HIPEC in Complementary Treatment to Cytoreductive Procedures: An Unexplained Issue After the PRODIGE 7 Trial

Abstract Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have long been used as a complementary treatment. Our purpose was to study the effect of hydroalcoholic Allium atroviolaceum L. extract on spermatogenesis in CP-treated mice. Results CP affected a significant decrease in sperm count, motility, viability, and morphology. Sperm count was significantly higher in the all extract groups than in the group of control (p<0.001) and CP group (p<0.001, p<0.01). Sperm motility was significantly greater in the extract (100 and 200mg/kg) groups than in the group of control (p<0.05 and <0.001). Sperm immotility and rotational movement were significantly higher in the CP group than in the CP+extract groups (p<0.001). The sperm viability was significantly greater in the CP+extract (200mg/kg) group than in the CP group (p<0.001). The number of headless sperm, sperm with initial tail, with coiled tail, and sperm with curved body, was significantly lower in the CP+extract (200mg/kg) group than in the CP group (p<0.001). Conclusion A. atroviolaceum extract treatment significantly improved CP-induced reproductive toxicity.

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Efficacy and safety of laparoscopic pyelolithotomy versus percutaneous nephrolithotomy for treatment of large renal stones: a meta-analysis

Journal of International Medical Research ◽

10.1177/0300060520983136 ◽

2021 ◽

Vol 49 (1) ◽

pp. 030006052098313

Author(s):

Tie Mao ◽

Na Wei ◽

Jing Yu ◽

Yinghui Lu

Keyword(s):

Blood Transfusion ◽

Blood Loss ◽

Percutaneous Nephrolithotomy ◽

Meta Analysis ◽

Renal Stones ◽

Efficacy And Safety ◽

Complementary Treatment ◽

Laparoscopic Pyelolithotomy ◽

Stone Free Rate ◽

Free Rate

Background We aimed to compare the efficacy and safety of laparoscopic pyelolithotomy (LPL) versus percutaneous nephrolithotomy (PCNL) for treating renal stones larger than 2 cm. Methods We searched the PubMed, Embase, Web of Science, SinoMed, and Chinese National Knowledge Infrastructure databases for studies that compared the surgical outcomes of LPL and PCNL. We conducted a meta-analysis of the retrieved studies, expressed as weighted mean difference or risk ratios with 95% confidence intervals. Results We included 25 studies (1831 patients). LPL was associated with a significantly higher stone-free rate, lower rates of blood loss, complementary treatment, blood transfusion, and complications, and less reduction in hemoglobin level compared with PCNL. LPL and PCNL were similar in terms of duration of hospital stay, conversion rate, changes in glomerular filtration rate and creatinine level, and mean time of postoperative analgesia. However, LPL was associated with a longer operation time than PCNL. Conclusion LPL appears to be more effective and safer than PCNL in patients with large renal stones, by increasing the stone-free rate and reducing blood loss, complementary treatment, blood transfusion, and complications compared with PCNL. LPL may thus be a useful modality for treating patients with large renal stones.

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Natural healers: a review of animal assisted therapy and activities as complementary treatment for chronic conditions

Revista Latino-Americana de Enfermagem ◽

10.1590/s0104-11692012000300025 ◽

2012 ◽

Vol 20 (3) ◽

pp. 612-618 ◽

Cited By ~ 11

Author(s):

Reiley Reed ◽

Lilian Ferrer ◽

Natalia Villegas

Keyword(s):

Chronic Conditions ◽

Primary Objective ◽

Animal Assisted Therapy ◽

Complementary Treatment ◽

Strict Adherence ◽

Positive Behaviors ◽

Child Patients ◽

Patient Profiles ◽

Living With Hiv ◽

Social Disabilities

The primary objective of this review is to synthesize the existing literature on the use of animal-assisted therapy and activity (AAT/A) as complementary treatment among people living with chronic disease and to discuss the possible application of this practice among children living with HIV. Relevant databases were searched between March 10 and April 11, 2011, using the words: animal assisted therapy or treatment and chronic conditions or diseases. Thirty-one articles were found and 18 followed the inclusion and exclusion criteria. Research suggests that AAT/A is effective for different patient profiles, particularly children. Interaction with dogs has been found to increase positive behaviors, such as sensitivity and focus, in children with social disabilities. Decreased levels of pain have also been reported among child patients as a result of AAT/A. More research should be done in the area of children living with chronic diseases that require strict adherence to treatment, such as HIV, and on AAT/A's prospective use as an educational tool to teach children about the importance of self-care for their medical conditions.

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Tratamento complementar da esclerose múltipla com vitamina D / Complementary treatment of multiple sclerosis with vitamin D

Brazilian Journal of Development ◽

10.34117/bjdv7n4-527 ◽

2021 ◽

Vol 7 (4) ◽

pp. 41066-41086

Author(s):

Vitor Taveira Takahashi ◽

Samantha Hosokawa Dias de Novoa Rocha ◽

João Vitor Romeu Bello Taveira ◽

Hugo Cardoso Pena

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Complementary Treatment ◽

Vitamina D

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Reduction of Chemotherapy–Induced Side Effects by Complementary Medicine in Breast Cancer Patients

Austin Journal of Medical Oncology ◽

10.26420/austinjmedoncol.2021.1063 ◽

2021 ◽

Vol 8 (2) ◽

Author(s):

Beuth J ◽

◽

Böwe R ◽

Keyword(s):

Breast Cancer ◽

Side Effects ◽

Cancer Patients ◽

Complementary Medicine ◽

Sodium Selenite ◽

Lens Culinaris ◽

Proteolytic Enzymes ◽

Clinical Investigation ◽

Breast Cancer Patients ◽

Complementary Treatment

This clinical investigation was performed to evaluate the benefit of Complementary Medicine (CM) in breast cancer patients undergoing adjuvant Chemotherapy (ChT). Patients and Methods: The patients (n=668) were treated according to international guidelines with adjuvant ChT. As to reduce the side effects, the patients were complementarily treated with a combination of sodium selenite, proteolytic plant enzymes (bromelaine and papain) and Lens culinaris lectin. On Case Report Formulas (CRFs) assessment of side effects of ChT was documented at defined times during adjuvant ChT and additional complementary treatment. Validation was carried out by scoring from 1 (no side-effects/optimal tolerability) to 6 (extreme side-effects/extremely bad tolerability), however, only patients suffering from severe side effects (symptom scores 4 and higher) were enrolled into this investigation. Results: The severity of side-effects of ChT was significantly reduced by complementary treatment. Mean scores of symptoms declined for sleep disorder, fatigue, lack of drive (p<0.05) and for arthralgia, hot flushes, mucosal dryness, nausea, vomiting, diarrhea, loss of appetite, pain of tumour (p<0.001). Conclusion: This investigation confirms benefits of indication-based complementary treatment with the combination of sodium selenite, proteolytic enzymes and Lens culinaris lectin in breast cancer patients, e.g. reduction of side-effects of adjuvant ChT.

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Hyperbaric Oxygenation (HBO) as a Complementary Treatment of Patients with Multibacillary Lepromatous Leprosy

Japanese journal of leprosy ◽

10.5025/hansen1977.56.159 ◽

1987 ◽

Vol 56 (4) ◽

pp. 159-165

Author(s):

F. F. WILKINSON ◽

PALAU, S. A. ROSASCO ◽

S. BESUSCHIO ◽

B. A. CALORI ◽

M. BERTHOLDS

Keyword(s):

Hyperbaric Oxygenation ◽

Lepromatous Leprosy ◽

Complementary Treatment

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Drugs that target early stages of Onchocerca volvulus: A revisited means to facilitate the elimination goals for onchocerciasis

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0009064 ◽

2021 ◽

Vol 15 (2) ◽

pp. e0009064

Author(s):

Shabnam Jawahar ◽

Nancy Tricoche ◽

Christina A. Bulman ◽

Judy Sakanari ◽

Sara Lustigman

Keyword(s):

Worm Burden ◽

Prophylactic Treatment ◽

Clinical Development ◽

Onchocerca Volvulus ◽

Complementary Treatment ◽

Comprehensive Strategy ◽

Treatment Regimens ◽

Therapeutic Drugs ◽

Helminth Infections ◽

Prophylactic Drugs

Several issues have been identified with the current programs for the elimination of onchocerciasis that target only transmission by using mass drug administration (MDA) of the drug ivermectin. Alternative and/or complementary treatment regimens as part of a more comprehensive strategy to eliminate onchocerciasis are needed. We posit that the addition of “prophylactic” drugs or therapeutic drugs that can be utilized in a prophylactic strategy to the toolbox of present microfilaricidal drugs and/or future macrofilaricidal treatment regimens will not only improve the chances of meeting the elimination goals but may hasten the time to elimination and also will support achieving a sustained elimination of onchocerciasis. These “prophylactic” drugs will target the infective third- (L3) and fourth-stage (L4) larvae of Onchocerca volvulus and consequently prevent the establishment of new infections not only in uninfected individuals but also in already infected individuals and thus reduce the overall adult worm burden and transmission. Importantly, an effective prophylactic treatment regimen can utilize drugs that are already part of the onchocerciasis elimination program (ivermectin), those being considered for MDA (moxidectin), and/or the potential macrofilaricidal drugs (oxfendazole and emodepside) currently under clinical development. Prophylaxis of onchocerciasis is not a new concept. We present new data showing that these drugs can inhibit L3 molting and/or inhibit motility of L4 at IC50 and IC90 that are covered by the concentration of these drugs in plasma based on the corresponding pharmacological profiles obtained in human clinical trials when these drugs were tested using various doses for the therapeutic treatments of various helminth infections.

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