cases, which we have called “classical”, show inclusions made up of straight fibrils that are immunologically cross-reactive with the paired helical filaments of AD. In other “generalized” cases, similar fibrils are coated by granular material and are less reactive with anticytoskeletal antibodies.In contrast to the cytoplasmic localization of the lesions in Pick's disease, it is the cell nucleus that shows abnormalities in neuronal intranuclear hyaline inclusion disease. This disease can present clinically as dementia of adult onset. Thus, either nuclear or cytoplasmic lesions can produce a pattern of neuronal dysfunction resulting in dementia.

scholarly journals Nonfluent/Agrammatic PPA with In-Vivo Cortical Amyloidosis and Pick’s Disease Pathology

2013 ◽  
Vol 26 (1-2) ◽  
pp. 95-106 ◽  
Author(s):  
Francesca Caso ◽  
Benno Gesierich ◽  
Maya Henry ◽  
Manu Sidhu ◽  
Amanda LaMarre ◽  
...  
Keyword(s):  
Inferior Frontal Gyrus ◽  
Primary Progressive Aphasia ◽  
Conclusive Evidence ◽  
Cortical Atrophy ◽  
Pick's Disease ◽  
Braak Stage ◽  
Precentral Gyrus ◽  
Pick’S Disease ◽  
Prospective Longitudinal

The role of biomarkers in predicting pathological findings in the frontotemporal dementia (FTD) clinical spectrum disorders is still being explored. We present comprehensive, prospective longitudinal data for a 66 year old, right-handed female who met current criteria for the nonfluent/agrammatic variant of primary progressive aphasia (nfvPPA). She first presented with a 3-year history of progressive speech and language impairment mainly characterized by severe apraxia of speech. Neuropsychological and general motor functions remained relatively spared throughout the clinical course. Voxel-based morphometry (VBM) showed selective cortical atrophy of the left posterior inferior frontal gyrus (IFG) and underlying insula that worsened over time, extending along the left premotor strip. Five years after her first evaluation, she developed mild memory impairment and underwent PET-FDG and PiB scans that showed left frontal hypometabolism and cortical amyloidosis. Three years later (11 years from first symptom), post-mortem histopathological evaluation revealed Pick's disease, with severe degeneration of left IFG, mid-insula, and precentral gyrus. Alzheimer’s disease (AD) (CERAD frequent/Braak Stage V) was also detected. This patient demonstrates that biomarkers indicating brain amyloidosis should not be considered conclusive evidence that AD pathology accounts for a typical FTD clinical/anatomical syndrome.

scholarly journals RIGHT VS. LEFT TEMPORAL LOBE SEMIOLOGY IN DEMENTIA: LESSONS FROM TWO CASES WITH FOCAL FRONTOTEMPORAL DEMENTIA SYNDROMES

2021 ◽  
Author(s):  
Vitor Arca ◽  
Pedro Albuquerque ◽  
Victor Correia ◽  
Amanda Pires ◽  
Hugo Araújo ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Temporal Lobe ◽  
Word Processing ◽  
Brain Mri ◽  
Cerebral Atrophy ◽  
Primary Progressive Aphasia ◽  
Left Temporal Lobe ◽  
Her Family ◽  
Mini Mental Status Examination ◽  
The Right

Background: Case 1: a 59-year old man presented to our service with 4 years of progressive cognitive and behavioral symptoms. He became forgetful and experienced difficulties managing his payments. After 4 years he could no longer recognise his relatives. Cognitive assessment showed a mini-mental status examination of 17/30. MRI and SPECT revealed respectively focal atrophy and hipoperfusion of the frontal regions and anterior right temporal lobe. Case 2: a 72-year-old woman was brought to evaluation with a 5-years history of progressive language and behavioral deterioration. Her family reported early speech errors and behavioral changes, with a marked aggressiveness, ritualistic behaviors and hyperorality. Cognitive evaluation revealed a MMSE of 6/30 mainly due to a relatively fluent afasia. Brain MRI showed asymmetric cerebral atrophy, more prominent in the anterior left temporal lobe. Objective: N/H Methods: N/H Results: N/H Conclusion: We describe two cases of suspected frontotemporal dementia (FTD) syndromes. The left ATL may receive proportionately more input from the lexical and phonological centers subserving word processing. The right ATL may receive more input from right-lateralized emotion processing hubs. Focal atrophy of the left anterior temporal lobe has been associated with the semantic type of primary progressive aphasia evolving to semantic dementia. In contrast, focal atrophy of the right temporal lobe has recently been described as a controversial entity reported as the right temporal variant of FTD.

A variant of normal-pressure hydrocephalus simulating Pick's disease on computerized tomography

1983 ◽  
Vol 59 (5) ◽  
pp. 902-904 ◽  
Author(s):  
Naman A. Salibi ◽  
Gerald L. Lourie ◽  
Herbert Lourie
Keyword(s):  
Computerized Tomography ◽  
Normal Pressure Hydrocephalus ◽  
Clinical Picture ◽  
Normal Pressure ◽  
Cortical Atrophy ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Content Type ◽  
Ventriculoperitoneal Shunting ◽  
Fine Print

✓ The authors present two cases of normal-pressure hydrocephalus that simulated Pick's disease radiographically and that were initially diagnosed as cortical atrophy. In both cases, Sylvian cisternoperitoneal shunts improved the clinical picture only temporarily, but ventriculoperitoneal shunting produced dramatic relief of all symptoms.

scholarly journals A Rare Case of Craniopharyngioma in the Temporal Lobe

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Sasan Razmjoo ◽  
Seyed Nematollah Jazayeri ◽  
Mohammad Bahadoram ◽  
Maedeh Barahman
Keyword(s):  
Head Trauma ◽  
Temporal Lobe ◽  
Rare Case ◽  
Cystic Mass ◽  
Prior History ◽  
Mr Images ◽  
Left Temporal Lobe ◽  
History Of

Herein, we report on a rare case of craniopharyngioma arising in the left temporal lobe with no prior history of head trauma or surgery. There was a solid-cystic mass in the left temporal lobe on MR images. To the best of our knowledge, this is the second case of a craniopharyngioma occurring in the temporal lobe.

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