The Location of Silicon Dioxide in Silicified Microcrystalline Cellulose

1999 ◽  
Vol 5 (6) ◽  
pp. 371-376 ◽  
Author(s):  
S. Edge ◽  
U.J. Potter ◽  
D.F. Steele ◽  
M.J. Tobyn ◽  
A. Chen ◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
Microcrystalline Cellulose

scholarly journals MECHANOCHEMICAL AND ULTRASONIC TREATMENT – A CONTROLLED METHOD FOR FORMING THE STRUCTURE AND PROPERTIES OF NANOCOMPOSITE GEL SYSTEMS

2021 ◽  
Vol 2 (446) ◽  
pp. 36-44
Author(s):  
А.О. Zhapekova ◽  
N.N. Mofa ◽  
B. Elouadi ◽  
R.S. Iminova ◽  
А.Е. Bakkara ◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
Microcrystalline Cellulose ◽  
Ultrasonic Treatment ◽  
Homogeneous System ◽  
The State ◽  
Gelling Agent ◽  
Structure And Properties ◽  
Colloidal Systems ◽  
Silica Powder ◽  
Highly Dispersed

In this work, the preparation of colloidal systems with microcrystalline cellulose as a gelling agent and silica powder as a filler was considered. By mechanochemical and ultrasonic treatment of a filler made of silicon dioxide and a colloidal base, varying the constituent ingredients, one can purposefully influence the structure of the system and regulate the properties of the resulting compositions. It is shown that the introduction of a filler made of highly dispersed silicon dioxide into a gel system based on cellulose, modified by ultrasonic treatment (UST) with acid additives, provides both acceleration of the gelation process and stabilization of the state of the obtained colloidal composition. As a result of UST, a nanostructured colloidal homogeneous system is formed.

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

Buckling Control of Silicon Dioxide Diaphragms for Sensitivity Enhancement of Piezoelectric Ultrasonic Microsensors

2011 ◽  
Vol 131 (7) ◽  
pp. 235-239 ◽  
Author(s):  
Kaoru Yamashita ◽  
Tomoya Yoshizaki ◽  
Minoru Noda ◽  
Masanori Okuyama
Keyword(s):  
Silicon Dioxide ◽  
Sensitivity Enhancement

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

β-Cyclodextrin Polymers on Microcrystalline Cellulose as a Granular Media for Organic Micropollutant Removal from Water

2018 ◽  
Author(s):  
Diego Alzate-Sanchez ◽  
Yuhan Ling ◽  
Chenjun Li ◽  
Benjamin Frank ◽  
Reiner Bleher ◽  
...  
Keyword(s):  
Microcrystalline Cellulose ◽  
Continuous Flow ◽  
Granular Media ◽  
Anaerobic Biodegradation ◽  
Thin Coating ◽  
Micropollutant Removal ◽  
Cyclodextrin Polymers ◽  
Flow Experiments ◽  
Aerobic And Anaerobic ◽  
Cellulose Composite

This manuscript describes cyclodextrin polymers formed as a thin coating on microcrystalline cellulose. The resulting polymer/cellulose composite shows promising performance for removing organic pollutants from water and can be packed into columns for continuous-flow experiments. The polymer/cellulose composite also shows excellent resistance to aerobic and anaerobic biodegradation.

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