Nithsdale Schizophrenia Surveys 20

BackgroundCognitive deficits are a core aspect of schizophrenia but there has been no study of cognitive function in a catchment-area-based population of patients with schizophrenia.AimsTo assess cognitive function in a population of patients with schizophrenia, and relate it to community functioning.MethodAll patients with schizophrenia in Nithsdale, south-west Scotland, were identified (n=182). Measures of assessment were: National Adult Reading Test (NART), Mini-Mental State Examination (MMSE), Rivermead Behavioural Memory Test (RBMT), Executive Interview (EXIT), FAS Verbal Fluency and Health of the Nation Outcome Scales (HoNOS).ResultsWe assessed 138 patients, mean age 48 years (standard deviation (s.d.) 15). Only 14% were in-patients. The mean premorbid IQ as assessed by NART was 98 (s.d. 14); 15% of patients had significant global cognitive impairment (MMSE); 81% had impaired memory (RBMT); 25% had executive dyscontrol (EXIT); and 49% had impaired verbal fluency (FAS). Scores on the functional impairment sub-scale of HoNOS correlated with all measures of cognitive impairment.ConclusionsCognitive dysfunction is pervasive in a community-based population of patients with schizophrenia.

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Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts

International Journal of Stroke ◽

10.1177/1747493020984552 ◽

2021 ◽

pp. 174749302098455

Author(s):

Nick A Weaver ◽

Angelina K Kancheva ◽

Jae-Sung Lim ◽

J Matthijs Biesbroek ◽

Irene MC Huenges Wajer ◽

...

Keyword(s):

Cognitive Impairment ◽

Middle Cerebral Artery ◽

Cerebral Artery ◽

Cognitive Deficits ◽

Mini Mental State Examination ◽

Left Middle Cerebral Artery ◽

Post Stroke ◽

Lesion Symptom Mapping ◽

State Examination ◽

Left Middle

Background Post-stroke cognitive impairment can occur after damage to various brain regions, and cognitive deficits depend on infarct location. The Mini-Mental State Examination (MMSE) is still widely used to assess post-stroke cognition, but it has been criticized for capturing only certain cognitive deficits. Along these lines, it might be hypothesized that cognitive deficits as measured with the MMSE primarily involve certain infarct locations. Aims This comprehensive lesion-symptom mapping study aimed to determine which acute infarct locations are associated with post-stroke cognitive impairment on the MMSE. Methods We examined associations between impairment on the MMSE (<5th percentile; normative data) and infarct location in 1198 patients (age 67 ± 12 years, 43% female) with acute ischemic stroke using voxel-based lesion-symptom mapping. As a frame of reference, infarct patterns associated with impairments in individual cognitive domains were determined, based on a more detailed neuropsychological assessment. Results Impairment on the MMSE was present in 420 patients (35%). Large voxel clusters in the left middle cerebral artery territory and thalamus were significantly (p < 0.01) associated with cognitive impairment on the MMSE, with highest odds ratios (>15) in the thalamus and superior temporal gyrus. In comparison, domain-specific impairments were related to various infarct patterns across both hemispheres including the left medial temporal lobe (verbal memory) and right parietal lobe (visuospatial functioning). Conclusions Our findings indicate that post-stroke cognitive impairment on the MMSE primarily relates to infarct locations in the left middle cerebral artery territory. The MMSE is apparently less sensitive to cognitive deficits that specifically relate to other locations.

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The Ten Point Clock Test: A Quick Screen and Grading Method for Cognitive Impairment in Medical and Surgical Patients

The International Journal of Psychiatry in Medicine ◽

10.2190/5a0f-936p-vg8n-0f5r ◽

1994 ◽

Vol 24 (3) ◽

pp. 229-244 ◽

Cited By ~ 144

Author(s):

Peter J. Manos ◽

Rae Wu

Keyword(s):

Cognitive Impairment ◽

Cognitive Deficits ◽

Neuropsychological Tests ◽

Medical Center ◽

Neuropsychological Test ◽

Hospitalized Patients ◽

Surgical Patients ◽

Tertiary Referral Center ◽

The Mean ◽

State Examination

Objective: The objective of this study was to evaluate the clinical utility of the ten point clock test in screening for and grading cognitive deficits in medical and surgical patients. Method: The setting was the hospital and clinics of Virginia Mason Medical Center, a tertiary referral center. Consecutive samples of hospitalized patients, and clinic outpatients—with and without a dementia—were administered the ten point clock test as well as a number of other neuropsychological tests and measures of cognitive impairment. Results: Clock scores correlated with neuropsychological test scores and with the mini-mental state examination. They were stable from rater to rater, and from day to day in stable patients. The mean clock score of elderly outpatient controls was 8.5, significantly different from the mean of 5.5 scored by patients with a dementia. A cut off score of seven identified 76 percent of outpatients with dementia and 78 percent of elderly controls. Clock scores correlated well with nurses' ratings of their inpatients' cognitive deficits (Spearman's rs = −0.61). The test was easy to administer, even to hospitalized patients. Conclusions: The ten point clock test is reliable, valid, and useful as a quick screen and grading method for cognitive deficits in medical and surgical patients.

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Study of cognitive functions in major idiopathic interstitial pneumonias

Egyptian Journal of Bronchology ◽

10.1186/s43168-020-00046-7 ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Mohamed W. Zakaria ◽

Reem I. El-Korashy ◽

Mostafa O. Shaheen ◽

Samah Selim ◽

Kwashi J. Amum

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Cognitive Dysfunction ◽

Mini Mental State Examination ◽

Mmse Score ◽

Control Group ◽

Healthy Individuals ◽

Co Morbidity ◽

Impaired Lung Function ◽

State Examination

Abstract Background Cognitive dysfunction in idiopathic interstitial pneumonia (IIP) is an important clinical co-morbidity that is associated with impaired lung function. The aim of the work is to assess cognitive function in major IIP and to find out the relation between cognitive dysfunction and the oxygenation parameters. Results Fifty individuals were involved in the study; 30 patients with major IIP and 20 healthy individuals. Patients with IIP had significantly lower mini mental state examination (MMSE) score compared to the control group (P < 0.001). Wechsler Deterioration Index (WDI) revealed that 33.3% (n = 10) of the patients with IIP had sure cognitive impairment and 26.6% (n = 8) had ongoing cognitive deterioration. Patients with idiopathic pulmonary fibrosis (IPF) had lower cognitive function than other IIP. Conclusion There is an impairment of cognitive function in patients with major IIP, particularly in IPF, as measured by WDI and MMSE. Further large studies are needed to assess the possible predictors of cognitive impairment and their effects on the patients’ outcome.

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Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive Function and Ageing Study I and II

10.21203/rs.2.17884/v1 ◽

2019 ◽

Author(s):

Carlota Grossi ◽

Kathryn Richardson ◽

George Savva ◽

Chris Fox ◽

Antony Arthur ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Older People ◽

Mini Mental State Examination ◽

Medication Use ◽

Anticholinergic Medication ◽

Older Population ◽

Clinically Significant ◽

State Examination ◽

Anticholinergic Burden

Abstract Background: Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality. The characteristics of the population who use anticholinergic medication are not known. Here we estimate the prevalence of anticholinergic use in England’s older population in 1991 and 2011, and describe changes in use by participant’s age, sex, cognition and disability. Methods: We compared data from participants aged 65+ years from the Cognitive Function and Ageing Studies (CFAS I and II), collected during 1990-1993 (N=7,635) and 2008-2011 (N=7,762). We estimated the prevalence of potent anticholinergic use (Anticholinergic Cognitive Burden [ACB] score=3) and average anticholinergic burden (sum of ACB scores), using inverse probability weights standardised to the 2011 UK population. These were stratified by age, sex, Mini-Mental State Examination score, and activities of daily living (ADL) or instrumental ADL (IADL) disability. Results: Prevalence of potent anticholinergic use increased from 5.7% (95% Confidence Interval [CI] 5.2-6.3%) of the older population in 1990-93 to 9.9% (9.3-10.7%) in 2008-11, adjusted odds ratio of 1.90 (95%CI 1.67 – 2.16). People with clinically significant cognitive impairment (MMSE [Mini Mental State Examination] 21 or less) were the heaviest users of potent anticholinergic in CFAS II (16.5% [95%CI 12.0-22.3%]). Large increases in the prevalence of the use medication with ‘any’ anticholinergic activity were seen in older people with clinically significant cognitive impairment (53.3% in CFAS I to 71.5% in CFAS II). Conclusions: Use of potent anticholinergic medications nearly doubled in England’s older population over 20 years with some of the greatest increases amongst those particularly vulnerable to anticholinergic side-effects. Key words: cognitive impairment, anticholinergic burden, polypharmacy

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Sleep Disorders and Cognitive Impairment in Peritoneal Dialysis: A Multicenter Prospective Cohort Study

Kidney & Blood Pressure Research ◽

10.1159/000502355 ◽

2019 ◽

Vol 44 (5) ◽

pp. 1115-1127 ◽

Cited By ~ 1

Author(s):

Youlu Zhao ◽

Yuhui Zhang ◽

Zhikai Yang ◽

Jinwei Wang ◽

Zuying Xiong ◽

...

Keyword(s):

Cohort Study ◽

Cognitive Impairment ◽

Peritoneal Dialysis ◽

Cognitive Function ◽

Sleep Disorders ◽

Mental State ◽

Mini Mental State Examination ◽

Multicenter Prospective Cohort Study ◽

State Examination ◽

Multicenter Prospective Cohort

Background: Patients with chronic kidney disease experience a high burden of sleep disorders, and there are associations between sleep disorders and cognitive impairment. Objectives: Based on our previous cross-sectional survey on cognitive impairment in peritoneal dialysis, we further explored the relationship between sleep disorders and cognitive impairment, and predictors for declining cognitive function. Method: We conducted a multicenter prospective cohort study enrolling 458 clinically stable patients on peritoneal dialysis who were then followed up for 2 years.Demographic data, comorbidities, depression, and biochemistry data were collected at baseline. Sleep disorders including insomnia, restless legs syndrome, sleep apnea syndrome, excessive daytime sleepiness, possible narcolepsy, sleep walking and nightmares, and possible rapid eye movement behavior disorders were assessed using a panel of specific sleep questionnaires at baseline and in a second survey. Global cognitive function was measured at baseline and in a second survey, using the Modified Mini-Mental State Examination. Specific cognitive domains were evaluated using Trail-Making Test Forms A and B for executive function, and subtests of the Battery for the Assessment of Neuropsychological Status were used to asses immediate and delayed memory, visuospatial skills, and language ability. Results: Sleep disorders were common among peritoneal dialysis patients. The prevalence of cognitive impairment evaluated by the Modified Mini-Mental State Examination (3MS) increased from 19.8 to 23.9%. Possible narcolepsy was associated with decreased Modified Mini-Mental State Examination scores at baseline. During follow-up, sleepwalking and nightmares were associated with higher risks of declined delayed memory in the longitudinal study. Conclusions: Possible narcolepsy was associated with general cognitive dysfunction, and sleep walking and nightmares were risk factors for impaired delayed memory.

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Cognitive function and risk factors in the older population: differences between the sexes

10.5327/1516-3180.387 ◽

2021 ◽

Author(s):

Vinícius Lúcio de Barros ◽

Larissa Gomes Peres Bomfim ◽

Melyssa Alves Souza ◽

Danielle Ginsicke ◽

Mileny Esbravatti Stephano Colovati ◽

...

Keyword(s):

Cognitive Function ◽

Mini Mental State Examination ◽

Mmse Score ◽

The Elderly ◽

Sao Paulo ◽

São Paulo ◽

Brain Health ◽

The Mean ◽

State Examination ◽

Study Inclusion

Background: Studies have shown a sex difference in the cognitive dysfunction in the elderly where women are more susceptible to Alzheimer’s disease than men. Physical activity (PA) is an important strategy for brain health, but the exact mechanism is unclear. Santos has the largest proportion of the elderly population in São Paulo State (22%), but no studies have whether there are differences between the sexes in cognitive function. Objective: To evaluate the differences between the sexes in the cognitive function of the elderly and which factors are associated with this difference. Methods: Ninety-seven women and sixty-nine men were eligible for the study. Inclusion criteria were >65 years old, no severe cognitive impairment, preserved activities of daily living. Cognitive function and PA were assessed by the mini-mental state examination (MMSE) and Baecke questionnaire. Results: The mean age was 75±7 and 73±7, for women and men, respectively. Both sexes showed a similar MMSE score (26, varying between 14 and 30) that was inversely associated with age. The influence of the schooling status on MMSE was greater in women (r=0.49, p=0.0001) compared to men (r= 0.30, p9. Conclusions: The MMSE score is affected by the aging process similarly between the sexes. The years of schooling have an influence on cognitive function in women that is attenuated by higher PA. Ethical Committee: CAAE 20938619.4.0000.5509. Financial Support: São Paulo Research Foundation.

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Ouvrier’s Modified Mini Mental State Examination as a screening test for cognitive impairment in school-aged children with epilepsy

Paediatrica Indonesiana ◽

10.14238/pi60.3.2020.136-40 ◽

2020 ◽

Vol 60 (3) ◽

pp. 136-40

Author(s):

Hariadi Edi Saputra ◽

Setyo Handryastuti ◽

Irawan Mangunatmadja ◽

Dwi Putro Widodo ◽

Sudung O. Pardede

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Mental State ◽

Predictive Value ◽

Mini Mental State Examination ◽

Diagnostic Value ◽

Pediatric Epilepsy ◽

Diagnostic Study ◽

Long Time ◽

State Examination

Background Epilepsy may affect children's development, including their cognitive function. The prevalence of cognitive impairment in epilepsy patients is quite high. Weschler Intelligence Scale for Children (WISC) takes a long time to administer and is expensive, so a simpler screening tool for cognitive evaluation is needed in pediatric epilepsy patients. Objective To assess the diagnostic value of Ouvrier’s Modified Mini Mental State Examination (MMSE) for detecting cognitive impairment in children aged 8-11 years with epilepsy. Methods This diagnostic study was conducted in December 2018 to February 2019 at Cipto Mangunkusumo and Fatmawati Hospitals in Jakarta. Data were collected with purposive sampling of children with epilepsy aged 8 to 11 years. Cognitive function was assessed by Ouvrier’s Modified MMSE and WISC. Ouvrier’s Modified MMSE was compared to WISC as and the gold standard. Results were analyzed using a 2x2 table. Results The prevalence of cognitive impairment in 8-11-year-old epilepsy patients was 72.9%. Ouvrier’s Modified MMSE had 83% sensitivity, 85% specificity, 94% positive predictive value, 65% negative predictive value, and 83% accuracy. Conclusions Ouvrier’s Modified MMSE has good diagnostic value, thus it may be useful for early detection of cognitive impairment in pediatric epilepsy.

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P4516Incremental prognostic values of cognitive impairment diagnosed by mini-mental state examination and mini-cog in older hospitalized patients with heart failure

European Heart Journal ◽

10.1093/eurheartj/ehz745.0909 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

H Saito ◽

M Yamashita ◽

Y Endo ◽

A Mizukami ◽

K Yoshioka ◽

...

Keyword(s):

Heart Failure ◽

Cognitive Impairment ◽

Cognitive Function ◽

Mental State ◽

Mini Mental State Examination ◽

Risk Model ◽

Heart Failure Patients ◽

Patients With Heart Failure ◽

State Examination ◽

Worse Prognosis

Abstract Introduction Cognitive impairment (CI) is associated with worse prognosis in patients with heart failure, especially in the elderly; however, its incremental prognostic ability in pre-existing prognostic models has not been well elucidated. Moreover, although some tools have been proposed for evaluating cognitive function, their difference in prognostic prediction has not been explicitly compared. Methods A total of 352 heart failure patients aged ≥75 years admitted to three hospitals were evaluated for their cognitive function using the Mini-Mental State Examination (MMSE) and Mini-cog during index hospitalization. We diagnosed CI if MMSE and Mini-cog were ≤23 and ≤2, respectively. The primary endpoint was all-cause death. Results The median age of the entire cohort was 85 (IQR: 80–88) years, and 47.7% of the subjects were male. Based on the MMSE and Mini-cog, the CI was diagnosed in 167 (47.4%) and 159 (45.2%) patients, respectively. The two diagnostic tools showed poor to moderate agreement (Cohen's kappa coefficient: 0.37, 95% CI: 0.27–0.47). During the follow-up period of median 346 (IQR: 195–489) days, 53 patients (15.1%) died. Although the Kaplan-Meier analysis showed that CI diagnosed using Mini-cog (CI-MC) was associated with significantly higher mortality (P=0.001), this association was not significant for CI diagnosed using MMSE (CI-MMSE) (P=0.059). On multivariate Cox regression analysis, CI-MMSE and CI-MC were individually associated with worse prognosis in older heart failure patients even after adjustment for Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk model and log B-type natriuretic peptide levels (CI-MMSE, HR: 2.05 [95% CI: 1.16–3.61]; and CI-MC, HR: 2.57 [95% CI: 1.46–4.53]). The receiver operating characteristic curve analysis for Mini-cog showed significantly higher area under the curve (AUC) than that for MMSE (0.61 vs. 0.52, p=0.045). To test the incremental prognostic capability, models were constructed by individually adding each score to the MAGGIC risk model, and the net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were evaluated. CI-MMSE did not show incremental prognostic predictability (NRI: 0.28, p=0.069; IDI: 0.01, p=0.090), whereas CI-MC (NRI: 0.45, p=0.001; IDI: 0.03, p=0.001) did. Adding CI-MC instead of CI-MMSE to the MAGGIC risk model showed significant reclassification improvement (NRI: 0.45, p=0.002, IDI: 0.02, p=0.041). Conclusion In older patients with heart failure, CI defined by Mini-Cog is superior in providing additive prognostic value than that defined by CI based on MMSE. Acknowledgement/Funding This study is partially funded by Japan Heart Foundation Research Grant and Novartis Research Grants.

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Music Training Improves Depressed Mood Symptoms in Elderly People: A Randomized Controlled Trial

The International Journal of Aging and Human Development ◽

10.1177/0091415019893988 ◽

2019 ◽

Vol 92 (1) ◽

pp. 115-133 ◽

Cited By ~ 1

Author(s):

Michele Biasutti ◽

Anthony Mangiacotti

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Depressed Mood ◽

Mini Mental State Examination ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Control Group ◽

Geriatric Depression ◽

Music Training ◽

State Examination

The effectiveness of music training on depressed mood and general cognitive function in elderly participants is verified in this study. Music activities consisted of improvisation exercises for stimulating interpersonal skills, mood, and cognitive functions. A mixed research method was adopted, including standardized measures (Mini-Mental State Examination and Geriatric Depression Scale) and follow-up semistructured interviews. The research design included pre- and postevaluation with randomized experimental and control groups. Participants were 45 care residents aged 62 to 95, healthy and with cognitive impairment. Results revealed a significant improvement in depression index (Geriatric Depression Scale) for the experimental period ( t = 1.450; p < .005; d = 0.453) while the control group had no improvement ( t = 0.080; p > .1; d = 0.025). In addition, a significant improvement was found in the cognitive level (Mini-Mental State Examination) for the experimental ( t = 2.300; p < .005; d = 0.668) than the control group that had a significant reduction ( t = 1.240; p < .05; d = 0.273). This study provides evidence that music training has a positive impact on depressed mood and general cognitive function in elderly participants. These types of music training sessions could provide aid to control the symptoms of depression, delay the deterioration of cognitive function, and enhance social–cognitive function, especially in individuals presenting with cognitive impairment.

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