Low frequency of bipolar disorder, dopamine dysregulation syndrome, and punding in Brazilian patients with Parkinson's disease

OBJECTIVE: To investigate the frequency of bipolar disorder, dopamine dysregulation syndrome and punding in Parkinson's disease patients from a Brazilian movement disorders clinic. METHOD: One hundred patients underwent a comprehensive psychiatric examination composed of MINI-plus and specific questionnaires to investigate dopamine dysregulation syndrome and punding. RESULTS: We identified, respectively, one and five Parkinson's disease patients with bipolar disorder type I and type II. All manic/hypomanic episodes occurred before Parkinson's disease onset. No patient was identified with dopamine dysregulation syndrome or punding. CONCLUSION: The frequency of manic/hypomanic episodes seems to decrease with Parkinson's disease onset, and local environmental factors (e.g. drug availability) may be responsible for the low frequency of dopamine dysregulation syndrome and punding in Brazilian Parkinson's disease patients.

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Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II

Journal of Child Psychology and Psychiatry ◽

10.1111/j.1469-7610.2011.02519.x ◽

2012 ◽

Vol 53 (7) ◽

pp. 775-781 ◽

Cited By ~ 12

Author(s):

Lindsay S. Schenkel ◽

Amy E. West ◽

Rachel Jacobs ◽

John A. Sweeney ◽

Mani N. Pavuluri

Keyword(s):

Bipolar Disorder ◽

Cognitive Dysfunction ◽

Pediatric Patients ◽

Type I ◽

Type Ii ◽

Disorder Type

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Childhood traumatic experiences of patients with bipolar disorder type I and type II

Journal of Affective Disorders ◽

10.1016/j.jad.2014.12.055 ◽

2015 ◽

Vol 175 ◽

pp. 92-97 ◽

Cited By ~ 39

Author(s):

Delfina Janiri ◽

Gabriele Sani ◽

Emanuela Danese ◽

Alessio Simonetti ◽

Elisa Ambrosi ◽

...

Keyword(s):

Bipolar Disorder ◽

Traumatic Experiences ◽

Type I ◽

Type Ii ◽

Disorder Type

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Impulsivity and Brain Volume in Patients with Bipolar Disorder type I and Bipolar Disorder Type II

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.241 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S75-S75

Author(s):

D. Janiri ◽

G. Giuseppin ◽

E. Spinazzola ◽

M. Maggiora ◽

G. Sani

Keyword(s):

Bipolar Disorder ◽

Negative Relationship ◽

Statistical Parametric Mapping ◽

Angular Gyrus ◽

Type I ◽

Type Ii ◽

Brain Volumes ◽

Competing Interest ◽

The Right ◽

Disorder Type

IntroductionImpulsivity is a key feature of both bipolar disorder (BD) type I (BDI) and type II (BDII).ObjectiveStructural neuroimaging studies help clarifying brain mechanisms underpinning the regulation of impulsivity in BDI and BDII.AimsTo address the question whether grey matter (GM) alterations relate differently with impulsivity in BDI and BDII.MethodsWe assessed 54 euthymic outpatients, diagnosed with BDI (n = 28) or BDII (n = 26) according to DSM-IV-TR criteria. They underwent a 3 T magnetic resonance imaging (MRI) investigation. GM brain volumes were analyzed on a voxel-by-voxel basis using Statistical Parametric Mapping 8. The Barratt Impulsiveness Scale (BIS), version 11A, was used to assess trait impulsivity.ResultsBDI and BDII patients present an inverse relationship between impulsivity and GM volume in two cerebral areas: the right cerebellum (right crus I) and the interface between the left angular gyrus and the left inferior parietal cortex (Brodmann Area 39, 7, 40). More specifically, a negative relationship for BPI and a positive relationship for BPII were found in both areas.ConclusionsResults suggest that the different diagnosis between BDI and BDII could have a significant effect on GM changes according to impulsivity severity and point up the importance of considering the BP subtype distinction in neuroimaging studies on this topic.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar disorder type I, type II, unaffected siblings and healthy controls

The British Journal of Psychiatry ◽

10.1192/bjp.2018.101 ◽

2018 ◽

Vol 213 (3) ◽

pp. 548-554 ◽

Cited By ~ 8

Author(s):

Sonya F. Foley ◽

Matthew Bracher-Smith ◽

Katherine E. Tansey ◽

Judith R. Harrison ◽

Greg D. Parker ◽

...

Keyword(s):

Bipolar Disorder ◽

Fractional Anisotropy ◽

Type I ◽

Healthy Controls ◽

Type Ii ◽

Uncinate Fasciculus ◽

Polygenic Risk ◽

The Right ◽

Main Effects ◽

Disorder Type

BackgroundFractional anisotropy in the uncinate fasciculus and the cingulum may be biomarkers for bipolar disorder and may even be distinctly affected in different subtypes of bipolar disorder, an area in need of further research.AimsThis study aims to establish if fractional anisotropy in the uncinate fasciculus and cingulum shows differences between healthy controls, patients with bipolar disorder type I (BD-I) and type II (BD-II), and their unaffected siblings.MethodFractional anisotropy measures from the uncinate fasciculus, cingulum body and parahippocampal cingulum were compared with tractography methods in 40 healthy controls, 32 patients with BD-I, 34 patients with BD-II, 17 siblings of patients with BD-I and 14 siblings of patients with BD-II.ResultsThe main effects were found in both the right and left uncinate fasciculus, with patients with BD-I showing significantly lower fractional anisotropy than both patients with BD-II and healthy controls. Participants with BD-II did not differ from healthy controls. Siblings showed similar effects in the left uncinate fasciculus. In a subsequent complementary analysis, we investigated the association between fractional anisotropy in the uncinate fasciculus and polygenic risk for bipolar disorder and psychosis in a large cohort (n= 570) of healthy participants. However, we found no significant association.ConclusionsFractional anisotropy in the uncinate fasciculus differs significantly between patients with BD-I and patients with BD-II and healthy controls. This supports the hypothesis of differences in the physiological sub-tract between bipolar disorder subtypes. Similar results were found in unaffected siblings, suggesting the potential for this biomarker to represent an endophenotype for BD-I. However, fractional anisotropy in the uncinate fasciculus seems unrelated to polygenic risk for bipolar disorder or psychosis.Declaration of interestNone.

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Novel, high-intensity exercise prescription improves muscle mass, mitochondrial function, and physical capacity in individuals with Parkinson's disease

Journal of Applied Physiology ◽

10.1152/japplphysiol.01277.2013 ◽

2014 ◽

Vol 116 (5) ◽

pp. 582-592 ◽

Cited By ~ 47

Author(s):

Neil A. Kelly ◽

Matthew P. Ford ◽

David G. Standaert ◽

Ray L. Watts ◽

C. Scott Bickel ◽

...

Keyword(s):

Skeletal Muscle ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Exercise Training ◽

Muscle Tissue ◽

High Intensity ◽

Physical Capacity ◽

High Intensity Exercise ◽

Type I ◽

Type Ii

We conducted, in persons with Parkinson's disease (PD), a thorough assessment of neuromotor function and performance in conjunction with phenotypic analyses of skeletal muscle tissue, and further tested the adaptability of PD muscle to high-intensity exercise training. Fifteen participants with PD (Hoehn and Yahr stage 2–3) completed 16 wk of high-intensity exercise training designed to simultaneously challenge strength, power, endurance, balance, and mobility function. Skeletal muscle adaptations ( P < 0.05) to exercise training in PD included myofiber hypertrophy (type I: +14%, type II: +36%), shift to less fatigable myofiber type profile, and increased mitochondrial complex activity in both subsarcolemmal and intermyofibrillar fractions (I: +45–56%, IV: +39–54%). These adaptations were accompanied by a host of functional and clinical improvements ( P < 0.05): total body strength (+30–56%); leg power (+42%); single leg balance (+34%); sit-to-stand motor unit activation requirement (−30%); 6-min walk (+43 m), Parkinson's Disease Quality of Life Scale (PDQ-39, −7.8pts); Unified Parkinson's Disease Rating Scale (UPDRS) total (−5.7 pts) and motor (−2.7 pts); and fatigue severity (−17%). Additionally, PD subjects in the pretraining state were compared with a group of matched, non-PD controls (CON; did not exercise). A combined assessment of muscle tissue phenotype and neuromuscular function revealed a higher distribution and larger cross-sectional area of type I myofibers and greater type II myofiber size heterogeneity in PD vs. CON ( P < 0.05). In conclusion, persons with moderately advanced PD adapt to high-intensity exercise training with favorable changes in skeletal muscle at the cellular and subcellular levels that are associated with improvements in motor function, physical capacity, and fatigue perception.

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