BILATERAL FAMILIAL PHAEOCHROMOCYTOMATA' WITH PAROXYSMAL HYPERTENSION: SUCCESSFUL SURGICAL REMOVAL OF TUMORS IN TWO CASES, WITH DISCUSSION OF CERTAIN DIAGNOSTIC PROCEDURES AND PHYSIOLOGICAL CONSIDERATIONS

1947 ◽  
Vol 7 (7) ◽  
pp. 475-492 ◽  
Author(s):  
EVAN CALKINS ◽  
JOHN EAGER HOWARD
2020 ◽  
Vol 8 ◽  
pp. 2050313X2094432
Author(s):  
Sudha Shahi ◽  
Tika Ram Bhandari ◽  
Prakash Bahadur Thapa ◽  
Deependra Shrestha ◽  
Kiran Shrestha

Foreign body esophagus remains one of the common medical emergencies which may lead to significant morbidity and mortality. Sharp objects, batteries, and elderly with foreign body esophagus should be treated with emergent removal owing to the complications that might ensue. Endoscopic removal is the preferred choice of treatment but for large foreign body, sharp foreign body, and so on, rigid esophagoscopic removal might be more preferable. Foreign body esophagus though an obvious situation might at times be missed. It is important to make an early definitive diagnosis. We report a unique case of missed foreign body (denture) esophagus despite the obvious signs and symptoms. Definitive diagnosis was made only after 6 years due to the lack of definitive diagnostic procedures and expertise. The foreign body was impacted in the mucosal wall of the esophagus requiring Gastric resection and anastomosis (with McKeown procedure). With this we have tried to highlight the pitfalls in the diagnosis and management of foreign body esophagus. We report a case of a 55-year-old female who presented to the Emergency Room with history of progressive dysphagia and odynophagia for 6 years which was aggravated for the past 6 months. A radiological diagnosis was made. It was followed by a failed attempt of endoscopic removal which warranted the surgical removal of the foreign body.


2014 ◽  
Vol 95 (6) ◽  
pp. 821-830 ◽  
Author(s):  
A Yu Kiprenskiy ◽  
M A Nechayenko ◽  
L M Kuznetsova ◽  
D N Fyodorov

Aim. To study the clinical, diagnostic, surgical and morphological features of non-mixoma primary tumors of the heart valves, the possibilities of their early diagnosis and to develop an optimal surgical approach. Methods. The surgical treatment of 331 patients with tumors of the heart was analysed, of which 45 (13.6%) were radically distant primary tumors of the heart valves including 33 (73.3%) myxoma and 12 (26.7%) non-myxoma tumors. Among considered in this study 12 non-myxoma tumors 9 cases were papillary fibroelastoma, 1 - neurolemmoma, 1 - lipoma, 1 - fibroma. Results. The leading non-invasive preoperative diagnostic procedures for non-myxoma primary tumors of the heart valves were transthoracic and transoesophageal echocardiographic studies, the sensitivity of which were 91.7 and 100% respectively. In unclear cases, a computer and magnetic resonance imaging were used. Additionally, electrocardiography, phonocardiography, radiological methods were performed, clinical and biochemical blood tests were analysed. Intraoperative revision and morphological verification ensures the establishment of tumors final clinical diagnosis. Patients with non-myxoma tumors of the heart valves had polymorphic symptomatic picture which included circulatory failure, false angina, arrhythmias, clinical signs imitating heart defects, embolic syndrome, dizziness and/or syncope, causeless fever. Surgical removal of the 12 non-myxoma tumor was performed by cardiopulmonary bypass and pharmacological cold cardioplegia, in 4 cases, the intervention combined with the replacement of the affected valves by artificial prostheses, in 1 case - coronary artery bypass grafting. Hospital mortality of patients was zero. Quality of life of operated patients was rated as good in 9 (75%) patients, satisfactory - in 2 (16.7%), unsatisfactory - in 1 (8.3%) patients, which was due to the death of the patient 13 months after removal of neurolemmoma in connection with multiple metastasis in the brain and spinal cord. Conclusion. Timely surgical intervention helped to stabilize the functional state of the patients, to create a favorable prognosis to improve the quality of life and increase its length.


2020 ◽  
Vol 73 (5-6) ◽  
pp. 165-169
Author(s):  
Jelena Nikolic ◽  
Marija Marinkovic ◽  
Dragana Lekovic-Stojanov ◽  
Isidora Djozic ◽  
Nada Vuckovic ◽  
...  

Introduction. Accessory breast is a congenital anomaly where ectopic breast tissue is found at any place other than the normal location. It is an extra tissue or a fully developed breast with a nipple. The incidence of this malformation is 0.4-6%. It is believed that this congenital malformation is associated with incomplete regression of the primitive milk streak during embryonic development. The diagnosis and treatment of accessory breasts is very important, because an ectopic breast tissue can undergo various pathological changes, as well as the normal breast tissue. Case Report. The authors present a 45-year-old female patient who was referred to a surgeon by a general practitioner with a diagnosis of lipomas in both axillary regions. After clinical examination and additional imaging diagnostic procedures (ultrasound and mammography) accessory breasts were suspected. The patient underwent surgery and the accessory tissue was resected. The histopathological examination confirmed the clinical diagnosis of ectopic breasts without any pathological processes. Conclusion. Accessory breast is a rare congenital malformation and its early diagnosis and surgical removal should prevent development of different pathological processes, including breast cancer.


2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
A Kriger ◽  
S Berelavichus ◽  
D Gorin ◽  
G Galkin ◽  
M Yukina ◽  
...  

Abstract Insulinoma is the most frequent functional neuroendocrine tumor of the pancreas, which causes organic hyperinsulinism with severe hypoglycemia. There are no cases of primary insulinoma of the liver described. A 63-year-old female was admitted to our center presenting symptoms of severe hypoglycemia due to confirmed endogenic hyperinsulinism. None of the performed diagnostic procedures could reveal a pancreatic tumor. However, a pathologic mass in the sixth segment of the liver was detected. We performed arterial calcium stimulation that showed increased levels of insulin and c-peptide in almost all stimulated arteries. The highest and most prolonged peaks were detected at the points of the common hepatic artery and the right hepatic artery. After the surgical removal of the liver tumor, the blood glucose level was stabilized within the normal range. Post-operative pathomorphological investigation confirmed the diagnosis of a neuroendocrine tumor. The long-term survival results show correct treatment tactics without any signs of disease recurrence.


2018 ◽  
Vol 7 (2) ◽  
pp. 11-15
Author(s):  
Anna Rzepakowska ◽  
Karolina Stańska ◽  
Ewa Osuch_Wójcikiewicz ◽  
Daniel Majszyk ◽  
Kazimierz Niemczyk

Sarcoidosis is a systemic disease of unknown etiology. It is characterized by a formation of lumps known as noncaseating granulomas, which are not affected by necrosis. Typical collections of inflammatory cells may be found in any organ tissues but mainly in the lungs, skin or lymph nodes. Head and neck organs involvement is rare, although sarcoidosis can be found in lymph nodes, salivary glands, larynx, and sinuses. A search was performed based on medical records of patients admitted to the Department of Otolaryngology within four previous years. We analyzed two cases of sarcoidosis of salivary glands (parotid and submandibular), two cases of larynx involvement and one case of lymphadenopathy due to sarcoidosis. Patients (4 women and 1 man), age range 26-76 years old, were directed to the Otolaryngology Department with neck lymphadenopathy or a suspicion of a neoplastic tumor of salivary gland or larynx. Only one patient had the previous diagnosis of pulmonary sarcoidosis. Preoperative diagnostic procedures such as ultrasonography, biopsy, chest radiography did not suggest sarcoidosis on the initial assessment of other patients. Surgical removal of the pathological findings and histopathological examination confirmed extrapulmonary sarcoidosis. The computed tomography of lungs confirmed coexisting pulmonary sarcoidosis in only one patient.


Thelorrhea is one of the most common reasons for consultation in mastology. In the cases of a discharge with a pathological appearance, an appropriate approach is important given the possibility of it originating in a malignant neoplasm. Its study currently includes advanced diagnostic procedures such as ductoscopy with biopsy or brushing. However, these kinds of diagnostic intervention are not available everywhere and therefore, the surgical removal of the affected duct continues to be of great value diagnostically as well as therapeutically, especially in women with unsatisfied parity.


Author(s):  
Bruce Mackay

The broadest application of transmission electron microscopy (EM) in diagnostic medicine is the identification of tumors that cannot be classified by routine light microscopy. EM is useful in the evaluation of approximately 10% of human neoplasms, but the extent of its contribution varies considerably. It may provide a specific diagnosis that can not be reached by other means, but in contrast, the information obtained from ultrastructural study of some 10% of tumors does not significantly add to that available from light microscopy. Most cases fall somewhere between these two extremes: EM may correct a light microscopic diagnosis, or serve to narrow a differential diagnosis by excluding some of the possibilities considered by light microscopy. It is particularly important to correlate the EM findings with data from light microscopy, clinical examination, and other diagnostic procedures.


2000 ◽  
Vol 42 (9) ◽  
pp. 646-647 ◽  
Author(s):  
Hilary Espezel ◽  
Carolyn Graves ◽  
James E Jan ◽  
Anton Miller ◽  
Karin Renner ◽  
...  

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