Feasibility and utility of influenza vaccination in hematology/oncology clinics.

2013 ◽  
Vol 31 (31_suppl) ◽  
pp. 166-166
Author(s):  
Navjeet Uppal ◽  
Swanee Tobin ◽  
Jennifer Cape ◽  
Matthew Muller ◽  
Lisa K. Hicks

166 Background: Seasonal influenza vaccination is recommended for cancer patients. However, many cancer clinics do not routinely offer flu shots. Early in January, 2013, Toronto experienced widespread influenza activity. Approximately 25% of hospitalizations on the hematology/oncology ward at St. Michael's Hospital (SMH) during this time were for suspected influenza. A large number of patients were noted to be unvaccinated. In-response, influenza vaccination was organized in parallel with regular hematology/oncology clinics at SMH. Aims: To determine the feasibility and utility of influenza vaccination in a cancer clinic. Methods: All patients seen in the SMH hematology/oncology clinic between January 14 and February 1, 2013, were eligible for influenza vaccination. A brief survey was administered to obtain vaccination history, willingness to receive flu vaccination, and beliefs about flu vaccination. Information regarding diagnosis, treatment, and family physician was obtained from the medical record. Univariate testing was completed with the Chi-squared and Fisher’s exact tests as appropriate. Results: 555 patients were seen during the period of interest; 206 completed the survey (37% response rate). Median age of respondents was 63 years, 42% were male, and 81% had cancer. 107(52%) of respondents had not received seasonal influenza vaccination of whom 41 (38%) accepted vaccination when offered. Among vaccinated patients, most received the flu shot from a family physician (70%). Reasons for not receiving the flu shot were personal preference (24%), belief that it was not necessary (19%), inconvenience (14%), concerns about side effects (8%), believe that it was contraindicated during chemotherapy (7%) and a perception that a medical practitioner advised against it (7%). Patients without a registered family physician were less likely to have received the seasonal flu shot (p=0.03). Patients with a malignant diagnosis and patients receiving IV chemotherapy tended to have lower rates of seasonal flu vaccination (p=0.09 and p=0.12 respectively). Conclusions: Administering influenza vaccination during hematology/oncology clinics is feasible and may address a care gap in this population.

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16496 ◽  
Author(s):  
Darius Soonawala ◽  
Guus F. Rimmelzwaan ◽  
Luc B. S. Gelinck ◽  
Leo G. Visser ◽  
Frank P. Kroon

2012 ◽  
Vol 17 (2) ◽  
Author(s):  
J P Cramer ◽  
T Mac ◽  
B Hogan ◽  
S Stauga ◽  
S Eberhardt ◽  
...  

The 2009 influenza pandemic has introduced the new re-assorted influenza A(H1N1)pdm09 virus which recirculated during the 2010/11 influenza season. Before that season, it was possible to acquire protective immunity either by pandemic or seasonal influenza vaccination against influenza A(H1N1)pdm09 or by natural infection. To obtain data on vaccination coverage and antibody levels in a reference population and to calculate whether or not the herd immunity threshold (HIT, calculated as 33% given an R0 of 1.5) was reached at the beginning of the 2010/11 season we performed a seroprevalence study in November 2010 in Hamburg, Germany. Antibody titres were assessed applying a haemagglutination inhibition test. Vaccination coverage was very low: 14% for pandemic and 11% for seasonal 2010/11 vaccinations. Even in those with underlying risk factors, vaccination coverage was not much higher: 17% for both vaccines. Serological analysis revealed antibody titres of ≥1:10 in 135 of 352 (38%) and of ≥1:40 in 61 of 352 study participants (17%). Specific antibodies were measurable in 26% of those without history of vaccination or natural infection, indicating a high proportion of subclinical and mild influenza disease. Nevertheless, the HIT was not reached, leaving the majority of the population susceptible to influenza A(H1N1)pdm09 and its potential complications.


2021 ◽  
Author(s):  
Sergey Yegorov ◽  
Daniel Celeste ◽  
Kimberly Braz Gomes ◽  
Jann C Ang ◽  
Colin Vandenhof ◽  
...  

The induction of broadly neutralizing antibodies (bNAbs) that target the hemagglutinin stalk domain is a promising strategy for the development of universal influenza virus vaccines. bNAbs can be boosted in adults by sequential exposure to heterosubtypic viruses through natural infection or vaccination. However, little is known about if/how bNAbs are induced by vaccination in more immunologically naive children. Here, we describe the impact of repeated seasonal influenza vaccination and vaccine type on induction of bNAbs in a well-characterized paediatric cohort enrolled in a series of randomized control trials of seasonal influenza vaccination. Repeated seasonal vaccination resulted in significant boosting of a durable bNAb response. Boosting of serological bNAbs titers was comparable within inactivated and live attenuated (LAIV) vaccinees and declined with age. These data provide new insights into vaccine-elicited bNAb induction in children, which has important implications for the design of universal influenza vaccine modalities in this critical population.


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