scholarly journals Long-Term Testosterone Administration Increases Visceral Fat in Female to Male Transsexuals1

1997 ◽  
Vol 82 (7) ◽  
pp. 2044-2047 ◽  
Author(s):  
Jolanda M. H. Elbers ◽  
Henk Asscheman ◽  
Jacob C. Seidell ◽  
Jos A. J. Megens ◽  
Louis J. G. Gooren
Keyword(s):  
Confidence Interval ◽  
Visceral Fat ◽  
Causal Relation ◽  
Magnetic Resonance Images ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Fat Depots ◽  
Testosterone Administration ◽  
The Mean

The amount of intraabdominal (visceral) fat is an important determinant of disturbances in lipid and glucose metabolism. Cross-sectional studies in women have found associations between high androgen levels and visceral fat accumulation. The causal relation between these phenomena is unknown. We, therefore, studied prospectively the effect of testosterone administration on body fat distribution in 10 young, nonobese, female to male transsexuals undergoing sex reassignment. Before, after 1 yr, and after 3 yr of testosterone administration, magnetic resonance images were obtained at the level of the abdomen, hip, and thigh to quantify both sc and visceral fat depots. After 1 yr of testosterone administration, sc fat depots at all levels showed significant reductions compared to baseline measurements. The mean visceral fat area did not change significantly, but subjects who gained weight in the first year after testosterone administration showed an increase in visceral fat. After 3 yr of testosterone administration, sc fat depots were no longer significantly lower compared to pretreatment measurements, but the mean visceral fat depot had increased significantly by 13 cm2 (95% confidence interval, 4–22 cm2), a relative increase of 47% (95% confidence interval, 8–91%) from baseline. The increase in visceral fat was most pronounced in those subjects who had gained weight. We conclude that long term testosterone administration in young, nonobese, female subjects increases the amount of visceral fat. In addition, an increase in weight in this hyperandrogenic state leads to a preferential storage of fat in the visceral depot.

scholarly journals Association Between Visceral Fat and Brain Cortical Thickness in the Elderly: A Neuroimaging Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Jaelim Cho ◽  
Seongho Seo ◽  
Woo-Ram Kim ◽  
Changsoo Kim ◽  
Young Noh
Keyword(s):  
Cortical Thickness ◽  
Visceral Fat ◽  
Reference Group ◽  
Subcutaneous Fat ◽  
Additive Model ◽  
The Elderly ◽  
Brain Regions ◽  
Magnetic Resonance Images ◽  
Visceral Fat Area ◽  
Cross Sectional

BackgroundDespite emerging evidence suggesting that visceral fat may play a major role in obesity-induced neurodegeneration, little evidence exists on the association between visceral fat and brain cortical thickness in the elderly.PurposeWe aimed to examine the association between abdominal fat and brain cortical thickness in a Korean elderly population.MethodsThis cross-sectional study included elderly individuals without dementia (n = 316). Areas of visceral fat and subcutaneous fat (cm2) were estimated from computed tomography scans. Regional cortical thicknesses (mm) were obtained by analyzing brain magnetic resonance images. Given the inverted U-shaped relationship between visceral fat area and global cortical thickness (examined using a generalized additive model), visceral fat area was categorized into quintiles, with the middle quintile being the reference group. A generalized linear model was built to explore brain regions associated with visceral fat. The same approach was used for subcutaneous fat.ResultsThe mean (standard deviation) age was 67.6 (5.0) years. The highest quintile (vs. the middle quintile) group of visceral fat area had reduced cortical thicknesses in the global [β = –0.04 mm, standard error (SE) = 0.02 mm, p = 0.004], parietal (β = –0.04 mm, SE = 0.02 mm, p = 0.01), temporal (β = –0.05 mm, SE = 0.02 mm, p = 0.002), cingulate (β = –0.06 mm, SE = 0.02 mm, p = 0.01), and insula lobes (β = –0.06 mm, SE = 0.03 mm, p = 0.02). None of the regional cortical thicknesses significantly differed between the highest and the middle quintile groups of subcutaneous fat area.ConclusionThe findings suggest that a high level of visceral fat, but not subcutaneous fat, is associated with a reduced cortical thickness in the elderly.

Effect of Medialization of the Trochlear Groove and Lateralization of the Tibial Tubercle on TT-TG Distance: A Cross-sectional Study of Dysplastic and Nondysplastic Knees

2021 ◽  
pp. 036354652098781
Author(s):  
Mathias Paiva ◽  
Lars Blønd ◽  
Per Hölmich ◽  
Kristoffer Weisskirchner Barfod
Keyword(s):  
Trochlear Dysplasia ◽  
Cross Sectional Study ◽  
Magnetic Resonance Images ◽  
Tibial Tubercle ◽  
Control Group ◽  
Trochlear Groove ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mean Values ◽  
The Mean

Background: Tibial tubercle–trochlear groove (TT-TG) distance is often used as a measure of lateralization of the TT and is important for surgical planning. Purpose: To investigate if increased TT-TG distance measured on axial magnetic resonance images is due to lateralization of the TT or medialization of the TG. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 84 knees (28 normal [NK], 28 with trochlear dysplasia [TD], and 28 with patellar dislocation without TD [PD]) were examined. The medial border of the posterior cruciate ligament (PCL) was chosen as the central anatomic landmark. The distance from the TT to PCL (TT-PCL) was measured to examine the lateralization of the TT. The distance from the TG to the PCL (TG-PCL) was measured to examine the medialization of the TG. Between-group differences were investigated by use of 1-way analysis of variance. Results: The mean values for TT-TG distance were 8.7 ± 3.6 mm for NK, 12.1 ± 6.0 mm for PD, and 16.7 ± 4.3 mm in the TD group ( P < .01). The mean values for TT-PCL distance were 18.5 ± 3.6 mm for NK, 18.5 ± 4.5 mm for PD, and 21.2 ± 4.2 mm in the TD group ( P = .03). The mean values for TG-PCL distance were 9.6 ± 3.0 mm for NK, 7.1 ± 3.4 mm for PD, and 5.1 ± 3.3 mm in the dysplastic group ( P < .01). Conclusion: The present results indicate that increased TT-TG distance is due to medialization of the TG and not lateralization of the TT. Knees with TD had increased TT-TG distance compared with the knees of the control group and the knees with PD. The TT-PCL distance did not differ significantly between groups, whereas the TG-PCL distance declined with increased TT-TG.

scholarly journals Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206945 ◽  
Author(s):  
Junko Kuwabara ◽  
Koichiro Kuwahara ◽  
Yoshihiro Kuwabara ◽  
Shinji Yasuno ◽  
Yasuaki Nakagawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Visceral Fat ◽  
Blood Pressure Variability ◽  
Cross Sectional Study ◽  
Home Blood Pressure ◽  
Impedance Method ◽  
Sectional Study ◽  
Visceral Fat Area ◽  
Cross Sectional

scholarly journals INDIRECT DECOMPRESSION BY LATERAL FUSION: ANALYSIS OF SAGITAL ALIGNMENT

2021 ◽  
Vol 20 (1) ◽  
pp. 50-54
Author(s):  
Thyago Guirelle Silva ◽  
Rodrigo Augusto do Amaral ◽  
Raphael Rezende Pratali ◽  
Luiz Pimenta
Keyword(s):  
Magnetic Resonance ◽  
Pelvic Incidence ◽  
Magnetic Resonance Images ◽  
Cross Sectional Area ◽  
Disc Height ◽  
Lower Limbs ◽  
Sectional Area ◽  
Cross Sectional ◽  
Indirect Decompression ◽  
The Mean

ABSTRACT Objective: To verify the effectiveness of indirect decompression after lateral access fusion in patients with high pelvic incidence. Methods: A retrospective, non-comparative, non-randomized analysis of 22 patients with high pelvic incidence who underwent lateral access fusion, 11 of whom were male and 11 female, with a mean age of 63 years (52-74), was conducted. Magnetic resonance exams were performed within one year after surgery. The cross-sectional area of the thecal sac, anterior and posterior disc heights, and bilateral foramen heights, measured pre- and postoperatively in axial and sagittal magnetic resonance images, were analyzed. The sagittal alignment parameters were measured using simple radiographs. The clinical results were evaluated using the ODI and VAS (back and lower limbs) questionnaires. Results: In all cases, the technique was performed successfully without neural complications. The mean cross-sectional area increased from 126.5 mm preoperatively to 174.3 mm postoperatively. The mean anterior disc height increased from 9.4 mm preoperatively to 12.8 mm postoperatively, while the posterior disc height increased from 6.3 mm preoperatively to 8.1 mm postoperatively. The mean height of the right foramen increased from 157.3 mm in the preoperative period to 171.2 mm in the postoperative period and that of the left foramen increased from 139.3 mm in the preoperative to 158.9 mm in the postoperative. Conclusions: This technique is capable of correcting misalignment in spinal deformity, achieving fusion and promoting the decompression of neural elements. Level of evidence III; Retrospective study.

scholarly journals A Cross-Sectional Study: Predicting Health Risks Among Female University Students

2020 ◽  
Vol 13 (1) ◽  
pp. 316-322
Author(s):  
Qassim I. Muaidi ◽  
Mohammad Ahsan
Keyword(s):  
Waist Circumference ◽  
Health Risks ◽  
Visceral Fat ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Anthropometric Measurements ◽  
Height Ratio ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Waist Height Ratio

Background: Good health is very important in our lives and plays a significant role. Many health risks are associated with an unhealthy lifestyle. These risks are responsible for raising the risk of chronic heart diseases and other health complications. Females are not exempted from these issues. Objective: To identify the obesity-associated health risks of female students by using selected anthropometric measurements. Methods: A cross-sectional study was conducted including 300 females aged 20.82 ± 5.23 years from the college of applied medical sciences, Imam Abdulrahman bin Faisal University. The anthropometric measurements (body mass index, percentage of body fat, visceral fat area, waist circumference, waist-hip ratio,and waist-height ratio) were taken with the help of an auto-calibrated bioelectric impedance device. The waist-height ratio was determined by dividing waist circumference with height. Cross tabulation was done to scrutinize the participant’s levels at risk and high risk. Linear regression analysis was done to see the relationship and prediction between selected anthropometric measurements. Results: The finding showed that BMI level was high in 55% of participants, Waist-height ratio over the average level was 46.67% and 21% of participants had a visceral fat area on risk. Linear regression analysis showed a strong association among body mass index, percentage of body fat, visceral fat area, waist circumference, waist-hip ratio,and waist-height ratio and statistically significant to each other at the 0.01 level. Conclusion: The selected anthropometric measurements can be used to identify health-related risks. Though, when any anthropometric measurement dichotomized as standard or high, BMI is the best measure to predict health risk.

scholarly journals Association of adiposity with thyroid nodules: a cross-sectional study of a healthy population in Beijing, China

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hui-xia Yang ◽  
Yu Zhong ◽  
Wei-hua Lv ◽  
Feng Zhang ◽  
Hong Yu
Keyword(s):  
Visceral Fat ◽  
Thyroid Nodules ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Continuous Variable ◽  
Overweight And Obesity ◽  
Healthy Population ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Beijing China

Abstract Background The relationship between thyroid nodules (TNs) and adiposity is controversial. This paper describes a cross-sectional investigation performed to determine the existence of any such relationship. To assess adiposity, body mass index (BMI) and visceral fat area (VFA) were utilized. Methods Between January 1, 2017 and March 3, 2019. Three thousand five hundred thirty four healthy people were examined using thyroid ultrasonography, visceral fat and anthropometric measurements, laboratory tests and questionnaire interview. Binary logistic regression analyses were used. Results Of the 3534 healthy subjects, 58.69% (2074/3534) of the subjects had TNs. A total of 55.91% (1976/3534) had BMI ≥ 25 kg/m2 and 39.67% (1402/3534) had VFA ≥ 100 cm2. After adjustment to address confounders, BMI-based overweight and obesity levels only correlated with higher risk TNs when used as a continuous variable (OR = 1.031, 95% CI: 1.008–1.055, P = 0.008), while VFA was both a continuous variable (OR = 1.003, 95% CI: 1.000–1.005, P = 0.034) and a categorical variable (OR = 1.198, 95% CI: 1.014–1.417, P = 0.034) associated with significantly elevated risk of TNs. Analyzing the subgroups, BMI ≥ 25 kg/m2 (OR = 1.500, 95% CI: 1.110–2.026, P = 0.008) was significantly correlated with TN risk in individuals with TG ≥ 1.7 mmol/L. VFA ≥ 100 cm2 correlated with the TN risk irrespective of age (< 50 years: OR = 1.374, 95% CI: 1.109–1.703, P = 0.004; ≥ 50 years: OR = 1.367, 95% CI: 1.063–1.759, P = 0.015) and in the following subgroups: women (OR = 4.575, 95% CI: 2.558–8.181, P = 0.000), FBG ≥ 6.1 mmol/L (OR = 1.522, 95% CI: 1.048–2.209, P = 0.027), and TG ≥ 1.7 mmol/L (OR = 1.414, 95% CI: 1.088–1.838, P = 0.010). Conclusions Adiposity correlates with TNs. To assess TN risk in Chinese individuals, VFA is better than BMI.

scholarly journals Association between breath methane concentration and visceral fat area: a population-based cross-sectional study

2020 ◽  
Vol 14 (2) ◽  
pp. 026008
Author(s):  
Naoki Ozato ◽  
Shinichiro Saito ◽  
Tohru Yamaguchi ◽  
Mitsuhiro Katashima ◽  
Itoyo Tokuda ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Methane Concentration ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Breath Methane

Assessment of Nonresearch Industry Payments to Otolaryngologists in 2014 and 2015

2018 ◽  
Vol 158 (6) ◽  
pp. 1028-1034 ◽  
Author(s):  
Neil Pathak ◽  
Rance J. T. Fujiwara ◽  
Saral Mehra
Keyword(s):  
Annual Variation ◽  
Public Awareness ◽  
Large Change ◽  
Cross Sectional ◽  
Food And Beverage ◽  
Long Term Trends ◽  
The Mean ◽  
Open Payments ◽  
Made In

Objective To characterize, describe, and compare nonresearch industry payments made to otolaryngologists in 2014 and 2015. Additionally, to describe industry payment variation within otolaryngology and among other surgical specialties. Study Design Retrospective cross-sectional database analysis. Setting Open Payments Database. Subjects and Methods Nonresearch payments made to US otolaryngologists were characterized and compared by payment amount, nature of payment, sponsor, and census region between 2014 and 2015. Payments in otolaryngology were compared with those in other surgical specialties. Results From 2014 to 2015, there was an increase in the number of compensated otolaryngologists (7903 vs 7946) and in the mean payment per compensated otolaryngologist ($1096 vs $1242), as well as a decrease in the median payment per compensated otolaryngologist ($169 vs $165, P = .274). Approximately 90% of total payments made in both years were attributed to food and beverage. Northeast census region otolaryngologists received the highest median payment in 2014 and 2015. Compared with other surgical specialists, otolaryngologists received the lowest mean payment in 2014 and 2015 and the second-lowest and lowest median payment in 2014 and 2015, respectively. Conclusion The increase in the mean payment and number of compensated otolaryngologists can be explained by normal annual variation, stronger industry-otolaryngologist relationships, or improved reporting; additional years of data and improved public awareness of the Sunshine Act will facilitate determining long-term trends. The large change in disparity between the mean and median from 2014 to 2015 suggests greater payment variation. Otolaryngologists continue to demonstrate limited industry ties when compared with other surgical specialists.

scholarly journals Metabolomics: a search for biomarkers of visceral fat and liver fat content

Metabolomics ◽  
2019 ◽  
Vol 15 (10) ◽  
Author(s):  
Sebastiaan Boone ◽  
Dennis Mook-Kanamori ◽  
Frits Rosendaal ◽  
Martin den Heijer ◽  
Hildo Lamb ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Diagnostic Value ◽  
Fat Content ◽  
Metabolite Concentration ◽  
Liver Fat ◽  
Plasma Metabolites ◽  
Liver Fat Content ◽  
Cross Sectional ◽  
Fat Depots ◽  
Cardiometabolic Disorders

Abstract Intoduction Excess visceral and liver fat are known risk factors for cardiometabolic disorders. Metabolomics might allow for easier quantification of these ectopic fat depots, instead of using invasive and costly tools such as MRI or approximations such as waist circumference. Objective We explored the potential use of plasma metabolites as biomarkers of visceral adipose tissue (VAT) and hepatic triglyceride content (HTGC). Methods We performed a cross-sectional analysis of a subset of the Netherlands Epidemiology of Obesity study. Plasma metabolite profiles were determined using the Biocrates AbsoluteIDQ p150 kit in 176 individuals with normal fasting plasma glucose. VAT was assessed with magnetic resonance imaging and HTGC with proton-MR spectroscopy. We used linear regression to investigate the associations of 190 metabolite variables with VAT and HTGC. Results After adjustment for age, sex, total body fat, currently used approximations of visceral and liver fat, and multiple testing, three metabolite ratios were associated with VAT. The strongest association was the lysophosphatidylcholines to total phosphatidylcholines (PCs) ratio [− 14.1 (95% CI − 21.7; − 6.6) cm2 VAT per SD of metabolite concentration]. Four individual metabolites were associated with HTGC, especially the diacyl PCs of which C32:1 was the strongest at a 1.31 (95% CI 1.14; 1.51) fold increased HTGC per SD of metabolite concentration. Conclusion Metabolomics may be a useful tool to identify biomarkers of visceral fat and liver fat content that have added diagnostic value over current approximations. Replication studies are required to validate the diagnostic value of these metabolites.

Myopenic obesity determined by visceral fat area strongly predicts long-term mortality in cirrhosis

2020 ◽  
Author(s):  
Hongjuan Feng ◽  
Xiaoyu Wang ◽  
Tianming Zhao ◽  
Lihong Mao ◽  
Yangyang Hui ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Visceral Fat Area ◽  
Long Term Mortality
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