scholarly journals CYCLIC AMP IN CEREBROSPINAL FLUID (CSF) OF PRETERM INFANTS WITH INTRAVENTRICULAR HEMORRHAGE / POST-HEMORRHAGIC HYDROCEPHALUS (IVH/PHH).† 2259

1996 ◽  
Vol 39 ◽  
pp. 379-379
Author(s):  
Massroor Pourcyrous ◽  
Helena Parfenova ◽  
Momoh Yakubu ◽  
Henrietta S Bada ◽  
Sheldon B Korones ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cyclic Amp ◽  
Preterm Infants ◽  
Intraventricular Hemorrhage

scholarly journals Elevated Pro-Inflammatory Cell-Free MicroRNA Levels in Cerebrospinal Fluid of Premature Infants after Intraventricular Hemorrhage

2020 ◽  
Vol 21 (18) ◽  
pp. 6870 ◽  
Author(s):  
Zsolt Fejes ◽  
Judit Erdei ◽  
Marianna Pócsi ◽  
Jun Takai ◽  
Viktória Jeney ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Inflammatory Cell ◽  
Cell Culture Supernatant ◽  
Protein Biomarkers ◽  
Choroid Plexus Epithelial Cell ◽  
Soluble Adhesion Molecules ◽  
Inflammatory Conditions

Intraventricular hemorrhage (IVH) represents a high risk of neonatal mortality and later neurodevelopmental impairment in prematurity. IVH is accompanied with inflammation, hemolysis, and extracellular hemoglobin (Hb) oxidation. However, microRNA (miRNA) expression in cerebrospinal fluid (CSF) of preterm infants with IVH has been unknown. Therefore, in the present study, candidate pro-inflammatory cell-free miRNAs were analyzed in CSF samples from 47 preterm infants with grade III or IV IVH vs. clinical controls (n = 14). miRNAs were quantified by RT-qPCR, normalized to “spike-in” cel-miR-39. Oxidized Hb and total heme levels were determined by spectrophotometry as well as IL-8, VCAM-1, ICAM-1, and E-selectin concentrations by ELISA. To reveal the origin of the investigated miRNAs, controlled hemolysis experiments were performed in vitro; in addition, human choroid plexus epithelial cell (HCPEpiC) cultures were treated with metHb, ferrylHb, heme, or TNF-α to replicate IVH-triggered cellular conditions. Levels of miR-223, miR-155, miR-181b, and miR-126 as well as Hb metabolites along with IL-8 were elevated in CSF after the onset of IVH vs. controls. Significant correlations were observed among the miRNAs, oxidized Hb forms, and the soluble adhesion molecules. During the post-IVH follow-up, attenuated expression of miRNAs and protein biomarkers in CSF was observed upon elimination of Hb metabolites. These miRNAs remained unaffected by a series of artificially induced hemolysis, which excluded red blood cells as their origin, while stimulation of HCPEpiCs with oxidized Hb fractions and heme resulted in increased extracellular miRNA levels in the cell culture supernatant. Overall, the hemorrhage-induced CSF miRNAs reflected inflammatory conditions as potential biomarkers in preterm IVH.

Osteopathic status of preterm infants with intraventricular hemorrhage

2020 ◽  
pp. 64-73
Author(s):  
L. K. Karimova ◽  
J. O. Kuzmina ◽  
Z. N. Zinnurova ◽  
E. M. Vasilevskaja
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage

scholarly journals Early Inflammatory Cytokine Expression in Cerebrospinal Fluid of Patients with Spontaneous Intraventricular Hemorrhage

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1123
Author(s):  
Wendy C. Ziai ◽  
Adrian R. Parry-Jones ◽  
Carol B. Thompson ◽  
Lauren H. Sansing ◽  
Michael T. Mullen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intraventricular Hemorrhage ◽  
Inflammatory Responses ◽  
Obstructive Hydrocephalus ◽  
External Ventricular Drainage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Injury Reduction ◽  
Positive Correlations ◽  
Factor Α ◽  
Perihematomal Edema

We investigated cerebrospinal fluid (CSF) expression of inflammatory cytokines and their relationship with spontaneous intracerebral and intraventricular hemorrhage (ICH, IVH) and perihematomal edema (PHE) volumes in patients with acute IVH. Twenty-eight adults with IVH requiring external ventricular drainage for obstructive hydrocephalus had cerebrospinal fluid (CSF) collected for up to 10 days and had levels of interleukin-1α (IL-1α), IL-1β, IL-6, IL-8, IL-10, tumor necrosis factor-α (TNFα), and C-C motif chemokine ligand CCL2 measured using enzyme-linked immunosorbent assay. Median [IQR] ICH and IVH volumes at baseline (T0) were 19.8 [5.8–48.8] and 14.3 [5.3–38] mL respectively. Mean levels of IL-1β, IL-6, IL-10, TNF-α, and CCL2 peaked early compared to day 9–10 (p < 0.05) and decreased across subsequent time periods. Levels of IL-1β, IL-6, IL-8, IL-10, and CCL2 had positive correlations with IVH volume at days 3–8 whereas positive correlations with ICH volume occurred earlier at day 1–2. Significant correlations were found with PHE volume for IL-6, IL-10 and CCL2 at day 1–2 and with relative PHE at days 7–8 or 9–10 for IL-1β, IL-6, IL-8, and IL-10. Time trends of CSF cytokines support experimental data suggesting association of cerebral inflammatory responses with ICH/IVH severity. Pro-inflammatory markers are potential targets for injury reduction.

Cerebral Oxygenation, Extraction, and Autoregulation in Very Preterm Infants Who Develop Peri-Intraventricular Hemorrhage

2013 ◽  
Vol 162 (4) ◽  
pp. 698-704.e2 ◽  
Author(s):  
Thomas Alderliesten ◽  
Petra M.A. Lemmers ◽  
Janneke J.M. Smarius ◽  
René E. van de Vosse ◽  
Willem Baerts ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Cerebral Oxygenation ◽  
Very Preterm Infants ◽  
Very Preterm

scholarly journals 1271 Risk Factors for Intraventricular Hemorrhage in Less Than 32 Weeks Gestation Preterm Infants - Prospective Study

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A363-A363
Author(s):  
M. Ognean ◽  
E. Olariu ◽  
O. Boanta ◽  
A. Nicula ◽  
V. Panait ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Preterm Infants ◽  
Intraventricular Hemorrhage

Role of Cyclic AMP in Cerebrospinal Fluid Production

1980 ◽  
pp. 17-27 ◽  
Author(s):  
Arthur M. Feldman ◽  
Mel H. Epstein ◽  
Saul W. Brusilow
Keyword(s):  
Cerebrospinal Fluid ◽  
Cyclic Amp ◽  
Fluid Production

scholarly journals Germinal Matrix-Intraventricular Hemorrhage: A Tale of Preterm Infants

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Walufu Ivan Egesa ◽  
Simon Odoch ◽  
Richard Justin Odong ◽  
Gloria Nakalema ◽  
Daniel Asiimwe ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Very Low Birth Weight ◽  
Preterm Neonates ◽  
Low Birth Weight Infants ◽  
Neurodevelopmental Outcomes ◽  
Germinal Matrix ◽  
Posthemorrhagic Hydrocephalus ◽  
Management Interventions ◽  
Incidence Risk

Germinal matrix-intraventricular hemorrhage (GM-IVH) is a common intracranial complication in preterm infants, especially those born before 32 weeks of gestation and very-low-birth-weight infants. Hemorrhage originates in the fragile capillary network of the subependymal germinal matrix of the developing brain and may disrupt the ependymal lining and progress into the lateral cerebral ventricle. GM-IVH is associated with increased mortality and abnormal neurodevelopmental outcomes such as posthemorrhagic hydrocephalus, cerebral palsy, epilepsy, severe cognitive impairment, and visual and hearing impairment. Most affected neonates are asymptomatic, and thus, diagnosis is usually made using real-time transfontanellar ultrasound. The present review provides a synopsis of the pathogenesis, grading, incidence, risk factors, and diagnosis of GM-IVH in preterm neonates. We explore brief literature related to outcomes, management interventions, and pharmacological and nonpharmacological prevention strategies for GM-IVH and posthemorrhagic hydrocephalus.

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