Heterogeneity of Depression

1994 ◽  
Vol 164 (3) ◽  
pp. 342-348 ◽  
Author(s):  
Kathleen Ries Merikangas ◽  
Werner Wicki ◽  
Jules Angst
Keyword(s):  
Suicide Attempts ◽  
Recurrent Depression ◽  
Major Depressive ◽  
Longitudinal Course ◽  
Epidemiological Sample ◽  
History Of ◽  
Severity Of Depression ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
Prospective Longitudinal

This paper describes the application of prospective longitudinal data from an epidemiological sample of young adults to define subtypes of major depression. Depression was classified on a spectrum from subthreshold manifestation of symptoms and duration at one end, to cases with recurrent episodes of depression meeting duration criteria for major depressive episodes at the other. There was a direct relationship between the severity of depression over the longitudinal course and both duration and recurrence of depressive episodes. The subgroup of depression with recurrence of both brief and longer duration episodes could be discriminated on most of the indicators of validity including symptoms, impairment, family history, and suicide attempts. In light of the young age of this cohort, the strong history of suicide attempts and other complications of depression among the subjects with recurrent depression was striking. These findings underscore the importance of employing course as a classification criterion of depression, and the inclusion of subthreshold episodes of depression in the characterisation of course.

Who Becomes a Depressive Ruminator? Developmental Antecedents of Ruminative Response Style

2002 ◽  
Vol 16 (4) ◽  
pp. 405-419 ◽  
Author(s):  
Jelena Spasojević ◽  
Lauren B. Alloy
Keyword(s):  
College Freshmen ◽  
Response Style ◽  
Major Depressive ◽  
History Of Childhood ◽  
Developmental Factors ◽  
History Of ◽  
Developmental Antecedents ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Developmental antecedents of ruminative response style were examined in 137 college freshmen, who were followed prospectively for 2.5 years. Reports of mothers’ and fathers’ psychologically overcontrolling parenting as well as a history of childhood sexual (for women only) and emotional maltreatment were all related to ruminative response style. In addition, ruminative response style mediated the relationships between these developmental factors and the number of major depressive episodes experienced by participants during the follow-up period. Potential explanations and important implications of these findings are discussed.

Core Beliefs and History of Major Depressive Episodes in Currently Non-depressed University Students

2008 ◽  
Vol 33 (1) ◽  
pp. 50-58 ◽  
Author(s):  
John R. Z. Abela ◽  
Randy P. Auerbach ◽  
Sabina Sarin ◽  
Zia Lakdawalla
Keyword(s):  
University Students ◽  
Core Beliefs ◽  
Major Depressive ◽  
History Of ◽  
Major Depressive Episodes ◽  
Depressive Episodes

scholarly journals Prospective study of risk factors for attempted suicide among patients with DSM–IV major depressive disorder

2005 ◽  
Vol 186 (4) ◽  
pp. 314-318 ◽  
Author(s):  
T. Petteri Sokero ◽  
Tarja K. Melartin ◽  
Heikki J. Rytsälä ◽  
Ulla S. Leskelä ◽  
Paula S. Lestelä-Mielonen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Attempted Suicide ◽  
Suicide Attempts ◽  
Structured Interviews ◽  
Major Depressive ◽  
Dsm Iv ◽  
Major Depressive Episodes ◽  
Depressive Episodes

BackgroundThere are few prospective studies on risk factors for attempted suicide among psychiatric out- and in-patients with major depressive disorder.AimsTo investigate risk factors for attempted suicide among psychiatric out- and in-patients with major depressive disorder inthe city of Vantaa, Finland.MethodThe Vantaa Depression Study included 269 patients with DSM–IV major depressive disorder diagnosed using semi-structured interviews and followed up at 6- and 18-month interviews with a life chart.ResultsDuring the 18-month follow-up, 8% of the patients attempted suicide. The relative risk of an attempt was 2.50 during partial remission and 7.54 during a major depressive episode, compared with full remission (P<0.001). Numerous factors were associated with this risk, but lacking a partner, previous suicide attempts and total time spent in major depressive episodes were the most robust predictors.ConclusionsSuicide attempts among patients with major depressive disorder are strongly associated with the presence and severity of depressive symptoms and predicted by lack of partner, previous suicide attempts and time spent in depression. Reducing the time spent depressed is a credible preventive measure.

P-516 - Does the severity of depression and psychosis correlate during major depressive episodes?

2012 ◽  
Vol 27 ◽  
pp. 1
Author(s):  
S.D. Østergaard ◽  
J. Bille ◽  
H. Søltoft-Jensen ◽  
N. Lauge ◽  
P. Bech
Keyword(s):  
Major Depressive ◽  
Severity Of Depression ◽  
Major Depressive Episodes ◽  
Depressive Episodes

scholarly journals Sex-dependent grades of haematopoietic modulation in patients with major depressive episodes are associated with suicide attempts

2020 ◽  
Vol 40 ◽  
pp. 17-30
Author(s):  
Patricia Martínez-Botía ◽  
Angela Velasco ◽  
Valeria Rolle ◽  
Luis Jiménez-Trevino ◽  
Lorena De la Fuente-Tomás ◽  
...  
Keyword(s):  
Suicide Attempts ◽  
Major Depressive ◽  
Major Depressive Episodes ◽  
Depressive Episodes

scholarly journals Global and reflective rumination are related to suicide attempts among patients experiencing major depressive episodes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hao Tang ◽  
Tingting Xiong ◽  
Jiabo Shi ◽  
Yu Chen ◽  
Xiaoxue Liu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Suicide Attempts ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Episode Frequency ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
The Relationship

Abstract Background Recent attention has focused on the role of rumination in suicidality, with evidence indicating that rumination may be positively related to suicidal ideation. There remains disagreement on the nature of the relationship between rumination and suicide attempts, especially in major affective disorders. This study was designed to identify whether rumination is a risk factor for attempted suicide. Methods A total of 309 patients with major depressive episodes were recruited for this study, including 170 patients with major depression and 139 patients with bipolar disorder. All participants were categorized into two groups based on a series of clinical assessments: suicide attempters (n = 87) and non-suicide attempters (n = 222). Rumination was evaluated with the Ruminative Responses Scale. A binary logistic regression analysis was carried out to evaluate the relationship between rumination and suicide attempts. Results Both global ruminative levels and the two subtypes of rumination, brooding and reflection, were significantly higher in the suicide attempters than the non-suicide attempters. After controlling for age, current depression and anxiety symptoms, and episode frequency, it was found that global rumination and reflection (but not brooding) were positively associated with suicide attempts. Conclusion These results suggest that rumination may be a risk factor for suicide attempts and highlight the maladaptive nature of reflection in patients with major depressive episodes.

scholarly journals Time to recovery of an inception cohort with hitherto untreated unipolar major depressive episodes

2000 ◽  
Vol 177 (4) ◽  
pp. 331-335 ◽  
Author(s):  
Toshiaki A. Furukawa ◽  
Toshinori Kitamura ◽  
Kiyohisa Takahashi
Keyword(s):  
Major Depression ◽  
Mood Disorder ◽  
Tertiary Care ◽  
Inception Cohort ◽  
Major Depressive ◽  
Follow Up Study ◽  
History Of ◽  
Major Depressive Episodes ◽  
Depressive Episodes

BackgroundGeneralisability of existing studies on the naturalistic history of major depression is undermined by overrepresentation of in-patients and tertiary care academic centres, inclusion of patients already on treatment and/or incomplete follow-up.AimsTo report the time to recovery of an inception cohort of unipolar major depressive episodes.MethodA multi-centre prospective follow-up study of patients with a mood disorder, who had been selected to be representative of the untreated first-visit patients at 23 psychiatric settings from all over Japan.ResultsThe median time to recovery of the index episode after treatment commencement was 3 months (95% CI 2.5–3.6): 26% of the cohort reached asymptomatic or minimally symptomatic status by I month, 63% by 3 months, 85% by 12 months and 88% by 24 months.ConclusionsOur estimate of the episode length was 25–50% shorter than estimates reported in the literature.

scholarly journals Quitting smoking does not increase the risk of major depressive episodes among users of Internet smoking cessation interventions

2009 ◽  
Vol 40 (3) ◽  
pp. 441-449 ◽  
Author(s):  
L. D. Torres ◽  
A. Z. Barrera ◽  
K. Delucchi ◽  
C. Penilla ◽  
E. J. Pérez-Stable ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Major Depressive ◽  
Quit Attempt ◽  
Quitting Smoking ◽  
History Of ◽  
English Speaking ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
Depression History ◽  
History Of Depression

BackgroundLimited evidence has suggested that quitting smoking increases the incidence of major depressive episodes (MDEs), particularly for smokers with a history of depression. Further evidence for this increase would have important implications for guiding smoking cessation.MethodSpanish- and English-speaking smokers without a current MDE (n=3056) from an international, online smoking cessation trial were assessed for abstinence 1 month after their initial quit date and followed for a total of 12 months. Incidence of screened MDE was examined as a function of abstinence and depression history.ResultsContinued smoking, not abstinence, predicted MDE screened at 1 month [smoking 11.5% v. abstinence 7.8%, odds ratio (OR) 1.36, 95% confidence interval (CI) 1.04–1.78, p=0.02] but not afterwards (smoking 11.1% v. abstinence 9.8%, OR 1.05, 95% CI 0.77–1.45, p=0.74). Depression history predicted MDE screened at 1 month (history 17.1% v. no history 8.6%, OR 1.71, 95% CI 1.29–2.27, p<0.001) and afterwards (history 21.7% v. no history 8.3%, OR 3.87, 95% CI 2.25–6.65, p<0.001), although the interaction between history and abstinence did not.ConclusionsQuitting smoking was not associated with increased MDE, even for smokers with a history of depression, although a history of depression was. Instead, not quitting was associated with increased MDE shortly following a quit attempt. Results from this online, large, international sample of smokers converge with similar findings from smaller, clinic-based samples, suggesting that in general, quitting smoking does not increase the incidence of MDEs.

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