scholarly journals Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity

2019 ◽  
Vol 104 (11) ◽  
pp. 5183-5194 ◽  
Author(s):  
Kamnesh R Pradhan ◽  
Yan Chen ◽  
Sogol Moustoufi-Moab ◽  
Kevin Krull ◽  
Kevin C Oeffinger ◽  
...  
Keyword(s):  
Physical Activity ◽  
Childhood Cancer ◽  
Metabolic Disorders ◽  
Childhood Cancer Survivors ◽  
Chronic Health Conditions ◽  
Health Conditions ◽  
Related Quality ◽  
Health Related

Abstract Context Childhood cancer survivors experience chronic health conditions that impact health-related quality of life (HRQOL) and participation in optimal physical activity. Objective The study aimed to determine independent effects of endocrine and metabolic disorders on HRQOL and physical activity. Design, Setting, and Patients Retrospective cohort with longitudinal follow-up of survivors of childhood cancer enrolled in the North American Childhood Cancer Survivor Study. Main Outcome Measures Medical Outcomes Short Form-36 estimated HRQOL, and participation in physical activity was dichotomized as meeting or not meeting recommendations from the Centers for Disease Control and Prevention. Log binomial regression evaluated the association of each endocrine/metabolic disorder with HRQOL scales and physical activity. Results Of 7287 survivors, with a median age of 32 years (range, 18 to 54 years) at their last follow-up survey, 4884 (67%) reported one or more endocrine/metabolic disorders. Survivors with either disorder were significantly more likely to be male, older, have received radiation treatment, and have experienced other chronic health conditions. After controlling for covariates, survivors with any endocrine/metabolic disorder were more likely to report poor physical function risk ratio (RR, 1.25; 95% CI, 1.05 to 1.48), increased bodily pain (RR, 1.27; 95% CI, 1.12 to 1.44), poor general health (RR, 1.49; 95% CI, 1.32 to 1.68), and lower vitality (RR, 1.21; 95% CI, 1.09 to 1.34) compared with survivors without. The likelihood of meeting recommended physical activity was lower among survivors with growth disorders (RR, 0.90; 95% CI, 0.83 to 0.97), osteoporosis (RR, 0.87; 95% CI, 0.76 to 0.99), and overweight/obesity (RR, 0.92; 95% CI, 0.88 to 0.96). Conclusion Endocrine and metabolic disorders are independently associated with poor HRQOL and suboptimal physical activity among childhood cancer survivors.

Health-related unemployment trends among survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS).

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10048-10048
Author(s):  
Neel S. Bhatt ◽  
Pamela Goodman ◽  
Wendy M. Leisenring ◽  
Gregory T. Armstrong ◽  
Eric Jessen Chow ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Chronic Health Conditions ◽  
Health Conditions ◽  
Health Related ◽  
Race Ethnicity ◽  
The Impact ◽  
Significant Health

10048 Background: The impact of treatment era and chronic health conditions on health-related unemployment among childhood cancer survivors has not been studied. Methods: Childhood cancer survivors (age ≥25 years) enrolled in the CCSS (3,420 diagnosed in the 1970s, 3,564 in the 1980s, and 2,853 in the 1990s) were matched 1:5 on sex, race/ethnicity, census bureau division, age, and year of survey to the Behavioral Risk Factor Surveillance System (BRFSS), a nationally representative population. Among survivors, health-related unemployment was defined as self-reported unemployment due to illness/disability and for BRFSS participants as self-reported inability to work. To standardize follow-up, health-related unemployment was assessed either in 2002-05 or 2014-16 for both cohorts. Sex stratified standardized prevalence ratio (SPR) and relative SPR (rSPR) with 95% confidence intervals (CI) for health-related unemployment were estimated using multivariable generalized linear models, with BRFSS background rates to assess the impact of treatment era and moderate to severe health conditions (per the Common Terminology Criteria for Adverse Events). Results: Prevalence of health-related unemployment in survivors (median age 9 years [range 0-20] at diagnosis and 33 years [25-54] at follow-up) was significantly higher compared to BRFSS participants (females: 11.3% vs 3.7%; SPR 3.0, 95% CI 2.7-3.3; males: 10.5% vs 3.0%; SPR 3.5, 95% CI 3.1-3.9). Health-related unemployment risks declined among survivors in more recent decades (ptrend< 0.001) for females: 1970s SPR 3.8, 95% CI 3.2-4.5, 1980s SPR 2.9, 95% CI 2.5-3.5, 1990s SPR 2.5, 95% CI 2.1-3.0; and males: 1970s SPR 3.6, 95% CI 2.9-4.4, 1980s SPR 3.8, 95% CI 3.1-4.7, 1990s SPR 3.0, 95% CI 2.5-3.7. Among survivors, multivariable models identified associations between presence of specific health conditions and elevated health-related unemployment (Table) adjusting for all statistically significant health conditions, race/ethnicity, treatment era, age at survey, and diagnosis. Among females, rSPR for endocrine conditions differed between 1970s and 1990s (interaction p = 0.04); fewer significant health conditions remained in the final model for males. Conclusions: While prevalence for health-related unemployment has declined over time, childhood cancer survivors remain at higher risk compared to the general population. These elevated risks are associated with chronic health conditions and affect female survivors more than male survivors.[Table: see text]

Health-Related Quality of Life in Former National Collegiate Athletic Association Division I Collegiate Athletes Compared With Noncollegiate Athletes: A 5-Year Follow-Up

2021 ◽  
Author(s):  
Janet E. Simon ◽  
Mallory Lorence ◽  
Carrie L. Docherty
Keyword(s):  
Physical Activity ◽  
Physical Function ◽  
National Collegiate Athletic Association ◽  
Division I ◽  
Related Quality ◽  
Health Related ◽  
Division I Athletes

Context The effect of athletic participation on lifelong health among elite athletes has received increasing attention, as sport-related injuries can have a substantial influence on long-term health. Objective To determine the current health-related quality of life (HRQoL) of former National Collegiate Athletic Association Division I athletes compared with noncollegiate athletes 5 years after an initial assessment. Design Cohort study. Setting Online survey. Patients or Other Participants From the former Division I athletes, 193 responses were received (response rate = 83.2%; 128 men, 65 women; age = 58.47 ± 6.17 years), and from the noncollegiate athletes, 169 surveys were returned (response rate = 75.1%; 80 men, 89 women; age = 58.44 ± 7.28 years). Main Outcome Measure(s) The independent variables were time (baseline, 5 years later) and group (former Division I athlete, noncollegiate athlete). Participants completed 7 Patient-Reported Outcomes Measurement Information System scales: sleep disturbance, anxiety, depression, fatigue, pain interference, physical function, and satisfaction with participation in social roles. Results Sleep disturbance, depression, fatigue, pain, and physical function were significant for a time × group interaction (P &lt; .05), with the largest differences seen in pain and physical function between groups at time point 2 (22.19 and 13.99 points, respectively). Former Division I athletes had worse scores for depression, fatigue, pain, and physical function at follow-up (P &lt; .05), with the largest differences seen on the depression, fatigue, and physical function scales (8.33, 6.23, and 6.61 points, respectively). Conclusions Because of the competitive nature of sport, the long-term risks of diminished HRQoL need to become a priority for health care providers and athletes during their athletic careers. Additionally, physical activity transition programs need to be explored to help senior student-athletes transition from highly structured and competitive collegiate athletics to lifestyle physical activity, as it appears that individuals in the noncollegiate athlete cohort engaged in more physical activity, weighed less, and had increased HRQoL.

scholarly journals Health-related quality of life in European childhood cancer survivors: Protocol for a study within PanCareLIFE (Preprint)

2020 ◽  
Author(s):  
Gabriele Calaminus ◽  
Katja Baust ◽  
Claire Berger ◽  
Julianne Byrne ◽  
Harald Binder ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Cns Tumours ◽  
Fertility Problems

BACKGROUND Survival after childhood cancer has improved to more than 80% during the last years, leading to an increased number of childhood cancer survivors. Cancer itself or its treatment may cause chronic health conditions, including somatic and mental sequelae, which may impact survivors’ Health related Quality of Life (HRQoL). OBJECTIVE The project PanCareLIFE aimed to establish a large database with comprehensive data on childhood cancer survivors from different European countries, including data on HRQoL. Within PanCareLIFE, we aimed to describe HRQoL in survivors, investigate predictors of HRQoL and describe the association with hearing and female fertility problems. This paper describes the design of the HRQoL study, the origin of the data, strategies for data collection and sampling characteristics of survivors from each contributing country. METHODS Six institutions from five European countries (Czech Republic, France, Germany, the Netherlands, Switzerland) provided data on HRQoL assessed with the Short-Form 36 (SF-36) and on relevant predictors. Depending on the institution, data were collected either before or after the start of the PanCareLIFE project. The central PanCareLIFE data centre aggregated the data and harmonized the variables between the institutions, including a minimal data-set from non-participants. Survivors were eligible if they were diagnosed with cancer according to the 12 main groups of ICCC-3 or Langerhans Cell Histiocytosis, were aged ≤18 years at diagnosis, were resident in the respective country at the time of diagnosis, had survived ≥5 years after cancer diagnosis, were aged ≥18 years at the time of the questionnaire survey and did not refuse to registration in national/local childhood cancer cohort. RESULTS We identified 25,050 eligible survivors. Of those, 19,268 survivors received a questionnaire and 9,871 survivors participated (response rate 39% of eligible, 51% of invited survivors). Of the participants, most were diagnosed with cancer between age 10-14 years (35%) or <5 years (32%). The median age was 8 years. Most participants were survivors of leukaemia (32%), lymphoma (21%) or Central Nervous System (CNS) tumours (14%). Ninety-three percent (93%) had no history of a subsequent tumour and 77% received chemotherapy with or without other treatments. More than half (55%) of the participants were aged 25-34 years at the time of the HRQoL study. Participating survivors differed from non-participants; participants were more often women, survivors of leukaemia or lymphoma and less frequent survivors of CNS tumours than non-participants. CONCLUSIONS PanCareLIFE has successfully assessed HRQoL and its predictors in 9871 European survivors of childhood cancer. This large population will permit detailed investigations of HRQoL after childhood cancer, in particular the impact of hearing impairment and female fertility problems on HRQoL.

scholarly journals Longitudinal association between physical activity and health-related quality of life among community-dwelling older adults: a longitudinal study of Urban Health Centres Europe (UHCE)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xuxi Zhang ◽  
Siok Swan Tan ◽  
Carmen Betsy Franse ◽  
Tamara Alhambra-Borrás ◽  
Arpana Verma ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Low Frequency ◽  
Health Related Quality ◽  
Longitudinal Association ◽  
Related Quality ◽  
Health Related ◽  
Mental Hrqol

Abstract Background Physical activity (PA) may play a key role in healthy aging and thus in promoting health-related quality of life (HRQoL). However, longitudinal studies on the association between PA and HRQoL are still scarce and have shown inconsistent results. In this study, we aimed to examine the longitudinal association between frequency of moderate PA and physical and mental HRQoL. Secondly, to assess the association between a 12-month change in frequency of moderate PA and HRQoL. Methods A 12-month longitudinal study was conducted in Spain, Greece, Croatia, the Netherlands, and the United Kingdom with 1614 participants (61.0% female; mean age = 79.8; SD = 5.2) included in the analyses. Two categories of the self-reported frequency of moderate PA including 1) ‘regular frequency’ and 2) ‘low frequency’ were classified, and four categories of the change in frequency of moderate PA between baseline and follow-up including 1) ‘continued regular frequency’, 2) ‘decreased frequency’, 3) ‘continued low frequency’ and 4) ‘increased frequency’ were identified. Physical and mental HRQoL were assessed by the 12-Item Short-Form Health Survey (SF-12). Results The frequency of moderate PA at baseline was positively associated with HRQoL at follow-up. Participants with a continued regular frequency had the highest HRQoL at baseline and follow-up. Participants who increased the frequency of moderate PA from low to regular had better physical and mental HRQoL at follow-up than themselves at baseline. After controlling for baseline HRQoL and covariates, compared with participants who continued a regular frequency, participants who decreased their frequency had significantly lower physical (B = -4.42; P < .001) and mental (B = -3.95; P < .001) HRQoL at follow-up; participants who continued a low frequency also had significantly lower physical (B = -5.45; P < .001) and mental (B = -4.10; P < .001) HRQoL at follow-up. The follow-up HRQoL of participants who increased their frequency was similar to those who continued a regular frequency. Conclusions Maintaining or increasing to a regular frequency of PA are associated with maintaining or improving physical and mental HRQoL. Our findings support the development of health promotion and long-term care strategies to encourage older adults to maintain a regular frequency of PA to promote their HRQoL.

Long‐term health‐related quality of life in young childhood cancer survivors and their parents

2021 ◽  
Author(s):  
Joanna E. Fardell ◽  
Claire E. Wakefield ◽  
Richard De Abreu Lourenco ◽  
Christina Signorelli ◽  
Maria McCarthy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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