scholarly journals Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar disorder type I, type II, unaffected siblings and healthy controls

2018 ◽  
Vol 213 (3) ◽  
pp. 548-554 ◽  
Author(s):  
Sonya F. Foley ◽  
Matthew Bracher-Smith ◽  
Katherine E. Tansey ◽  
Judith R. Harrison ◽  
Greg D. Parker ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Fractional Anisotropy ◽  
Type I ◽  
Healthy Controls ◽  
Type Ii ◽  
Uncinate Fasciculus ◽  
Polygenic Risk ◽  
The Right ◽  
Main Effects ◽  
Disorder Type

BackgroundFractional anisotropy in the uncinate fasciculus and the cingulum may be biomarkers for bipolar disorder and may even be distinctly affected in different subtypes of bipolar disorder, an area in need of further research.AimsThis study aims to establish if fractional anisotropy in the uncinate fasciculus and cingulum shows differences between healthy controls, patients with bipolar disorder type I (BD-I) and type II (BD-II), and their unaffected siblings.MethodFractional anisotropy measures from the uncinate fasciculus, cingulum body and parahippocampal cingulum were compared with tractography methods in 40 healthy controls, 32 patients with BD-I, 34 patients with BD-II, 17 siblings of patients with BD-I and 14 siblings of patients with BD-II.ResultsThe main effects were found in both the right and left uncinate fasciculus, with patients with BD-I showing significantly lower fractional anisotropy than both patients with BD-II and healthy controls. Participants with BD-II did not differ from healthy controls. Siblings showed similar effects in the left uncinate fasciculus. In a subsequent complementary analysis, we investigated the association between fractional anisotropy in the uncinate fasciculus and polygenic risk for bipolar disorder and psychosis in a large cohort (n= 570) of healthy participants. However, we found no significant association.ConclusionsFractional anisotropy in the uncinate fasciculus differs significantly between patients with BD-I and patients with BD-II and healthy controls. This supports the hypothesis of differences in the physiological sub-tract between bipolar disorder subtypes. Similar results were found in unaffected siblings, suggesting the potential for this biomarker to represent an endophenotype for BD-I. However, fractional anisotropy in the uncinate fasciculus seems unrelated to polygenic risk for bipolar disorder or psychosis.Declaration of interestNone.

Impulsivity and Brain Volume in Patients with Bipolar Disorder type I and Bipolar Disorder Type II

2017 ◽  
Vol 41 (S1) ◽  
pp. S75-S75
Author(s):  
D. Janiri ◽  
G. Giuseppin ◽  
E. Spinazzola ◽  
M. Maggiora ◽  
G. Sani
Keyword(s):  
Bipolar Disorder ◽  
Negative Relationship ◽  
Statistical Parametric Mapping ◽  
Angular Gyrus ◽  
Type I ◽  
Type Ii ◽  
Brain Volumes ◽  
Competing Interest ◽  
The Right ◽  
Disorder Type

IntroductionImpulsivity is a key feature of both bipolar disorder (BD) type I (BDI) and type II (BDII).ObjectiveStructural neuroimaging studies help clarifying brain mechanisms underpinning the regulation of impulsivity in BDI and BDII.AimsTo address the question whether grey matter (GM) alterations relate differently with impulsivity in BDI and BDII.MethodsWe assessed 54 euthymic outpatients, diagnosed with BDI (n = 28) or BDII (n = 26) according to DSM-IV-TR criteria. They underwent a 3 T magnetic resonance imaging (MRI) investigation. GM brain volumes were analyzed on a voxel-by-voxel basis using Statistical Parametric Mapping 8. The Barratt Impulsiveness Scale (BIS), version 11A, was used to assess trait impulsivity.ResultsBDI and BDII patients present an inverse relationship between impulsivity and GM volume in two cerebral areas: the right cerebellum (right crus I) and the interface between the left angular gyrus and the left inferior parietal cortex (Brodmann Area 39, 7, 40). More specifically, a negative relationship for BPI and a positive relationship for BPII were found in both areas.ConclusionsResults suggest that the different diagnosis between BDI and BDII could have a significant effect on GM changes according to impulsivity severity and point up the importance of considering the BP subtype distinction in neuroimaging studies on this topic.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals P300 component in euthymic patients with bipolar disorder type I, bipolar disorder type II and healthy controls

Neuroreport ◽  
2015 ◽  
Vol 26 (4) ◽  
pp. 206-210 ◽  
Author(s):  
Francesco S. Bersani ◽  
Amedeo Minichino ◽  
Francesco Fattapposta ◽  
Daniela Mannarelli ◽  
Caterina Pauletti ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Type I ◽  
Healthy Controls ◽  
Type Ii ◽  
P300 Component ◽  
Disorder Type

scholarly journals Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II

2012 ◽  
Vol 53 (7) ◽  
pp. 775-781 ◽  
Author(s):  
Lindsay S. Schenkel ◽  
Amy E. West ◽  
Rachel Jacobs ◽  
John A. Sweeney ◽  
Mani N. Pavuluri
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Dysfunction ◽  
Pediatric Patients ◽  
Type I ◽  
Type Ii ◽  
Disorder Type

Childhood traumatic experiences of patients with bipolar disorder type I and type II

2015 ◽  
Vol 175 ◽  
pp. 92-97 ◽  
Author(s):  
Delfina Janiri ◽  
Gabriele Sani ◽  
Emanuela Danese ◽  
Alessio Simonetti ◽  
Elisa Ambrosi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Traumatic Experiences ◽  
Type I ◽  
Type Ii ◽  
Disorder Type

scholarly journals White matter abnormalities in adults with bipolar disorder type-II and unipolar depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna Manelis ◽  
Adriane Soehner ◽  
Yaroslav O. Halchenko ◽  
Skye Satz ◽  
Rachel Ragozzino ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Anterior Part ◽  
Mean Diffusivity ◽  
Unipolar Depression ◽  
Type Ii ◽  
White Matter Abnormalities ◽  
White Matter Microstructure ◽  
The Right ◽  
Disorder Type

AbstractDiscerning distinct neurobiological characteristics of related mood disorders such as bipolar disorder type-II (BD-II) and unipolar depression (UD) is challenging due to overlapping symptoms and patterns of disruption in brain regions. More than 60% of individuals with UD experience subthreshold hypomanic symptoms such as elevated mood, irritability, and increased activity. Previous studies linked bipolar disorder to widespread white matter abnormalities. However, no published work has compared white matter microstructure in individuals with BD-II vs. UD vs. healthy controls (HC), or examined the relationship between spectrum (dimensional) measures of hypomania and white matter microstructure across those individuals. This study aimed to examine fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD) across BD-II, UD, and HC groups in the white matter tracts identified by the XTRACT tool in FSL. Individuals with BD-II (n = 18), UD (n = 23), and HC (n = 24) underwent Diffusion Weighted Imaging. The categorical approach revealed decreased FA and increased RD in BD-II and UD vs. HC across multiple tracts. While BD-II had significantly lower FA and higher RD values than UD in the anterior part of the left arcuate fasciculus, UD had significantly lower FA and higher RD values than BD-II in the area of intersections between the right arcuate, inferior fronto-occipital and uncinate fasciculi and forceps minor. The dimensional approach revealed the depression-by-spectrum mania interaction effect on the FA, RD, and AD values in the area of intersection between the right posterior arcuate and middle longitudinal fasciculi. We propose that the white matter microstructure in these tracts reflects a unique pathophysiologic signature and compensatory mechanisms distinguishing BD-II from UD.

scholarly journals Low frequency of bipolar disorder, dopamine dysregulation syndrome, and punding in Brazilian patients with Parkinson's disease

2010 ◽  
Vol 32 (1) ◽  
pp. 62-65 ◽  
Author(s):  
Arthur Kummer ◽  
Fernando M. V. Dias ◽  
Francisco Cardoso ◽  
Antonio L. Teixeira
Keyword(s):  
Parkinson’S Disease ◽  
Bipolar Disorder ◽  
Parkinson's Disease ◽  
Disease Onset ◽  
Low Frequency ◽  
Type I ◽  
Type Ii ◽  
Psychiatric Examination ◽  
Dopamine Dysregulation Syndrome ◽  
Disorder Type

OBJECTIVE: To investigate the frequency of bipolar disorder, dopamine dysregulation syndrome and punding in Parkinson's disease patients from a Brazilian movement disorders clinic. METHOD: One hundred patients underwent a comprehensive psychiatric examination composed of MINI-plus and specific questionnaires to investigate dopamine dysregulation syndrome and punding. RESULTS: We identified, respectively, one and five Parkinson's disease patients with bipolar disorder type I and type II. All manic/hypomanic episodes occurred before Parkinson's disease onset. No patient was identified with dopamine dysregulation syndrome or punding. CONCLUSION: The frequency of manic/hypomanic episodes seems to decrease with Parkinson's disease onset, and local environmental factors (e.g. drug availability) may be responsible for the low frequency of dopamine dysregulation syndrome and punding in Brazilian Parkinson's disease patients.

Mood instability in bipolar disorder type I versus type II-continuous daily electronic self-monitoring of illness activity using smartphones

2015 ◽  
Vol 186 ◽  
pp. 342-349 ◽  
Author(s):  
Maria Faurholt-Jepsen ◽  
Christian Ritz ◽  
Mads Frost ◽  
Rie Lambæk Mikkelsen ◽  
Ellen Margrethe Christensen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Type I ◽  
Type Ii ◽  
Self Monitoring ◽  
Mood Instability ◽  
Disorder Type

Affective and non-affective cognition in patients with bipolar disorder type I and type II in full or partial remission: Associations with familial risk

2021 ◽  
Vol 283 ◽  
pp. 207-215
Author(s):  
Mette Bagge Jensen ◽  
Hanne Lie Kjærstad ◽  
Klara Coello ◽  
Sharleny Stanislaus ◽  
Sigurd Melbye ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Partial Remission ◽  
Familial Risk ◽  
Type I ◽  
Type Ii ◽  
Disorder Type

scholarly journals Neurocognition in Unaffected First-Degree Relatives of Patients With Bipolar Disorder Type I From India

SAGE Open ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. 215824401143635 ◽  
Author(s):  
Raman Deep Pattanayak ◽  
Rajesh Sagar ◽  
Manju Mehta
Keyword(s):  
Bipolar Disorder ◽  
Verbal Memory ◽  
Formal Education ◽  
Type I ◽  
Trail Making Test ◽  
Healthy Controls ◽  
Cross Sectional ◽  
First Degree Relatives ◽  
Trail Making ◽  
Disorder Type

The study aims to evaluate the neuropsychological functions of unaffected first-degree relatives of patients with bipolar disorder Type I (BD-I) in comparison with healthy controls. The method was a cross-sectional assessment of 20 first-degree relatives of patients with BD-I and 20 healthy controls. Inclusion criteria for all participants included age between 18 and 55 years, ≥5 years of formal education, right-handedness as per Edinburgh handedness inventory, absence of color blindness as per Ishihara’s isochromatic charts, and a score of >24 on Hindi mental state examination. None of the participants had a current or lifetime diagnosis of a mental disorder on Structured Clinical Interview for DSM-IV, Clinician Version. Neuropsychological assessment was conducted with Trail Making Test A and B, Stroop color and word test, N-Back Verbal Memory Test, and Post Graduate Institute (PGI) Memory Scale. Both the groups were comparable in age, gender distribution, and education. The unaffected first-degree relatives performed poorly on Trail Making Test B and (B-A), indicating a poor cognitive flexibility and set-shifting. The relative group also performed poorly on Mental Balance subtest of PGI Memory Scale. The unaffected first-degree relatives of patients with BD display certain impairments in dorsal prefrontal executive functions which can serve as vulnerability markers for BD.

Sign in / Sign up

Export Citation Format

Share Document