Protein Adsorption in Intravenous Drug Delivery

2003 ◽  
Author(s):  
Martin Malmsten
Keyword(s):  
Drug Delivery ◽  
Protein Adsorption ◽  
Intravenous Drug

scholarly journals Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes

2021 ◽  
pp. 153537022110107
Author(s):  
Noah Trac ◽  
Eun Ji Chung
Keyword(s):  
Drug Delivery ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Metastasis ◽  
Subcutaneous Administration ◽  
Mononuclear Phagocyte ◽  
Intravenous Drug ◽  
Rapid Clearance ◽  
Nanoparticle Design ◽  
Lymph Node Targeting

The lymph nodes are major sites of cancer metastasis and immune activity, and thus represent important clinical targets. Although not as well-studied compared to subcutaneous administration, intravenous drug delivery is advantageous for lymph node delivery as it is commonly practiced in the clinic and has the potential to deliver therapeutics systemically to all lymph nodes. However, rapid clearance by the mononuclear phagocyte system, tight junctions of the blood vascular endothelium, and the collagenous matrix of the interstitium can limit the efficiency of lymph node drug delivery, which has prompted research into the design of nanoparticle-based drug delivery systems. In this mini review, we describe the physiological and biological barriers to lymph node targeting, how they inform nanoparticle design, and discuss the future outlook of lymph node targeting.

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

Intravenous Drug Delivery

2021 ◽  
pp. 1-9
Author(s):  
Sebastian Scioli Montoto ◽  
Maria Esperanza Ruiz
Keyword(s):  
Drug Delivery ◽  
Intravenous Drug

Hydroxyapatite nanosheet-assembled porous hollow microspheres: DNA-templated hydrothermal synthesis, drug delivery and protein adsorption

2012 ◽  
Vol 22 (42) ◽  
pp. 22642 ◽  
Author(s):  
Chao Qi ◽  
Ying-Jie Zhu ◽  
Bing-Qiang Lu ◽  
Xin-Yu Zhao ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrothermal Synthesis ◽  
Protein Adsorption ◽  
Hollow Microspheres

Intravenous drug delivery in neonates: lessons learnt

2014 ◽  
Vol 99 (6) ◽  
pp. 590-594 ◽  
Author(s):  
C. M. T. Sherwin ◽  
N. J. Medlicott ◽  
D. M. Reith ◽  
R. S. Broadbent
Keyword(s):  
Drug Delivery ◽  
Intravenous Drug ◽  
Lessons Learnt

Second Consensus Development Conference on the Safety of Intravenous Drug Delivery Systems—2008

2009 ◽  
Vol 66 (2) ◽  
pp. 185-192 ◽  
Author(s):  
Michael D. Sanborn ◽  
Mary L. Moody ◽  
Kathleen A. Harder ◽  
Ginette A. Pepper ◽  
Matthew Scanlon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Intravenous Drug ◽  
Consensus Development ◽  
Consensus Development Conference

Preparation of Spherical Porous Granules Composed of Rod-Shaped Hydroxyapatite and Evaluation of their Protein Adsorption Properties

2007 ◽  
Vol 361-363 ◽  
pp. 83-86 ◽  
Author(s):  
Toshiharu Takahashi ◽  
Masanobu Kamitakahara ◽  
Giichiro Kawachi ◽  
Koji Ioku
Keyword(s):  
Drug Delivery ◽  
Protein Adsorption ◽  
Drug Delivery System ◽  
Hydrothermal Treatment ◽  
Delivery System ◽  
Phosphate Buffer ◽  
Adsorption Properties ◽  
The Other ◽  
Emulsion Method ◽  
Sintering Method

The present study examined the possibility of using spherical porous granules of hydroxyapatite (HA, Ca10(PO4)6(OH)2) composed of rod-shaped particles as the drug delivery system. The granules composed of rod-shaped HA were successfully prepared by an emulsion method and a hydrothermal treatment. When the rod-shaped granules were soaked in phosphate buffer salines containing lysozyme chloride or albumin, the granules of rod-shaped HA adsorbed more albumin than lysozyme. On the other hand, the HA granules prepared by a normal sintering method adsorbed little lysozyme chloride or albumin. The HA granules composed of rod-shaped particles are expected to be useful as carriers of negatively charged substances.

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