Nutritional Modifications in the Immediate Postnatal Period Can Cause Metabolic Programming in Adulthood

Abstract The global prevalence of obesity has been rising at an alarming rate, accompanied by an increase in both childhood and maternal obesity. The concept of metabolic programming is highly topical, and in this context, describes a predisposition of offspring of obese mothers to the development of obesity independent of environmental factors. Research published in this issue of Clinical Science conducted by Litzenburger and colleagues (Clin. Sci. (Lond.) (2020) 134, 921–939) have identified sex-dependent differences in metabolic programming and identify putative signaling pathways involved in the differential phenotype of adipose tissue between males and females. Delineating the distinction between metabolically healthy and unhealthy obesity is a topic of emerging interest, and the precise nature of adipocytes are key to pathogenesis, independent of adipose tissue volume.

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Review for "miR‐148a controls metabolic programming and survival of mature CD19‐negative plasma cells in mice"

10.1002/eji.202048993/v2/review2 ◽

2020 ◽

Keyword(s):

Plasma Cells ◽

Metabolic Programming

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Targeted Gene Arrays across the Severely-Discordant growth Monochorionic Twin Placenta: Implications for Angiogenesis and Metabolic Programming

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/s-0031-1293261 ◽

2011 ◽

Vol 215 (S 01) ◽

Author(s):

S Schrey ◽

D Baczyk ◽

B Fitzgerald ◽

G Ryan ◽

J Kingdom ◽

...

Keyword(s):

Metabolic Programming ◽

Gene Arrays ◽

Monochorionic Twin

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Vitamin D Provision in High-Yield Dairy Cows During the Winter Housing Period

Agricultural science and practice ◽

10.15407/agrisp1.01.042 ◽

2014 ◽

Vol 1 (1) ◽

pp. 42-46

Author(s):

L. Yuskiv ◽

V. Vlizlo

Keyword(s):

Vitamin D ◽

Alkaline Phosphatase Level ◽

Mineral Metabolism ◽

Physiological State ◽

Blood Parameters ◽

Postnatal Period ◽

High Yield ◽

Oral Supplementation ◽

Calcium Phosphorus ◽

Vitamin D 3

Aim. To investigate the vitamin D status in highly productive cows during winter housing period and effect of cholecalciferol by various ways of vitamin D 3 injection to cows in last days of gestation and after calving. Methods. Enzyme-linked immunoassay, spectrophotometry. Results. It has been stated that intramuscular injection of cholecalciferol into cows caused increase of the vitamin D 3 active metabolite – 25-OHD 3 , calcium, phosphorus and magnesium levels together with decrease of alkaline phosphatase level in pre- and post-natal periods. Oral supplementation makes little infl uence on the studied blood parameters of cows. Conclusions. Extrabuccal administration and oral supplementation of cholecalciferol in winter housing period to high-yield cows in the last days of gestation and after calving is accompanied by increased levels of its metabolites and their effect on mineral metabolism in the postnatal period. The nature of these changes depends on the mode of vitamin D administration and the physiological state of the cows.

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