Vitamin D Status and Muscle Mass, Muscle Strength and Physical Function in a Diverse Sample of Men.

AbstractA positive association has been reported between vitamin D status, muscle strength and physical function in older Caucasian women. However, little is known about this relationship in UK South Asian older women. This cross-sectional study aimed to explore the association between vitamin D status, muscle strength and physical function in UK South Asian (Pakistani and Indian) older women.One hundred and twenty community-dwelling women were recruited via visiting community centres, mosques, Indian temples (Gurdwara) and by word of mouth (between January to May 2018). Inclusion criteria were: community-dwelling, South Asian women, age 60 years and above, able to communicate effectively and able to give written or verbal consent. A general interview (demographic, anthropometric, self-reported exhaustion, health history, supplementation use/duration/dose), handgrip strength (kg), short physical performance battery (single chair stand, repeated chair stands, balance, timed up-and-go test), and blood 25 hydroxyvitamin D (25(OH)D, nmol/l) concentration were performed. Dietary intake and self-reported physical activity was also assessed using multiple-pass 24-hour diet recall method and International Physical Activity Questionnaire (IPAQ) short form respectively.Overall, 47% of participants had insufficient blood 25(OH)D concentration (< 50nmol/L) and 53% had sufficient blood 25(OH)D (≥ 50nmol/L) using the IOM classification. As expected 86% of current vitamin D supplement users had adequate vitamin D status and only 14% of women who reported current vitamin D supplement use had insufficient vitamin D status. Amongst supplement non-users 68% had insufficient vitamin D status and only 32% had adequate levels. An inverse correlation (Spearman's analysis) was found between vitamin D status and single chair stand test (sec) (r = -0.25, p = 0.006); repeated chair stand test (sec) (r = -0.29, p = 0.002) and timed up-and-go test (sec) (r = -0.20, p = 0.02). No correlation was observed between vitamin D status and handgrip strength (r = 0.09, p = 0.30).The prevalence of vitamin D insufficiency is high in post-menopausal South Asian women not taking vitamin D supplements. Significant association was observed between vitamin D status and some aspects of muscle strength and physical function. We are now conducting a randomized control trial to investigate whether vitamin D supplementation may restore muscle strength and function in this population.

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Relationship of Vitamin D Status with Muscle Mass and Muscle Strength in Young Indian Adults – Evidence from Andhra Pradesh Children and Parents Study Cohort

European Journal of Nutrition & Food Safety ◽

10.9734/ejnfs/2015/21163 ◽

2015 ◽

Vol 5 (5) ◽

pp. 918-919 ◽

Cited By ~ 1

Author(s):

Bharati Kulkarni ◽

Hannah Kuper ◽

Sanjay Kinra ◽

M Charyulu ◽

Yoav Ben-Shlomo ◽

...

Keyword(s):

Vitamin D ◽

Muscle Strength ◽

Muscle Mass ◽

Andhra Pradesh ◽

Study Cohort ◽

Vitamin D Status ◽

Children And Parents ◽

Relationship Of

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Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

Nutrients ◽

10.3390/nu9040379 ◽

2017 ◽

Vol 9 (4) ◽

pp. 379 ◽

Cited By ~ 24

Author(s):

Antoneta Granic ◽

Tom Hill ◽

Karen Davies ◽

Carol Jagger ◽

Ashley Adamson ◽

...

Keyword(s):

Vitamin D ◽

Muscle Strength ◽

Prospective Study ◽

Physical Performance ◽

Vitamin D Status ◽

Very Old ◽

Old Adults ◽

Performance Decline ◽

A Prospective Study

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Vitamin D Status in Obesity Is Associated with Skeletal Muscle Mass Independent of Adiposity

10.1210/endo-meetings.2011.part1.p9.p1-207 ◽

2011 ◽

pp. P1-207-P1-207

Author(s):

Prapimporn Shantavasinkul ◽

Pariya Phanachet ◽

Orawan Puchaiwattananon ◽

La-or Chailurkit ◽

Boonsong Ongphiphadhanakul ◽

...

Keyword(s):

Skeletal Muscle ◽

Vitamin D ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Vitamin D Status

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Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

10.21203/rs.3.rs-697981/v1 ◽

2021 ◽

Author(s):

Hiroto Minamino ◽

Masao Katsushima ◽

Mie Torii ◽

Wataru Yamamoto ◽

Yoshihito Fujita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Muscle Mass ◽

Gait Speed ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

High Prevalence

Abstract Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum vitamin D (25(OH)D) affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 Patients (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait-speed. Furthermore, multiple regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08). In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH) status. In conclusion, vitamin D levels are associated with severe sarcopenia and its components, and modification of vitamin D status including vitamin D supplementation may play a role in improving sarcopenia in RA.

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Effects of vibration therapy on muscle mass, muscle strength and physical function in older adults with sarcopenia: a systematic review and meta-analysis

European Review of Aging and Physical Activity ◽

10.1186/s11556-020-00247-5 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Shuang Wu ◽

Hong-Ting Ning ◽

Su-Mei Xiao ◽

Ming-Yue Hu ◽

Xin-Yin Wu ◽

...

Keyword(s):

Systematic Review ◽

Older Adults ◽

Muscle Strength ◽

Physical Function ◽

Muscle Mass ◽

Meta Analysis ◽

Whole Body Vibration ◽

Whole Body ◽

Local Vibration ◽

Vibration Therapy

Abstract Background Sarcopenia, a progressive loss of muscle mass and function with advancing age, is a prevalent condition among older adults. As most older people are too frail to do intensive exercise and vibration therapy has low risk and ease of participation, it may be more readily accepted by elderly individuals. However, it remains unclear whether vibration therapy would be effective among older adults with sarcopenia. This systematic review and meta-analysis examined the effect of vibration therapy including local vibration therapy and whole-body vibration therapy, for enhancing muscle mass, muscle strength and physical function in older people with sarcopenia. Methods A systematic literature search was conducted in March 2019 in the following 5 electronic databases: PubMed, CINAHL, Embase, PEDro, and the Cochrane Central Register of Controlled Trials, with no restriction of language or the year of publication. Randomized controlled trials and quasi-experimental studies examining effects of vibration therapy on muscle mass, muscle strength or physical function in older adults with sarcopenia were included in this systematic review. Two reviewers independently assessed the methodological quality of the selected studies. Results Of the 1972 identified studies, seven publications from six studies involving 223 participants were included in this systematic review. Five of them conducted whole-body vibration therapy, while two conducted local vibration therapy. A meta-analysis of randomized controlled studies indicated that muscle strength significantly increased after whole-body vibration therapy (SMD 0.69, 95% CI 0.28 to 1.11, I2 = 0%, P = 0.001) and local vibration therapy (SMD 3.78, 95% CI 2.29 to 5.28, P < 0.001). Physical performance measured by the sit-to-stand test and the timed-up-and-go test were significantly improved after the intervention (SMD -0.79, 95% CI − 1.21 to − 0.37, I2 = 0%, P < 0.001) and SMD -0.83, 95% CI − 1.56 to − 0.11, I2 = 64%, P = 0.02, respectively). Conclusion Vibration therapy could be a prospective strategy for improving muscle strength and physical performance in older adults with sarcopenia. However, due to the limited number of the included studies, caution is needed when interpreting these results. More well-designed, large sample size studies should be conducted to further explore and validate the benefits of vibration therapy for this population.

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