Calcium Metabolism in Children Suffering from Homozygous ß-Thalassaemia after Oral Administration of 47Ca

1976 ◽  
Vol 15 (02) ◽  
pp. 77-79 ◽  
Author(s):  
D. Liakakos ◽  
P. Ylachos ◽  
Ch. Anoussakis ◽  
C. Constantinides ◽  
I. Tsakalosos
Keyword(s):  
Oral Administration ◽  
Intestinal Absorption ◽  
Calcium Metabolism

SummaryThe study of calcium metabolism in ten thalassaemic children comperatively with controls after oral administration of 47Ca has shown diminished intestinal absorption. It is suggested that this finding is propably related in part with the pathogenesis of the osteoporosis in thalassaemia.

scholarly journals Intestinal Absorption and First-Pass Elimination of 2',3'-Dideoxynucleosides Following Oral Administration in Rats.

1996 ◽  
Vol 19 (4) ◽  
pp. 599-603 ◽  
Author(s):  
Tetsuya HASEGAWA ◽  
Kazuhiko JUNI ◽  
Mineo SANEYOSHI ◽  
Takeo KAWAGUCHI
Keyword(s):  
Oral Administration ◽  
Intestinal Absorption ◽  
First Pass

One-hour test for estimating intestinal absorption of calcium by using stable strontium as a marker

1994 ◽  
Vol 40 (2) ◽  
pp. 257-259 ◽  
Author(s):  
A J Sips ◽  
J C Netelenbos ◽  
R Barto ◽  
P Lips ◽  
W J van der Vijgh
Keyword(s):  
Clinical Practice ◽  
Intestinal Absorption ◽  
Broad Spectrum ◽  
Calcium Metabolism ◽  
Calcium Absorption ◽  
Area Under The Curve ◽  
Close Correlation ◽  
Reliable Information ◽  
Simple Test ◽  
Stable Strontium

Abstract Intestinal absorption of calcium is a relevant marker in a broad spectrum of diseases; however, its determination in clinical practice is difficult. Our aim was to design a simple test for this based on stable strontium (88Sr). The correlation between the intestinal absorption of simultaneously administered 45Ca and 88Sr was investigated in patients with various disorders of the bone and calcium metabolism. The area under the curve for the period 0-60 min after dosing (AUC0-60 in mmol.L-1.min), being a representative measure of intestinal absorption, showed a close correlation between both elements (r = 0.90, P < 0.001). Moreover, the measure of agreement in classifying the patients as low, intermediate, or high absorbers was high (kappa = 0.80). We conclude that a test based on measuring AUC0-60 of strontium is a fast and inexpensive way to obtain reliable information about the level of intestinal calcium absorption.

REVERSAL OF BETAMETHASONE-INDUCED INHIBITION OF INTESTINAL CALCIUM ABSORPTION BY 1α-HYDROXYCHOLECALCIFEROL

1978 ◽  
Vol 78 (2) ◽  
pp. 187-194 ◽  
Author(s):  
J. FOX ◽  
A. D. CARE ◽  
D. H. MARSHALL
Keyword(s):  
Absorption Coefficient ◽  
Oral Administration ◽  
Intestinal Absorption ◽  
Calcium Absorption ◽  
Mean Value ◽  
Intestinal Calcium Absorption ◽  
Control Value ◽  
Isotope Technique ◽  
Intravenous And Oral Administration ◽  
Double Isotope

SUMMARY The intestinal absorption of calcium has been studied in conscious, unstressed pigs, using a modification of the double isotope technique. The oral administration of betamethasone (1 mg/day) to four pigs (25–33 kg) for 4 weeks reduced the calcium absorption coefficient, calculated after the intravenous and oral administration of 47Ca2+, by a mean value of 66%. The oral administration of 1α-hydroxycholecalciferol (2 μg/day) in combination with betamethasone (1 mg/day) for a further 4 weeks returned the absorption coefficient to the control value.

The experimental production of ‘green yolks’ by the oral administration of sodium copper chlorophyllin

1955 ◽  
Vol 46 (3) ◽  
pp. 384-385 ◽  
Author(s):  
Alastair N. Worden ◽  
J. Bunyan ◽  
A. W. Davies ◽  
M. Kleissner
Keyword(s):  
Oral Administration ◽  
Intestinal Absorption ◽  
Gelatin Capsule ◽  
Experimental Production ◽  
Extraction Procedures ◽  
Chlorophyll Derivative ◽  
Sodium Copper Chlorophyllin

1. A condition that appears to be identical with ‘green yolks’ as observed in natural cases has been reproduced by the oral administration in gelatin capsule of from 250 to 1000 mg. sodium copper chlorophyllin 100% daily for 4 days upwards to Light Sussex hens in second lay.2. Following suitable extraction procedures the presence of a chlorophyll derivative has been determined spectrophotometrically in the affected yolks.3. Quantities of sodium copper chlorophyllin of the order of 1 mg. have been recovered from affected yolks.4. It is considered that the passage of chlorophyll to the yolk indicates that intestinal absorption has occurred.

Intestinal Absorption of Calcium and Calcium Metabolism in Patients With Essential Hypertension and Normal Renal Function

1991 ◽  
Vol 4 (5 Pt 1) ◽  
pp. 404-409 ◽  
Author(s):  
M. Gadallah ◽  
S. G. Massry ◽  
R. Bigazzi ◽  
R. L. Horst ◽  
P. Eggena ◽  
...  
Keyword(s):  
Renal Function ◽  
Essential Hypertension ◽  
Intestinal Absorption ◽  
Normal Renal Function ◽  
Calcium Metabolism

Bifidobacterium breve MCC1274 with glycosidic activity enhances in vivo isoflavone bioavailability

2019 ◽  
Vol 10 (5) ◽  
pp. 521-531 ◽  
Author(s):  
R. Yao ◽  
C.B. Wong ◽  
K. Nakamura ◽  
E. Mitsuyama ◽  
A. Tanaka ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Gut Microbiota ◽  
Oral Administration ◽  
Kinetic Analysis ◽  
Intestinal Absorption ◽  
Relative Abundance ◽  
Intestinal Metabolism ◽  
Control Groups ◽  
Bifidobacterium Breve

Polyphenols are plant derived compounds that exert many beneficial health effects to the human host. However, associated health benefits of dietary polyphenol are highly dependent on their intestinal metabolism, bioavailability, and absorption. Bifidobacteria, which represent the key members of gut microbiota, have been suggested to promote gut microbial homeostasis and may be involved in the metabolism of polyphenols. In this study, the capabilities of thirteen Bifidobacterium strains in hydrolysing polyphenol glycosides were evaluated. Among the tested strains, Bifidobacterium breve MCC1274 was found to possess the highest β-glucosidase activity and strong capability to convert daidzin and trans-polydatin to their aglycones; while kinetic analysis revealed that B. breve MCC1274 hydrolysed more than 50% of daidzin and trans-polydatin at less than 3 h of incubation. Further investigation using rats with an antibiotics-disturbed microbiome revealed that following the ingestion of daidzin glycoside, oral administration of B. breve MCC1274 significantly enhanced the plasma concentration of daidzein in rats pre-treated with antibiotics as compared to antibiotics-pre-treated control and non-treated control groups. The relative abundance of Actinobacteria and the total numbers of B. breve were also significantly higher in antibiotics-pre-treated rats administered with B. breve MCC1274 than that of the control groups. These findings suggest that B. breve MCC1274 is effective in enhancing the bioavailability of daidzein in the gut under dysbiosis conditions and may potentially improve intestinal absorption of isoflavones and promote human health.

scholarly journals Metabolic studies of [75Se]selenomethionine and [75Se]selenite in the rat

1973 ◽  
Vol 30 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Christine D. Thomson ◽  
R. D. H. Stewart
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Tissue Distribution ◽  
Intestinal Absorption ◽  
Initial Period ◽  
Similar Rate ◽  
Whole Body ◽  
Body Retention ◽  
Metabolic Pool

1. Information was sought concerning the long-term fate of orally and intravenously administered [75Se]selenomethionine and [75Se]selenite in rats.2. Urinary and faecal radioactivity was assayed during the 1st week and whole-body radio-activity was determined weekly for 16 weeks. Rats were killed at intervals for analysis of 75Se tissue distribution.3. Intestinal absorption after oral administration was estimated to be 91–93% for selenite and 95–97% for selenomethionine.4. Urinary excretion of absorbed [75Se]selenite was greater than that of [75Se]selenomethionine during the 1st week.5. After the 1st week, whole-body retention diminished exponentially at a similar rate in rats given either selenomethionine or selenite. Except for the erythrocytes, 75Se content of individual tissues also decreased exponentially.6. It appears that, after an initial period, 75Se from either selenomethionine or selenite is metabolized similarly, suggesting that Se from both potential dietary sources is ultimately incorporated into the same metabolic pool.

scholarly journals Nanoemulsions of Hydroxysafflor Yellow A for Enhanced Brain Delivery in Cerebral Ischemia Reperfusion-injured mice: Physicochemical and In Vivo Performances

2021 ◽  
Author(s):  
Qiong Wang ◽  
Cailing Zhong ◽  
Jingqing Zhang ◽  
Hua Zhao ◽  
Yuru Huang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cerebral Ischemia ◽  
Oral Administration ◽  
Reperfusion Injury ◽  
Intestinal Absorption ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hydroxysafflor Yellow A ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion Injury

Abstract Stroke has always been a disease threatening human life and health worldwide. Here, we synthesized a new type of hyaluronic acid-modified multi-walled carbon nanotube. Then we prepared hydroxysafflor yellow A-hydroxypropyl-β-cyclodextrin phospholipid complex water-in-oil nanoemulsion with hyaluronic acid-modified multi-walled carbon nanotubes and chitosan (HC@HMC) for oral treatment of ischemic stroke. First, we measured the intestinal absorption and pharmacokinetics of HC@HMC in rats. We found that the intestinal absorption and the pharmacokinetic behavior of HC@HMC is better than HYA. Then we detected intracerebral concentrations after oral administration of HC@HMC and found that more HYA crossed the blood-brain barrier (BBB). Finally, we evaluated the efficacy of HC@HMC in middle cerebral artery occlusion/reperfusion (MCAO/R)-treated mice. In MCAO/R mice, oral administration of HC@HMC demonstrated a significant protection against cerebral ischemia-reperfusion injury (CIRI). And we also found HC@HMC may exert a protective effect on cerebral ischemia-reperfusion injury through COX2/PGD2/DPs pathway. These results suggest that oral administration of HC@HMC may be a new strategy for the treatment of stroke.

The effect of intravenous administration of phosphorus on phosphorus and calcium metabolism in sheep

1978 ◽  
Vol 29 (3) ◽  
pp. 587 ◽  
Author(s):  
KM Towns ◽  
RC Boston ◽  
DD Leaver
Keyword(s):  
Theoretical Model ◽  
Intestinal Absorption ◽  
Intravenous Infusion ◽  
Calcium Metabolism ◽  
Control Period ◽  
Phosphorus Concentration ◽  
Calcium Balance ◽  
Phosphorus Excretion ◽  
Infusion Period ◽  
Plasma Phosphorus

Four Dorset × Merino wethers were given an intravenous infusion of phosphorus at the rate of 1.5 g/day and the phosphorus and calcium balance determined between 5 and 11 days inclusive after the commencement of the infusion. These results were compared with phosphorus and calcium balance measured during a control period. In three of the four sheep the infused phosphorus was recovered in the faeces, but in one animal 0.37 g/day was excreted in the urine. Although the retention of phosphorus and calcium increased marginally during the infusion period, the increase was not significant. The additional phosphorus was therefore quantitatively eliminated from the animal without significantly influencing calcium balance. A theoretical model of phosphorus movement was constructed on the basis that salivary phosphorus excretion is related to plasma phosphorus concentration. In order to account for the observed recovery of phosphorus in the faeces, it was necessary to postulate either a decrease in the intestinal absorption of phosphorus or an increase in the endogenous secretion of phosphorus which was unrelated to the plasma phosphorus concentration.

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