Detection of Caspase-3, Neuron Specific Enolase, and High-sensitivity C-reactive Protein Levels in Both Cerebrospinal Fluid and Serum of Patients after Aneurysmal Subarachnoid Hemorrhage

Neurosurgery ◽  
2008 ◽  
Vol 62 (6) ◽  
pp. E1384
Author(s):  
Taner Tanriverdi
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Hemorrhage ◽  
Caspase 3 ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Neuron Specific Enolase ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

DETECTION OF CASPASE-3, NEURON SPECIFIC ENOLASE, AND HIGH-AENSITIVITY C-REACTIVE PROTEIN LEVELS IN BOTH CEREBROSPINAL FLUID AND SERUM OF PATIENTS AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE

Neurosurgery ◽  
2007 ◽  
Vol 60 (4) ◽  
pp. 674-680 ◽  
Author(s):  
Tibet Kacira ◽  
Rahsan Kemerdere ◽  
Pinar Atukeren ◽  
Hakan Hanimoglu ◽  
Galip Zihni Sanus ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Hemorrhage ◽  
Caspase 3 ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Neuron Specific Enolase ◽  
Enzyme Linked Immunosorbent Assay ◽  
Prospective Clinical Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Number Of Patients

Abstract OBJECTIVE The purpose of this study is to explore whether or not the levels of caspase-3 (Casp3), neuron-specific enolase (NSE), and high-sensitivity C-reactive protein (hsCRP) were elevated in cerebrospinal fluid (CSF) and serum of patients after aneurysmal subarachnoid hemorrhage (SAH). METHODS This prospective clinical study consisted of 20 patients who experienced recent aneurysmal SAH and 15 control patients who experienced hydrocephalus without any other central nervous system disease. CSF and serum samples obtained within the first 3 days, and on the fifth and seventh days of SAH were assayed for Casp3, NSE, and hsCRP by using enzyme-linked immunosorbent assay. RESULTS Levels of Casp3, NSE, and hsCRP in the CSF (P = 0.00001, P = 0.00001, and P <0.003, respectively) and in the serum (P = 0.00001, P <0.01, and P = 0.00001, respectively) of SAH patients were found to be elevated when compared with controls with normal pressure hydrocephalus. CONCLUSION The authors have demonstrated the synchronized elevation of Casp3, NSE, and hsCRP in both CSF and serum of patients with aneurysmal SAH. Further studies with a large number of patients are recommended to more accurately determine the roles of these molecules in aneurysmal SAH.

scholarly journals Serum C-reactive protein levels predict neurological outcome after aneurysmal subarachnoid hemorrhage

2012 ◽  
Vol 70 (3) ◽  
pp. 202-205 ◽  
Author(s):  
Flávio Ramalho Romero ◽  
Eduardo de Freitas Bertolini ◽  
Eberval G. Figueiredo ◽  
Manoel Jacobsen Teixeira
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
C Reactive Protein ◽  
Clinical Prognosis ◽  
Protein Levels ◽  
Reactive Protein ◽  
Fisher Grade ◽  
Serial Serum ◽  
Gcs Score ◽  
Serum Crp

OBJECTIVES: Our aim was to evaluate the relationship between serum C-reactive protein (CRP) levels and the neurological prognosis and development of vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). METHODS: Eighty-two adult patients with aSAH diagnoses were prospectively evaluated. Glasgow Coma Scale (GCS) score, Hunt and Hess grade, Fisher grade, cranial CT scans, digital subtraction angiography studies and daily neurological examinations were recorded. Serial serum CRP measurements were obtained daily between admission and the tenth day. Glasgow Outcome Scale (GOS) and the modified Rankin Scale (mRS) were used to assess the prognosis. RESULTS: Serum CRP levels were related to severity of aSAH. Patients with lower GCS scores and higher Hunt and Hess and Fisher grades presented statistically significant higher serum CRP levels. Patients with higher serum CRP levels had a less favorable prognosis. CONCLUSIONS: Increased serum CRP levels were strongly associated with worse clinical prognosis in this study.

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