Strategies to Improve Systemic and Local Availability of Drugs Administered via Vaginal Route

Author(s):  
Maria Cristina Bonferoni ◽  
Giuseppina Sandri ◽  
Silvia Rossi ◽  
Franca Ferrari ◽  
Carla Caramella
Keyword(s):  

2002 ◽  
Vol 186 (4) ◽  
pp. 852 ◽  
Author(s):  
Renaud de Tayrac ◽  
Hervé Fernandez


2016 ◽  
Vol 28 (4) ◽  
pp. 271 ◽  
Author(s):  
Zahra Dehbashi ◽  
Mahmood Moosazadeh ◽  
Mahdi Afshari


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Michel Robert Fortuné Odent

Abstract In the age of hospital births, it is commonplace to contrast the vaginal route and the abdominal route as the basic classification. From the “point of view” of the foetus/neonate, we provide reasons to contrast “birth without labour” (that is birth by pre-labour caesarean section) and all the other vaginal and abdominal modes of birth. From a great diversity of theoretical reasons, one can anticipate that babies born by pre-labour caesarean sections are different from the others. We also provide reasons to popularize the concepts of “in labour non-emergency caesarean sections” and “planned in-labour caesarean sections”.



Author(s):  
Gil Dubernard ◽  
Roman Rouzier ◽  
Bassam Haddad ◽  
Philippe Dubois ◽  
Bernard-Jean Paniel


Author(s):  
DIVYA VARDAINI

Objective: The objective of this study was to compare and evaluate the efficacy, safety, adverse effects, and patient compliance of vaginal versus oral misoprostol in medical termination of pregnancy after tablet misoprostol up to 49 days of gestation. Methods: A comparative study of 100 patients divided randomly assigned to two control groups. Results: The study showed that 200 mg mifepristone followed by 800 mcg vaginal misoprostol is more effective for medical termination in gestational age up to 49 days as compared to 200 mg mifepristone followed by 400 mcg oral misoprostol. Conclusion: While both routes of administration are safe, gastrointestinal side effects are more with oral misoprostol. The vaginal route is more acceptable to the patients enrolled in the study.



2009 ◽  
Vol 54 (No. 3) ◽  
pp. 138-141 ◽  
Author(s):  
N. Timurkaan ◽  
M. Aydin ◽  
F. Yilmaz ◽  
A. Cevik

: This paper describes a case of fibroleiomyoma seen in the vagina of a cow, diagnosed on the basis of macroscopic, microscopic and immunohistochemical findings. A five year-old female, Simmental and Brown Swiss crossbreed cow presented with six neoplastic masses located on the vaginal wall. The masses were surgically removed through the vaginal route and were firm and well demarcated. Microscopic examination showed that the non-encapsulated neoplastic nodules consisted of the admixture of smooth muscle and connective tissue. Immunohistochemical examination revealed strong focal positive reactions for smooth muscle actin and vimentin, but no positive reaction for CD 68. The tumour reported here was considered benign because of the lack of clear pleomorphism, invasivness, multinuclear giant cells and atypia, and low mitotic activity.



2019 ◽  
Vol 14 (1) ◽  
pp. 48-51
Author(s):  
Ujwal Rai ◽  
Monasha Vaidya ◽  
Gehanath Baral ◽  
Smrity Mool Joshi ◽  
Sunita Ray

Aims: To audit and evaluate the surgical indications, routes of surgery and types of hysterectomies performed along with histopathological analysis of those hysterectomies in respect to disease of endometrium, myometrium, cervix and fallopian tubes and ovaries for benign conditions. Methods: This is retrospective cross sectional study of all hysterectomy specimens received in the department of Pathology, B and C teaching hospital and research center, Jhapa, Birtamode, Nepal from May 2017 to May 2019. Clinical details were received from the data provided by gynecologists in histopathological requisition forms. Only specimens received for the benign indication for hysterectomy were taken. Results: Out of 115 specimens, the number was equal on both abdominal and vaginal route. The common indications were leiomyoma (60%, n=69), abnormal uterine bleeding (24%, n=28) and uterine prolapsed in 11% (n=13). Uterovaginal prolapse was seen commonest indication for hysterectomy in age group of 5th and 6th decade of life. Myometrial pathology was seen in 74% (n=75) comprising mostly of leiomyoma. Endometrial pathology was present in 14% (n=16) and chronic non-specific cervicitis in 24% (n=28). Abnormal tubo-ovarian pathology was found in 40% (n=51). Conclusions: Leiomyoma, abnormal uterine bleding and uterovaginal prolapsed are the common benign conditions undergoing hysterectomy.  



1937 ◽  
Vol 30 (8) ◽  
pp. 811-816
Author(s):  
Olin S. Cofer
Keyword(s):  




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