Effects of equivalent weight loss, with or without exercise, on sex hormones related to breast cancer risk in postmenopausal women: The SHAPE-2 trial.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 1504-1504 ◽  
Author(s):  
Anne Maria May ◽  
Willemijn van Gemert ◽  
Petra Peeters ◽  
Job van der Palen ◽  
Jantine Schuit ◽  
...  
2010 ◽  
Vol 17 (1) ◽  
pp. 125-134 ◽  
Author(s):  
Christy G Woolcott ◽  
Yurii B Shvetsov ◽  
Frank Z Stanczyk ◽  
Lynne R Wilkens ◽  
Kami K White ◽  
...  

To add to the existing evidence that comes mostly from White populations, we conducted a nested case–control study to examine the association between sex hormones and breast cancer risk within the Multiethnic Cohort that includes Japanese American, White, Native Hawaiian, African American, and Latina women. Of the postmenopausal women for whom we had a plasma sample, 132 developed breast cancer during follow-up. Two controls per case, matched on study area (Hawaii, Los Angeles), ethnicity/race, birth year, date and time of blood draw and time fasting, were randomly selected from the women who had not developed breast cancer. Levels of estradiol (E2), estrone (E1), androstenedione, dehydroepiandrosterone (DHEA), and testosterone were quantified by RIA after organic extraction and Celite column partition chromatography. E1 sulfate, DHEA sulfate (DHEAS), and sex hormone-binding globulin (SHBG) were quantified by direct immunoassays. Based on conditional logistic regression, the sex hormones were positively associated and SHBG was negatively associated with breast cancer risk. All associations, except those with DHEAS and testosterone showed a significant linear trend. The odds ratio (OR) associated with a doubling of E2 levels was 2.26 (95% confidence interval (CI) 1.58–3.25), and the OR associated with a doubling of testosterone levels was 1.34 (95% CI 0.98–1.82). The associations in Japanese American women, who constituted 54% of our sample, were similar to or nonsignificantly stronger than in the overall group. This study provides the best evidence to date that the association between sex hormones and breast cancer risk is generalizable to an ethnically diverse population.


1994 ◽  
Author(s):  
DV SCHAPIRA ◽  
PA WOLFF ◽  
NB KUMAR ◽  
JJB ANDERSON ◽  
NM AZIZ ◽  
...  

2020 ◽  
Vol 31 (12) ◽  
pp. 1115-1128
Author(s):  
S. Hurley ◽  
D. Goldberg ◽  
J. Von Behren ◽  
J. Clague DeHart ◽  
S. Wang ◽  
...  

Cancer ◽  
2020 ◽  
Vol 126 (21) ◽  
pp. 4687-4696
Author(s):  
Eun Young Kim ◽  
Yoosoo Chang ◽  
Jiin Ahn ◽  
Ji‐Sup Yun ◽  
Yong Lai Park ◽  
...  

2015 ◽  
Vol 150 (3) ◽  
pp. 643-653 ◽  
Author(s):  
Bernard Rosner ◽  
A. Heather Eliassen ◽  
Adetunji T. Toriola ◽  
Susan E. Hankinson ◽  
Walter C. Willett ◽  
...  

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