Genitourinary disease risks among 5-year ovarian cancer survivors in a population-based cohort study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 10073-10073
Author(s):  
Mia Hashibe ◽  
Yuji Chen ◽  
Brenna Blackburn ◽  
Yuan Wan ◽  
Kerry G. Rowe ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Population Based ◽  
General Population Cohort ◽  
Disease Risks ◽  
After Cancer

10073 Background: In the US, there are approximately 235,200 ovarian cancer survivors today. Five-year survival for ovarian cancer has increased from 36% for women who were diagnosed in 1975-1977 to 46% for women diagnosed between 2005-2011. Long term follow-up studies among ovarian cancer survivors are uncommon and late effects have not been well characterized in a population-based cohort. Although genitourinary complications during treatment are well known, long term impacts need to be investigated. Methods: A total of 602 first primary invasive ovarian cancer cases diagnosed between 1996-2012 who survived for > 5 years were identified in the Utah Population Database and compared to a general population cohort of women. Genitourinary disease diagnoses were identified through ICD codes from hospital electronic medical records and statewide ambulatory surgery and inpatient data. Cox regression models were used to estimate hazard ratios for disease risks by time since cancer diagnosis with adjustments on matching factors, baseline BMI, baseline Charlson Comorbidity Index (CCI), and race. Results: The overall risk of genitourinary diseases for ovarian cancer patients in comparison to the general population cohort was 1.51 (95%CI = 1.30-1.74) 5-10 years after cancer diagnosis. Approximately 54.6% of ovarian cancer survivors were diagnosed with a genitourinary disease 5-10 years after cancer diagnosis. The most common genitourinary diseases among the ovarian cancer survivors were urinary tract infections (10.1%), acute renal failure (5.5%), and chronic kidney disease (4.4%). The greatest risks were observed for hydronephrosis (HR = 10.65, 95%CI = 3.68-30.80), pelvic peritoneal adhesions (HR = 5.81, 95%CI = 1.11-30.39), cystitis and urethritis (HR = 2.67, 95%CI = 1.21-6.38), and acute renal failure (HR = 2.30, 95%CI = 1.36-3.88). Conclusions: Ovarian cancer survivors experience increased risks of various genitourinary diseases in the 5-10 year period following cancer diagnosis. Understanding the multimorbidity trajectory among ovarian cancer survivors is of vital importance to improve their clinical care after cancer diagnosis and allow for increased attention to these potential late effects.

scholarly journals Health and life insurance-related problems in very long-term cancer survivors in Germany: a population-based study

2021 ◽  
Author(s):  
Melissa S. Y. Thong ◽  
Daniela Doege ◽  
Linda Weißer ◽  
Lena Koch-Gallenkamp ◽  
Heike Bertram ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Population Based ◽  
Additional Contribution ◽  
Population Based Study ◽  
Prostate Cancer Survivors ◽  
Regional Population ◽  
Prostate Cancers ◽  
After Cancer

Abstract Purpose Limited research suggests that cancer survivors have problems with insurance. Our study aimed to gain insight into the proportion of very long-term (14–24 years post-diagnosis) survivors of breast, colorectal, and prostate cancers who had problems with health (HI) and life (LI) insurance. Methods We used data from CAESAR (CAncEr Survivorship—A multi-Regional population-based study). Participants completed questions on change in insurance providers since cancer diagnosis, problems with requesting (additional) HI or LI, and how potential problems were resolved. We conducted logistic regression to determine factors associated with change in statutory HI. Results Of the 2714 respondents, 174 (6%) reported having changed HI providers. Most switched between different statutory HI providers (86%), 9% from statutory to private, and 5% from private to statutory. Respondents who changed statutory HI providers were more likely to be prostate cancer survivors (OR 2.79, 95% CI 1.01–7.68) while being ≥ 65 years at time of diagnosis (OR 0.58, 95% CI 0.35–0.96) and having ≥ 2 comorbid conditions (OR 0.61, 95% CI 0.40–0.92) were associated with reduced odds for change. Problems in changing HI were minimal and were resolved with additional contribution. Of the 310 respondents who tried to get LI, 25 respondents reported having difficulties, of whom the majority had their request rejected. Conclusion Most cancer survivors did not change their HI nor tried to buy LI after cancer diagnosis. Problems with changing statutory HI were generally resolved with additional contribution while the main problem encountered when buying LI was rejection of request.

Causes of death among women with epithelial ovarian cancer by length of survival post-diagnosis: a population-based study in British Columbia, Canada

2018 ◽  
Vol 29 (3) ◽  
pp. 593-598 ◽  
Author(s):  
Nimisha Arora ◽  
Aline Talhouk ◽  
Jessica N. McAlpine ◽  
Michael R. Law ◽  
Gillian E. Hanley
Keyword(s):  
Colorectal Cancer ◽  
Ovarian Cancer ◽  
British Columbia ◽  
Cancer Survivors ◽  
Epithelial Ovarian Cancer ◽  
Cancer Patients ◽  
Cancer Diagnosis ◽  
Causes Of Death ◽  
Population Based

ObjectivesLittle is known regarding the health of women who survive more than 5 years following their ovarian cancer diagnosis. To bridge an important gap in our knowledge about long term health of ovarian cancer survivors, we examined the causes of death among women diagnosed with epithelial ovarian cancer between 1990 and 2014 in British Columbia. These causes were stratified by years since diagnosis, and compared with age- standardized causes of death among women who have not been diagnosed with ovarian cancer.MethodsWe examined all women with epithelial ovarian cancer in British Columbia 1990–2014 using population- based administrative datasets. We stratified women into three groups: all epithelial ovarian cancer patients; women surviving 5 to 9 years post-diagnosis, and women surviving 10 or more years since diagnosis. All- cause and cause specific standardized mortality ratios (SMRs) were calculated.ResultsThere were 4246 deaths among 6427 women with epithelial ovarian cancer. About 55.9% of deaths were from ovarian cancer. When compared with the general population, the highest SMRs (SMR of 5 or higher) were for deaths from other cancers and external causes (44.4% from falls) among women surviving 5–9 years and 10 or more years post-diagnosis. Mortality from other cancers can largely be explained by deaths from breast cancer (15.8%), lung cancer (12.3%), and colorectal cancer (11%).ConclusionsWhile the majority of epithelial ovarian cancer patients continue to die from their ovarian cancer, our results suggest that long term ovarian cancer survivors are particularly vulnerable to deaths from other cancers and from falls in elderly survivors. These data could indicate closer surveillance for breast, lung, and colorectal cancer, and closer attention to bone health is warranted among women surviving for 5 or more years following their epithelial ovarian cancer diagnosis.

scholarly journals Genitourinary disease risks among ovarian cancer survivors in a population-based cohort study

2020 ◽  
Vol 157 (2) ◽  
pp. 529-535
Author(s):  
Chun-Pin Chang ◽  
Yuji Chen ◽  
Brenna Blackburn ◽  
Sarah Abdelaziz ◽  
Kerry Rowe ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cohort Study ◽  
Cancer Survivors ◽  
Population Based ◽  
Disease Risks

Secondary malignancies in long-term ovarian cancer survivors: results of the ‘Carolin meets HANNA’ study

2021 ◽  
pp. ijgc-2020-002155
Author(s):  
Hannah Woopen ◽  
Carolin Rolf ◽  
Elena Ioana Braicu ◽  
Nina Buttmann-Schweiger ◽  
Benjamin Barnes ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Cancer Survival ◽  
Secondary Malignancy ◽  
Secondary Cancer ◽  
Secondary Malignancies ◽  
Primary Ovarian Cancer ◽  
Long Term Survivors

ObjectiveTo evaluate the rate of secondary malignancies in long-term survivors with ovarian cancer.MethodsLong-term survivors with ovarian cancer (survival ≥8 years after initial diagnosis) with multiple malignancies were identified within the Tumorbank Ovarian Cancer and our study ‘Carolin meets HANNA – Holistic Analyses of Long-term Survivors with Ovarian Cancer’.ResultsOf a total of 225 long-term survivors with ovarian cancer, 36 patients (16%) had at least one more cancer diagnosis before, concomitant with, or after, ovarian cancer. Median age was 52.5 years (range 37–79). A total of 60% were diagnosed with stage III/IV and most tumors were high-grade (88.6%), as well as of serous histology (63.9%). Median overall survival was 10 years (range 8–19). Secondary cancer after ovarian cancer was found in 17 long-term survivors (7.6%). Breast cancer was the most frequent secondary malignancy. Median duration between diagnosis of primary ovarian cancer and secondary cancer diagnosis was 78.5 months (range 12–220). BRCA was tested in 11 patients with seven patients being BRCA1 and one patient BRCA2 positive. Secondary cancers were detected by screening in 35.3% and self-detected in 29.4% of patients (breast self-examination).ConclusionA secondary malignancy was diagnosed in 7.6% of long-term survivors. Routine follow-up and cancer screening should be performed in long-term ovarian cancer survivors.

Abstract 5797: Genitourinary disease risks among ovarian cancer survivors in a population-based cohort study

2020 ◽  
Author(s):  
Chun-Pin Chang ◽  
Yuji Chen ◽  
Brenna Blackburn ◽  
Sarah Abdelaziz ◽  
Kerry Rowe ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cohort Study ◽  
Cancer Survivors ◽  
Population Based ◽  
Disease Risks

Long-term risk of cardiovascular disease among colorectal cancer survivors in a population-based cohort study.

2018 ◽  
Vol 36 (7_suppl) ◽  
pp. 113-113 ◽  
Author(s):  
David Baraghoshi ◽  
Makenzie L. Hawkins ◽  
Sarah Abdelaziz ◽  
Jihye Park ◽  
Yuan Wan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cardiovascular Disease ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Cvd Risk ◽  
Colorectal Cancer Survivors ◽  
Increased Risk ◽  
After Cancer

113 Background: In the United States, colorectal cancer is the fourth most common cancer and one of the leading causes of cancer death. Few studies have examined the relationship between colorectal cancer survivorship and long-term cardiovascular disease (CVD) risk. Methods: Individuals diagnosed with colorectal cancer were identified using the Utah Population Database. For a comparison group, up to 5 cancer-free individuals were matched by birth year, birth state, follow-up time and sex to each cancer case. For individuals with > 10 years of follow-up, we estimated CVD risk > 10 years after cancer diagnosis. Cox regression models were used to estimate hazard ratios (HR) and 95% Confidence Intervals. Results: Among 1,749 colorectal cancer survivors who had survived for at least 10 years, 1,001 (57.2%) were diagnosed with CVD > 10 years after cancer diagnosis. Compared to the general population, colorectal cancer survivors had an increased risk of CVD > 10 years after cancer diagnosis: HR = 2.84 (95% CI = 2.59, 3.11) for hypertension; HR = 2.66 (95% CI 2.37, 2.98) for diseases of the heart; HR = 3.91 (95% CI = 3.33, 4.58) for diseases of the arteries, arterioles and capillaries; HR = 2.58 (95% CI = 2.46, 2.99) for diseases of the veins and lymphatics; HR = 2.98 (95% CI = 2.36, 3.76) for cerebrovascular disease. Colorectal cancer survivors with ≥1 comorbidity had an increased risk of CVD > 10 years after cancer diagnosis compared to survivors with no comorbidities (HR = 1.7, 95% CI = 1.49, 1.95). Colorectal cancer survivors who were ≥65 years had an increased risk of CVD > 10 years after cancer diagnosis. Colorectal cancer survivors who were obese at the time of diagnosis had an increased risk of CVD > 10 years after cancer diagnosis when compared to survivors with normal BMIs (HR = 1.25; 95% CI = 1.06, 1.49). Conclusions: Compared to the general population, colorectal cancer survivors had an increased risk of CVD during the > 10 year follow-up period. Within colorectal cancer survivors, there was an increased risk of CVD for those that were older, had ≥1 comorbidity and were obese. The increased risk of CVD among survivors may be attributable to the lifestyle risk factors shared by colorectal cancer and CVD.

scholarly journals Food Insecurity and Forgone Medical Care Among Cancer Survivors

2020 ◽  
Vol 16 (9) ◽  
pp. e922-e932 ◽  
Author(s):  
Jean A. McDougall ◽  
Jessica Anderson ◽  
Shoshana Adler Jaffe ◽  
Dolores D. Guest ◽  
Andrew L. Sussman ◽  
...  
Keyword(s):  
Food Insecurity ◽  
Cancer Survivors ◽  
Medical Care ◽  
Treatment Adherence ◽  
Cancer Diagnosis ◽  
Prescription Medication ◽  
Population Based ◽  
Tumor Registry ◽  
Patients With Cancer ◽  
After Cancer

PURPOSE: Financial hardship is increasingly understood as a negative consequence of cancer and its treatment. As patients with cancer face financial challenges, they may be forced to make a trade-off between food and medical care. We characterized food insecurity and its relationship to treatment adherence in a population-based sample of cancer survivors. METHODS: Individuals 21 to 64 years old, diagnosed between 2008 and 2016 with stage I-III breast, colorectal, or prostate cancer were identified from the New Mexico Tumor Registry and invited to complete a survey, recalling their financial experience in the year before and the year after cancer diagnosis. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95%CIs. RESULTS: Among 394 cancer survivors, 229 (58%) were food secure in both the year before and the year after cancer diagnosis (persistently food secure), 38 (10%) were food secure in the year before and food insecure in the year after diagnosis (newly food insecure), and 101 (26%) were food insecure at both times (persistently food insecure). Newly food-insecure (OR, 2.82; 95% CI, 1.02 to 7.79) and persistently food-insecure (OR, 3.04; 95% CI,1.36 to 6.77) cancer survivors were considerably more likely to forgo, delay, or make changes to prescription medication than persistently food-secure survivors. In addition, compared with persistently food-secure cancer survivors, newly food-insecure (OR, 9.23; 95% CI, 2.90 to 29.3), and persistently food-insecure (OR, 9.93; 95% CI, 3.53 to 27.9) cancer survivors were substantially more likely to forgo, delay, or make changes to treatment other than prescription medication. CONCLUSION: New and persistent food insecurity are negatively associated with treatment adherence. Efforts to screen for and address food insecurity among individuals undergoing cancer treatment should be investigated as a strategy to reduce socioeconomic disparities in cancer outcomes.

scholarly journals 2122

2017 ◽  
Vol 1 (S1) ◽  
pp. 24-24
Author(s):  
Lisa M. Shandley ◽  
Lauren M. Daniels ◽  
Jessica B. Spencer ◽  
Ann C. Mertens ◽  
Penelope P. Howards
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Unintended Pregnancy ◽  
Cancer Diagnosis ◽  
Breast Cancer Survivors ◽  
The United States ◽  
Population Based ◽  
Reproductive Age ◽  
Bilateral Oophorectomy ◽  
After Cancer

OBJECTIVES/SPECIFIC AIMS: In the United States, it is estimated that approximately half of all pregnancies are unintended. This study examines the prevalence of unintended pregnancy in a cohort of cancer survivors and identifies factors associated with unintended pregnancy after cancer. METHODS/STUDY POPULATION: The FUCHSIA Women’s Study is a population-based study of female cancer survivors at a reproductive age of 22–45 years. Cancer survivors diagnosed between the ages of 20 and 35 years and at least 2 years postdiagnosis were recruited in collaboration with the Georgia Cancer Registry. Participants were interviewed about their reproductive histories. The prediagnosis analysis included all women who completed the interview; the postdiagnosis analysis excluded those who had a hysterectomy, bilateral oophorectomy, or tubal ligation by cancer diagnosis. RESULTS/ANTICIPATED RESULTS: Of the 1282 survivors interviewed, 57.5% reported at least 1 pregnancy before cancer diagnosis; of which, 44.5% were unintended. Of the 1088 survivors included in the postdiagnosis analysis, 36.9% reported a post-cancer pregnancy. Among those who had a pregnancy after cancer diagnosis, 38.6% reported at least 1 pregnancy was unintended. Of the 80 breast cancer survivors who had a pregnancy after diagnosis, 52.5% of them were unintended. Predictors of unintended pregnancy in cancer survivors included being younger than 30 years at diagnosis [odds ratio (OR) 2.1; 95% confidence interval (CI) 1.4, 2.9], identifying as Black (OR 1.6, 95% CI 1.1, 2.3, comparison: White), and having resumption of menses after cancer treatment (OR 8.1, 95% CI 2.0, 33.0). Compared with being <4 years from cancer diagnosis, those who were farther from diagnosis at the time of the interview also had increased odds of unintended pregnancy (4–7 years: OR 1.5, 95% CI 0.9, 2.7; 8–10 years: OR 1.3, 95% CI 0.7, 2.4; >10 years: OR 2.7, 95% CI 1.6, 4.7). DISCUSSION/SIGNIFICANCE OF IMPACT: Despite being at higher risk of infertility, cancer survivors may still be at considerable risk of unintended pregnancy. Women with certain types of cancer that are more likely to be hormone responsive, such as some types of breast cancer, may be hesitant to use hormonal birth control and thus be at higher risk of unintended pregnancy. Counseling for cancer survivors should include a discussion of the risk of unintended pregnancy and contraceptive options.

Abstract 5795: Long-term diabetes risk among ovarian cancer survivors in a population-based cohort study

2020 ◽  
Author(s):  
Seungmin Kim ◽  
Kerry Rowe ◽  
John Snyder ◽  
Alison Fraser ◽  
Ken Smith ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cohort Study ◽  
Cancer Survivors ◽  
Population Based ◽  
Diabetes Risk

scholarly journals Association of pre-existing depression with all-cause, cancer-related, and noncancer-related mortality among 5-year cancer survivors: a population-based cohort study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ahryoung Ko ◽  
Kyuwoong Kim ◽  
Joung Sik Son ◽  
Hye Yoon Park ◽  
Sang Min Park
Keyword(s):  
Cohort Study ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Clinical Status ◽  
Population Based ◽  
Term Survival ◽  
Patients With Cancer ◽  
Hazard Ratios ◽  
After Cancer ◽  
Related Mortality

AbstractPrevious studies on the association between mental health and mortality in patients with cancer have reported contradictory results. We conducted a population-based cohort study to determine whether pre-existing depression is associated with all-cause and cause-specific mortality after cancer diagnosis. We included 5-year cancer survivors, identified from the National Health Insurance Scheme Health Screening Cohort between January 1, 2004 and December 31, 2009. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals (CI) to assess the association between pre-existing depression and all-cause, cancer-related, and noncancer-related mortality among 5-year cancer survivors. After adjustment for sociodemographics, lifestyle, and clinical status, the multivariable adjusted hazard ratios (95% CIs) for all-cause, cancer-related, and noncancer-related mortality among 5-year cancer survivors with pre-existing depression were 1.52 (1.13–2.05), 1.17 (0.75–1.81), and 2.07 (1.38–3.10) compared with those without pre-existing depression, respectively. Significant associations between pre-existing depression and mortalities (all-cause and noncancer-related mortality) were only observed among male cancer survivors. Our findings suggest that depression is associated with all-cause mortality after cancer diagnosis and that greater efforts should be focused on the long-term survival of patients with cancer with pre-existing depression, especially in male cancer survivors.

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