Imaging and Gross Pathological Appearance of Changes in the Parasagittal Grooves of Thoroughbred Racehorses

(1) Background: Parasagittal groove (PSG) changes are often present on advanced imaging of racing Thoroughbred fetlocks and have been suggested to indicate increased fracture risk. Currently, there is limited evidence differentiating the imaging appearance of prodromal changes in horses at risk of fracture from horses with normal adaptive modelling in response to galloping. This study aims to investigate imaging and gross PSG findings in racing Thoroughbreds and the comparative utility of different imaging modalities to detect PSG changes. (2) Methods: Cadaver limbs were collected from twenty deceased racing/training Thoroughbreds. All fetlocks of each horse were examined with radiography, low-field magnetic resonance imaging (MRI), computed tomography (CT), contrast arthrography and gross pathology. (3) Results: Horses with fetlock fracture were more likely to have lateromedial PSG sclerosis asymmetry and/or lateral PSG lysis. PSG lysis was not readily detected using MRI. PSG subchondral bone defects were difficult to differentiate from cartilage defects on MRI and were not associated with fractures. The clinical relevance of PSG STIR hyperintensity remains unclear. Overall, radiography was poor for detecting PSG changes. (4) Conclusions: Some PSG changes in Thoroughbred racehorses are common; however, certain findings are more prevalent in horses with fractures, possibly indicating microdamage accumulation. Bilateral advanced imaging is recommended in racehorses with suspected fetlock pathology.

Molecular and Cellular Modelling of Salivary Gland Tumors Open New Landscapes in Diagnosis and Treatment

Salivary gland tumors are neoplasms affecting the major and minor salivary glands of the oral cavity. Their complex pathological appearance and overlapping morphological features between subtypes, pose major challenges in the identification, classification, and staging of the tumor. Recently developed techniques of three-dimensional culture and organotypic modelling provide useful platforms for the clinical and biological characterization of these malignancies. Additionally, new advances in genetic and molecular screenings allow precise diagnosis and monitoring of tumor progression. Finally, novel therapeutic tools with increased efficiency and accuracy are emerging. In this review, we summarize the most common salivary gland neoplasms and provide an overview of the state-of-the-art tools to model, diagnose, and treat salivary gland tumors.

Morton Neuroma Surgery: Relation Clinical Results to Excised Sample Length

Background:Morton’s neuroma (MN) is mechanical neuropathy of plantar interdigital nerve. It is one of the most common causes of forefoot pain. One of the most undesirable complications of MN surgery is recurrent neuroma. Excision level of MN is important to prevent recurrence. In this study, we aimed to find the relation resection lenght of MN to clinical results of MN surgery cases. Methods:76 samples sent with the diagnosis of Morton neuroma to the pathology department of our hospital between years 2010-2019. 66 patients whose clinical results were available were included in the study. Mean age was 41,5 (between 21 to 70). All of 66 patients were primary diagnosed 22 of them was left foot and the other 170 were right foot. 50 of them were female, and 16 were male. Recurrent neuromas, pathological sample more than one piece from one surgical site were excluded from the study. 72 of them were evaluated as a clinically and compare the sample lenght.Results:76 pathological specimens were prepared and examined by the same pathologist. Gross pathological appearance and histopathology findings were recorded. Mean sample length was 2,05 cm (between 0,7cm and 3,5 cm). 68 samples was smaller (89.5%) than 3 cm and only 8 sample (10.5%) was bigger than 3 cm. Average interdigital neuroma score improved from 20 to 62 points following the surgery (p<0.05).Conclusion:We recommend that, the common digital nerve should be cut from the proximal as much as possible to bury the proximal stump into the lumbrical muscles regardless of the sample size and using loupe magnification, careful and sharp dissection can be prevent injury to the PDNB.Level of Evidence: 2

A mysterious peripheral ossifying fibroma: Case report

A case of peripheral ossifying fibroma (POF) in the anterior mandible of a 63-year-old woman is described. The 17 x 23 x 16mm nodular mass was sessile, displaced teeth and had a non-ulcerated, pink surface. Due to the variations in radiographic, clinical and pathological appearance, initially the diagnosis of peripheral odontogenic fibroma was reached. Complex nomenclature and variation in clinical, radiological and pathological appearance of POF and similar masses is discussed.

Level of Excision Matters in Morton Neuroma Surgery.

Introduction: Morton’s neuroma (MN) is mechanical neuropathy of plantar interdigital nerve. It is one of the most common causes of forefoot pain. One of the most undesirable complications of MN surgery is recurrent neuroma. Excision level of MN is important to prevent recurrence. In this study, we aimed to figure out preferred excision levels of orthopedic surgeons by evaluating pathological samples. Methods: 192 samples sent with the diagnosis of Morton neuroma to the pathology department of our hospital between years 2010-2017 were added to our study. Mean age was 45,8 (between 23 to 73). All of 192 patients were primary diagnosed 22 of them was left foot and the other 170 were right foot was. 139 of them were female, and 53 were male. Recurrent neuromas, pathological sample more than one piece from one surgical site were excluded from the study. Results: 192 pathological specimens were prepared and examined by the same pathologist. Gross pathological appearance and histopathology findings were recorded. Mean sample length was 2,05 cm (between 0,8cm and 6 cm).145 samples was smaller (75.5%) than 3cm and only 47 sample (24.5%) was bigger than 3 cm.Conclusion: In conclusion our database results showed that majority of surgeons didn't take into account plantarly directed nerve branches.

Microductectomy: Current Surgical Technique for Pathological Ductal Discharge

Thelorrhea is one of the most common reasons for consultation in mastology. In the cases of a discharge with a pathological appearance, an appropriate approach is important given the possibility of it originating in a malignant neoplasm. Its study currently includes advanced diagnostic procedures such as ductoscopy with biopsy or brushing. However, these kinds of diagnostic intervention are not available everywhere and therefore, the surgical removal of the affected duct continues to be of great value diagnostically as well as therapeutically, especially in women with unsatisfied parity.

Neurologic Manifestations of Organic Chemicals

Organic chemicals can produce many different effects on the nervous system. The nervous system functions are affected by a variety of different organic chemicals. Organic chemicals that induce neurotoxicity may be naturally occurring or synthetic. Those that are naturally occurring products of plants or animals are referred to as “toxins,” whereas those that are synthetic are referred to as “toxicants”; however, publications and regulations sometimes use these terms interchangeably. Underlying these functional changes are cellular and subcellular changes that mediate the clinical and pathological appearance of the neurotoxicity. The ability to make a diagnosis of organic-chemical-induced neurotoxicity is dependent on being able to link a clinical situation with an exposure in a dose-related manner. Treatment and management of organic-chemical-induced neurotoxicity in affected individuals is dependent upon the specific chemical involved and the underlying mechanism by which toxicity occurs.

Impact of urban environment on the occurrence pathological signs in hardwood species

The article is devoted to date the impact of negative factors on the urban environment plants. Causes of pathologies can be divided into groups: induced mutations, abiotic factors, human factors, biotic factors. As authors of the research objectives was determined on the basis of an attempt of a pathological condition of the trees reveal the influence of certain groups of factors. Results of the study was to identify the most resistant O-types in the urban environment, a comparison with the pathological appearance-marks on woody plants in the conditions of the urban environment.

Verrucous carcinoma and squamous cell papilloma of the oral cavity: Report of two cases and review of literature

ABSTRACTVerrucous carcinoma (VC) of oral cavity is a rare variant of well-differentiated squamous cell carcinoma and squamous papilloma is a benign proliferation of the stratified squamous epithelium, which results in a papillary or verrucous exophytic mass. There is a certain clinical similarity between squamous cell papilloma and VC. We presented a report of two cases which are VC and squamous cell papilloma that are showed the same clinical appearance but different pathological appearance, with a review of the literature.