Inner Ear Hair Cell Bundle Mechanics

Biomechanics ◽  
2014 ◽  
pp. 18-1-18-14
Author(s):  
Wally Grant
Keyword(s):  
Hair Cell ◽  
Inner Ear

Hair cell regeneration in the inner ear

1994 ◽  
Vol 111 (3) ◽  
pp. 281-301 ◽  
Author(s):  
T TSUE ◽  
E OESTERLE ◽  
E RUBEL
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Cell Regeneration ◽  
Hair Cell Regeneration

Hair Cell Damage in the Inner Ear of the Guinea Pig Due to Noise in a Workshop

1987 ◽  
Vol 103 (5) ◽  
pp. 204-211 ◽  
Author(s):  
B. Erlandsson ◽  
H. Hakanson ◽  
A. Ivarsson ◽  
P. Nilsson ◽  
J. Wersall
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Damage ◽  
Hair Cell Damage

scholarly journals FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway

Autophagy ◽  
2021 ◽  
pp. 1-22
Author(s):  
Zu-Hong He ◽  
Ming Li ◽  
Qiao-Jun Fang ◽  
Fu-Ling Liao ◽  
Sheng-Yu Zou ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Survival ◽  
Inner Ear ◽  
Autophagy Pathway

scholarly journals Cell of the month: An outer hair cell of the inner ear

2004 ◽  
Vol 6 (2) ◽  
pp. 96-96
Author(s):  
Mei Zhang ◽  
Patrick J. Antonelli
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Outer Hair Cell

Functional Recovery of Hearing following AMPA-Induced Reversible Disruption of Hair Cell Afferent Synapses in the Avian Inner Ear

2001 ◽  
Vol 6 (2) ◽  
pp. 66-78 ◽  
Author(s):  
Diana Reng ◽  
Marcus Müller ◽  
Jean W.T. Smolders
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Functional Recovery ◽  
Avian Inner Ear

Hes1 is a negative regulator of inner ear hair cell differentiation

Development ◽  
2000 ◽  
Vol 127 (21) ◽  
pp. 4551-4560 ◽  
Author(s):  
J.L. Zheng ◽  
J. Shou ◽  
F. Guillemot ◽  
R. Kageyama ◽  
W.Q. Gao
Keyword(s):  
Cell Differentiation ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Fate ◽  
Hair Cells ◽  
Outer Hair Cells ◽  
Negative Regulator ◽  
Pcr Analysis ◽  
Loss Of Function ◽  
Hair Cell Differentiation

Hair cell fate determination in the inner ear has been shown to be controlled by specific genes. Recent loss-of-function and gain-of-function experiments have demonstrated that Math1, a mouse homolog of the Drosophila gene atonal, is essential for the production of hair cells. To identify genes that may interact with Math1 and inhibit hair cell differentiation, we have focused on Hes1, a mammalian hairy and enhancer of split homolog, which is a negative regulator of neurogenesis. We report here that targeted deletion of Hes1 leads to formation of supernumerary hair cells in the cochlea and utricle of the inner ear. RT-PCR analysis shows that Hes1 is expressed in inner ear during hair cell differentiation and its expression is maintained in adulthood. In situ hybridization with late embryonic inner ear tissue reveals that Hes1 is expressed in supporting cells, but not hair cells, of the vestibular sensory epithelium. In the cochlea, Hes1 is selectively expressed in the greater epithelial ridge and lesser epithelial ridge regions which are adjacent to inner and outer hair cells. Co-transfection experiments in postnatal rat explant cultures show that overexpression of Hes1 prevents hair cell differentiation induced by Math1. Therefore Hes1 can negatively regulate hair cell differentiation by antagonizing Math1. These results suggest that a balance between Math1 and negative regulators such as Hes1 is crucial for the production of an appropriate number of inner ear hair cells.

High-Voltage Electron Microscopic Study of the Inner Ear: Technique and Preliminary Results

1983 ◽  
Vol 92 (1_suppl) ◽  
pp. 3-12 ◽  
Author(s):  
Tomonori Takasaka ◽  
Hideich Shinkawa ◽  
Kozo Watanuki ◽  
Sho Hashimoto ◽  
Kazutomo Kawamoto
Keyword(s):  
Electron Microscopy ◽  
Hair Cell ◽  
Inner Ear ◽  
High Voltage ◽  
Hair Cells ◽  
Outer Hair Cells ◽  
Tectorial Membrane ◽  
Preliminary Results ◽  
Voltage Electron ◽  
Cuticular Plate

The technique and some preliminary results of the application of high-voltage electron microscopy (HVEM) to the study of inner ear morphology in the guinea pig are reported in this paper. The main advantage of HVEM is that sharp images of thicker specimens can be obtained because of the greater penetrating power of high energy electrons. The optimum thickness of the sections examined with an accelerating voltage of 1,000 kV was found to be between 500 to 800 nm. The sections below 500 nm in thickness often had insufficient contrast, while those above 800 nm were rather difficult to interpret due to overlap of images of the organelles. The whole structure of the sensory hairs from the tip to the rootlet was more frequently observed in the 800-nm thick sections. Thus the fine details of the hair attachment to the tectorial membrane as well as the hair rootlet extension into the cuticular plate could be thoroughly studied in the HVEM. In specimens fixed in aldehyde containing 2% tannic acid, the attachment of the tips of the outer hair cell stereocilia to the tectorial membrane was observed. For the inner hair cells, however, the tips of the hairs were separated from the undersurface of the tectorial membrane. The majority of the rootlets of the outer hair cells terminated at the midportion of the cuticular plate, while most of the inner hair cell rootlets traversed the entire width of the cuticular plate and extended into the apical cytoplasm. These differences in ultrastructural appearance may indicate that the two kinds of hair cells play different roles in the acoustic transduction process. The three-dimensional arrangement of the nerve endings on the hair cells was also studied by the serial thick-sectioning technique in the HVEM. In general, an entire arrangement of the nerve endings was almost completely cut in less than ten 800-nm thick sections instead of the 50- to 100-ultrathin (ie, less than 100 nm) conventional sections for transmission electron microscopy. The present study confirms an earlier report that the first row outer hair cells in the third cochlear turn are innervated by nearly equal numbers of efferent and afferent endings, the average number being nine.

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