Role of Particle Therapy in Future Radiotherapy Practice

α-Particle irradiation of cancerous tissue is increasingly recognized as a potent therapeutic option. We briefly review the physics, radiobiology, and dosimetry of α-particle emitters, as well as the distinguishing features that make them unique for radiopharmaceutical therapy. We also review the emerging clinical role of α-particle therapy in managing cancer and recent studies on in vitro and preclinical α-particle therapy delivered by antibodies, other small molecules, and nanometer-sized particles. In addition to their unique radiopharmaceutical characteristics, the increased availability and improved radiochemistry of α-particle radionuclides have contributed to the growing recent interest in α-particle radiotherapy. Targeted therapy strategies have presented novel possibilities for the use of α-particles in the treatment of cancer. Clinical experience has already demonstrated the safe and effective use of α-particle emitters as potent tumor-selective drugs for the treatment of leukemia and metastatic disease.

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Correction: The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)

Biomaterials Science ◽

10.1039/d1bm90027g ◽

2021 ◽

Vol 9 (7) ◽

pp. 2743-2744

Author(s):

Pengyuan Qi ◽

Qianyuan Chen ◽

Dong Tu ◽

Songhuan Yao ◽

Yupeng Zhang ◽

...

Keyword(s):

Boron Neutron Capture Therapy ◽

Neutron Capture ◽

Potential Role ◽

Particle Therapy ◽

Neutron Capture Therapy ◽

Boron Neutron Capture

Correction for ‘The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)’ by Pengyuan Qi et al., Biomater. Sci., 2020, 8, 2778–2785, DOI: 10.1039/D0BM00318B.

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A Review of Particle Therapy for Skull Base Tumors: Modern Considerations and Future Directions

International Journal of Particle Therapy ◽

10.14338/ijpt-20-00083 ◽

2021 ◽

Vol 8 (1) ◽

pp. 168-178

Author(s):

Eugen B. Hug ◽

Maciej Pelak ◽

Steven J. Frank ◽

Piero Fossati

Keyword(s):

Skull Base ◽

Clinical Investigation ◽

Particle Therapy ◽

Future Research ◽

Benign Tumors ◽

Skull Base Tumors ◽

Carbon Ion Therapy ◽

Ion Therapy ◽

Future Research Directions

Abstract Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. This review summarizes these topics, assesses the present status, and reflects on future research directions focusing on the management of chordomas, one of the most aggressive skull base tumors. In addition, the role of particle therapy for benign tumors of the skull base, including pituitary adenoma and acoustic neuroma, is reviewed.

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