Cellular Models in Schizophrenia Research

Schizophrenia (SZ) is a prevalent functional psychosis characterized by clinical behavioural symptoms and underlying abnormalities in brain function. Genome-wide association studies (GWAS) of schizophrenia have revealed many loci that do not directly identify processes disturbed in the disease. For this reason, the development of cellular models containing SZ-associated variations has become a focus in the post-GWAS research era. The application of revolutionary clustered regularly interspaced palindromic repeats CRISPR/Cas9 gene-editing tools, along with recently developed technologies for cultivating brain organoids in vitro, have opened new perspectives for the construction of these models. In general, cellular models are intended to unravel particular biological phenomena. They can provide the missing link between schizophrenia-related phenotypic features (such as transcriptional dysregulation, oxidative stress and synaptic dysregulation) and data from pathomorphological, electrophysiological and behavioural studies. The objectives of this review are the systematization and classification of cellular models of schizophrenia, based on their complexity and validity for understanding schizophrenia-related phenotypes.

FORMS OF HUMAN RIGHTS VIOLATIONS FACED BY PEOPLE WITH SCHIZOPHRENIA

On this occasion, we will present brief information about Schizophrenia as a form of mental disorder that lasts for the long term. Pe ople with mental disorders are people who experience disturbances in thoughts, behaviors, and feelings manifested in the form of a set of symptoms and / or changes in meaningful behavior, and can cause suffering and obstacles in carrying out people's functions as humans. This is to differentiate from people with psychiatric problems are people who have physical, mental, social, growth and development problems, and / or quality of life so that they have the risk of experiencing mental disorders. This explanation was taken from Law No. 18 of 2014 concerning Mental Health. Schizophrenia comes from Greek, schizein which means separate or broken and phren which means soul. Breaking out or mismatch between cognitive and behavioral effects. Schizophrenia is a functional psychosis with major disturbances in the thinking process and disharmony between thought processes, affect or emotion, will and psychomotor accompanied by distortion of reality, mainly due to delusions and hallucinations, divided associations so that appear incoherence, affect and emotional inadekuat, and psychomotor shows withdrawal, ambivalence and bizar behavior.

Psychosis and dementia: risk factor, prodrome, or cause?

ABSTRACTBackground:Progression of dementia is often associated with the emergence of neuropsychiatric symptoms (NPS), though there is recent evidence that NPS may occur in prodromal dementia (PrD) and impact clinical course. Mood and anxiety symptoms are the NPS that tend to occur most frequently in PrD and thus have been most extensively studied. Comparatively, there has been little focus on psychotic symptoms in PrD.Methods:The authors review the existing literature on psychosis in PrD, including the functional psychosis of early and late onset, with a focus on epidemiology, phenomenology, and clinical course and treatment considerations.Results:Patients with psychotic disorders at baseline such as schizophrenia may be more at risk for developing dementia over time, although this is not completely clear. Psychotic symptoms are likely more common in PrD than previously understood based on factor analysis studies, although they are much more common in established dementia. Variability in findings may reflect the heterogeneous nature of PrD studies to date and the lack of inclusion of patients with late onset psychosis in most clinical studies. The presence of psychosis in patients with PrD may be associated with a worse prognosis in terms of mortality and conversion to dementia.Conclusions:Research to date suggests that psychosis in PrD may be more common than previously thought and impact clinical course negatively. Future studies incorporating patients with late onset psychotic disorders, and focusing on the impact of early recognition and treatment, are required to more fully understand the role of psychosis in PrD.

Parenting and Family Adjustment among Parents of children and adolescents with Intellectual Disability and functional psychosis: A Comparative Study

Background: Parenting, a wonderful and rewarding experience, are often accompanied by high levels of stress, because of the difficulties, frustrations, and challenges that parents face in everyday life. This study examined the profile of Parenting and Family Adjustment among Parents of children and adolescents with Intellectual Disability and functional psychosis. Methods: This study was a cross-sectional hospital based study. The study samples were selected through purposive sampling technique. The sample size was 40 parent among which 20 parents of children and adolescent with intellectual disability and 20 parents of children and adolescent with functional psychosis taken from Erna Hoch Child and Adolescent Psychiatry Unit and Charak Outpatient Department, of the Central Institute of Psychiatry, Kanke, Ranchi. Parenting and Family Adjustment Scale used for the data collection. Data were analyzed by Statistical Package for Social Sciences (SPSS- 21 version). Results and Conclusions: The results indicated that parents of children and adolescents with functional psychosis reported higher mean in the subscales of Parental consistency, Corrective parenting, Positive encouragement, Parent child-relationship, Family relationship and parents of children and adolescents with intellectual disability reported higher mean in the subscale of Parental teamwork. Key words: Parenting, Family Adjustment, Psychosis, Intellectual Disability Â

A Role for EMDR in the Treatment of Trauma in Patients Suffering From a Psychosis: Four Vignettes

Many patients with a functional psychosis are likely to have a history of trauma and symptoms of posttraumatic stress disorder (PTSD); some may be traumatized by their psychotic symptoms. We present a series of vignettes to describe eye movement desensitization and reprocessing (EMDR) treatment of 4 patients suffering from a functional psychotic illness who had a significant history of trauma. After receiving EMDR, each patient showed an improvement in their PTSD symptoms and reported an improvement in the quality of their lives. Follow-up at 3–6 years indicated that the treatment effects were maintained, with changes evident in elimination of trauma-related delusions, reduction in anxiety and depression, fewer hospital admissions, and overall improved quality of life. Because a history of trauma and PTSD symptoms are more frequent in patients with a psychosis, and trauma may be an etiological component of psychosis, EMDR treatment needs to be researched and explored as a treatment opportunity.