Hypertension and beta-blocker use as prognostic and predictive factors in metastatic colorectal cancer: A retrospective analysis of NCIC CTG CO.17.

: Colorectal cancer represents the third most frequently occurring cancer worldwide. In the last decade, the survival of patients affected by metastatic colorectal cancer (mCRC) has improved through the introduction of biological drugs. However, in this new and dynamic therapeutic context, research about prognostic and predictive factors is important to guide the oncologists to effective therapies as well as to improve the understanding of colorectal cancer biology. Their identification is an intensive area of research and our future goal will be to depict tumour-specific "molecular signatures" in order to predict the clinical course of the disease and the best treatments. : In this report, we describe clinical, pathological and molecular biomarkers that can play a role as prognostic or predictive factors in mCRC.

Download Full-text

Metastatic Colorectal Cancer Clinical and Genetic Prognostic and Predictive Factors. Summary of the Doctoral Thesis

10.25143/prom-rsu_2020-14-dts ◽

2020 ◽

Author(s):

◽

Elīna Sīviņa

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Predictive Factors ◽

Doctoral Thesis ◽

Prognostic And Predictive Factors

Download Full-text

PREDICTIVE FACTORS IN THE CHOICE OF SURGICAL TREATMENT FOR COLORECTAL CANCER WITH LAPAROSCOPIC OR "OPEN" ACCESS

Problems in oncology ◽

10.37469/0507-3758-2017-63-3-470-474 ◽

2017 ◽

Vol 63 (3) ◽

pp. 470-474

Author(s):

Rustem Topuzov ◽

Georgiy Manikhas ◽

Eskender Topuzov ◽

Mikhail Khanevich ◽

Magomed Abdulaev ◽

...

Keyword(s):

Colorectal Cancer ◽

Surgical Treatment ◽

Postoperative Complications ◽

Open Access ◽

Comparative Study ◽

Retrospective Analysis ◽

Predictive Factors

There are presented results of surgical treatment of 347 patients with colorectal cancer. Based on the retrospective analysis a comparative study of results of surgical treatment for colorectal cancer using laparoscopic technologies and “open” access was carried out. Predictive factors that correlate with the risk of postoperative complications with laparoscopic and “open” access at the surgical stage of treatment for colorectal cancer were determined.

Download Full-text

Predictive factors of severe early treatment-related toxicity in patients receiving first-line treatment for metastatic colorectal cancer: Pooled analysis of 2190 patients enrolled in Fédération Francophone de Cancérologie Digestive (FFCD) trials

European Journal of Cancer ◽

10.1016/j.ejca.2021.04.040 ◽

2021 ◽

Vol 153 ◽

pp. 40-50

Author(s):

Clémence Breton ◽

Thomas Aparicio ◽

Karine Le Malicot ◽

Michel Ducreux ◽

Thierry Lecomte ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Predictive Factors ◽

Early Treatment ◽

Pooled Analysis ◽

Line Treatment ◽

First Line ◽

Cancérologie Digestive ◽

First Line Treatment

Download Full-text

Efficacy of panitumumab in older patients with metastatic colorectal cancer: a retrospective analysis using the database of the Hellenic Oncology Research Group (HORG)

Journal of Geriatric Oncology ◽

10.1016/j.jgo.2018.08.002 ◽

2019 ◽

Vol 10 (1) ◽

pp. 143-148 ◽

Cited By ~ 3

Author(s):

Natalia Asimakopoulou ◽

John Souglakos ◽

Nikolaos Kentepozidis ◽

Athanasios Karampeazis ◽

Athanasios Kotsakis ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Retrospective Analysis ◽

Research Group ◽

Older Patients ◽

Oncology Research

Download Full-text

Impact of biomarkers and primary tumor location on the metastatic colorectal cancer first-line treatment landscape in five European countries

Future Oncology ◽

10.2217/fon-2020-0976 ◽

2021 ◽

Author(s):

George Kafatos ◽

Victoria Banks ◽

Peter Burdon ◽

David Neasham ◽

Kimberly A Lowe ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Primary Tumor ◽

Treatment Strategies ◽

Treatment Decisions ◽

Tumor Location ◽

First Line ◽

Primary Tumor Location ◽

The Uk ◽

Prognostic And Predictive Factors

Background: Advances in therapies for patients with metastatic colorectal cancer (mCRC) and improved understanding of prognostic and predictive factors have impacted treatment decisions. Materials & methods: This study used a large oncology database to investigate patterns of monoclonal antibody (mAb) plus chemotherapy treatment in France, Germany, Italy, Spain and the UK in mCRC patients treated in first line in 2018. Results: Anti-EGFR mAbs were most often administered to patients with RAS wild-type mCRC and those with left-sided tumors, while anti-VEGF mAbs were preferred in RAS mutant and right-sided tumors. Adopted treatment strategies differed between countries, largely due to reimbursement. Conclusion: Biomarker status and primary tumor location steered treatment decisions in first line. Adopted treatment strategies differed between participating countries.

Download Full-text