Selective Dysarthria due to Clival Chordoma

2021 ◽  
pp. 10.1212/CPJ.0000000000001104
Author(s):  
Carlos Pérez-López ◽  
María José Abenza-Abildúa ◽  
Victor Rodriguez-Dominguez ◽  
Laura González-Martin ◽  
Borja Jesús Hernández-García
Keyword(s):  
Age Of Onset ◽  
Cranial Nerves ◽  
Axial Skeleton ◽  
Central Nervous System Tumors ◽  
Malignant Bone Tumor ◽  
Intracranial Neoplasms ◽  
Nervous System Tumors ◽  
The Mean ◽  
Lower Cranial Nerves ◽  
Slow Growing

Chordoma is a rare, slow-growing malignant bone tumor originating from the remains of the notochord and predominantly affecting the axial skeleton (especially the sacrum and occipital region). Clival chordomas represent 1-4% of intracranial neoplasms and only 0.2% of central nervous system tumors, so their prevalence is very low (1 case per 2 million inhabitants). The mean age of onset is in the 4th decade of life and its usual symptoms are diplopia due to involvement of the ocular pairs, dysphagia and headache (1,2). More rarely, it affects phonetics in isolation due to the involvement of the lower cranial nerves (hypoglossal or glossopharyngeal) (3-5).

scholarly journals Glomus Jugulare Presenting with Isolated Facial Nerve Palsy

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Angelica A. Nunez ◽  
Luis R. Ramos-Duran ◽  
Albert C. Cuetter
Keyword(s):  
Nerve Palsy ◽  
Facial Nerve Palsy ◽  
Cranial Nerves ◽  
Petrous Bone ◽  
Jugular Foramen ◽  
Facial Weakness ◽  
Glomus Jugulare ◽  
Vascular Structures ◽  
Lower Cranial Nerves ◽  
Slow Growing

Glomus jugulare is a rare slow growing tumor occurring within the jugular foramen that rarely presents with isolated symptoms. Although histologically benign, these tumors are locally destructive because of their proximity to the petrous bone, the lower cranial nerves, and the major vascular structures (Miller et al. (2009) and Silverstone (1973)). We wish to report a glomus jugulare tumor eroding the petrous bone and producing an ipsilateral peripheral facial weakness. The mechanism of this erosion is discussed.

scholarly journals P08.01 Impact of cannabis use on quality of life in patients with central nervous system tumors

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii37-iii37
Author(s):  
J E Rodriguez Almaraz ◽  
N A Butowski ◽  
S M Chang ◽  
N A E Oberheim-Bush ◽  
J R Clarke ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Global Health ◽  
Cannabis Use ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors ◽  
The Mean

Abstract BACKGROUND Nearly 80,000 new cases of primary brain tumors are expected to be diagnosed this year in the United States: 32% of CNS tumors are malignant. Anecdotally, patients who report use of cannabis, frequently describe higher quality of life scores (QOL) in standardized instruments. However, the lack of available tools that allow systematic documentation of cannabis use results in a barrier to accurately assess efficacy and potential benefits and risks. MATERIAL AND METHODS We conducted a single center, observational study: patients with primary brain tumors answered a previously validated instrument to explore cannabis use. QOL was assessed using the instruments from the European Organisation for Research and Treatment of Cancer(EORTC): QLQ-C30 and its complementary module BN-20 as well as the EuroQol group’s instrument EQ-5D-5L. Eligible participants were identified as cannabis users or non-users, completing the instruments in a self-administered fashion. RESULTS To date, 45 patients who signed informed consent were enrolled and answered the questionnaires, mean age was 51 (SD 13.5) years, 31 were male, 25 were considered active cannabis users (624% males and 36% females). At baseline, the mean Global Health score in the QLQ-C30 instrument was 68.6 (SD: 20.6) among cannabis users and 82 (SD: 18.05) among non-users. The mean difference in Global Health QOL scores between users and non-users was 13.35 (95%CI: 1.34, 25.35; p=0.03). In contrast the difference between cannabis users and non-users in QOL index in the EQ-5D-5L instrument was 0.13 (0.77 vs 0.91; p=0.002). Among cannabis users, patients perceive their symptoms as moderate before using cannabis and mild after using cannabis (p>0.001). CONCLUSION In our analysis, patients who use cannabis have, on average, lower QOL scores signaling that sicker patients resort to cannabis to improve their symptoms and ultimately their quality of life. Patients’ perception is one of improvement in the overall quality of life when using cannabis. Our findings provide background support to perform prospective studies in the impact of cannabis in quality of life of patients with central nervous system tumors.

Effect of High Plane of Nutrition on Blood Biochemical Profile and Onset of Puberty in Prepubertal HF X Kankrej Crossbred Heifers

2019 ◽  
Vol 15 (02) ◽  
pp. 14-17
Author(s):  
K K Hadiya ◽  
A J Dhami ◽  
D V Chaudhari ◽  
P M Lunagariya
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Plasma Levels ◽  
Age Of Onset ◽  
The Body ◽  
Monthly Interval ◽  
Control Group ◽  
Blood Biochemical ◽  
Lower Protein ◽  
The Mean

This study was initiated on 24 prepubertal Holstein x Kankrej crossbred heifers of nearly identical age (7-9 months) and body weight (130-140 kg) at University farm to evaluate the effect of high plane of nutrition on blood biochemical and minerals profile and the age at puberty. Twelve heifers were managed under routine farm feeding (control) and the rest 12 under ideal optimum feeding regime (treatment) that included extra 1 kg concentrate, 30 g min mix and ad-lib dry fodder. The body weight and ovarian ultrasonography together with blood sampling was carried out at monthly interval from 10 to 18 months of age to study the ovarian dynamics and blood biochemical changes. High plane of nutrition to growing heifers was beneficial in reducing the age of onset of puberty (by 2-3 months) compared to routine farm fed group. The mean plasma total protein and cholesterol concentrations showed a rising trend with significant variations from 10 to 16 months of age, where it got mostly stabilized indicating adult profile. The activity of enzymes GOT and GPT also rose gradually and significantly from 10 months till 14-15 months of age, and thereafter it remained more or less static till 18 months of age. The levels of both these enzymes were higher, with lower protein and cholesterol, in control than the treatment group from 15-16 months of age onwards. The mean plasma levels of both calcium and phosphorus increased gradually and significantly with advancing age till 16-17 months of age, with little higher values in supplemented than a control group. The plasma levels of zinc, iron, copper, and cobalt also showed rising trend with significant differences between 10th and 12th-14th months of age, and from 15th to 18th months of age the levels were statistically the same in all the groups with slightly higher values in the treatment group.

Endonasal access to lower cranial nerves: From foramina to upper parapharyngeal space

Head & Neck ◽  
2021 ◽  
Author(s):  
Lifeng Li ◽  
Nyall R. London ◽  
Daniel M. Prevedello ◽  
Ricardo L. Carrau
Keyword(s):  
Parapharyngeal Space ◽  
Cranial Nerves ◽  
Lower Cranial Nerves
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