scholarly journals Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis

2007 ◽  
Vol 191 (S51) ◽  
pp. s123-s127 ◽  
Author(s):  
Julia Lappin ◽  
Paola Dazzan ◽  
Kevin Morgan ◽  
Craig Morgan ◽  
Xavier Chitnis ◽  
...  
Keyword(s):  
White Matter ◽  
Medical Records ◽  
Grey Matter ◽  
Insular Cortex ◽  
First Episode Psychosis ◽  
First Episode ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Prodromal Phase ◽  
Episode Psychosis

BackgroundFirst-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioningAimsTo examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosisMethodsEighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis. The duration of the prodromal phase was estimated from detailed interviews and medical records. Voxel-based morphometry was used to assess neuroanatomical abnormalitiesResultsA long prodromal phase was associated with smaller grey matter volumes in the cingulate, frontal and left insular cortex, and with less white matter volume bilaterally in the superior longitudinal and uncinate fasciculi and the cingulumConclusionsThe severity of volumetric abnormalities in first-episode psychosis was greater in those with a long prodrome

Poster #M62 WHITE MATTER VOLUME REDUCTIONS IN FIRST EPISODE PSYCHOSIS ARE ASSOCIATED WITH CORTISOL LEVELS

2014 ◽  
Vol 153 ◽  
pp. S211
Author(s):  
Renate L. Reniers ◽  
Belinda Garner ◽  
Christina Phassouliotis ◽  
Lisa Phillips ◽  
Connie Markulev ◽  
...  
Keyword(s):  
White Matter ◽  
First Episode Psychosis ◽  
First Episode ◽  
White Matter Volume ◽  
Matter Volume ◽  
Episode Psychosis ◽  
Cortisol Levels

scholarly journals Altered Activation of Innate Immunity Associates with White Matter Volume and Diffusion in First-Episode Psychosis

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125112 ◽  
Author(s):  
Teemu Mäntylä ◽  
Outi Mantere ◽  
Tuukka T. Raij ◽  
Tuula Kieseppä ◽  
Hanna Laitinen ◽  
...  
Keyword(s):  
Innate Immunity ◽  
White Matter ◽  
First Episode Psychosis ◽  
First Episode ◽  
White Matter Volume ◽  
Matter Volume ◽  
Episode Psychosis ◽  
And Diffusion

scholarly journals Grey matter abnormalities in Brazilians with first-episode psychosis

2007 ◽  
Vol 191 (S51) ◽  
pp. s117-s122 ◽  
Author(s):  
Maristela S. Schaufelberger ◽  
Fabio L. S. Duran ◽  
Julia M. Lappin ◽  
Marcia Scazufca ◽  
Edson Amaro ◽  
...  
Keyword(s):  
Grey Matter ◽  
First Episode Psychosis ◽  
High Income ◽  
First Episode ◽  
Voxel Based Morphometry ◽  
Middle Income ◽  
Middle Income Countries ◽  
Episode Psychosis ◽  
Structural Abnormalities ◽  
The Right

BackgroundIn low-and middle-income countries people with schizophrenia are reported to experience better outcomes than those in high-income countriesAimsTo examine structural brain differences in people with first-episode psychosis and controls in BrazilMethodMagnetic resonance imaging using voxel-based morphometry was performed on 122 people with first-episode psychosis and 94 controlsResultsThere were significant decreases in grey matter in the left superior temporal and inferior prefrontal cortices, insula bilaterally and the right hippocampal region in first-episode psychosis (P<0.05, corrected for multiple comparisons). The subgroup of people with schizophrenia (n=62) exhibited a similar pattern of decrease in grey matter relative to controlsConclusionsStructural abnormalities reported in psychosis in high-income countries are also present in first-episode psychosis in Brazil

scholarly journals Combined Grey Matter VBM and White Matter TBSS Analysis in Young First Episode Psychosis Patients With and Without Cannabis Consumption

2013 ◽  
Vol 26 (4) ◽  
pp. 641-647 ◽  
Author(s):  
Sven Haller ◽  
Logos Curtis ◽  
Maryse Badan ◽  
Séverine Bessero ◽  
Mara Albom ◽  
...  
Keyword(s):  
White Matter ◽  
Grey Matter ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Cannabis Consumption

scholarly journals Impact on the Onset of Psychosis of a Polygenic Schizophrenia-Related Risk Score and Changes in White Matter Volume

2018 ◽  
Vol 48 (3) ◽  
pp. 1201-1214 ◽  
Author(s):  
Fabienne Harrisberger ◽  
Renata Smieskova ◽  
Tobias Egli ◽  
Andor E. Simon ◽  
Anita Riecher-Rössler ◽  
...  
Keyword(s):  
At Risk ◽  
White Matter ◽  
Mental State ◽  
First Episode Psychosis ◽  
First Episode ◽  
White Matter Volume ◽  
Matter Volume ◽  
Related Risk ◽  
Episode Psychosis ◽  
At Risk Mental State

Background: Reductions in the volume of brain white matter are a common feature in schizophrenia and bipolar disorder while the association between white matter and polygenic schizophrenia-related risk is unclear. To look at the intermediate state between health and the full-blown disorder, we investigated this aspect in groups of patients before and after the onset of psychosis. Methods: On a 3 Tesla scanner, total and regional white matter volumes were investigated by structural magnetic resonance imaging (MRI) in the following groups: 37 at-risk mental state patients (ARMS), including 30 with no transition to psychosis (ARMS-NT) and 7 with a transition to psychosis (ARMS-T) pooled with 25 first episode psychosis (FEP) patients. These T1-weighted images were automatically processed with the FreeSurfer software and compared with an odds-ratio-weighted polygenic schizophrenia-related risk score (PSRS) based on the publicly available top white matter single-nucleotide polymorphisms. Results: We found no association, only a trend, between PSRS and white matter volume over all groups (β = 0.24, p = 0.07, 95% confidence interval = [-0.02 – 0.49]). However, a higher PSRS was significantly associated with a higher probability of being assigned to the ARMS-T + FEP group rather than to the ARMS-NT group (β = 0.70, p = 0.02, 95% confidence interval = [0.14 – 1.33]); there was no such association with white matter volume. Additionally, a positive association was found between PSRS and the Brief Psychiatric Rating Scale (BPRS) total score for the pooled ARMS-NT/ARMS-T+FEP sample and for the ARMS-T + FEP group also, but none for the ARMS-NT group only. Conclusion: These findings suggest that at-risk mental state patients with a transition and first-episode psychosis patients have a higher genetic risk for schizophrenia than at-risk mental state patients with no transition to psychosis; this risk was associated with psychopathological symptoms. Further analyses may allow polygenic schizophrenia-related risk scores to be used as biomarkers to predict psychosis.

A voxel based morphometry study investigating brain structural changes in first episode psychosis

2012 ◽  
Vol 227 (1) ◽  
pp. 91-99 ◽  
Author(s):  
David R. Watson ◽  
Julie M.E. Anderson ◽  
Feng Bai ◽  
Suzanne L. Barrett ◽  
T. Martin McGinnity ◽  
...  
Keyword(s):  
Structural Changes ◽  
First Episode Psychosis ◽  
First Episode ◽  
Voxel Based Morphometry ◽  
Episode Psychosis

VARIATION IN GREY MATTER VOLUME WITH DEGREE OF INSIGHT IN FIRST EPISODE PSYCHOSIS AND CHRONIC SCHIZOPHRENIA

2010 ◽  
Vol 117 (2-3) ◽  
pp. 340
Author(s):  
J. McFarland ◽  
D. Cannon ◽  
H. Schmidt ◽  
M. Ahmed ◽  
S. Hehir ◽  
...  
Keyword(s):  
Grey Matter ◽  
Chronic Schizophrenia ◽  
First Episode Psychosis ◽  
First Episode ◽  
Grey Matter Volume ◽  
Matter Volume ◽  
Episode Psychosis

scholarly journals White Matter Microstructural Abnormalities in the Broca’s-Wernicke’s-Putamen “Hoffman Hallucination Circuit” and Auditory Transcallosal Fibers in First-Episode Psychosis With Auditory Hallucinations

2020 ◽  
Author(s):  
Dean F Salisbury ◽  
Yiming Wang ◽  
Fang-Cheng Yeh ◽  
Brian A Coffman
Keyword(s):  
White Matter ◽  
Left Hemisphere ◽  
Structural Integrity ◽  
Right Hemisphere ◽  
First Episode Psychosis ◽  
Auditory Hallucinations ◽  
First Episode ◽  
Psychotic Episode ◽  
Arcuate Fasciculus ◽  
Episode Psychosis

Abstract Background Functional connectivity abnormalities between Broca’s and Wernicke’s areas and the putamen revealed by functional magnetic resonance imaging (fMRI) are related to auditory hallucinations (AH). In long-term schizophrenia, reduced white matter structural integrity revealed by diffusion imaging in left arcuate fasciculus (connecting Broca’s and Wernicke’s areas) is likely related to AH. The structural integrity of connections with putamen and their relation to AH are unknown. Little is known about this relationship in first-episode psychosis (FEP), although auditory transcallosal connections were reported to play a role. White matter in the Broca’s-Wernicke’s-putamen language-related circuit and auditory transcallosal fibers was examined to investigate associations with AH in FEP. Methods White matter connectivity was measured in 40 FEP and 32 matched HC using generalized fractional anisotropy (gFA) derived from diffusion spectrum imaging (DSI). Results FEP and HC did not differ in gFA in any fiber bundle. In FEP, AH severity was significantly inversely related to gFA in auditory transcallosal fibers and left arcuate fasciculus. Although the right hemisphere arcuate fasciculus-AH association did not attain significance, the left and right arcuate fasciculus associations were not significantly different. Conclusions Despite overall normal gFA in FEP, AH severity was significantly related to gFA in transcallosal auditory fibers and the left hemisphere connection between Broca’s and Wernicke’s areas. Other bilateral tracts’ gFA were weakly associated with AH. At the first psychotic episode, AH are more robustly associated with left hemisphere arcuate fasciculus and interhemispheric auditory fibers microstructural deficits, likely reflecting mistiming of information flow between language-related cortical centers.

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