Subclinical cardiac toxicity and health-related quality of life (hql) in childhood cancer survivors

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 9018-9018
Author(s):  
C. L. Cox ◽  
S. N. Rai ◽  
D. Rosenthal ◽  
S. Phipps ◽  
M. M. Hudson
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Nyha Class ◽  
Cardiac Risk ◽  
Self Report ◽  
Health Related Quality ◽  
Cardiac Risk Factors ◽  
Related Quality ◽  
Health Related

9018 Background: Despite substantial information about late cardiotoxicity, little is known about its impact on the adolescent/young adult survivor's health-related quality of life (HQL). Using cross-sectional data, we assessed how HQL and New York Heart Association (NYHA) functional classification are related to survivors’ cardiac performance, cardiac risk factors, and treatment history. Methods: HQL indicators were examined in 164 long-term survivors of pediatric cancer (age 16–40 years), who had (n=132; 10 years (mean) after diagnosis of predominantly leukemia or lymphoma) or had not (n=32; 11 years (mean) after diagnosis of predominantly solid tumors) received anthracyclines and/or thoracic irradiation. Survivors underwent extensive noninvasive clinical and laboratory cardiac risk evaluation and completed a self-report questionnaire on selected subscales of the SF-36 (HQL). Results: Reported general health was lower in the cardiotoxic-therapy group (P = 0.05). Sex, current age, time since diagnosis, cardiac function, and cardiac risk factors were independent predictors of HQL subscales and NYHA class in multivariable analysis. Female sex and higher LDL cholesterol interacted to predict diminished reported vitality (P = 0.04) and physical health (P = 0.05) shown in table . Conclusions: Even in the absence of clinically evident cardiotoxicity, cardiac dysfunction and cardiac risk were strongly linked to decreased HQL and NYHA class, particularly among female survivors. Reduced HQL may be an indicator of unidentified sequelae that should be investigated and monitored. No significant financial relationships to disclose. [Table: see text]

The Vietnamese Version of the Health-related Quality of Life Measure for Children with Epilepsy (CHEQOL-25): Reliability

MedPharmRes ◽  
2017 ◽  
Vol 1 (1) ◽  
pp. 9-14
Author(s):  
Tri Doan ◽  
Tuan Tran ◽  
Han Nguyen ◽  
◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Good Practice ◽  
The Self ◽  
Self Report ◽  
Health Related Quality ◽  
Life Measure ◽  
Related Quality ◽  
Health Related ◽  
Parent Proxy

Purpose: This study aimed to translate and culturally adapt the self-report and parent-proxy Health-Related Quality of Life Measure for Children with Epilepsy (CHEQOL-25) into Vietnamese and to evaluate their reliability. Methods: Both English versions of the self-report and parent-proxy CHEQOL-25 were translated and culturally adapted into Vietnamese by using the Principles of Good Practice for the Translation and Cultural Adaptation Process. The Vietnamese versions were scored by 77 epileptic patients, who aged 8–15 years, and their parents/caregivers at neurology outpatient clinic of Children Hospital No. 2 – Ho Chi Minh City. Reliability of the questionnaires was determined by using Cronbach’s coefficient α and intra-class correlation coefficient (ICC). Results: Both Vietnamese versions of the self-report and parent-proxy CHEQOL-25 were shown to be consistent with the English ones, easy to understand for Vietnamese children and parents. Thus, no further modification was required. Cronbach’s α coefficient for each subscale of the Vietnamese version of the self-report and parent-proxy CHEQOL-25 was 0.65 to 0.86 and 0.83 to 0.86, respectively. The ICC for each subscale of the self-report and parent-proxy CHEQOL-25 was in the range of 0.61 to 0.86 and 0.77 to 0.98, respectively. Conclusion: The Vietnamese version of the self-report and parent-proxy CHEQOL-25 were the first questionnaires about quality of life of epileptic children in Vietnam. This Vietnamese version was shown to be reliable to assess the quality of life of children with epilepsy aged 8–15 years.

scholarly journals Risk factors and health related quality of life among adult patients of depression presenting at psychiatric OPD clinic of Aziz Fatima Medical College and Hospital Faisalabad.

2020 ◽  
Vol 27 (09) ◽  
pp. 1976-1982
Author(s):  
Subhan Ullah ◽  
Zubash Aslam ◽  
Ghulam Abbas Shiekh
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Depressive Disorder ◽  
Adult Patients ◽  
World Health ◽  
Health Related Quality ◽  
World Health Organization Quality ◽  
Related Quality ◽  
Health Related

Objectives: To determine the risk factors of depressive disorders and health related quality of life among adult patients of depression presenting at psychiatric OPD clinic of Aziz Fatima Hospital Faisalabad. Study Design: Cross-sectional study. Setting: Psychiatric OPD clinic of Aziz Fatima Hospital Faisalabad Pakistan. Period: 1st August 2019 to 31st December 2019. Material & Method: 150 patients for the screening of depression Patient Health Questionnaire (PHQ) was used. For measuring health related quality of life World Health Organization Quality of Life (WHOQOL-Brief) was used. Results: It was found that out of 150 patients with depressive disorder 104(69.3%) were female and 46(30.7%) were male patients. Findings of the study assessed that depressive disorder not only impacts on the patients' mood but it also impairs the individuals overall perception of their general health, physical health, psychological wellbeing, social relationship and also distorted perception of their surrounding psychosocial environment. Conclusion: Depressive disorder is common in patients visiting psychiatric OPD clinic and findings of study suggested that age, education level, socio-economic status, death of parent at early age, unemployment, workplace issues, parental separation, loss of partner and family history of depression are important demographic variables which plays the role of significant risk factor for depression and impairs the quality of life among depressive patients.

scholarly journals A history of health-related quality of life outcomes in psychiatry

2014 ◽  
Vol 16 (2) ◽  
pp. 127-135 ◽  
Keyword(s):  
Quality Of Life ◽  
Psychiatric Patients ◽  
Clinical Care ◽  
Self Report ◽  
Psychiatric Research ◽  
Health Related Quality ◽  
Patient Centered ◽  
Related Quality ◽  
Health Related

Health-related quality of life (HRQoL) is a multidimensional concept that includes subjective reports of symptoms, side effects, functioning in multiple life domains, and general perceptions of life satisfaction and quality. Rather than estimating it from external observations, interview, or clinical assessment, it is best measured by direct query. Due to a perception that respondents may not be reliable or credible, there has been some reluctance to use self-report outcomes in psychiatry. More recently, and increasingly, HRQoL assessment through direct patient query has become common when evaluating a range of psychiatric, psychological, and social therapies. With few exceptions, psychiatric patients are credible and reliable reporters of this information. This article summarizes studies that highlight the development, validation, and application of HRQoL measures in psychiatry. Thoughtful application of these tools in psychiatric research can provide a much-needed patient perspective in the future of comparative effectiveness research, patient-centered outcomes research, and clinical care.

scholarly journals Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients

2021 ◽  
Author(s):  
Shinya Tsuzuki ◽  
Yusuke Miyazato ◽  
Mari Terada ◽  
Shinichiro Morioka ◽  
Norio Ohmagari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Disease Burden ◽  
Self Report ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Long Duration ◽  
Related Quality ◽  
Health Related ◽  
Basic Characteristics

AbstractBackgroundThe empirical basis for a quantitative assessment of the disease burden imposed by long-COVID is currently scant. We aimed to assess the disease burden caused by long-COVID in Japan.MethodsWe conducted a cross sectional self-report questionnaire survey. The questionnaire was mailed to 530 eligible patients, who were recovered from acute COVID-19 in April 2021. Answers were classified into two groups; participants who have no symptom and those who have any ongoing symptoms that lasted longer than four weeks at the time of the survey. We compared health-related quality of life scores estimated by the EQ-5D-3L questionnaire between these two groups after adjusting basic characteristics of the participants by propensity score matching.Results349 participants reported no symptoms and 108 reported any symptoms at the time of the survey. The participants who reported any symptoms showed a lower value on a Visual Analogue Scale (median 70 [IQR 60-80]) and on the EQ-5D-3L (median 0.81 [IQR 0.77-1.0]) than those reporting no symptoms (median 85 [IQR 75-90] and 1.0 [IQR 1.0-1.0], respectively). After adjusting for background characteristics, these trends did not change substantially (Visual Analog Scale: median 70 [IQR 60-80] vs 80 [IQR 77-90], EQ-5D-3L: median 0.81 [IQR 0.76-1.0] vs 1.0 [IQR 1.0-1.0]).ConclusionsDue to their long duration, long-COVID symptoms represent a substantial disease burden expressed in impact on health-related quality of life.Trial registrationNot applicable.

scholarly journals Cardiovascular Disease Risk and Health-Related Quality of Life among People with Serious Mental Illness in Supportive Housing

2020 ◽  
Author(s):  
Ana Stefancic ◽  
Nathaniel Lu ◽  
Xiaoyan Wang ◽  
Lauren Bochicchio ◽  
Christopher Weatherly ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Supportive Housing ◽  
Cumulative Number ◽  
Health Related Quality ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Related Quality ◽  
Health Related

Abstract Background: Given indications of widening disparities in mortality for people with serious mental illness, understanding and reducing their risk of cardiovascular disease (CVD) and improving health-related quality of life is an urgent public health priority. This study examined CVD risk factor clustering, health-related quality of life (HRQoL), and their correlates among people with SMI who were overweight/obese (i.e., BMI ≥ 25) and living in supportive housing. Methods: Baseline data were used from participants enrolled in a clinical trial examining the effectiveness of a peer-led healthy lifestyle program. univariate analyses were used to describe the distribution of individual risk factors and the cumulative number of CVD risk factors. Bivariate and regression analyses were used to explore correlates of individual CVD risk factors, the cumulative number of risk factors, and HRQoL Physical and Mental Health Composite Scores. Results: Participants were 48.7 years old, on average (sd = 11.6) and the majority identified as male (57.3%) and as racial/ethnic minorities (82%; primarily non-Hispanic black). Most participants (75.4%) had at least two co-occurring CVD risk factors and almost half (46.7%) had three or more, most commonly obesity, smoking, and hypertension. Prevalence of individual risk factors, particularly smoking and diabetes, varied by demographic and clinical characteristics. Identifying as female, older age, and taking second generation antipsychotic medication were associated with having more co-occurring CVD risk factors, while having completed high school was associated with fewer risks. Number of co-occurring CVD risk factors, identifying as female, and greater psychiatric symptoms were negatively associated with physical HRQoL. Older age, lower psychiatric symptoms, and greater internal locus of control were positively associated with mental HRQoL.Conclusion: Even when compared to other studies examining CVD risk among individuals diagnosed with schizophrenia, our study sample generally had higher rates of clustering of multiple risk factors, highlighting the need for urgent intervention among those living in supportive housing. Demographic and clinical factors further identify those who may have the highest risk as well as factors that may adversely affect perceived health status and functioning. Reducing CVD risk and improving HRQoL will likely require expanding access to quality care, adapting intervention approaches to subpopulations, and providing increased support to facilitate health behavior change and perceived control for modifiable risk factors.Trial Registration: This trial was registered through ClinicalTrials.gov on June 26, 2014. The registration number is NCT02175641.

scholarly journals Health-Related Quality of Life in the Spironolactone to Reduce ICD Therapy (SPIRIT) Trial

2020 ◽  
Author(s):  
Ana Carolina Sauer Liberato ◽  
Merritt H Raitt ◽  
Ignatius GE Zarraga ◽  
Karen S MacMurdy ◽  
Cynthia Dougherty
Keyword(s):  
Quality Of Life ◽  
Kansas City ◽  
Short Form ◽  
Nyha Class ◽  
Health Related Quality ◽  
Icd Therapy ◽  
Related Quality ◽  
Health Related ◽  
Icd Shock

Purpose: The Spironolactone to Reduce ICD Therapy (SPIRIT) trial was designed to determine whether once daily spironolactone would: 1) reduce the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF), and 2) improve health related quality of life (HRQOL) and symptoms. The purpose of this paper is to describe the long term HRQOL outcomes in the SPIRIT trial and compare QOL in those who did or did not receive implantable cardioverter defibrillator (ICD) shocks during follow-up. Methods: Ninety participants age 66+10 years, 96% men, 75% with NYHA class II, with an ICD at moderately high risk for recurrent VT/VF were randomized to spironolactone 25mg (N=44) or placebo (N=46). HRQOL was measured every 6 months for 24 months using 3 instruments: Patient Concerns Assessment (PCA), Short Form Health Survey-Veterans Version (SF-36V), and the Kansas City Cardiomyopathy Questionnaire (KCCQ). Linear mixed modeling was used to compare changes in HRQOL across 24-months. ANCOVA was used to compare HRQOL between those getting an ICD shock or not. Results: Over 24-months, there were no differences in HRQOL between the spironolactone vs. placebo groups. Those who experienced at least 1 ICD shock vs. those with no ICD shocks, reported significantly lower HRQOL and more symptoms at 6-months and 24 months. Conclusions: Spironolactone had no significant impact on HRQOL. Patients receiving one or more ICD shocks reported significant reductions in HRQOL and higher symptoms.

scholarly journals Cervical kyphosis in asymptomatic populations: incidence, risk factors, and its relationship with health-related quality of life

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Shuang Ao ◽  
Yu Liu ◽  
Yu Wang ◽  
Hao Zhang ◽  
Hui Leng
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Cervical Lordosis ◽  
Health Related Quality ◽  
Cervical Kyphosis ◽  
T1 Slope ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related

Abstract Background Cervical kyphosis has been pointed out in asymptomatic populations. The purposes of this study were (1) to investigate the incidence of cervical kyphosis in asymptomatic populations, (2) to identify risk factors related to cervical kyphosis, and (3) to assess the relationship between cervical kyphosis and health-related quality of life (HRQOL). Methods A cohort of 235 asymptomatic volunteers’ records was retrospectively analyzed. Radiographic parameters of the coronal and sagittal planes were measured in the full-length spine x-ray. All patients were classified into two groups based on the cervical lordosis angle: cervical lordosis (CL) and cervical kyphosis (CK). HRQOL was evaluated by EQ-5D and SF-36 (PCS and MCS) questionnaires. Results CK was observed in 90 of 235 (38.3%) participants. There was a significant difference with regard to age between volunteers with CK and CL (32.23 ± 8.12 vs. 42.12 ± 6.14, p < 0.05). Several parameters had a significant relationship with CK, including TK, T1 slope, TIA, SVA, and CT. Logistic regression analysis identified age, TK, T1 slope, and SVA as independent risk factors of CK. In addition, there was a negative correlation between CK and the parameters of HRQOL (EQ-5D, − 0.63; PCS, − 0.68; MCS, − 0.59). Conclusions The incidence of CK in normal populations is 38.3%. Some spinal parameters are related to CK. CK is associated with the HRQOL.

scholarly journals P.072 Agreement between children and their parents’ ratings of the health-related quality of life of children with Duchenne Muscular Dystrophy

2018 ◽  
Vol 45 (s2) ◽  
pp. S35-S35
Author(s):  
S Brar ◽  
C Campbell ◽  
E McColl ◽  
W Martens ◽  
M McDermott ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Self Report ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Parent Proxy ◽  
Level Of Agreement

Background: When measuring young Duchenne Muscular Dystrophy (DMD) patients’ health-related quality of life (HRQoL), parent-proxy reports are heavily relied on. Therefore, it is imperative that the relationship between parent-proxy and child self-report HRQoL is understood. This study examined the level of agreement between children and their parent-proxy rating of the child’s HRQoL. Methods: We used FOR-DMD clinical trial baseline data. HRQoL, measured using the PedsQL inventory, was reported by 178 parent and child (ages 4 to 7 years) dyads. Intracorrelation coefficients (ICC) measured absolute agreement while paired t-tests determined differences in the average HRQoL ratings between groups. Results: The level of agreement between child and parent-proxy ratings of HRQoL was poor for the generic PedsQL scale (ICC: 0.29) and its subscales; and, similarly low for the neuromuscular disease module (ICC:0.16). On average, parents rated their child’s HRQoL as poorer than the children rated themselves in all scales except for psychosocial and school functioning. Conclusions: Child and parent-proxy HRQoL ratings are discordant in this study sample, as occurs in other chronic pediatric diseases. This should be taken into account when interpreting clinical and research HRQoL findings in this population. Future studies should examine reasons for parents’ perception of poorer HRQoL than that reported by their children.

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