Artemisinin-derived Antimalarial Dry Suspensions for Pediatric Use

2011 ◽  
pp. 74-85
Keyword(s):  
Pediatric Use

scholarly journals 3D Printing of Mini Tablets for Pediatric Use

2021 ◽  
Vol 14 (2) ◽  
pp. 143
Author(s):  
Julius Krause ◽  
Laura Müller ◽  
Dorota Sarwinska ◽  
Anne Seidlitz ◽  
Malgorzata Sznitowska ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Dosage Forms ◽  
Small Scale ◽  
Fused Deposition ◽  
On Demand ◽  
Pediatric Diseases ◽  
Deposition Modeling ◽  
Manufacturing Techniques ◽  
Pediatric Use

In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.

scholarly journals Matched Case-Control Study of Effectiveness of Live, Attenuated S79 Mumps Virus Vaccine against Clinical Mumps

2008 ◽  
Vol 15 (9) ◽  
pp. 1425-1428 ◽  
Author(s):  
Chuanxi Fu ◽  
Jianhua Liang ◽  
Ming Wang
Keyword(s):  
Virus Vaccine ◽  
Case Control Study ◽  
Early Adulthood ◽  
Mumps Virus ◽  
Control And Prevention ◽  
Matched Case ◽  
Pediatric Use ◽  
Computerized System ◽  
Matched Case Control Study ◽  
Control Study

ABSTRACT Mumps virus infection is a potentially serious viral infection of childhood and early adulthood. In China, live, attenuated S79 mumps virus vaccine has been licensed for pediatric use since 1990. There has been no assessment of its efficacy. Thus, the objective of this study was to determine the effectiveness of live, attenuated S79 mumps virus vaccine against clinical mumps. Cases were selected from the China Information System for Disease Control and Prevention during September 2004 to March 2005. Each case was matched to a control by gender, age, and area of residency. In all, 469 cases and 469 controls were enrolled in the study. Vaccination information was obtained from the Children's EPI Administrative Computerized System. Vaccine effectiveness (VE) was calculated for one or two doses of S79 vaccine, with 95% confidence intervals (CI). VE of mumps virus vaccine for one dose versus none was protection of 86.0% (95% CI, 77.2% to 91.5%) of recipients, and VE was much higher in the first 4 years than in the 5 to 12 years after vaccination. The S79 vaccine can effectively prevent clinical mumps, and a second dose of mumps virus vaccine is necessary for the protection of children in China.

STUDIES OF PENICILLIN IN PEDIATRICS

PEDIATRICS ◽  
1950 ◽  
Vol 5 (4) ◽  
pp. 664-671
Author(s):  
B. M. KAGAN ◽  
M. NIERENBERG ◽  
D. GOLDBERG ◽  
A. MILZER
Keyword(s):  
Intramuscular Injection ◽  
Room Temperature ◽  
Serum Levels ◽  
Sesame Oil ◽  
Peanut Oil ◽  
Penicillin G ◽  
Procaine Penicillin ◽  
Pertinent Data ◽  
Significant Difference ◽  
Pediatric Use

Table I summarizes most of the pertinent data in this report on the serum penicillin concentrations 12 and 24 hours after intramuscular injection of K penicillin G in peanut oil and beeswax, which is fluid at room temperature, and of three different procaine penicillin preparations. These three preparations are procaine penicillin G in sesame oil, procaine penicillin G in peanut oil with 2% aluminum monostearate, and procaine penicillin G in water with Na-carboxymethylcellulose. When they were given in a dosage of 8000 u./lb. to infants and children, weighing between 4.5 and 18.0 kg., there was no statistically significant difference in the serum levels obtained. A dosage schedule for these preparations is suggested for pediatric use. The aqueous preparation offers some advantages which are discussed. Experiences are reported which emphasize the necessity of avoiding intravenous administration of all these preparations.

scholarly journals Development and Validation of a Method to Quantify Midazolam in a New Oral Formulation for Pediatric Use

2012 ◽  
Vol 03 (08) ◽  
pp. 552-558 ◽  
Author(s):  
Carmen Flores Pérez ◽  
Juan Luis Chávez Pacheco ◽  
Janett Flores Pérez ◽  
Hugo Juárez Olguín ◽  
Blanca Ramírez Mendiola ◽  
...  
Keyword(s):  
Oral Formulation ◽  
Pediatric Use ◽  
Development And Validation

scholarly journals Off-Label Prescribing in Pediatric Inpatients With Pneumonia in a Children's Hospitaal

2018 ◽  
Vol 16 (1) ◽  
pp. 25
Author(s):  
Hesty Utami Ramadaniati ◽  
Heni Safarini ◽  
Aishah A Regine
Keyword(s):  
Clinical Trials ◽  
Medical Records ◽  
Product Information ◽  
Drug Label ◽  
Off Label ◽  
National Drug ◽  
Different Types ◽  
Pediatric Use ◽  
Official Information ◽  
Study Hospital

Off-label is a term used in which a  drug prescribed outside the official information of the marketing authorization.  Off-label prescribing may occur as the result of several factors including  lack of clinical trials data involving pediatrics and suitable formulations for medicines commonly prescribed to this fragile population. Objective: This study aimed to estimate the nature and prevalence of off-label prescribing in pediatric inpatients with pneumonia. Material and Methods: a retrospective study was conducted in a study hospital using medical records from pediatric inpatients with pneumonia during the period of January-December 2015. Patient and prescribing data were collected, and drugs were classified as on-label or off-label based on the Indonesia National Drug Information (IONI) and British National Formulary for Children (BNFC). Thereafter, off-label drugs were categorized with a hierarchical system of age, indication, route of administration and dosage. Results: There were 1141 drugs with 77 different types of drug were administered to 207 patient during the study period. The data uncovered that 405 (35,5%) of the drug prescriptions were used off-label based on IONI, and 319 (28%) of the drug were used off-label based on BNFC. Based on IONI and BNFC, most off-label drugs were from anti infection drugs. Conclusion: The prevalence of off-label use in pediatric inpatients with pneumonia is not high. The off-label prescribing may not be necessarily  be considered irrational, yet this fact reveals that the use of drugs does not comply with the drug label. Clinical trials for pediatric drugs are essential to provide  complete product information for pediatric use.

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