scholarly journals Population-based Data at Ages 31 and 46 Show Decreased HRQoL and Life Satisfaction in Women with PCOS Symptoms

2020 ◽  
Vol 105 (6) ◽  
pp. 1814-1826 ◽  
Author(s):  
Salla Karjula ◽  
Laure Morin-Papunen ◽  
Stephen Franks ◽  
Juha Auvinen ◽  
Marjo-Riitta Järvelin ◽  
...  
Keyword(s):  
Life Satisfaction ◽  
Health Status ◽  
Polycystic Ovary ◽  
Population Based ◽  
Longitudinal Assessment ◽  
Related Quality ◽  
Health Related ◽  
Reported Health ◽  
Self Reported Health Status ◽  
The Impact

Abstract Context Polycystic ovary syndrome (PCOS) is associated with decreased health-related quality of life (HRQoL), but longitudinal data beyond the reproductive years are lacking, and the impact of isolated PCOS symptoms is unclear. Objective To study generic HRQoL using the 15D questionnaire, life satisfaction, and self-reported health status in women with PCOS symptoms at ages 31 and 46 years. Design A longitudinal assessment using the Northern Finland Birth Cohort 1966. Setting General community. Participants The 15D data were available for women reporting isolated oligo-amenorrhea (OA; at age 31 years, 214; and 46 years, 211), isolated hirsutism (H; 31 years, 211; and 46 years, 216), OA + H (PCOS; 31 years, 74; and 46 years, 75), or no PCOS symptoms (controls; 31 years, 1382; and 46 years, 1412). Data for life satisfaction and current health status were available for OA (31 years, 329; and 46 years, 247), H (31 years, 323; and 46 years, 238), PCOS (31 years, 125; and 46 years, 86), control (31 years, 2182; and 46 years, 1613) groups. Intervention(s) None. Main Outcome Measure(s) 15D HRQoL, questionnaires on life satisfaction, and self-reported health status. Results HRQoL was lower at ages 31 and 46 in women with PCOS or H than in the controls. PCOS was an independent risk factor for low HRQoL, and the decrease in HRQoL in PCOS was similar to that of women with other chronic conditions, such as asthma, migraine, rheumatoid arthritis, and depression. The risk for low HRQoL in PCOS remained significant after adjusting for body mass index, hyperandrogenism, and socioeconomic status. Mental distress was the strongest contributing factor to HRQoL. PCOS was also associated with a risk for low life satisfaction and a 4-fold risk for reporting a poor health status. Conclusions Women with PCOS present with low HRQoL, decreased life satisfaction, and a poorer self-reported health status up to their late reproductive years. Assessments and interventions aiming to improve HRQoL in PCOS should be targeted beyond the fertile age.

EUROQoL-5D as a valid patient-reported outcome measurement (PROM) tool to predict health-related quality of life (HRQoL) and survival in patients with hematological malignancies.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19141-e19141
Author(s):  
Raul Cordoba ◽  
Adriana Pascual ◽  
Javier Martinez-Peromingo ◽  
Ana-Isabel Hormigo ◽  
Elham Askari ◽  
...  
Keyword(s):  
Health Status ◽  
Outcome Measurement ◽  
Patient Reported Outcome ◽  
Patient Reported ◽  
Related Quality ◽  
Health Related ◽  
Euroqol 5D ◽  
Reported Health ◽  
Self Reported Health Status

e19141 Background: Patient-Reported Outcome Measurement (PROM) is the way to collect not only Health-Related Quality of Life (HRQoL) but also symptoms. EUROQOL-5D is a PROM tool explored widely in patients with cancer, although is not specific for cancer patients. The primary end-point of this project is to analyse the significance of impairments in EUROQOL-5D domains in overall survival of patients with hematological malignances, and the utility to incorporate as a PROM tool in a daily clinical practice. Methods: Patients with hematologic malignancies attended at Fundacion Jimenez Diaz University Hospital were assessed with EUROQOL-5D prior to receive any therapy. Self-reported health status stated as better, equal or worse was recorded at the time of assessment. Other variables such as age, sex, diagnosis and ECOG was collected to analyze their impact in survival. Results: From January 1, 2017 to December 31, 2019, 390 consecutive patients were included. Median age was 72 years (range 18-92), 194 (49.7%) were female, with a diagnosis of lymphoma in 257 (65.9%) and myeloma in 70 (17.9%), and ECOG 0-1 in 78.2% of patients. With a median follow-up of 10.5 months (range 0-32 months), we registered 72 events for overall survival. In the univariate analysis, age > 76 years (AUC 0.739, Likelyhood Ratio 3.321, p < 0.0001), ECOG 2-4 (OR 11.161, 95% CI 5.276-23.610, p < 0.0001), impairment in EUROQOL-5D domains such us mobility (OR 2.896, 95%CI 1.406-5.967, p = 0.003), self-care (OR 3.959, 95%CI 1.732-9.050, p = 0.001) and usual activities (OR 3.190, 95%CI 1.573-6.467, p = 0.001), but not pain/disconfort nor anxiety/depression were identified as prognostic factors for shorter survival. Self-reported health status (OR 3.975, 95%CI 1.845-8.565, p < 0.0001) was also a prognostic factor for survival. Impairments in EUROQOL-5D were also prognostic in patients with ECOG 0-1 (p < 0.001). In the multivariate analysis, only ECOG 2-4 and self-reported health status remained with statistical significance. Conclusions: EUROQOL-5D is a valid tool to be incorporated as a PROM tool in pacients with hematological malignancies. Impairments in mobility, self-care and usual activities will identify a poorer prognosis group that would need closer monitoring.

scholarly journals Control of diabetes and fibrinogen levels as well as improvement in health care might delay low cognitive performance in societies aging progressively

2015 ◽  
Vol 73 (1) ◽  
pp. 22-29
Author(s):  
Daniele Almeida Lopes ◽  
Suzana Alves de Moraes ◽  
Isabel Cristina Martins de Freitas
Keyword(s):  
Health Care ◽  
Health Status ◽  
Cognitive Performance ◽  
Adult Population ◽  
Population Based ◽  
Sitting Time ◽  
Health Related ◽  
Control Of Diabetes ◽  
Reported Health ◽  
Self Reported Health Status

ObjectiveTo know the prevalence and factors associated to low cognitive performance in a representative sample of the adult population in a society aging progressively.MethodCross-sectional population-based study carried out in a three-stage sampling: 81 census tracts (primary sampling unity) were randomly selected, followed by 1,672 households and 2,471 participants (weighted sample) corresponding to the second and third stages, respectively. The outcome prevalence was calculated according sociodemographic, behavioral and health related variables. Crude and adjusted prevalence ratios were estimated using Poisson regression.ResultsThe prevalence of low cognitive performance was high, mainly among females, and indicated linear trends into categories of age, schooling, income, plasma fibrinogen and self-reported health status. In multivariate models, gender, diabetes, fibrinogen and self-reported health status presented positive associations, while schooling, employment and sitting time presented negative associations with the outcome.ConclusionInterventions related to diabetes and fibrinogen levels control as well as improvement in health care might delay low cognitive performance in societies aging progressively as such the study population.

scholarly journals Perceptions of Health and Relationships to Disability Measures Among People with Multiple Sclerosis

2009 ◽  
Vol 11 (2) ◽  
pp. 57-65 ◽  
Author(s):  
Heather Becker ◽  
Alexa Stuifbergen
Keyword(s):  
Multiple Sclerosis ◽  
Health Status ◽  
Functional Limitations ◽  
Reliability And Validity ◽  
Time Frame ◽  
Population Based ◽  
Physical And Mental Health ◽  
Health Related ◽  
Reported Health ◽  
Self Reported Health Status

Researchers use various measures to assess health status, impairment, functional limitations, and disability among people with multiple sclerosis (MS). Conceptual and empirical associations among measures are not always clear, however. The purpose of this study was to examine the relationships among measures of impairment, disability, functional status, and health-related outcomes in a sample of 443 individuals with MS. A secondary purpose was to compare the self-reported health status of this sample with that of a population-based sample of individuals with and without disabilities. Although both the MS sample and a population-based sample of individuals with activity limitations indicated poorer health than did their nondisabled counterparts, the MS sample reported more days in the preceding month when their physical and mental health were not good and more days when poor health kept them from usual activities than the population-based sample of individuals with disabilities. Most measures were moderately intercorrelated, but the pattern suggests that issues such as the time frame specified may affect the relationships. Researchers should carefully consider operational as well as conceptual definitions, length of proposed measures, and appropriate time frame, in addition to the more traditional criteria of reliability and validity, when selecting study measures.

scholarly journals Meeting Psychosocial Needs to Improve Health: A Prospective Cohort Study

2019 ◽  
Author(s):  
Austyn Snowden ◽  
Jenny Young ◽  
Jan Savinc
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Health Status ◽  
Cancer Type ◽  
Cancer Stage ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Abstract Background Cancer impacts on patients and their families across a range of different domains. For that reason, optimal cancer care has moved away from a disease-centric focus to a more holistic approach in order to proactively support people with their individual needs and concerns. While international policy clearly advocates this agenda, implementation into routine care is limited. Therefore, relevant interventions that measurably improve patient outcomes are essential to understand if this ideal is to become routine multidisciplinary practice. The aim of this study was to analyse the impact of a proactive, holistic, community-based intervention on health-related quality of life in a cohort of people diagnosed with cancer. Secondary aim was to explore the relationship between changes in health status and: cancer type, cancer stage, number of concerns expressed and change in severity of concerns pre and post intervention. Method Prospective observational cohort study. A convenience sample of 437 individuals were referred to the service ‘Improving the Cancer Journey (ICJ) in the UK. Each completed the Euroqol EQ-5D-3L and visual analogue scale (VAS) and a Holistic Needs Assessment (HNA) during initial visit to the service and again at follow-up review, approximately 4 months later. Change between scores was tested with paired t-tests and relationships between variables with multiple regression models. Results Participants were White British with median age between 50-64 years. Cancer type and stage were varied. There was a statistically significant improvement in EQ-5D scores over time (t(330)=7.48, p<.001). The strongest predictor of change was a decrease in severity of concerns. Cancer stage ‘palliative care’ contributed to a reduction in health status. Conclusion This study is the first to show that a holistic community intervention dedicated to supporting the individual concerns of participants has a statistically and meaningful impact on participants’ health-related quality of life. The mean change in EQ-5D scores was more than the ‘minimally important clinical difference’ described in the literature. This is important because while quality of life has multiple determinants this study has reported that it is possible to capture a meaningful improvement as a function of reducing someone’s personally identified concerns.

scholarly journals Effect of Inotropes on Patient-Reported Health Status in End-Stage Heart Failure

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
John-Ross D. Clarke ◽  
Ralph Riello ◽  
Larry A. Allen ◽  
Mitchell A. Psotka ◽  
John R. Teerlink ◽  
...  
Keyword(s):  
Health Status ◽  
Health Related Quality ◽  
Reduced Ejection Fraction ◽  
Randomized Controlled ◽  
Patient Reported ◽  
Related Quality ◽  
Health Related ◽  
Reported Health ◽  
End Stage

Background: A growing population of patients with end-stage heart failure (HF) with reduced ejection fraction has limited treatment options to improve their quality and quantity of life. Although positive inotropes have failed to show survival benefit, these agents may enhance patient-reported health status, that is, symptoms, functional status, and health-related quality of life. We sought to review the available clinical trial data on positive inotrope use in patients with end-stage HF and to summarize evidence supporting the use of these agents to improve health status of patients with end-stage HF. Methods: A literature review of randomized controlled trials examining the use of positive inotropy in HF with reduced ejection fraction was conducted. We searched MEDLINE, SCOPUS, and Web of Science between January 1980 to December 2018 for randomized controlled trials that used as their main outcome measures the effects of inotrope therapy on (1) morbidity/mortality, (2) symptoms, (3) functional status, or (4) health-related quality of life. Inotropes of interest included adrenergic agents, phosphodiesterase inhibitors, calcium sensitizers, myosin activators, and SERCA2a (sarcoplasmic reticulum Ca 2+ -ATPase) modulators. Results: Twenty-two out of 26 inotrope randomized controlled trials measured the effect of inotropes on at least one patient-reported health status domain. Among the 22 studies with patient-related health status outcomes, 11 (50%) gauged symptom response, 15 (68%) reported functional capacity changes, and 12 (54%) reported health-related quality of life measures. Fourteen (64%) of these trials noted positive outcomes in at least one health status domain measured; 11 (79%) of these positive studies used agents that worked through phosphodiesterase inhibition. Conclusions: There has been a lack of standardization surrounding measurement of patient-centered outcomes in studies of inotropes for end-stage HF with reduced ejection fraction. The degree to which positive inotropes can improve patient-reported health status and the adverse risk they pose remains unknown.

scholarly journals Living with Migraine in Canada – A National Community-Based Study

2019 ◽  
Vol 46 (2) ◽  
pp. 216-223
Author(s):  
Kristianne Chelsea Altura ◽  
Scott B. Patten ◽  
Jeanne V. A. Williams ◽  
Kirsten M. Fiest ◽  
Nathalie Jetté
Keyword(s):  
Health Status ◽  
Age Groups ◽  
Health Utility Index ◽  
Health Utility ◽  
Community Based ◽  
Cross Sectional ◽  
Utility Index ◽  
Related Quality ◽  
Health Related ◽  
The Impact

ABSTRACT:Objective: To develop a detailed profile of individuals living with migraine in Canada. Such a profile is important for planning and administration of services. Methods: The 2011–2012 Survey of Living with Neurological Conditions in Canada (SLNCC), a cross-sectional community-based survey, was used to examine a representative sample of migraineurs (N = 949) aged 15 years and older. Several health-related variables were examined (e.g., general health, health utility index (HUI) [a measure of health status and health-related quality of life, where dead = 0.00 and perfect health = 1.00], stigma, depression, and social support). Respondents were further stratified by sex, age, and age of migraine onset. Weighted overall and stratified prevalence estimates and odds ratios, both with 95% CIs, were used to estimate associations. Results: Overall, males had poorer health status compared with females (e.g., mean HUI was 0.67 in males vs. 0.82 in females; men had over two times the odds of their migraine limiting educational and job opportunities compared with females). Poorer health-related variables were seen in the older age groups (35–64 years/≥65 years) compared with the 15–34-year age group. There were no differences between those whose migraine symptoms began before versus after the age of 20 years. Conclusions: In this Canadian sample, migraine was associated with worse health-related variables in men compared with women. However, both men and women were significantly affected by migraine across various health-related variables. Thus, it is important to improve clinical and public health interventions addressing the impact of migraine across individuals of all ages, sexes, and sociodemographic backgrounds.

scholarly journals The impact of irritable bowel syndrome on health-related quality of life in women with polycystic ovary syndrome

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Fatemeh Bazarganipour ◽  
Seyed-Abdolvahab Taghavi ◽  
Zatollah Asemi ◽  
Helen Allan ◽  
Zahra Khashavi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Polycystic Ovary ◽  
Health Related Quality ◽  
Ovary Syndrome ◽  
Related Quality ◽  
Health Related ◽  
Irritable Bowel ◽  
The Impact
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