Lactate response during acute exercise in cancer survivors undergoing exercise rehabilitation.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e23047-e23047
Author(s):  
Nicholas Harman ◽  
Arjun Ramani ◽  
Benjamin Jacob George ◽  
Reid Hayward
Keyword(s):  
Cancer Survivors ◽  
Blood Lactate ◽  
Lactate Threshold ◽  
Acute Exercise ◽  
Rehabilitation Program ◽  
Physiological Parameters ◽  
Lactate Accumulation ◽  
Significant Difference ◽  
Volitional Fatigue ◽  
Cancerous Cells

e23047 Background: Cancerous cells express a markedly different metabolic profile characterized by lactate production even when oxygen is plentiful. Lactate accumulation is a common marker for energy production and utilization, yet it is currently unclear how blood lactate responds during acute exercise to volitional fatigue in individuals with cancer and how this response is modified with exercise-based rehabilitation. The purpose of the current study is to assess the effect of an acute exercise bout to volitional fatigue on lactate accumulation before and after an exercise-based rehabilitation program for cancer survivors. Methods: 33 cancer survivors (female, n = 18; male, n = 15) were recruited to participate in a 12-week exercise-based rehabilitation program. All participants performed an initial assessment of physiological parameters, including blood lactate accumulation (LA) during a progressive treadmill protocol to volitional fatigue. LA was quantified every 2 minutes during treadmill testing via finger stick. The exercise intervention consisted of one hour sessions, three days per week, and included cardiovascular endurance, muscular strength, balance, and flexibility exercises. After 12 weeks of rehabilitation, participants completed a follow-up evaluation of physiological parameters. Results: There was a significant increase in LA at volitional fatigue after 12 weeks of training (Initial: 6.17 ± 2.61 mM, Post 12 Weeks: 7.26 ± 2.10 mM; p = 0.04), with no significant difference in resting blood lactate. The workload at which anaerobic lactate threshold presented was significantly increased after 12 weeks (Initial: 5.87 ± 1.59 METs, Post 12 weeks: 7.35 ± 1.85 METs; p = 0.02). Conclusions: Cancer survivors respond to acute exercise to volitional fatigue in a manner similar to healthy controls. Furthermore, similar to the response observed in healthy populations, cancer survivors exhibited an increase in lactate threshold and an increase in peak lactate accumulation at volitional fatigue after completing an exercise-based rehabilitation program. Thus, although many cancerous cells have a unique glycolytic profile, this does not appear to influence training-induced adaptations in blood lactate.

Anaerobic Threshold Prediction Using the OMNI-Walk/Run Scale in Long-Distance Runners: A Preliminary Study

2021 ◽  
Vol 16 (5) ◽  
pp. 727-730
Author(s):  
Yuri de Almeida Costa Campos ◽  
Jeferson M. Vianna ◽  
Miller P. Guimarães ◽  
Hiago L.R. Souza ◽  
Raúl Domínguez ◽  
...  
Keyword(s):  
Blood Lactate ◽  
Anaerobic Threshold ◽  
Lactate Threshold ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Rating Of Perceived Exertion ◽  
Distance Runners ◽  
Long Distance ◽  
Incremental Test ◽  
Significant Difference

Purpose: To identify the anaerobic threshold through the lactate threshold determined by Dmax and rating of perceived exertion (RPE) threshold by Dmax and to evaluate the agreement and correlation between lactate threshold determined by Dmax and RPE threshold by Dmax during an incremental test performed on the treadmill in long-distance runners. Methods: A total of 16 long-distance runners volunteered to participate in the study. Participants performed 2 treadmill incremental tests for the collection of blood lactate concentrations and RPE separated by a 48-hour interval. The incremental test started at 8 km·h−1, increasing by 1.2 km·h−1 every third minute until exhaustion. During each stage of the incremental test, there were pauses of 30 seconds for the collection of blood lactate concentration and RPE. Results: No significant difference was found between methods lactate threshold determined by Dmax and RPE threshold by Dmax methods (P = .664). In addition, a strong correlation (r = .91) and agreement through Bland–Altman plot analysis were found. Conclusions: The study demonstrated that it is possible to predict anaerobic threshold from the OMNI-walk/run scale curve through a single incremental test on the treadmill. However, further studies are needed to evaluate the reproducibility and objectivity of the OMNI-walk/run scale for anaerobic threshold determination.

Muscle respiratory capacity and fiber type as determinants of the lactate threshold

1980 ◽  
Vol 48 (3) ◽  
pp. 523-527 ◽  
Author(s):  
J. L. Ivy ◽  
R. T. Withers ◽  
P. J. Van Handel ◽  
D. H. Elger ◽  
D. L. Costill
Keyword(s):  
Blood Lactate ◽  
Lactate Threshold ◽  
Fiber Type ◽  
Work Rate ◽  
Respiratory Capacity ◽  
Lactate Accumulation ◽  
Blood Lactate Accumulation ◽  
Slow Twitch ◽  
The Absolute ◽  
Slow Twitch Fibers

This study examined the relationship between the respiratory capacity of an individual's skeletal muscle and the work rate at which blood lactate accumulation begins (lactate threshold). Comparisons were also made among fiber type, VO2max, and the lactate threshold. Muscle biopsies were taken from the vastus lateralis muscle for determination of respiratory capacity and fiber type (myosin ATPase). The lactate threshold was assessed in terms of both the absolute work rate (VO2) and relative work rate (%VO2max). The capacity of muscle homogenates to oxidize pyruvate was significantly (P less than 0.01) related to the absolute (r = 0.94) and relative (r = 0.83) lactate thresholds. Significant positive correlations (P less than 0.01) were also found between the percent of slow-twitch fibers and absolute (r = 0.74) and relative (r = 0.70) lactate thresholds. The results suggest that the muscle's respiratory capacity is of primary importance in determining the work rate at which blood lactate accumulation begins. They also suggest that the proportion of slow-twitch fibers may play an important role in determining the relative lactate threshold.

Potassium and ventilation during incremental exercise in trained and untrained men

1992 ◽  
Vol 73 (4) ◽  
pp. 1287-1290 ◽  
Author(s):  
M. McCoy ◽  
M. Hargreaves
Keyword(s):  
Oxygen Uptake ◽  
Endurance Training ◽  
Blood Lactate ◽  
Maximal Oxygen Uptake ◽  
Lactate Threshold ◽  
Plasma Potassium ◽  
Incremental Exercise ◽  
Volitional Fatigue ◽  
The Relationship ◽  
K Response

The present investigation was undertaken to examine the relationship between plasma potassium (K+) and ventilation (VE) during incremental exercise. Blood lactate (La-) was also measured, and its relationship with VE was similarly examined. Eight endurance-trained triathletes (ET) and eight active but untrained men (UT) performed an incremental cycling test to volitional fatigue. Maximal oxygen uptake (VO2max) and oxygen uptake (VO2) at lactate threshold (LT) were higher (P < 0.05) in ET (VO2max 4.60 +/- 0.10 l/min, LT 2.77 +/- 0.85 l/min) than in UT (VO2max 3.79 +/- 0.11 l/min, LT 1.94 +/- 0.60 l/min). There were significant (P < 0.05) correlations between VE and K+ (UT 0.87, ET 0.77) and between VE and La- (UT 0.88, ET 0.85). In ET compared with UT, VE was lower (P < 0.05) at 330 W, K+ was lower at 300 and 330 W, and La- was lower at all work loads > 90 W. These results suggest that K+ may make an important contribution to the regulation of ventilation during incremental exercise and that endurance training attenuates the K+ response to that exercise.

scholarly journals Evaluation of a Web-Based Cognitive Rehabilitation Program in Cancer Survivors Reporting Cognitive Symptoms After Chemotherapy

2017 ◽  
Vol 35 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Victoria J. Bray ◽  
Haryana M. Dhillon ◽  
Melanie L. Bell ◽  
Michael Kabourakis ◽  
Mallorie H. Fiero ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cancer Survivors ◽  
Cognitive Rehabilitation ◽  
Standard Care ◽  
Primary Outcome ◽  
Intervention Group ◽  
Rehabilitation Program ◽  
Cognitive Symptoms ◽  
Significant Difference

Purpose Cognitive impairment is reported frequently by cancer survivors. There are no proven treatments. We evaluated a cognitive rehabilitation program (Insight) and compared it with standard care in cancer survivors self-reporting cognitive symptoms. Patients and Methods We recruited adult cancer survivors with a primary malignancy (excluding central nervous system malignancies) who had completed three or more cycles of adjuvant chemotherapy in the previous 6 to 60 months and reported persistent cognitive symptoms. All participants received a 30-minute telephone consultation and were then randomly assigned to the 15-week, home-based intervention or to standard care. Primary outcome was self-reported cognitive function (Functional Assessment of Cancer Therapy Cognitive Function [FACT-COG] perceived cognitive impairment [PCI] subscale): difference between groups after intervention (T2) and 6 months later (T3). Results A total of 242 participants were randomly assigned: median age, 53 years; 95% female. The primary outcome of difference in FACT-COG PCI was significant, with less PCI in the intervention group at T2 ( P < .001). This difference was sustained at T3 ( P < .001). At T2, there was a significant difference in all FACT-COG subscales, favoring the intervention. Neuropsychological results were not significantly different between the groups at T2 or T3. There were significantly lower levels of anxiety/depression and fatigue in the intervention group at T2. There were significant improvements in stress in the intervention group at both time points. There was no significant difference in quality of life between the groups at T2, but the intervention group had better quality of life at T3. Conclusion The intervention, Insight, led to improvements in cognitive symptoms compared with standard care. To our knowledge, this is the first large randomized controlled trial showing an improvement in self-reported cognitive function in cancer survivors, indicating that this intervention is a feasible treatment.

Sign in / Sign up

Export Citation Format

Share Document