Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: Incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 1583-1583
Author(s):  
Takaharu Kato ◽  
Koichi Suzuki ◽  
Yuta Muto ◽  
Junichi Sasaki ◽  
Shingo Tsujinaka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Cancer Patients ◽  
Sporadic Colorectal Cancer ◽  
Multiple Primary Malignancies ◽  
Multiple Primary ◽  
Colorectal Cancer Patients

Synchronous gastric cancer in primary sporadic colorectal cancer patients in Korea

2007 ◽  
Vol 23 (1) ◽  
pp. 61-65 ◽  
Author(s):  
S. B. Lim ◽  
S. Y. Jeong ◽  
H. S. Choi ◽  
D. K. Sohn ◽  
C. W. Hong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Cancer Patients ◽  
Sporadic Colorectal Cancer ◽  
Synchronous Gastric Cancer ◽  
Colorectal Cancer Patients

scholarly journals Reduced Plasma Levels of Very-Long-Chain Dicarboxylic Acid 28:4 in Italian and Brazilian Colorectal Cancer Patient Cohorts

Metabolites ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 91 ◽  
Author(s):  
Paul Wood ◽  
Michelle Donohue ◽  
John Cebak ◽  
Taylor Beckmann ◽  
Márcia Messias ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dicarboxylic Acid ◽  
Cancer Patients ◽  
Plasma Levels ◽  
High Resolution Mass Spectrometry ◽  
Sporadic Colorectal Cancer ◽  
Inherited Susceptibility ◽  
Potential Biomarker ◽  
Colorectal Cancer Patients ◽  
Long Chain

Background: There are currently no blood-based biomarkers for early diagnosis of colorectal cancer. Previous research has suggested that very-long-chain dicarboxylic acid (VLCDCA) 28:4 might be such a biomarker. Methods: Using high-resolution mass spectrometry, we analyzed VLCDCA 28:4 in the plasma of colorectal cancer patients in Italian [n = 62] and Brazilian [n = 52] cohorts. Additionally, we investigated individuals diagnosed with familial adenomatous polyposis (FAP; n = 27), one of the most important clinical forms of inherited susceptibility to colorectal cancer. Results: Decrements in plasma levels of VLCDCA 28:4 were monitored in colorectal cancer patients. These decreases were independent of the stage of tumor development and the individual’s age. However, no decrements in VLCDCA 28:4 were monitored in FAP patients. Conclusions: The plasma levels of VLCDCA 28:4 represent a potential biomarker of sporadic colorectal cancer. In addition, it is possible that resupply of this anti-inflammatory lipid may represent a new therapeutic strategy for CRC and inflammatory disorders.

scholarly journals Detection of c-Ki-ras mutations in faecal samples from sporadic colorectal cancer patients.

Gut ◽  
1995 ◽  
Vol 36 (1) ◽  
pp. 81-86 ◽  
Author(s):  
J Smith-Ravin ◽  
J England ◽  
I C Talbot ◽  
W Bodmer
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Sporadic Colorectal Cancer ◽  
Ras Mutations ◽  
Faecal Samples ◽  
Colorectal Cancer Patients

Mismatch Repair Protein MSH2 Expression and Prognosis of Colorectal Cancer Patients

2004 ◽  
Vol 19 (3) ◽  
pp. 190-195 ◽  
Author(s):  
C.G. Bernardo ◽  
J.J. Gonzílez ◽  
L. Sanz ◽  
E. Barbón ◽  
J.G. Noval ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Vascular Invasion ◽  
Sporadic Colorectal Cancer ◽  
Repair Protein ◽  
N Stage ◽  
Colorectal Cancer Patients ◽  
Mismatch Repair Protein

Introduction and aims The role of genetic factors in the etiology and prognosis of patients with sporadic colorectal cancer is controversial. We have therefore investigated the biological and clinicopathological influence of immunohistochemical MSH2 expression in colorectal cancer. Patients and methods A total of 49 consecutive patients with unselected colorectal cancer operated on in our unit were included in the study. All tumors were resected and tumor specimens were evaluated for MSH2 expression. Clinicopathological data and patient survival were correlated with MSH2 staining. Uni- and multivariate analyses were performed. The minimum follow-up period was five years. Results Curative resection was performed in 34 patients (64.9%), 14 of whom subsequently relapsed. At the end of the overall follow-up 25 (51%) patients had died, 21 of cancer-related causes. Twenty-eight patients (57.1%) were negative for MSH2 staining. Only vascular invasion was significantly correlated with MSH2 expression (lower median values; p=0.04). The overall median survival was 47.9 months (95% CI=27–86.6%). Multivariate analysis of variables in relation to survival showed that T stage (p=0.001), N stage (p<0.001) and MSH2 expression (p=0.01) were independent factors for survival. Conclusions Reduced MSH2 expression is frequent in unselected colorectal cancer patients. Only vascular invasion was correlated with MSH2 expression in this study. Survival was related to TN stage and MSH2 staining.

scholarly journals Prevalence and Risk Factors of Gastric Adenoma and Gastric Cancer in Colorectal Cancer Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Dae Hyun Tak ◽  
Hee Seok Moon ◽  
Sun Hyung Kang ◽  
Jae Kyu Sung ◽  
Hyun Yong Jeong
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Cancer Patients ◽  
Patient Group ◽  
Gastrointestinal Endoscopy ◽  
Control Group ◽  
Upper Gastrointestinal Endoscopy ◽  
Gastric Adenoma ◽  
Colorectal Cancer Patients ◽  
Upper Gastrointestinal

Background/Aims. To evaluate the incidence of gastric adenoma and gastric cancer in colorectal cancer patients, as well as the clinicopathological features that affect their incidence.Methods. Among patients who underwent surgery after being diagnosed with colorectal cancer between January 2004 and December 2013 at Chungnam National University Hospital, 142 patients who underwent follow-up upper gastrointestinal endoscopy were assigned to the patient group. The control group included 426 subjects randomly selected. The patient group was subdivided into two: one that developed gastric adenoma or cancer and one that did not. Clinicopathological characteristics were compared between these groups.Results. In total, 35 (24.6%) colorectal cancer patients developed a gastric adenoma or gastric cancer, which was higher than the number in the control group (20 [4.7%] patients;p<0.001). Age, alcohol history, and differentiation of colorectal cancer were associated with higher risks of gastric adenoma or gastric cancer, with odds ratios of 1.062, 6.506, and 5.901, respectively.Conclusions. In colorectal cancer patients, screening with upper gastrointestinal endoscopy is important, even if no lesions are noted in the upper gastrointestinal tract at colorectal cancer diagnosis. Endoscopic screening is particularly important with increasing age, history of alcohol consumption, and poor cancer differentiation.

scholarly journals Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 119
Author(s):  
Tanja Gumpenberger ◽  
Stefanie Brezina ◽  
Pekka Keski-Rahkonen ◽  
Andreas Baierl ◽  
Nivonirina Robinot ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Molecular Mechanisms ◽  
Low Risk ◽  
Colorectal Adenomas ◽  
Colorectal Carcinogenesis ◽  
Sporadic Colorectal Cancer ◽  
Molecular Features ◽  
Colorectal Cancer Patients

Sporadic colorectal cancer is characterized by a multistep progression from normal epithelium to precancerous low-risk and high-risk adenomas to invasive cancer. Yet, the underlying molecular mechanisms of colorectal carcinogenesis are not completely understood. Within the “Metabolomic profiles throughout the continuum of colorectal cancer” (MetaboCCC) consortium we analyzed data generated by untargeted, mass spectrometry-based metabolomics using plasma from 88 colorectal cancer patients, 200 patients with high-risk adenomas and 200 patients with low-risk adenomas recruited within the “Colorectal Cancer Study of Austria” (CORSA). Univariate logistic regression models comparing colorectal cancer to adenomas resulted in 442 statistically significant molecular features. Metabolites discriminating colorectal cancer patients from those with adenomas in our dataset included acylcarnitines, caffeine, amino acids, glycerophospholipids, fatty acids, bilirubin, bile acids and bacterial metabolites of tryptophan. The data obtained discovers metabolite profiles reflecting metabolic differences between colorectal cancer and colorectal adenomas and delineates a potentially underlying biological interpretation.

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