scholarly journals Relationship between white matter integrity and serum cortisol levels in drug-naive patients with major depressive disorder: Diffusion tensor imaging study using tract-based spatial statistics

2016 ◽  
Vol 208 (6) ◽  
pp. 585-590 ◽  
Author(s):  
Xiaodan Liu ◽  
Keita Watanabe ◽  
Shingo Kakeda ◽  
Reiji Yoshimura ◽  
Osamu Abe ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Diffusion Tensor ◽  
Serum Cortisol ◽  
White Matter Integrity ◽  
Uncinate Fasciculus ◽  
Major Depressive ◽  
Drug Naïve ◽  
Cortisol Levels ◽  
Anterior Thalamic Radiation

BackgroundHigher daytime cortisol levels because of a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). The elevated glucocorticoids inhibit the proliferation of the oligodendrocytes that are responsible for myelinating the axons of white matter fibre tracts.AimsTo evaluate the relationship between white matter integrity and serum cortisol levels during a first depressive episode in drug-naive patients with MDD (MDD group) using a tract-based spatial statistics (TBSS) method.MethodThe MDD group (n = 29) and a healthy control group (n = 47) underwent diffusion tensor imaging (DTI) scans and an analysis was conducted using TBSS. Morning blood samples were obtained from both groups for cortisol measurement.ResultsCompared with the controls, the MDD group had significantly reduced fractional anisotropy values (P<0.05, family-wise error (FWE)-corrected) in the inferior fronto-occipital fasciculus, uncinate fasciculus and anterior thalamic radiation. The fractional anisotropy values of the inferior fronto-occipital fasciculus, uncinate fasciculus and anterior thalamic radiation had significantly negative correlations with the serum cortisol levels in the MDD group (P<0.05, FWE-corrected).ConclusionsOur findings indicate that the elevated cortisol levels in the MDD group may injure the white matter integrity in the frontal–subcortical and frontal–limbic circuits.

Relationship between the hippocampal shape abnormality and serum cortisol levels in first-episode and drug-naïve major depressive disorder patients

2017 ◽  
Vol 34 (5) ◽  
pp. 401-409 ◽  
Author(s):  
Rieko Watanabe ◽  
Shingo Kakeda ◽  
Keita Watanabe ◽  
Xiaodan Liu ◽  
Asuka Katsuki ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serum Cortisol ◽  
First Episode ◽  
Major Depressive ◽  
Drug Naïve ◽  
Cortisol Levels

scholarly journals Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Ziwei Liu ◽  
Lijun Kang ◽  
Aixia Zhang ◽  
Chunxia Yang ◽  
Min Liu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Quality Indicators ◽  
Diffusion Tensor ◽  
Superior Longitudinal Fasciculus ◽  
Major Depressive ◽  
First Degree Relatives ◽  
Corticospinal Tracts ◽  
Anterior Thalamic Radiation

At present, the etiology and pathogenesis of major depressive disorder (MDD) are still not clear. Studies have found that the risk of first-degree relatives of MDD is 2–3 times that of the general population. Diffusion tensor imaging (DTI) has been previously used to explore the pathogenesis of MDD. The purpose of this study is to explore the etiology of MDD by DTI and further to explore the correlation between its clinical characteristics and the structural changes of white matter in the brain. The study included 27 first-episode, drug-naive patients with MDD, 16 first-degree relatives without MDD, and 28 healthy control subjects with no family history of MDD (HC). Results showed that the fractional anisotropy (FA) differences among the three groups were mainly in the left anterior thalamic radiation (LATR), right anterior thalamic radiation (RATR), left corticospinal tracts (LCST), forceps major (FMa), right inferior longitudinal fasciculus (RILF), and left superior longitudinal fasciculus (temporal) (LSLF(T)). Among the 6 sites, LCST, FMa, and LSLF(T) showed significant differences between MDD and First-degree relatives compared to HC. MDD patients had significant emotional symptoms, somatic symptoms, and cognitive impairment. FMa FA was significantly positively correlated with delayed memory score ( r = 0.43 , P = 0.031 ), and RILF FA was significantly negatively correlated with the FSS score ( r = − 0.42 , P = 0.028 ). These results revealed that the white matter characteristics of MDD-susceptible patients were LCST, FMa, and LSLF(T) lesions, all of which may be quality indicators of MDD.

scholarly journals Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
LeHoa Nguyen ◽  
Shingo Kakeda ◽  
Keita Watanabe ◽  
Asuka Katsuki ◽  
Koichiro Sugimoto ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serum Cortisol ◽  
Brain Morphology ◽  
Morphometric Study ◽  
First Episode ◽  
Major Depressive ◽  
Neuropsychiatric Diseases ◽  
Drug Naïve ◽  
Cortisol Levels

AbstractHigher cortisol levels due to a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). Increased cortisol levels change both the brain morphology and function in MDD patients. The multivariate source-based morphometry (SBM) technique has been applied to investigate neuroanatomical changes in some neuropsychiatric diseases, but not MDD. We aimed to examine the alterations in gray matter (GM) networks and their relationship with serum cortisol levels in first-episode, drug-naïve MDD patients using SBM. Forty-two patients with MDD and 39 controls were recruited via interviews. Morning serum cortisol levels were measured, and high-resolution T1-weighted imaging followed by SBM analysis was performed in all participants. The patients had significantly higher serum cortisol levels than the controls. We found two GM sources, which were significantly different between patients with MDD and controls (prefrontal network, p < .01; insula-temporal network, p < .01). Serum cortisol levels showed a statistically significant negative correlation with the loading coefficients of the prefrontal network (r = − 0.354, p = 0.02). In conclusion, increased serum cortisol levels were associated with reductions in the prefrontal network in the early stage of MDD, and SBM may be a useful approach for analyzing structural MRI data.

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