scholarly journals The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue

Development ◽  
2016 ◽  
Vol 143 (7) ◽  
pp. 1099-1107 ◽  
Author(s):  
Yinan Wan ◽  
Alexandra D. Almeida ◽  
Steffen Rulands ◽  
Naima Chalour ◽  
Leila Muresan ◽  
...  
Keyword(s):  
Marginal Zone ◽  
Time Lapse ◽  
Ciliary Marginal Zone

scholarly journals Purinergic Signals Regulate Daily S-Phase Cell Activity in the Ciliary Marginal Zone of the Zebrafish Retina

2011 ◽  
Vol 26 (2) ◽  
pp. 107-117 ◽  
Author(s):  
Maria Jimena Ricatti ◽  
Ariadna Gabriela Battista ◽  
Maria Zorrilla Zubilete ◽  
Maria Paula Faillace
Keyword(s):  
Marginal Zone ◽  
Cell Activity ◽  
S Phase ◽  
Phase Cell ◽  
Ciliary Marginal Zone

Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye

2010 ◽  
Vol 239 (7) ◽  
pp. 2066-2077 ◽  
Author(s):  
W. Zac Stephens ◽  
Megan Senecal ◽  
Minhtu Nguyen ◽  
Tatjana Piotrowski
Keyword(s):  
Adenomatous Polyposis Coli ◽  
Marginal Zone ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Ciliary Marginal Zone

scholarly journals A role for the ciliary marginal zone in the melanopsin-dependent intrinsic pupillary light reflex

2014 ◽  
Vol 119 ◽  
pp. 8-18 ◽  
Author(s):  
Ma'ayan Semo ◽  
Carlos Gias ◽  
Ahmad Ahmado ◽  
Anthony Vugler
Keyword(s):  
Marginal Zone ◽  
Pupillary Light Reflex ◽  
Light Reflex ◽  
Pupillary Light ◽  
Ciliary Marginal Zone

The marginal zone and its contribution to the hypoblast and primitive streak of the chick embryo

Development ◽  
1990 ◽  
Vol 109 (3) ◽  
pp. 667-682 ◽  
Author(s):  
C.D. Stern
Keyword(s):  
Chick Embryo ◽  
Marginal Zone ◽  
Primitive Streak ◽  
Time Lapse ◽  
Study Time ◽  
Fate Mapping ◽  
Deep Part ◽  
Germ Layers ◽  
Gut Endoderm ◽  
Transplantation Experiments

The marginal zone of the chick embryo has been shown to play an important role in the formation of the hypoblast and of the primitive streak. In this study, time-lapse filming, fate mapping, ablation and transplantation experiments were combined to study its contribution to these structures. It was found that the deep (endodermal) portion of the posterior marginal zone contributes to the hypoblast and to the junctional endoblast, while the epiblast portion of the same region contributes to the epiblast of the primitive streak and to the definitive (gut) endoderm derived from it. Within the deep part of the posterior marginal zone, a subpopulation of HNK-1-positive cells contributes to the hypoblast. Removal of the deep part of the marginal zone prevents regeneration of the hypoblast but not the formation of a primitive streak. Removal of both layers of the marginal zone leads to a primitive streak of abnormal morphology but mesendodermal cells nevertheless differentiate. These results show that the two main properties of the posterior marginal zone (contributing to the hypoblast and controlling the site of primitive streak formation) are separable, and reside in different germ layers. This conclusion does not support the idea that the influence of the posterior marginal zone on the development of axial structures is due to it being the source of secondary hypoblast cells.

A comparative study of neurogenesis in the retinal ciliary marginal zone of homeothermic vertebrates

2002 ◽  
Vol 134 (1-2) ◽  
pp. 31-41 ◽  
Author(s):  
R Kubota ◽  
J.N Hokoc ◽  
A Moshiri ◽  
C McGuire ◽  
T.A Reh
Keyword(s):  
Comparative Study ◽  
Marginal Zone ◽  
Ciliary Marginal Zone

Sonic hedgehog regulates proliferation of the retinal ciliary marginal zone in posthatch chicks

2005 ◽  
Vol 233 (1) ◽  
pp. 66-75 ◽  
Author(s):  
Ala Moshiri ◽  
Christopher R. McGuire ◽  
Thomas A. Reh
Keyword(s):  
Sonic Hedgehog ◽  
Marginal Zone ◽  
Ciliary Marginal Zone

scholarly journals Her9/Hes4 is required for retinal photoreceptor development, maintenance, and survival

2019 ◽  
Author(s):  
Cagney E. Coomer ◽  
Stephen G. Wilson ◽  
Kayla F. Titialii-Torres ◽  
Jessica D. Bills ◽  
Laura A. Krueger ◽  
...  
Keyword(s):  
Marginal Zone ◽  
Rod Photoreceptor ◽  
Lineage Specification ◽  
Extrinsic Factors ◽  
Helix Loop Helix ◽  
Retinal Photoreceptor ◽  
Vertebrate Photoreceptor ◽  
Photoreceptor Development ◽  
Ciliary Marginal Zone

AbstractThe intrinsic and extrinsic factors that regulate vertebrate photoreceptor specification and differentiation are complex, and our understanding of all the players is far from complete. Her9, the zebrafish ortholog of human HES4, is a basic helix-loop-helix-orange (bHLH-O) transcriptional repressor that regulates neurogenesis in several developmental contexts. We have previously shown that her9 is upregulated during chronic rod photoreceptor degeneration and regeneration in adult zebrafish, but little is known about the role of her9 during retinal development. To better understand the function of Her9 in the retina, we generated zebrafish her9 CRISPR mutants. Her9 homozygous mutants displayed striking retinal phenotypes, including decreased numbers of rods and red/green cones, whereas blue and UV cones were relatively unaffected. The reduction in rods and red/green cones correlated with defects in photoreceptor subtype lineage specification. The remaining rods and double cones displayed abnormally truncated outer segments, and elevated levels of apoptosis. In addition to the photoreceptor defects, her9 mutants also possessed a reduced proliferative ciliary marginal zone, and decreased and disorganized Müller glia. Mutation of her9 was larval lethal, with no mutants surviving past 13 days post fertilization. Our results reveal a previously undescribed role for Her9/Hes4 in photoreceptor differentiation, maintenance, and survival.

scholarly journals Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Stephan Heermann ◽  
Lucas Schütz ◽  
Steffen Lemke ◽  
Kerstin Krieglstein ◽  
Joachim Wittbrodt
Keyword(s):  
Marginal Zone ◽  
Eye Development ◽  
Optic Vesicle ◽  
Basal Surface ◽  
Morphogenetic Protein ◽  
Retinal Determination ◽  
Optic Cup ◽  
Morphological Transformations ◽  
Vertebrate Eye ◽  
Ciliary Marginal Zone

The hemispheric, bi-layered optic cup forms from an oval optic vesicle during early vertebrate eye development through major morphological transformations. The overall basal surface, facing the developing lens, is increasing, while, at the same time, the space basally occupied by individual cells is decreasing. This cannot be explained by the classical view of eye development. Using zebrafish (Danio rerio) as a model, we show that the lens-averted epithelium functions as a reservoir that contributes to the growing neuroretina through epithelial flow around the distal rims of the optic cup. We propose that this flow couples morphogenesis and retinal determination. Our 4D data indicate that future stem cells flow from their origin in the lens-averted domain of the optic vesicle to their destination in the ciliary marginal zone. BMP-mediated inhibition of the flow results in ectopic neuroretina in the RPE domain. Ultimately the ventral fissure fails to close resulting in coloboma.

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