scholarly journals Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics

2004 ◽  
Vol 89 (6) ◽  
pp. 2557-2562 ◽  
Author(s):  
Anthony P. Coll ◽  
I. Sadaf Farooqi ◽  
Benjamin G. Challis ◽  
Giles S. H. Yeo ◽  
Stephen O’Rahilly
Keyword(s):  
Energy Balance ◽  
Energy Homeostasis ◽  
Skin Pigmentation ◽  
Biologically Active ◽  
Melanocortin System ◽  
Active Peptides ◽  
Adrenal Steroidogenesis ◽  
Human Energy ◽  
Biologically Active Peptides ◽  
Synthesis And Processing

Abstract Proopiomelanocortin (POMC) undergoes extensive and tissuespecific posttranslational processing to yield a range of biologically active peptides. Historically, the most clearly defined roles of these peptides are in the control of adrenal steroidogenesis by corticotroph-derived ACTH and skin pigmentation by αMSH. However, a rapidly expanding body of work has established that POMC-derived peptides synthesized in neurons of the hypothalamus play a central role in the control of energy homeostasis. We review how inherited abnormalities in POMC synthesis and processing and defects in the action of POMC-derived peptides in both humans and mice have helped shape our current understanding of the importance of the melanocortin system in human energy balance.

Effects of pro-opiomelanocortin (POMC) on food intake and body weight: mechanisms and therapeutic potential?

2007 ◽  
Vol 113 (4) ◽  
pp. 171-182 ◽  
Author(s):  
Anthony P. Coll
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Therapeutic Potential ◽  
Signalling Pathway ◽  
Biologically Active ◽  
Melanocortin System ◽  
Design And Development ◽  
Active Peptides ◽  
Melanocyte Stimulating Hormone ◽  
Biologically Active Peptides

POMC (pro-opiomelanocortin) is a complex polypeptide precursor which is cleaved into smaller biologically active peptides such as the melanocortins, α-, β- and γ-melanocyte-stimulating hormone. Data from human genetic and murine studies convincingly show that an intact central melanocortin signalling pathway is critical for normal energy homoeostasis. Not only does a loss of normal melanocortin signalling lead to obesity, but there are also data implicating increased melanocortin activity in the pathogenesis of cachexia. The study of POMC biology has lead to some fundamental insights into the mechanisms controlling food intake and body weight. This increased understanding of the physiological roles of the melanocortin system has opened up the potential for the design and development of rational therapies to treat perturbations in energy homoeostasis.

scholarly journals Concepts for Biologically Active Peptides

2010 ◽  
Vol 16 (30) ◽  
pp. 3390-3400 ◽  
Author(s):  
Abba J. Kastin ◽  
Weihong Pan
Keyword(s):  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides

scholarly journals Multifunctional roles of growth factors or biologically active peptides in salivary glands and saliva

2008 ◽  
Vol 12 (4) ◽  
pp. 115-123 ◽  
Author(s):  
Masahiko Mori ◽  
Shinichiro Sumitomo ◽  
Prashanta Shrestha ◽  
Shiro Tanaka ◽  
Yoshiaki Takai ◽  
...  
Keyword(s):  
Growth Factors ◽  
Salivary Glands ◽  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides

New Chemical Descriptors Relevant for the Design of Biologically Active Peptides. A Multivariate Characterization of 87 Amino Acids

1998 ◽  
Vol 41 (14) ◽  
pp. 2481-2491 ◽  
Author(s):  
Maria Sandberg ◽  
Lennart Eriksson ◽  
Jörgen Jonsson ◽  
Michael Sjöström ◽  
Svante Wold
Keyword(s):  
Amino Acids ◽  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Chemical Descriptors
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