The aminergic and peptidergic innervation of insect salivary glands

1997 ◽  
Vol 200 (14) ◽  
pp. 1941-1949 ◽  
Author(s):  
D Ali
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Physiological Role ◽  
Salivary Secretion ◽  
Stick Insect ◽  
Stomatogastric Nervous System ◽  
Related Family ◽  
Aminergic Innervation ◽  
Peptidergic Innervation

Insect salivary glands are glands associated with nutrient intake whose secretions are generally involved in the digestion and lubrication of food. They are under the control of neuroactive substances and may be innervated from several sources including the suboesophageal ganglion, the stomatogastric nervous system and the unpaired median nerves. Both amines and peptides have been suggested to play roles in the control of insect salivation, as indicated by their association with terminals on salivary glands, their effects in salivary gland bioassays and their ability to alter second messenger levels and ion channel conformations. Serotonin and dopamine appear to be the most prominent amines associated with insect salivary glands. Either one or both of these amines are found associated with the salivary glands of the locust, stick insect, cockroach, cricket, dragonfly, mosquito, adult moth and kissing bug. Their roles, although not fully elucidated, appear to be in the control of salivary secretion. Several peptides, including members of the FMRFamide-related family of peptides, are also found associated with insect salivary glands. Sources of peptidergic innervation are as varied as those for aminergic innervation, but information regarding the physiological role of these peptides is lacking. The relevance of the different levels of complexity of salivary gland innervation, which range from the absence of innervation in some species (blowfly) to the presence of several distinct sources in others (locust, cockroach), is not well understood. This review serves to consolidate what is known of the phenotype of salivary neurones in relation to the control of salivation.

scholarly journals Mature salivary gland rests within sonic hedgehog–positive medulloblastoma: case report and insights into the molecular genetics and embryopathology of ectopic intracranial salivary gland analogs

2016 ◽  
Vol 18 (6) ◽  
pp. 708-712 ◽  
Author(s):  
Berje Shammassian ◽  
Sunil Manjila ◽  
Efrem Cox ◽  
Kaine Onwuzulike ◽  
Dehua Wang ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Salivary Glands ◽  
Molecular Genetics ◽  
Posterior Fossa ◽  
Sonic Hedgehog ◽  
Unique Case ◽  
Cerebellar Medulloblastoma ◽  
Disseminated Disease

Intracranial ectopic salivary gland rests within dural-based lesions are reported very infrequently in the literature. The authors report the unique case of a 12-year-old boy with a cerebellar medulloblastoma positive for sonic hedgehog (Shh) that contained intraaxial mature ectopic salivary gland rests. The patient underwent clinical and radiological monitoring postoperatively, until he died of disseminated disease. An autopsy showed no evidence of salivary glands within disseminated lesions. The intraaxial presence of salivary gland rests and concomitant Shh positivity of the described tumor point to a disorder in differentiation as opposed to ectopic developmental foci, which are uniformly dural based in the described literature. The authors demonstrate the characteristic “papilionaceous” appearance of the salivary glands with mucicarmine stain and highlight the role of Shh signaling in explaining the intraaxial presence of seromucous gland analogs. This article reports the first intraaxial posterior fossa tumor with heterotopic salivary gland rests, and it provides molecular and embryopathological insights into the development of these lesions.

Gastropod predation sites: the role of predator and prey in chemical attraction of the hermit crab Clibanarius vittatus

1990 ◽  
Vol 70 (3) ◽  
pp. 583-596 ◽  
Author(s):  
D. Rittschof ◽  
C.M. Kratt ◽  
A.S. Clare
Keyword(s):  
Salivary Gland ◽  
Ionic Strength ◽  
Salivary Glands ◽  
Hermit Crab ◽  
Sea Water ◽  
Hermit Crabs ◽  
Muscle Proteins ◽  
Clibanarius Vittatus ◽  
Low Ionic Strength

Gastropod shells are essential to most hermit crabs. Shell availability limits hermit crab populations. Shells provide protection and the degree of shell-fit controls crab growth and fecundity. Crabs locate new gastropod shells from a distance under water by molecules released from gastropod flesh during predation events. Here we test the hypothesis that the salivary glands of the predatory gastropod are the source of enzymes that digest muscle proteins and release peptide attractants. We describe the anatomy of both the acinous salivary glands and the tubular accessory salivary glands of Busycon contrarium which are similar to those of B. carica. The salivary gland ducts empty at the mouth, suggesting a role in the primary digestion of food. We show that gastropod muscle proteins, extracted by salt solutions with the ionic strength of sea water and purified by precipitation in low ionic strength can be digested by gastropod salivary gland enzymes to generate peptides attractive to the hermit crab, Clibanarius vittatus, in field assays.

scholarly journals Effects of Local and Systemic Immune Challenges on the Expression of Selected Salivary Genes in the Malaria Mosquito Anopheles coluzzii

Pathogens ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1300
Author(s):  
Giulia Bevivino ◽  
Bruno Arcà ◽  
Fabrizio Lombardo
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Antimicrobial Properties ◽  
Transcript Abundance ◽  
Structural Features ◽  
Anopheles Coluzzii ◽  
Transcriptional Modulation ◽  
Immune Challenges

Salivary glands play a crucial tripartite role in mosquito physiology. First, they secrete factors that greatly facilitate both sugar and blood meal acquisition. Second, the transmission of pathogens (parasites, bacteria and viruses) to the vertebrate host requires both the recognition and invasion of the salivary glands. Third, they produce immune factors that both protect the organ from invading pathogens and are also able to exert their activity in the crop and the midgut when saliva is re-ingested during feeding. Studies on mosquito sialomes have revealed the presence of several female and/or male salivary gland-specific or enriched genes whose function is completely unknown so far. We focused our attention on these orphan genes, and we selected, according to sequence and structural features, a shortlist of 11 candidates with potential antimicrobial properties. Afterwards, using qPCR, we investigated their expression profile at 5 and 24 h after an infectious sugar meal (local challenge) or thoracic microinjection (systemic challenge) of Gram-negative (Escherichia coli, EC) or Gram-positive (Staphylococcus aureus, SA) bacteria. We observed a general increase in the transcript abundance of our salivary candidates between 5 and 24 h after local challenge. Moreover, transcriptional modulation was determined by the nature of the stimulus, with salivary gland-enriched genes (especially hyp15 upon SA stimulus) upregulated shortly after the local challenge and later after the systemic challenge. Overall, this work provides one of the first contributions to the understanding of the immune role of mosquito salivary glands. Further characterization of salivary candidates whose expression is modulated by immune challenge may help in the identification of possible novel antimicrobial peptides.

scholarly journals Forskolin as an activator of cyclic AMP accumulation and secretion in blowfly salivary glands

1982 ◽  
Vol 204 (1) ◽  
pp. 147-151 ◽  
Author(s):  
I Litosch ◽  
Y Saito ◽  
J N Fain
Keyword(s):  
Salivary Gland ◽  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Salivary Glands ◽  
Mammalian Cells ◽  
Salivary Secretion ◽  
Gland Secretion ◽  
Cyclic Amp Accumulation ◽  
Salivary Gland Secretion ◽  
Stimulation Of

Forskolin is a diterpene that activates adenylate cyclase in a variety of mammalian cells. In addition of forskolin to blowfly salivary glands increased cyclic AMP accumulation and salivary secretion. There was a small increase in transepithelial movement of labelled Ca2+. Forskolin did not induce breakdown of labelled phosphatidylinositol or inhibit the stimulation of phosphatidylinositol breakdown caused by 5-hydroxytryptamine. These data indicate that forskolin can mimic all the effects of 5-hydroxytryptamine on salivary-gland secretion that have been attributed to cyclic AMP.

scholarly journals VIRUS AS A CAUSE OF SALIVARY GLAND DISEASES

2019 ◽  
Vol 6 (1) ◽  
pp. 37
Author(s):  
Etis Duhita Rahayuningtyas ◽  
Riani Setiadhi
Keyword(s):  
Salivary Gland ◽  
Viral Infection ◽  
Salivary Glands ◽  
Salivary Flow ◽  
Salivary Secretion ◽  
Coxsackie Virus ◽  
Parasympathetic Nerves ◽  
Barr Virus ◽  
Salivary Gland Diseases ◽  
Simplex Virus

Background: Enlargement in the extraoral region with the absence of abnormal dental and periodontal structures are sometimes seen in dental practice, sometimes followed by xerostomia. Enlargement of the acute nonsuppurative salivary glands has been associated with several types of viruses. The purpose of this paper is to review salivary gland diseases associated with non-HIV and HIV viral infections.Discussion: Non-HIV viruses which were detected in the salivary glands including Paramyxovirus, cytomegalovirus (CMV), Hepatitis C virus (HCV), human papilloma viruses (HPV), Epstein-Barr virus (EBV), human herpes simplex virus (HHSV-8), and coxsackie virus. HIV-associated salivary gland disease typically presents with xerostomia and/or intraglandular lymph nodes, and diffuse infiltrative lymphocytosis syndrome (DILS). The most common viral infection conditions in salivary gland disorders are mumps and HIV. Enlargement and inflammation of the glandular structures will affects the control of salivary secretion by nerves. Parasympathetic nerves block conducted signals to the salivary glands, so the salivary flow isdecreased.Conclusion: There is association between viral infection and diseases of thesalivary gland. By knowing sequelae viruses on the salivary gland, dentists are expected to understand the clinical condition and therapeutic that should be given to the patients.

The Role of the Salivary Glands in Feeding in Rhodnius Prolixus

1981 ◽  
Vol 94 (1) ◽  
pp. 219-230 ◽  
Author(s):  
J.M. C. Ribeiro ◽  
E. S. Garcia
Keyword(s):  
Injection Site ◽  
Salivary Glands ◽  
Blood Vessels ◽  
Salivary Secretion ◽  
Rhodnius Prolixus ◽  
Intradermal Injection

The effect of salivarectomy on feeding in Rhodnius prolixus was studied. Salivarectomized insects drew less blood and at a lower rate than controls when fed on a rabbit. Operated insects also pierced host skin much more often (10 times in 5 min) than controls (1 or 2 times in 5 min). None of these differences was observed when feeding was performed artificially through latex membranes. Intradermal injection of salivary secretion in rat tails increased the duration of bleeding induced by small cuts made on the injection site. It is suggested that the antihaemostatic action of saliva is important for positioning of the maxillae inside blood vessels.

Sialoscintigraphy – Shopworn or Bestselling? A Traditional Procedure with New Prominent Role in Theranostics and Immuno-Oncology

2020 ◽  
Vol 59 (05) ◽  
pp. 375-380
Author(s):  
Barbara Kreppel ◽  
Florian C. Gaertner ◽  
Markus Essler
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Clinical Relevance ◽  
Checkpoint Inhibitors ◽  
Dental Health ◽  
Nuclear Imaging ◽  
Salivary Gland Function ◽  
Traditional Procedure ◽  
Gland Function

AbstractSialoscintigraphy has been used in nuclear imaging for almost sixty years. It allows functional assessment and quantification of all large salivary glands. Physiological function of the salivary glands is essential for the preservation of the oral mucosa, the sense of taste and dental health. Impaired salivary gland function may lead to reduced or even absent salivation resulting in various complaints such as loss of taste reducing quality of life. During the recent years clinical relevance of assessment of salivary gland function has been rising. As novel radiopharmaceuticals such as 225Ac-PSMA or 177Lu-PSMA may cause damage to the salivary glands in a subset of patients, reliable methods for quantification of salivary gland function are vital for therapy planning and follow-up. Standardized protocols for the implementation and interpretation of this procedure are necessary to achieve comparable results from individual theranostic centers and to facilitate multicenter trials. Sialocintigraphy is also of clinical relevance for immunooncology. Treatments with checkpoint inhibitors such as Ipilimumab or Nivulomab frequently cause autoimmune disorders affecting the salivary glands that may lead to reduced production of saliva and finally loss of taste. Therefore, standardized procedure protocols for sialoscintigraphy are also important for general oncology.Here we suggest a protocol for sialoscintigraphy that may be used as standard in centers for theranostics or immunooncology and discuss the potential future role of this traditional procedure.

scholarly journals Neuronal Innervation of the Subgenual Organ Complex and the Tibial Campaniform Sensilla in the Stick Insect Midleg

Insects ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 40 ◽  
Author(s):  
Johannes Strauß
Keyword(s):  
Physiological Role ◽  
Stick Insect ◽  
Campaniform Sensilla ◽  
Innervation Pattern ◽  
Branching Points ◽  
Stick Insects ◽  
Sensory Structures ◽  
Evolutionary Comparisons ◽  
Subgenual Organ

Mechanosensory organs in legs play are crucial receptors in the feedback control of walking and in the detection of substrate-borne vibrations. Stick insects serve as a model for the physiological role of chordotonal organs and campaniform sensilla. This study documents, by axonal tracing, the neural innervation of the complex chordotonal organs and groups of campaniform sensilla in the proximal tibia of the midleg in Sipyloidea sipylus. In total, 6 nerve branches innervate the different sensory structures, and the innervation pattern associates different sensilla types by their position. Sensilla on the anterior and posterior tibia are innervated from distinct nerve branches. In addition, the variation in innervation is studied for five anatomical branching points. The most common variation is the innervation of the subgenual organ sensilla by two nerve branches rather than a single one. The fusion of commonly separated nerve branches also occurred. However, a common innervation pattern can be demonstrated, which is found in >75% of preparations. The variation did not include crossings of nerves between the anterior and posterior side of the leg. The study corrects the innervation of the posterior subgenual organ reported previously. The sensory neuroanatomy and innervation pattern can guide further physiological studies of mechanoreceptor organs and allow evolutionary comparisons to related insect groups.

scholarly journals Disruption of Plasmodium Sporozoite Transmission by Depletion of Sporozoite Invasion-Associated Protein 1

2009 ◽  
Vol 8 (4) ◽  
pp. 640-648 ◽  
Author(s):  
Sabine Engelmann ◽  
Olivier Silvie ◽  
Kai Matuschewski
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Gliding Motility ◽  
Insect Vector ◽  
Targeted Disruption ◽  
Apicomplexan Parasites ◽  
Complex Development ◽  
Fluorescent Tagging ◽  
And Migration

ABSTRACT Accumulation of infectious Plasmodium sporozoites in Anopheles spp. salivary glands marks the final step of the complex development of the malaria parasite in the insect vector. Sporozoites are formed inside midgut-associated oocysts and actively egress into the mosquito hemocoel. Traversal of the salivary gland acinar cells correlates with the sporozoite's capacity to perform continuous gliding motility. Here, we characterized the cellular role of the Plasmodium berghei sporozoite invasion-associated protein 1 (SIAP-1). Intriguingly, SIAP-1 orthologs are found exclusively in apicomplexan hemoprotozoa, parasites that are transmitted by arthropod vectors, e.g., Plasmodium, Babesia, and Theileria species. By fluorescent tagging with mCherry, we show that SIAP-1 is expressed in oocyst-derived and salivary gland-associated sporozoites, where it accumulates at the apical tip. Targeted disruption of SIAP-1 does not affect sporozoite formation but causes a partial defect in sporozoite egress from oocysts and abolishes sporozoite colonization of mosquito salivary glands. Parasites with the siap-1(−) mutation are blocked in their capacity to perform continuous gliding motility. We propose that arthropod-transmitted apicomplexan parasites specifically express secretory factors, such as SIAP-1, that mediate efficient oocyst exit and migration to the salivary glands.

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