Serum tumor markers to predict cancer-related venous thromboembolism in gastric cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15526-e15526
Author(s):  
Yan Yang ◽  
Yang Yang ◽  
Jie Shen ◽  
Xia Jie ◽  
Lixia Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Venous Thromboembolism ◽  
Tumor Markers ◽  
Measurement Data ◽  
Combination Group ◽  
Curative Surgery ◽  
Predictive Values ◽  
Logistic Regression Models ◽  
Serum Tumor Markers ◽  
Preoperative Serum

e15526 Background: To investigate the relationship between the preoperative level of serum tumor markers and cancer-related venous thromboembolism in patients with gastric cancer. Methods: 1005 patients with gastric cancer who underwent curative resection were finally enrolled in this study. Serum tumor markers including CEA, CA19-9, CA242, CA72-4, CA125 were tested within one week before curative surgery. Measurement data between groups were compared with t test. The sensitivity, specificity, positive predictive values, and negative predictive values of five biomarkers and the combination group were calculated, respectively. The odds ratios were calculated via both univariate and multivariate logistic regression models. Results: Cancer-related venous thromboembolism was found in 540 (53.73%) patients. The increase of each cancer marker is remarkably related with cancer-related venous thromboembolism. The more abnormal serum tumor markers come out, the high the risk of positive cancer-related venous thromboembolism can be. The possibility of positive cancer-related venous thromboembolism would be 2.9 times as much as a normal patient as any of the tumor markers increases. With the increase of any 4 of the tumor markers can make the risk 16.4 times Conclusions: The status of postoperative cancer-related venous thromboembolism can be predicted from preoperative serum tumor markers. For those patients with a high risk of positive cancer-related venous thromboembolism, more aggressive treatment should be arranged.

Serum tumor markers predict cancer-related venous thromboembolism in gastric cancer

2017 ◽  
Vol 6 (2) ◽  
pp. 322-331
Author(s):  
Yan Yang ◽  
Yang Yang ◽  
Jie Shen ◽  
Jie Xia ◽  
Lixia Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Venous Thromboembolism ◽  
Tumor Markers ◽  
Serum Tumor Markers

scholarly journals Construction of a Lymph Node Metastasis Nomogram Prediction Model Based on Dual-Energy CT Radiomics of Gastric Cancer Lesions

2021 ◽  
Author(s):  
Hong-li CUN ◽  
Qian-ting DUAN ◽  
Ying-ying DING ◽  
Da-fu Zhang ◽  
Ling YANG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Markers ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Test Set ◽  
Serum Tumor Markers ◽  
Node Metastasis ◽  
Preoperative Serum ◽  
Auc Value

Abstract Background This study aimed to explore the value of gastric cancer (GC) tumor markers and dual-energy CT（DECT） scans of arterial and venous GC lesions with quantitative iodine concentration (IC) and radiomics, to predict lymph node metastasis (LNM) in patients with GC. Methods This prospective study comprised of 177 patients that underwent dual-energy CT scans before surgery, and were subsequently diagnosed with GC by postoperative pathology. Serum tumor markers and arterial phases (AP) and venous phases (VP) of GC lesion iodine concentration (IC) and normalized iodine concentration (nIC) were analyzed. Patients were divided into either the LNM group or non-LNM group according to pathological results. The Wilcoxon rank-sum test was used to compare the serum tumor markers, IC, and nIC of the 2 groups, and a ROC curve was drawn to evaluate their effectiveness in predicting LNM in patients with GC. After using the Siemens syngo.via Frontier Radiomics software to extract radiomics features , all patients were randomly divided into a train set and a test set with a 7:3 ratio to predict GC LNM. Results Among the 177 patients with GC, 83 were diagnosed with LNM, while 94 did not have LNM. The preoperative serum tumor markers CA125, CA199, and CEA were statistically significant for predicting the presence of LNM (P<0.05). In the transfer group, AP and VP IC were 2.63 mg/ml (2.3, 3.00) and 3.60 mg/ml (3.23, 4.03) respectively, with corresponding areas under the curve (AUC) of 0.83 and 0.91. The nIC was 0.18 mg/ml (0.15, 0.21) and 0.78 mg/ml (0.65, 0.86); the AUC curve was 0.79 and 0.87. Both the IC and nIC were higher in the patients with LNM than those without LNM (P<0.05). Establishing a random forest (RF) model based on the radiomics extracted from the GC lesions had a high diagnostic value in predicting whether the lymph nodes in patients with GC were metastatic. The RF model AUC value was 0.959 for the train set and 0.977 for the test set. The AUC value of the nomogram predicting LNM was 0.996 for the train set and 0.976 for the test set. Conclusion Models based on preoperative serum tumor markers (CA125, CA199, and CEA) in patients with GC, quantitative dual-energy CT parameter values of the lesions (AP and VP IC, nIC), and radiomics have a higher diagnosis of LNM. The value of nomogram in combination with multi-parameter analysis is higher diagnosis of LNM, which can provide a reliable basis for preoperative evaluation of LNM.

scholarly journals The association of five preoperative serum tumor markers and pathological features in patients with breast cancer

2019 ◽  
Vol 33 (5) ◽  
Author(s):  
Mingjian Lian ◽  
Cuixia Zhang ◽  
Dongdong Zhang ◽  
Ping Chen ◽  
Huijing Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Markers ◽  
Pathological Features ◽  
Serum Tumor Markers ◽  
Preoperative Serum

scholarly journals Expression of serum tumor markers in gastric cancer with different degrees of differentiation: Significance for monitoring tumor recurrence

2019 ◽  
Vol 27 (6) ◽  
pp. 361-366
Author(s):  
Yong-Shun Gao ◽  
Yi-Ming Wang ◽  
Jing-Jing Huang ◽  
Yun-Fei Zhang ◽  
Peng Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Markers ◽  
Tumor Recurrence ◽  
Serum Tumor Markers

scholarly journals The Prognostic Value of Preoperative Serum Tumor Markers in Non-Small Cell Lung Cancer Varies With Radiological Features and Histological Types

2021 ◽  
Vol 11 ◽  
Author(s):  
Haiqing Chen ◽  
Fangqiu Fu ◽  
Yue Zhao ◽  
Haoxuan Wu ◽  
Hong Hu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Small Cell Lung Cancer ◽  
Tumor Markers ◽  
Cell Lung Cancer ◽  
Carbohydrate Antigen ◽  
Small Cell ◽  
Small Cell Lung ◽  
Serum Tumor Markers ◽  
Preoperative Serum

ObjectivesTo assess the association between common-used serum tumor markers and recurrence of lung adenocarcinoma and squamous cell carcinoma separately and determine the prognostic value of serum tumor markers in lung adenocarcinoma featured as ground glass opacities.MethodsA total of 2,654 non-small cell lung cancer patients undergoing surgical resection between January 2008 and September 2014 were analyzed. The serum levels of carcinoma embryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), neuron-specific enolase (NSE), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153) and carbohydrate antigen 199 (CA199) were tested preoperatively. Survival analyses were performed with COX proportional hazard regression.ResultsAmong patients with lung adenocarcinoma, elevated preoperative serum CEA(HR=1.246, 95%CI:1.043-1.488, P=0.015), CYFRA21-1(HR=1.209, 95%CI:1.015-1.441, P=0.034) and CA125(HR=1.361, 95%CI:1.053-1.757, P=0.018) were significantly associated with poorer recurrence free survival (RFS). Elevated preoperative serum CA199 predicted worse RFS in patients diagnosed with lung squamous cell carcinoma (HR=1.833, 95%CI: 1.216-2.762, P=0.004). Preoperative serum CYFRA21-1(HR=1.256, 95%CI:1.044-1.512, P=0.016) and CA125(HR=1.373, 95%CI: 1.050-1.795, P=0.020) were independent prognostic factors for patients with adenocarcinoma presenting as solid nodules while serum CEA (HR=2.160,95%CI:1.311-3.558, P=0.003) and CA125(HR=2.475,95%CI:1.163-5.266, P=0.019) were independent prognostic factors for patients with adenocarcinoma featured as ground glass opacities.ConclusionsThe prognostic significances of preoperative serum tumor markers in non-small cell lung cancer were associated with radiological features and histological types.

scholarly journals CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

2020 ◽  
Author(s):  
Yilin Tong ◽  
Yan Zhao ◽  
Zexing Shan ◽  
Jianjun Zhang
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Tumor Markers ◽  
Cox Regression ◽  
Locally Advanced ◽  
Multivariable Analysis ◽  
Categorical Variables ◽  
Youden Index ◽  
Curative Surgery ◽  
Gastrointestinal Malignancies

Abstract Background: Serum tumor markers including AFU, AFP, CEA, CA199, CA125 and CA724, are of great importance in the diagnosis, prognostic prediction and recurrence monitoring of gastrointestinal malignancies. However, their significance in gastric cancer (GC) patients with neoadjuvant therapy (NCT) is still uncertain. The aim of this study was to evaluate the predictive value of these six tumor markers in locally advanced GC patients who underwent NCT and curative surgery. Methods: In total, 290 locally advanced GC patients who underwent NCT and D2 radical gastrectomy were retrospectively analyzed. Data on their tumor markers before (pre-) and after (post-) NCT and pathological characteristics were extracted from the database of our hospital. The optimal cutoff values of the six tumor markers were calculated by the ROC curve and Youden index. Their predictive significance was analyzed and survival curves for overall survival (OS) were obtained by the Kaplan-Meier method. Associations between categorical variables were explored by the chi-square test or Fisher's exact test. Multivariate analyses were performed by the Cox regression model. Results: Pre- and post-CA199, -CA125 and -CA724 could predict overall survival (all P < 0.05), but only the change (diff-) of CA199 was related to prognosis (P = 0.05). In the multivariable analysis, pre- (P = 0.014) and post-CA724 (P = 0.036) remained significant, though diff-CA724 was not an independent prognostic factor (P = 0.581). In addition, pre- and post-CA199, -CA125 and -CA724 were associated with lymph node metastasis (N- vs N+) and pathological stage (Ⅰ-Ⅱ vs Ⅲ) (all P < 0.05). Moreover, post-CA724 was related to the vascular or lymphatic invasion (P = 0.019), while pre-CA724 was not (P = 0.082). However, AFU, AFP and CEA showed no association with survival (P > 0.05). Conclusions: CA724 is an independent factor for prognosis and could be used to predict ypN and ypTNM stage in locally advanced GC patients undergoing NCT and curative resection.

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