Preparation of Spherical Porous Granules Composed of Rod-Shaped Hydroxyapatite and Evaluation of their Protein Adsorption Properties

The present study examined the possibility of using spherical porous granules of hydroxyapatite (HA, Ca10(PO4)6(OH)2) composed of rod-shaped particles as the drug delivery system. The granules composed of rod-shaped HA were successfully prepared by an emulsion method and a hydrothermal treatment. When the rod-shaped granules were soaked in phosphate buffer salines containing lysozyme chloride or albumin, the granules of rod-shaped HA adsorbed more albumin than lysozyme. On the other hand, the HA granules prepared by a normal sintering method adsorbed little lysozyme chloride or albumin. The HA granules composed of rod-shaped particles are expected to be useful as carriers of negatively charged substances.

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DESIGN AND CHARACTERIZATION OF CHLORZOXAZONE FLOATING BIOADHESIVE DRUG DELIVERY SYSTEM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i11.27693 ◽

2018 ◽

Vol 11 (11) ◽

pp. 222

Author(s):

Manish Kumar Pal ◽

Ganesh Deshmukh

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

The Other ◽

Direct Compression ◽

Total Dosage ◽

Carbopol 934P

Objective: The objective of the work is to formulate chlorzoxazone floating bioadhesive tablets which will significantly improve the bioavailability of drugs under the condition of prolonged use of drugs and reduce the total dosage of administered drug and reduce the side effect.Methods: Floating bioadhesive tablet was prepared by direct compression of polymer such as HPMCK4M and Carbopol934p in combination.Result: After analysis of different evaluation parameter and drug release, F9 batch was selected as promising formulation for delivery of chlorzoxazone floating bioadhesive tablets with 92.1% drug release at 12th h.Conclusion: It was observed that the combination of polymers in 22.5% (HPMCK4M) and 12.5% (Carbopol 934p) give the best drug release and sustain the drug release for 12 h. Among the other batches, F9 batch was selected as an optimized batch because the pre- and post-compression parameters results are satisfactory.

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Study of pH-Responsive and Polyethylene Glycol-Modified Doxorubicin-Loaded Mesoporous Silica Nanoparticles for Drug Delivery

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.17885 ◽

2020 ◽

Vol 20 (10) ◽

pp. 5997-6006

Author(s):

Yujie Qin ◽

Xiaoqian Shan ◽

Yu Han ◽

Hang Jin ◽

Ying Gao

Keyword(s):

Drug Delivery ◽

Polyethylene Glycol ◽

Drug Release ◽

Mesoporous Silica ◽

Drug Delivery System ◽

Delivery System ◽

Phosphate Buffer ◽

Drug Loading ◽

Phosphate Buffer Solution ◽

Tumor Cell Death

Tumor-targeted drug delivery systems represent challenging and widely investigated strategies to enhance cancer chemotherapy. In this study, we introduce a novel high-hydrophilic mesoporous silica nanoparticle system with a pH-sensitive drug release. The resultant composite nanoparticles appear as spheres of uniform size (450±25 nm) with a porous structure, which enables a high drug-loading ratio. Through modification of chitosan and polyethylene glycol monomethyl ether, the modified mesoporous silica was non-toxic to normal cells, but effective at inducing tumor cell death. With regard to the characteristics of drug release, the modified mesoporous silica clearly displayed a pH-stimulated release of the model drug doxorubicin hydrochloride in an acidic phosphate buffer solution (pH 4.0 and 6.0). The release was much greater than that observed in neutral or alkaline phosphate buffer solutions (pH 7.3 and 8.0). Furthermore, the release behavior was in accordance with the Higuchi model, indicating that this modified mesoporous silica drug delivery system can exhibit controlled release. The above results imply that the modified mesoporous silica is an effective drug delivery system for cancer therapy.

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Drug Delivery System in Pakistan: A Review

Research in Pharmacy and Health Sciences ◽

10.32463/rphs.2016.v02i03.35 ◽

2016 ◽

Vol 2 (3) ◽

pp. 174-178

Author(s):

Shumaila Arshad ◽

Ali Aun ◽

Muhammad Uzair Yousaf

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Developed Countries ◽

Dosage Forms ◽

Delivery Systems ◽

The Other ◽

Pharmaceutical Dosage Forms ◽

Sites Of Action

Drug Delivery systems are the means by which drug molecules are delivered to sites of action within the body.There are several pharmaceutical dosage forms (delivery Systems) available in Pakistan that is being used in different health care centers. Both conventional and advance dosage forms are used now days depending upon the condition of the patient, the disease state and available resources. But unfortunately Pakistan is a way behind in the field of technology among the other developing and developed countries in the world. There are few private setups which are well equipped with high class technology that caters the need of advanced drug delivery system in Pakistan. Mostly advanced drug dosage forms are imported from the other countries, thus it costs Pakistan a lot. In the present study Drug Delivery Systems in Pakistan is thoroughly studied and represented according to the generations of drug delivery system.

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LIPOSOMAL DRUG DELIVERY SYSTEM – A REVIEW

Journal of Applied Pharmaceutical Sciences and Research ◽

10.31069/japsr.v3i3.2 ◽

2020 ◽

pp. 7-10

Author(s):

Anchal Srivastava ◽

Amresh Gupta ◽

Arpita Singh

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Body Part ◽

The Body ◽

The Other ◽

Time Range ◽

Liposomal Drug ◽

Advantages And Disadvantages ◽

Effective Part

A liposome is the drug delivery system which is used for the administration of various types of drugs or active substance(1) are essential for the treatment of various types of disease. A liposome is a very effective drug delivery system to Target the active medicament to an effective part of the body without entrapping or affecting the other body part that's why it is also called the targeted drug delivery system. Liposomes are available in various sizes to the range for treatment to various types of disease as the carrier for targeted the medicament or drug to active site at a predetermined rate & time range, without affecting the other body part for the treatment of a particular disease. they are colloidal spheres of cholesterol non-poisonous surfactants, sphingolipids, glycolipids, long-chain unsaturated fats, and even layer proteins and active atoms or it is also called vesicular system. (2) this review discusses the advantages and disadvantages, various methods of preparation, evaluation, etc.

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Formulation and Evaluation of Modified Pulsincap as Pulsatile Drug Delivery System for Treatment of Rheumatoid Arthritis

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2016.9.5.5 ◽

2016 ◽

Vol 9 (5) ◽

pp. 3476-3487

Author(s):

Chavda D Hiral ◽

Sonpal N Rakshit ◽

Paresh Prajapati A ◽

Madhabhai M Patel

Keyword(s):

Rheumatoid Arthritis ◽

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Phosphate Buffer ◽

Lag Time ◽

Contour Plot ◽

Independent Variables ◽

Pulsatile Drug Delivery

The aim of the present study was to design and evaluate a modified pulsincap pulsatile drug delivery system of etodolac for treatment of rheumatoid arthritis. Capsule body was made water insoluble by cross linking with formaldehyde vapour. It was filled with drug, osmogen NaCl and super disintegrant sodium starch glycolate to expel the drug after predetermined lag time. A hydro gel plug made of HPMC K4M was placed in the capsule body to achieve desired drug release after lag time for chronotherapy of rheumatoid arthritis. Untreated cap was then fitted to the treated body was sealed. Entire unit was coated with 5% Eudragit S-100 to prevent variable gastric emptying. A 32 full factorial design was used for optimization in which concentration ratio of NaCl and SSG (X1), and the weight of hydrogel plug (X2) were selected as independent variables while lag time and t90% were taken as dependent variables. FTIR and DSC studies confirmed drug excipient compatibility. Developed formulation was evaluated for in-vitro drug release in pH 1.2, phosphate buffer pH 6.8 and phosphate buffer pH 7.4. Statistical analysis confirmed the significance of selected independent variables. Response surface plot and contour plot indicate augmentation of the line toward the weight of hydrogel plug factor indicating greater significance. Formulation with highest desirability containing 34.4 mg of SSG, 137.6 mg of NaCl and 48 mg of HPMC K4M plug was selected as an optimized formulation as it provided the desired lag time of 6 hours and t90% of about 477 mins. Accelerated stability study performed on optimized formulation suggested stable and viable formulation. A stable, efficient formulation modified pulsincap of Etodolac as a pulsatile drug delivery system was developed with proposed increased patient compliance and improved dosage form efficiency.

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Design and Evaluation of Chronomodulated Drug Delivery of Tramadol Hydrochloride

Drug Research ◽

10.1055/s-0043-119072 ◽

2017 ◽

Vol 68 (03) ◽

pp. 174-180 ◽

Cited By ~ 2

Author(s):

Thota Alekya ◽

Dudhipala Narendar ◽

Donthi Mahipal ◽

Narala Arjun ◽

Banala Nagaraj

Keyword(s):

Rheumatoid Arthritis ◽

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Phosphate Buffer ◽

Lag Time ◽

Physical Parameters ◽

Tramadol Hydrochloride ◽

Eudragit S100

AbstractRheumatoid arthritis is an auto immune disease which requires chronotherapy as it occurs during early morning. Tramadol hydrochloride (TH) is an analgesic drug, used to treat rheumatoid arthritis. The aim of the present investigation was to develop chronomodulated drug delivery system of tramadol hydrochloride such that it releases the drug early in the morning, during which the symptoms of rheumatoid arthritis worsen. To develop chronomodulated drug delivery system of TH, initially core tablets of TH were prepared using three different supradisintegrants followed by coating with pH dependent polymer of Eudragit S100. The prepared core tablets are evaluated for physical parameters and an optimal system was identified. Further, coating composition of Eudragit S100 was optimized and coating tablets of TH was prepared. The prepared coated tablets were evaluated for weight variation, hardness, drug content and in vitro release studies in 0.1N HCl, pH 6.8 phosphate buffer and pH 7.4 phosphate buffer. Formulation with 7.5% of coating solution (ES2) had shown a significant drug release after a lag time of 3 h (in pH 6.8 medium), 6 h (in pH 6.8 medium) and 8 h (in pH 7.4 medium), respectively. DSC studies revealed that no interaction between core and coated materials with drug was observed. Thus, chronomodulated drug delivery system of TH was formulated and assuming that if a tablet is administered around 9 pm to 10 pm, the drug release starts after a lag time of 6 h i. e., around 3am to 4 am.

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