Preface

Development ◽  
1991 ◽  
Vol 113 (Supplement_2) ◽  
pp. NP-NP
Author(s):  
Hugh Perry ◽  
Andrew Lumsden ◽  
Roger Keynes ◽  
Nigel Holder ◽  
Dennis Bray
Keyword(s):  
Developmental Biology ◽  
Nervous System ◽  
Annual Meeting ◽  
Cell Biology ◽  
Common Ground ◽  
Brain Research ◽  
British Society ◽  
Research Association ◽  
Scientific Society ◽  
The Brain

In recent years, the British Society for Cell Biology (BSCB) and the British Society for Developmental Biology (BSDB), have held their Annual Meetings conjointly, an arrangement that has brought many benefits in terms of increased numbers of participants and shared interests. Topics each year have been selected independently by the two societies and have not in general been coordinated, although there is enough common ground to make most talks accessible to all. In the 1991 Annual Meeting, however, the societies moved a step closer by choosing the same topic for the two main symposia - the proceedings of which are customarily published as Supplements to Development and The Journal of Cell Science. In conjunction with a third scientific society - the Brain Research Association (BRA) - it was decided to focus on the development of the nervous system, with special emphasis on its cellular basis.

scholarly journals A brief history of the British Neuroscience Association

2018 ◽  
Vol 2 ◽  
pp. 239821281879924
Author(s):  
Steven P. Rose ◽  
Yvonne S. Allen ◽  
Ian M. Varndell
Keyword(s):  
Life Science ◽  
Brain Research ◽  
Discussion Group ◽  
Professional Society ◽  
Research Association ◽  
Neuroscience Research ◽  
History Of ◽  
Key Events ◽  
The Brain

As the British Neuroscience Association commemorates 50 years of existence in 2018, this article recalls its founding as a discussion group, its establishment as the Brain Research Association, its transition to a professional society encompassing all aspects of neuroscience research, both clinical and non-clinical, and its re-branding as the British Neuroscience Association in the late 1990s. Neuroscience as a branch of life science has expanded hugely in the last 25 years and the British Neuroscience Association has adapted, frequently working with partner societies, to serve as an interdisciplinary hub for professionals working in this exciting and crucial field. The authors have attempted to highlight some key events in the Association’s history and acknowledge the contributions made by many people over half a century.

scholarly journals Nodal signalling and asymmetry of the nervous system

2016 ◽  
Vol 371 (1710) ◽  
pp. 20150401 ◽  
Author(s):  
Iskra A. Signore ◽  
Karina Palma ◽  
Miguel L. Concha
Keyword(s):  
Developmental Biology ◽  
Nervous System ◽  
Conceptual Framework ◽  
Detailed Analysis ◽  
Context Dependency ◽  
Directional Asymmetry ◽  
Visceral Organ ◽  
Left Right Asymmetry ◽  
The Brain

The role of Nodal signalling in nervous system asymmetry is still poorly understood. Here, we review and discuss how asymmetric Nodal signalling controls the ontogeny of nervous system asymmetry using a comparative developmental perspective. A detailed analysis of asymmetry in ascidians and fishes reveals a critical context-dependency of Nodal function and emphasizes that bilaterally paired and midline-unpaired structures/organs behave as different entities. We propose a conceptual framework to dissect the developmental function of Nodal as asymmetry inducer and laterality modulator in the nervous system, which can be used to study other types of body and visceral organ asymmetries. Using insights from developmental biology, we also present novel evolutionary hypotheses on how Nodal led the evolution of directional asymmetry in the brain, with a particular focus on the epithalamus. We intend this paper to provide a synthesis on how Nodal signalling controls left–right asymmetry of the nervous system. This article is part of the themed issue ‘Provocative questions in left–right asymmetry’.

scholarly journals Anatomy of the Opioid-Systems of the Brain

1984 ◽  
Vol 11 (1) ◽  
pp. 14-23 ◽  
Author(s):  
Karl M. Knigge ◽  
Shirley A. Joseph
Keyword(s):  
Nervous System ◽  
Brain Research ◽  
Current Knowledge ◽  
Neurological Diseases ◽  
Pituitary Hormones ◽  
Isolation And Identification ◽  
Cord Injury ◽  
The Central Nervous System ◽  
Releasing Factors ◽  
The Brain

In 1969, Roger Guillemin and Andrew Schally independently reported the isolation and identification of the first hypothalamic neuropeptide, thyrotropin releasing factor (TRF). Following this landmark event in neuroendocrinology the ensuing years have witnessed a cascade of isolations of new neuropeptides and a virtual revolution in neurobiology. The discipline of neuroendocrinology has been remarkably impacted by the evidence that all of the “hypophysiotrophic” releasing factors presently identified are distributed widely throughout the brain with neurotransmitter or neuromodulator roles quite different from their actions of regulating the secretion of pituitary hormones. The study of these neuropeptide systems in activity of the central nervous system looms as one of the most exciting and significant eras in brain research. Although it is premature to assign specific roles for the presently known neuropeptides in pathogenesis of neurological diseases, our limited current knowledge already points to a numberof syndromes and clinical disorders which may be related to neuropeptide imbalance. Congential insensitivity to pain undoubtedly involves several peptide systems including Substance P, enkephalin, somatostatin and the endorphins. The opiocortins (β-endorphin, ACTH) of the brain as well as those of the pituitary gland are directly involved in the homeostatic mechanisms brought into action by such trauma as brain and spinal cord injury, septic shock and hemorrhage. The role of peptides in regulation of cerebral circulation will likely be identified with the etiology of stroke and the production of painful hemicranial syndromes. Among the most prevelant disorders of the human nervous system are the dementias and psychoses (Alzheimer’s disease, schizophrenia); subtle changes in brain peptide and receptor activity are being considered as responsible contributors to these diseases.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

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