scholarly journals SAT-017 Relationship Between Vitamin D Levels and Signs of Polycystic Ovary Syndrome

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Anastasia Smykalova ◽  
Svetlana Kalinchenko ◽  
Aigul Safi ◽  
Mekan Orazov ◽  
Alexander Nizhnik
Keyword(s):  
Vitamin D ◽  
Waist Circumference ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
The Body ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Abstract An analysis of the structure of the causes of infertility shows that up to almost 25% of women of reproductive age ovulation disorders are observed. Hormonal disorders leading to the absence of ovulation, began to play a leading role in the etiology of infertility, special vitamin D deficiency, while today it has been established that its D receptors (VDR) are localized in most organs, including reproductive ones. VDR affect the expression of 1000 genes and play a crucial role in the implementation of sex hormones function. The aim of the study was to assess the vitamin D level in women of reproductive age, depending on the presence of signs of PCOS and waist circumference (WC). 71 women from 19 to 44 years old were examined of these, 41 patients were diagnosed with PCOS and impaired ovulatory function, in 30 patients the ovulatory cycle was preserved, and signs of PCOS were not detected. The level of vitamin 25 (OH) D3 in the serum of the subjects was evaluated by tandem chromato-mass spectrometry at the ArchiMed clinic of new medical technologies, Moscow. In the recommendations of the Canadian “The Vitamin D society”, 40-60 ng/ml the optimal level of serum vitamin D, a concentration of 20-40 ng/ml insufficiency, <20 ng/ml as a deficiency. Vitamin D deficiency was detected in 57% of women in both groups, with a pronounced deficiency (<10 ng/ml) in 17%, insufficiency was observed in 43% of cases, a sufficient level was not detected in any of the subjects. The average level of vitamin D in patients with PCOS was 18.2 (2 to 32.3) ng/ml, the value in patients without signs of PCOS was 18.5 (6.8 to 31) ng/ml. Comparison of the vitamin D value with WC showed that in women with PCOS with an WC <80 cm the value of this indicator was 18.8 ng/ml, and for WC ≥ 80 cm it was statistically significantly lower - 13.3 ng/ml (p<0.05). Conclusion. High prevalence of vitamin D deficiency among patients of reproductive age, with no differences in the magnitude of this indicator depending on the presence of signs of PCOS and persistent ovulation. Difference was established between the levels of vitamin D in patients with PCOS depending on the waist circumference - its insufficiency increases with an increase in WC. The results of the study suggest that the deficiency of vitamin D in the body increases with the aggravation of hormonal dysfunction in PCOS, which should be taken into account by specialists during the management of this category of patients and the treatment of infertility.

scholarly journals VITAMIN D DEFICIENCY;

2012 ◽  
Vol 19 (02) ◽  
pp. 208-213
Author(s):  
MUHAMMAD ASLAM ◽  
ZAHID MASOOD ◽  
Abdul SATTAR ◽  
Maria Qudsia
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Sampling Technique ◽  
Reproductive Age ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Vitamin D 3

Objective: To study the Prevalence of Vitamin D deficiency in pregnant women. Study Design: A Cross-sectional analyticalstudy through convenient sampling technique. Setting and duration: At a private Clinic located at East Canal Road Faisalabad, from March2011 to June 2011. Material and method: The study included consecutive 61 pregnant women of reproductive age and non-pregnant womenwere excluded. Blood samples were taken in morning i.e. overnight fasting samples, by venepuncture by disposable syringes sample weretaken and samples were stored at -20 degree centigrade till they were analyzed. Our interest was in age and serum Vitamin D 3 levels. Results:Out of 61 pregnant women results showed that 87.0% pregnant women were having Vitamin D deficiency, 10.0% were having Vitamin Dinsufficiency, 3.0% had Vitamin D sufficiency and none shows Vitamin D intoxication. Vitamin D deficiency was more prevalent in pregnantwomen of younger age group. Furthermore prevalence was higher among the pregnant mothers with high parity. Moreover, 65% women werenot exposed to sunlight properly, 60% women had muscle cramps and bony aches. 90% women never were tested for tested Vitamin D levelsbefore. Conclusions: Prevalence of Vitamin D deficiency is significant in pregnant women. It is also important for its effects on various organsand systems of body as well as on pregnancy and neonate. The different aspects of study led to conclusion to emphasize that Health educationbe imparted to pregnant women and their families in terms of diet, proper sunlight exposure and taking Vitamin D supplements in pregnancy. It isthus recommended to perform Vitamin D levels in every pregnant woman.

scholarly journals Role Of Vitamin D And Adipose Tissue Hormones In Women With Reproductive Disorders

Folia Medica ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 5-10
Author(s):  
Presiyana V. Nyagolova ◽  
Mitko D. Mitkov ◽  
Maria M. Orbetsova
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
Reproductive Function ◽  
Reproductive Disorders ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Relationship

Abstract The role of vitamin D beyond that it plays in bone metabolism and calcium homeostasis has been lately quite emphasized. In this respect, vitamin D deficiency has been associated with higher risk of cardiovascular disease, metabolic syndrome, and reproductive disorders. Growing evidence has suggested that vitamin D deficiency is implicated in the pathogenesis of insulin resistance and the development of metabolic disorders in the polycystic ovary syndrome. The goal of the review is to present contemporary concepts of the relationship between hormones affecting the metabolic body status, serum vitamin D levels and the reproductive function.

scholarly journals Vitamin D deficiency and metabolic syndrome in elderly Chinese individuals: evidence from CLHLS

2020 ◽  
Author(s):  
Ling Liu ◽  
Zhaojin Cao ◽  
Feng Lu ◽  
Yingchun Liu ◽  
Yuebin Lv ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Waist Circumference ◽  
Vitamin D Deficiency ◽  
Elderly People ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Elderly Chinese ◽  
25 Hydroxy Vitamin D

Abstract Objectives : Both low vitamin D status and metabolic syndrome (MetS) are worldwide concerns, and low vitamin D levels are associated with MetS; however, related epidemiological evidence based on elderly Chinese individuals, especially those over 80 years of age, is limited. In the present study, we aimed to evaluate the association between serum 25-hydroxy vitamin D and MetS in elderly Chinese individuals. Method: Serum 25-hydroxy vitamin D (25(OH)D3) was measured in a cross-sectional sample of 2493 elderly people aged 65-112 years from eight areas of China in which the density of centenarians is exceptionally high. MetS was diagnosed according to blood pressure, lipid, and blood sugar levels; waist circumference; and body mass index (BMI). Adjusted multivariable logistic regression was used to analyze the associations between vitamin D and MetS based on different diagnostic criteria. Results: A total of 890 (35.7%) of the recruited elderly individuals had insufficient levels of vitamin D, and 1029 participants (41.3%) were vitamin D deficient. High serum vitamin D concentrations were associated with a low prevalence of MetS according to the modified Adult Treatment Panel III (ATP III) criteria for adequate versus deficient vitamin D levels (OR: 0.63, 95% CI: 0.45, 0.88) and inadequate versus deficient vitamin D levels (OR: 0.70, 95% CI: 0.52, 0.92). Each 10 ng/ml increase in serum vitamin D was significantly associated with a decreased prevalence of MetS according to the modified ATP III criteria for people with normal waist circumference (WC) (OR: 0.55, 95% CI: 0.43,0.71). However, no significant statistical correlation was found among elderly people with a high WC. Additionally, in the analysis of the individual components, the ORs of adequate versus deficient vitamin D levels were 0.46 (95% CI: 0.30, 0.71) for elevated triglycerides and 0.64 (95% CI: 0.42, 0.97) for reduced high-density lipoprotein cholesterol (HDL-C) after adjustment for other components. Conclusions: Vitamin D deficiency is very common among elderly Chinese individuals. Vitamin D deficiency may be a risk factor for MetS; however, the association was only statistically significant among elderly people with noncentral obesity. Further studies are needed to examine the causal direction of the association.

Association of vitamin D deficiency to the risk of preeclampsia in Saudi Arabia

2020 ◽  
pp. 1-14
Author(s):  
Aisha Mansoor Ali ◽  
Munazzah Rafique ◽  
Zarqa Saleem
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Geographic Area ◽  
Normal Pregnancy ◽  
Reproductive Age ◽  
Retrospective Case ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Medical City

Abstract Objective: Vitamin D levels have shown significant geographical distribution, therefore, this study was conducted to evaluate its relationship to a specific geographic area with a high prevalence of vitamin D deficiency to the important maternal manifestation of preeclampsia. This study established the association of vitamin D deficiency to preeclampsia among women of reproductive age. Method: It is a retrospective case-control study done to measure serum vitamin D levels in pregnant women receiving care at the King Fahad Medical City Riyadh with preeclampsia (n=100) and normal pregnancy (controls, n=200) from 2012 to 2014. Odds of developing preeclampsia with vitamin D deficiency were calculated using logistic regression analysis. Results: The mean serum vitamin D level was 25.35?ng/ml in controls and 15.95?ng/ml in pre-eclampsia women. Comparing to those who had a serum vitamin D level of ?50?ng/ml, the odds ratio of developing preeclampsia in women with vitamin D deficiency was 4.2 (95% CI=1.23-14.35) while adjusting for age, BMI and duration of pregnancy. Conclusion: The risk of developing preeclampsia might increase by up to 4-fold in women with vitamin D deficiency. Since preeclampsia could lead to maternal and neonatal complications, vitamin D could be added during pregnancy to decrease these adverse consequences. Keywords: Vitamin D deficiency; preeclampsia; BMI; hypertension. Continuous...

scholarly journals Vitamin D deficiency and metabolic syndrome in elderly Chinese individuals: evidence from CLHLS

2020 ◽  
Author(s):  
Ling Liu ◽  
Zhaojin Cao ◽  
Feng Lu ◽  
Yingchun Liu ◽  
Yuebin Lv ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Waist Circumference ◽  
Vitamin D Deficiency ◽  
Elderly People ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Elderly Chinese ◽  
25 Hydroxy Vitamin D

Abstract Objectives : Both low vitamin D status and metabolic syndrome (MetS) are worldwide concerns, and low vitamin D levels are associated with MetS; however, related epidemiological evidence based on elderly Chinese individuals, especially those over 80 years of age, is limited. In the present study, we aimed to evaluate the association between serum 25-hydroxy vitamin D and MetS in elderly Chinese individuals. Method: Serum 25-hydroxy vitamin D (25(OH)D3) was measured in a cross-sectional sample of 2493 elderly people aged 65-112 years from eight areas of China in which the density of centenarians is exceptionally high. MetS was diagnosed according to blood pressure, lipid, and blood sugar levels; waist circumference; and body mass index (BMI). Adjusted multivariable logistic regression was used to analyze the associations between vitamin D and MetS based on different diagnostic criteria. Results: A total of 890 (35.7%) of the recruited elderly individuals had insufficient levels of vitamin D, and 1029 participants (41.3%) were vitamin D deficient. High serum vitamin D concentrations were associated with a low prevalence of MetS according to the modified Adult Treatment Panel III (ATP III) criteria for adequate versus deficient vitamin D levels (OR: 0.63, 95% CI: 0.45, 0.88) and inadequate versus deficient vitamin D levels (OR: 0.70, 95% CI: 0.52, 0.92). Each 10 ng/ml increase in serum vitamin D was significantly associated with a decreased prevalence of MetS according to the modified ATP III criteria for people with normal waist circumference (WC) (OR: 0.55, 95% CI: 0.43,0.71). However, no significant statistical correlation was found among elderly people with a high WC. Additionally, in the analysis of the individual components, the ORs of adequate versus deficient vitamin D levels were 0.46 (95% CI: 0.30, 0.71) for elevated triglycerides and 0.64 (95% CI: 0.42, 0.97) for reduced high-density lipoprotein cholesterol (HDL-C) after adjustment for other components. Conclusions: Vitamin D deficiency is very common among elderly Chinese individuals. Vitamin D deficiency may be a risk factor for MetS; however, the association was only statistically significant among elderly people with noncentral obesity. Further studies are needed to examine the causal direction of the association.

scholarly journals VITAMIN-D LEVELS AND LOW BACK PAIN

2018 ◽  
Vol 25 (04) ◽  
pp. 615-619
Author(s):  
Rahman Rasool Akhtar ◽  
Junaid Khan ◽  
Tehreem Zahid ◽  
Riaz Ahmed
Keyword(s):  
Vitamin D ◽  
Low Back Pain ◽  
Back Pain ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
The Body ◽  
Low Back ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels

Objectives: To determine the number of patients with low back pain who havelow serum Vitamin-D levels along with associated risk factors in our local population. StudyDesign: Descriptive Study. Place and Duration: At the Department of Orthopedics, BenazirBhutto Hospital, Rawalpindi, for a duration of 01 year from 20th March 2016 to 19th March 2017.Patients and Methods: 600 patients were included in the study who met the inclusion criteria,i.e. patients presenting to the Out Patient Department (OPD) with low back pain for a duration ofless than six months aged between 15 to 55 years. Venous blood withdrawn and serum levelsof Vitamin-D measured. According to serum Vitamin-D levels, categorized as deficient, sufficientor excess. Results: Mean age of patients included in the study 44.21 ± 11.92 years. Out of thetotal, 337 (56.17%) were males and 263 (43.83%) females. Out of the total, 20.67%, 26.17%and 28.83% had mild, moderate and severe Vitamin-D deficiency, respectively. Predominantlypatients with severe Vitamin-D deficiency presented in winters (October – February) (17.16%)as compared to other seasons. The most pre-dominant risk factor in patients with low Vitamin-Dlevels was smoking (21.33%). Conclusion: Vitamin D plays a crucial role in the musculoskeletalframework of the body. The deficiency is more prevalent in the youth due to sedentary lifestyleand indoor preference.

scholarly journals Evaluation of vitamin D status and depression in thyroid patients referred to Yazd Diabetes Center clinic in 2020

2021 ◽  
Author(s):  
Marzieh Shukohifar ◽  
Ali Dadbinpour ◽  
Zohre Sadat Mozafari ◽  
Mohadeseh Zarei Yazdeli
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Significant Negative Correlation ◽  
The Body ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Mean ◽  
Diabetes Center

Introduction: Vitamin D is a hormonal precursor that in addition to known roles, may have an important effect on mental disorders such as depression. Therefore, this study was performed to determine the extent of vitamin D deficiency and depression and their relationship in thyroid patients referred to The clinic of Yazd Diabetes Center has been performed. Methods: The present study is a cross-sectional-analytical study that was performed on 150 thyroid patients referred to the Yazd Diabetes Center Clinic. Results: In this study, 150 thyroid patients including 55 men and 11. women with a mean age of 41.40± 7.61years participated. The mean score of Beck depression among these patients was 28.71± 8.34 .The mean level of vitamin D in these patients was 20.58 ± 7.21  ng / ml so that a total of 85% of thyroid patients were in the group of insufficient levels of vitamin D. A significant negative correlation was observed between depression score and serum vitamin D levels (r = -0.79 and p <0.001). Conclusion: The results of this study indicate a high prevalence of depression and vitamin D deficiency in thyroid patients. Another finding of this study was the relationship between vitamin D deficiency and depression, so that the less vitamin D in the body, the lower the rate of depression in The person becomes more. The use of vitamin D supplements in the treatment of thyroid patients with depression, as a clinical trial, can be a good solution in the treatment of patients.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (&#62;15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as &#60;20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

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