scholarly journals Role of cardiometabolic risk in the association between accumulation of affective symptoms across adulthood and mid-life cognitive function: national cohort study

2020 ◽  
pp. 1-7
Author(s):  
Amber John ◽  
Roopal Desai ◽  
Marcus Richards ◽  
Darya Gaysina ◽  
Joshua Stott
Keyword(s):  
Cognitive Function ◽  
Sex Education ◽  
Verbal Fluency ◽  
Cardiometabolic Risk ◽  
Later Life ◽  
Information Processing Speed ◽  
Immediate Memory ◽  
Affective Symptoms ◽  
Path Models

Background Affective symptoms are associated with cognition in mid-life and later life. However, the role of cardiometabolic risk in this association has not been previously examined. Aims To investigate how cardiometabolic risk contributes to associations between affective symptoms and mid-life cognition. Method Data were used from the National Child Development Study (NCDS), a sample of people born in Britain during one week in 1958. Measures of immediate and delayed memory, verbal fluency and information processing speed and accuracy were available at age 50. Affective symptoms were assessed at ages 23, 33 and 42 years and a measure of accumulation was derived. A cardiometabolic risk score was calculated from nine cardiometabolic biomarkers at age 44. Path models were run to test these associations, adjusting for sex, education, socioeconomic position and affective symptoms at age 50. Results After accounting for missing data using multiple imputation, path models indicated significant indirect associations between affective symptoms and mid-life immediate memory (β = −0.002, s.e. = 0.001, P = 0.009), delayed memory (β = −0.002, s.e. = 0.001, P = 0.02) and verbal fluency (β = −0.002, s.e. = 0.001, P = 0.045) through cardiometabolic risk. Conclusions These findings suggest that cardiometabolic risk may play an important role in the association between affective symptoms and cognitive function (memory and verbal fluency). Results contribute to understanding of biological mechanisms underlying associations between affective symptoms and cognitive ageing, which can have implications for early detection of, and intervention for, those at risk of poorer cognitive outcomes.

scholarly journals The role of cardiometabolic risk in the association between accumulation of affective symptoms across adulthood and midlife cognitive function

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Amber John ◽  
Roopal Desai ◽  
Marcus Richards ◽  
Darya Gaysina ◽  
Joshua Stott
Keyword(s):  
Cognitive Function ◽  
Cardiometabolic Risk ◽  
Affective Symptoms

scholarly journals Longitudinal associations of affective symptoms with mid-life cognitive function: evidence from a British birth cohort

2019 ◽  
Vol 215 (5) ◽  
pp. 675-682 ◽  
Author(s):  
Amber John ◽  
Sarah-Naomi James ◽  
Urvisha Patel ◽  
Jennifer Rusted ◽  
Marcus Richards ◽  
...  
Keyword(s):  
Information Processing ◽  
Cognitive Function ◽  
Processing Speed ◽  
Verbal Fluency ◽  
Sensitive Period ◽  
Information Processing Speed ◽  
Longitudinal Trajectories ◽  
Affective Symptoms ◽  
Processing Accuracy ◽  
Longitudinal Associations

BackgroundAffective disorders are associated with poorer cognition in older adults; however, whether this association can already be observed in mid-life remains unclear.AimsTo investigate the effects of affective symptoms over a period of 30 years on mid-life cognitive function. First, we explored whether timing (sensitive period) or persistence (accumulation) of affective symptoms predicted cognitive function. Second, we tested how different longitudinal trajectories of affective symptoms were associated with cognitive function.MethodThe study used data from the National Child Development Study. Memory, verbal fluency, information processing speed and accuracy were measured at age 50. Affective symptoms were measured at ages 23, 33, 42 and 50 and used to derive longitudinal trajectories. A structured modelling approach compared a set of nested models in order to test accumulation versus sensitive period hypotheses. Linear regressions and structural equation modelling were used to test for longitudinal associations of affective symptoms with cognitive function.ResultsAccumulation of affective symptoms was found to be the best fit for the data, with persistent affective symptoms being associated with poorer immediate memory (b = −0.07, s.e. = 0.03, P = 0.01), delayed memory (b = −0.13, s.e. = 0.04, P < 0.001) and information processing accuracy (b = 0.18, s.e. = 0.08, P = 0.03), but not with information processing speed (b = 3.15, s.e. = 1.89, P = 0.10). Longitudinal trajectories of repeated affective symptoms were associated with poorer memory, verbal fluency and information processing accuracy.ConclusionsPersistent affective symptoms can affect cognitive function in mid-life. Effective management of affective disorders to prevent recurrence may reduce risk of poor cognitive outcomes and promote healthy cognitive ageing.Declaration of interestNone.

Early Child–Parent Relationship Quality and Cognitive Function in Older Rural Chinese Adults: The Mediating Role of Educational Attainment

2021 ◽  
pp. 089826432199656
Author(s):  
Changmin Peng ◽  
Jeffrey A. Burr ◽  
Dong Yang ◽  
Nan Lu
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Educational Attainment ◽  
Relationship Quality ◽  
Later Life ◽  
Life Course Perspective ◽  
Early Child ◽  
Mediating Role ◽  
Parent Relationship

Objectives: Framed within a life course perspective and cognitive reserve theory, this study examined the mediating role of educational attainment for the association between child–parent relationships during childhood and cognitive function among older adults in rural China. Methods: Data were obtained from three waves of the China Health and Retirement Longitudinal Study ( N = 9809). We employed latent growth curve modeling to test the association among early child–parent relationship quality, educational attainment, and cognitive function in later life. Results: Early child–mother relationship quality was associated with the level and change in cognitive function. Early child–father relationship quality was only related to baseline cognitive function. Educational attainment mediated the relationship between early child–parent relationship quality with mothers and fathers and cognitive function. Discussion: Parental relationship experience in childhood was one distal factor related to cognitive function among older adults. The findings supported the long-term impacts of childhood conditions for later life health consequences.

scholarly journals Learning in Later Life: The Perspective of Successful Ageing

2015 ◽  
Vol 12 (1) ◽  
pp. 11-23
Author(s):  
Salomėja Šatienė
Keyword(s):  
Adult Education ◽  
Cognitive Function ◽  
Older Adult ◽  
Personal Growth ◽  
Positive Impact ◽  
Later Life ◽  
Psychological Resources ◽  
Successful Ageing ◽  
Older Adult Education

Abstract The integrated approach to the development of educational theory of later life learning should be informed by comprehensive knowledge of ageing as a social construct. Establishment of the role of later life learning in the context of successful ageing paradigm encompasses both sociological and educational perspectives taking into consideration the complexity of older people’s engagement in society and participation in education with regard to social use for the learning outcomes and personal growth. In the context of successful ageing, it should provide the answers to the questions related to the meaning and role of learning in later life. The present research aims to explore the role of learning in the construct of successful ageing and to analyze the characteristic features of non-formal later life learning in Lithuania in the perspective of successful ageing based on the review some recent literature on psychological and social aspects of successful ageing and older adult education and research in the fields of educational and psychosocial gerontology. It pursues answers to the questions as to “How can learning in later life contribute to successful ageing? What are the implications for the role of learning in the models of successful ageing? How is the role of third-age learning conceptualized in the perspective of successful ageing?” The answers to these questions provide better insight into the conceptual background of older adult education and suggests prospective research on the issue of the role of learning in older age. The multidimensional nature of the concept of successful ageing revealed by the literature review suggests that the role of learning in the construct of successful ageing is analyzable in relationship with health, psychological and social domains. The role of learning in later life is manifested through its impact on maintenance of cognitive function, psychological resources and social functioning. The positive impact of learning in later life on mental health through maintenance of cognitive function and the utilization of psychological resources through stimulation of personal growth and self-efficacy of older adult learners has been supported by findings of many recent studies. Education has been identified as one of the predictors of active engagement with life as an essential component of successful ageing.

Cardiometabolic Risk and Cognitive Decline: The Role of Socioeconomic Status in Childhood and Adulthood

2019 ◽  
Vol 60 (3) ◽  
pp. 326-343 ◽  
Author(s):  
Katsuya Oi ◽  
Steven Haas
Keyword(s):  
Socioeconomic Status ◽  
Cognitive Decline ◽  
Cardiometabolic Risk ◽  
Later Life ◽  
Socioeconomic Attainment ◽  
Childhood Socioeconomic Status ◽  
Using Data ◽  
The Impact ◽  
Retirement Study

Socioeconomic conditions in childhood predict cognitive functioning in later life. It is unclear whether poor childhood socioeconomic status (SES) also predicts the acceleration of cognitive decline. One proposed pathway is via cardiometabolic risk, which has been linked to both childhood SES and earlier onset of cognitive impairment. Using data from the Health and Retirement Study, we examine the impact of childhood SES on cognitive trajectories over six years and test whether it operates through increased cardiometabolic risk and adult SES. We find that higher childhood SES leads to slower cognitive decline, partially due to lower levels of cardiometabolic risk. However, these pathways operate entirely through adult socioeconomic attainment. The results have important implications for future trends in cognitive population health within the context of growing social inequality and reduced social mobility.

scholarly journals Does Education Moderate the Relationship between Social Capital and Cognitive Function among Older Adults? Evidence from Suzhou City, China

2020 ◽  
Vol 17 (18) ◽  
pp. 6560
Author(s):  
Jingyue Zhang ◽  
Nan Lu ◽  
Wenxiu Wang
Keyword(s):  
Older Adults ◽  
Social Capital ◽  
Cognitive Function ◽  
Group Analysis ◽  
Later Life ◽  
Multiple Group ◽  
Education Group ◽  
Quota Sampling ◽  
The Relationship

While social capital is recognized as an important protective determinant of cognitive function in later life, there is a lack of research examining the potential moderators and mediators in the mechanisms linking social capital to cognitive function. This study investigated the moderating role of education on the relationship between social capital and cognitive function among older adults in urban Chinese communities. Data were derived from a community survey conducted in Suzhou, Jiangsu Province, China, in late 2015. A quota sampling method was applied to recruit respondents aged 60 years or older from 16 communities in the Gusu district. The final analytic sample size was 446. Multiple group analysis was applied to test the proposed model. The results show that cognitive social capital was significantly associated with cognitive function in the high education group only. Structural social capital was not significantly associated with cognitive function. The findings highlight the important role of social capital in influencing cognitive function in later life. Social capital interventions could be particularly useful as a preventive approach to help older adults sustain their cognitive function levels. Policy and intervention implications are discussed.

Abstract WMP115: The Metabolic Syndrome Components and Cognitive Decline: The Atherosclerosis Risk in Communities (ARIC) Study

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Jennifer L Dearborn ◽  
David Knopman ◽  
Richey Sharrett ◽  
Andrea L Schneider ◽  
Clifford Jack ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Sex Education ◽  
Later Life ◽  
Cognitive Change ◽  
Word Recall ◽  
Digit Symbol Substitution Test ◽  
The Metabolic Syndrome ◽  
Aric Study

Background: Midlife obesity is associated with dementia in later life, but how the metabolic syndrome (MetS) relates to cognitive change is less understood. We hypothesized that MetS would be more predictive of 6-year cognitive decline than its individual components in a large biethnic cohort (the ARIC study) and that combinations of risk factors would further increase likelihood of change. Methods: The MetS was defined in 1987-89 on 10,687 participants with two cognitive assessments at two time points. In subjects aged 44 to 66, obesity measures included body mass index (BMI) and waist-to-hip ratio (WTHR). The main outcome measure was change in 1990-92 to 96-99 of three cognitive tests: Delayed Word Recall (DWR), Digit Symbol Substitution Test (DSST), and Word Fluency Test (WFT). Linear and logistic regressions were all adjusted for age, combined race-center, sex, education, smoking, drinking, coronary artery disease and prior stroke. Change was measured as the difference divided by the number of years between visits. Results: At baseline, the prevalence of MetS was 22% (mean age 54 years, 27% black, 55% female, and 28% BMI>30 kg/m2). Subjects with MetS performed in the lowest test quintile (adjusted ORs: DWR 1.3 95% CI 1.1-1.4) in 1996-99, and much of this effect size was explained by an elevated WTHR (DWR OR 1.3 CI 1.1-1.5) and diabetes (DWR OR 1.4 CI 1.2-1.7). MetS was not associated with annual cognitive change, and diabetes was the only significant component associated with change (adjusted beta: DWR 0.03 p=.01, DSST 0.2 p<.001, WFT 0.09 p=.01). Conclusion: MetS at ages 44 to 66 was associated with worse cognitive function at follow-up, but not with annual cognitive decline over several years. Elevated WTHR and diabetes explained most of the association of MetS with cognitive function measures, and diabetes with cognitive decline. Until we have a definition of the MetS more based on pathophysiology, the components of the MetS should be the focus of analysis in future studies.

scholarly journals Pet ownership and cognitive decline in older people

2019 ◽  
Vol 5 (2) ◽  
Author(s):  
Nicola Veronese ◽  
Lee Smith ◽  
Vania Noventa ◽  
Guillermo F. López-Sánchez ◽  
Jacopo Demurtas ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Verbal Fluency ◽  
Later Life ◽  
Positive Influence ◽  
Pet Ownership ◽  
Cross Sectional ◽  
Positive Effects ◽  
Significant Difference ◽  
Dog Owners

Animals can have a positive influence on human health. However, it is not yet known whether pet ownership can prevent cognitive decline. Therefore, we aimed to investigate cross-sectional and prospective associations between pet ownership and cognitive function in a large, representative sample of older adults. Data were from the English Longitudinal Study of Ageing (ELSA) using data collected in wave 5 and six years later in wave 8. Pet ownership was categorized as no pet, dog, cat or other pet. Cognitive function was assessed using tests of verbal fluency (assessed by asking how many different animals the participants could name in 60 seconds) and memory (sum of immediate and delayed verbal recall). Multiple linear regression, adjusted for potential confounders, was used to test the associations between pet ownership and cognitive function. A total of 8291 people (mean age: 66.72 years) were included. In cross-sectional analyses, dog owners had better verbal fluency than individuals with no pet, but there was no significant difference between cat or other pet owners and those with no pet. In prospective analyses, dog owners had a significantly larger decline in recall than those with no pet, whilst cat owners had a significantly smaller decline in verbal fluency. These results provide some evidence to suggest that pet ownership may have positive effects on cognition in later life. However, benefits of pet ownership were not unilaterally observed across different types of pet and measures of cognitive function suggesting that further research is required.

scholarly journals Accumulation of affective symptoms and midlife cognitive function: The role of inflammation

2020 ◽  
Vol 84 ◽  
pp. 164-172 ◽  
Author(s):  
Amber John ◽  
Jennifer Rusted ◽  
Marcus Richards ◽  
Darya Gaysina
Keyword(s):  
Cognitive Function ◽  
Affective Symptoms
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