Twirler: A Mutant Affecting the Inner Ear of the House Mouse

Development ◽  
1958 ◽  
Vol 6 (1) ◽  
pp. 105-116
Author(s):  
Mary F. Lyon
Keyword(s):  
Cleft Palate ◽  
Inner Ear ◽  
House Mouse ◽  
Mus Musculus ◽  
Horizontal Plane ◽  
The Other ◽  
Genetic Tests ◽  
Postural Reflexes ◽  
New Born ◽  
Mode Of Inheritance

The mutant twirler, symbol Tw, of the house mouse, Mus musculus, was first recognized by the ‘waltzing’ behaviour which the heterozygotes show. It was later found to affect the morphology of the inner ear and, when homozygous, to cause death of new-born animals through harelip and cleft palate. This paper describes the behaviour and ear defects of heterozygotes and the appearance of homozygotes. It also describes the genetic tests carried out to determine the mode of inheritance. Twirler heterozygotes show head-shaking in a horizontal plane, combined often with circling, and less often with vertical head-shaking. Postural reflexes are abnormal. For example, normal mice of about a week old, if held up by the tail, respond to this change of position by extending the back and stretching the forelimbs forward. Twirler mice, on the other hand, flex the back, tuck the head under, and draw the limbs back.

Two types of mouse (Mus musculus domesticus) Y chromosomes in Quebec

Genome ◽  
1992 ◽  
Vol 35 (3) ◽  
pp. 534-537
Author(s):  
Yutaka Nishioka
Keyword(s):  
Y Chromosome ◽  
House Mouse ◽  
Mus Musculus ◽  
Repetitive Sequence ◽  
The Other ◽  
Chromosome Polymorphism ◽  
Mus Musculus Domesticus ◽  
Y Chromosomes

A Y chromosomal repetitive sequence identified two types of Y chromosomes in mice (Mus musculus domesticus) caught near Ste. Anne de Bellevue, Quebec. One type is apparently identical to the Y chromosome found in Maryland, Delaware, and California, whereas the other type is similar, but not identical, to the Y chromosome present in M.m. poschiavinus, an Alpine race of M.m. domesticus. These findings suggest that the domesticus Y chromosome is highly polymorphic and thus useful for elucidating the relationships among American and European house mouse populations.Key words: mouse Y chromosome, polymorphism, Mus musculus domesticus, repetitive sequence, Quebec.

ANOTHER ESTERASE VARIANT IN THE KIDNEY OF THE HOUSE MOUSE, MUS MUSCULUS

1969 ◽  
Vol 11 (1) ◽  
pp. 97-102 ◽  
Author(s):  
Michael L. Petras ◽  
Patricia Sinclair
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Population Data ◽  
Inbred Strains ◽  
Wild Animal ◽  
Autosomal Locus ◽  
Multiple Band ◽  
Zone Ii ◽  
Sensitivity Data ◽  
Mode Of Inheritance

Electrophoretic studies of kidney homogenates of the house mouse, Mus musculus, have revealed two patterns in zone II of the esterase zymogram. Animals of inbred strains C3H and C57BL/10 possess seven bands in this region and mice derived from a mating between a wild animal and a C3H mouse have only two bands of considerable activity in zone II. Breeding results are consistent with a two-allele, one-autosomal-locus mode of inheritance, with the allele for the absence of the multiple-band phenotype being dominant. Sensitivity data indicate that the esterases in zone II are aliesterases. Breeding and population data revealed that the zone II esterase-controlling locus is closely linked with but not identical to Es-1, Es-2 and Es-5 loci and so has been tentatively designated Es-6.

Ultrastructure and Staining of Developing Elastic Tissue

1971 ◽  
Vol 29 ◽  
pp. 244-245
Author(s):  
E. N. Albert
Keyword(s):  
Fine Structure ◽  
Phosphotungstic Acid ◽  
Staining Method ◽  
Rat Aorta ◽  
Uranyl Acetate ◽  
The Other ◽  
Elastic Fibers ◽  
Elastic Tissue ◽  
Lead Citrate ◽  
New Born

Silver tetraphenylporphine sulfonate (Ag-TPPS) was synthesized in this laboratory and used as an electron dense stain for elastic tissue (Fig 1). The procedures for the synthesis of tetraphenylporphine sulfonate and the staining method for mature elastic tissue have been described previously.The fine structure of developing elastic tissue was observed in fetal and new born rat aorta using tetraphenylporphine sulfonate, phosphotungstic acid, uranyl acetate and lead citrate. The newly forming elastica consisted of two morphologically distinct components. These were a central amorphous and a peripheral fibrous. The ratio of the central amorphous and the peripheral fibrillar portion changed in favor of the former with increasing age.It was also observed that the staining properties of the two components were entirely different. The peripheral fibrous component stained with uranyl acetate and/or lead citrate while the central amorphous portion demonstrated no affinity for these stains. On the other hand, the central amorphous portion of developing elastic fibers stained vigorously with silver tetraphenylporphine sulfonate, while the fibrillar part did not (compare figs 2, 3, 4). Based upon the above observations it is proposed that developing elastica consists of two components that are morphologically and chemically different.

Kerentanan Palatogenesis Mencit (Mus musculus L.) terhadap Induksi Cleft Palate TCDD

2011 ◽  
Vol 16 (2) ◽  
Author(s):  
Salomo Hutahaean ◽  
Soesanto Mangkoewidjojo ◽  
Mammed Sagi ◽  
Widya Asmara
Keyword(s):  
Cleft Palate ◽  
Mus Musculus ◽  
Cervical Dislocation

Telah dilakukan percobaan untuk menentukan tahapan palatogenesis pada mencit (Mus musculus L.) yang rentan terhadap efek polutan 2,3,7,8-Tetraklorodibenzo-p-dioksin (TCDD). Percobaan dirancang mengikuti Rancangan Acak Lengkap dengan pola faktorial (4X3). Empat puluh delapan ekor mencit bunting dicekok TCDD dengan dosis 0 (kontrol), 5, 10, atau 20 μg/kg bb. Perlakuan diberikan pada hari kebuntingan (Hk) 9−10, 11−12, atau 13−14. Mencit kontrol dicekok pelarut saja (98,5% minyak wijen + 1,5% DMSO). Pada Hk 18 mencit dibius lalu dibunuh dengan teknik cervical dislocation, persentase fetus cleft palate (cp) dihitung, derajat penutupan palatum diberi skor, preparat dengan ketebalan 6 µm dibuat, dan mikrostruktur kraniofasial diamati. Hasil menunjukkan, pemberian TCDD antara hari ke 9 dan 12 menginduksi cacat cp, dengan kecenderungan hasil tertinggi pada pemberian Hk 910. Perlakuan TCDD dosis 10 atau 20 μg/kg bb pada Hk 910 menghasilkan fetus cacat cp >90%. Persentase fetus cp tetap tinggi pada pemberian Hk 1112, khususnya pada kelompok dosis 20 μg/kg bb (87,3%). TCDD dosis terendah (5 μg/kg bb) menginduksi cp dominan bercelah sempit, menunjukkan adanya hambatan pada tahap fusi. Dosis 10 dan 20 μg/kg bb menginduksi cp bercelah sedang atau lebar, mengisyaratkan terjadi hambatan pada tahap inisiasi atau elevasi. Disimpulkan, seluruh tahapan palatogenesis rentan terhadap efek TCDD, namun tahap paling rentan adalah tahap fusi palatum.

Early Cold Exposure: Effects on Behavioral and Physiological Thermoregulation in the House Mouse, Mus musculus

1976 ◽  
Vol 49 (2) ◽  
pp. 191-199 ◽  
Author(s):  
G. Robert Lynch ◽  
Carol Becker Lynch ◽  
Marjory Dube ◽  
Cynthia Allen
Keyword(s):  
House Mouse ◽  
Cold Exposure ◽  
Mus Musculus

scholarly journals Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Megan Phifer-Rixey ◽  
Michael W Nachman
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Genetic Model ◽  
Inbred Strains ◽  
Mendelian Inheritance ◽  
Model Organisms ◽  
House Mice ◽  
Small Subset ◽  
Wild Mice ◽  
Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

Mixed sex allocation strategies in a polytocous mammal, the house mouse (Mus musculus)

2011 ◽  
Vol 65 (12) ◽  
pp. 2209-2217 ◽  
Author(s):  
Adam Dušek ◽  
Luděk Bartoš ◽  
František Sedláček
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Sex Allocation ◽  
Allocation Strategies ◽  
Polytocous Mammal
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