Release of sodium diclofenac from vehicles prepared with hydrogenated soya lecithin and methyl palmitate.

The high frequency of occurrence of candidiasis as well as high mortality of patients with immunosuppression cause a tendency toward better understanding of Candida albicans species virulence factors and developing sensitive and specific diagnostic methods, and appropriate strategies of candidiasis treatment. In recent decades the incidence of fungal infections has alarming increases because of advanced medical treatments. In this study was analyzed possible ultrastructural changes of the species C. albicans cells following treatment with sodium diclofenac at various concentrations. Following treatment of C. albicans cells with sodium diclofenac 1 mM and 2 mM changes in the plasmalemma can be noticed, changes in the density of cell wall, disruption and necrotic appearance of the cytoplasm.

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Synthesis and characterization of Layered Double Hydroxides aimed at encapsulation of sodium diclofenac: Theoretical and experimental study

Journal of Molecular Liquids ◽

10.1016/j.molliq.2021.116677 ◽

2021 ◽

pp. 116677

Author(s):

Samra Amamra ◽

Hayet Elkolli ◽

Yacine Benguerba ◽

Alessandro Erto ◽

Marco Balsamo ◽

...

Keyword(s):

Experimental Study ◽

Layered Double Hydroxides ◽

Synthesis And Characterization ◽

Sodium Diclofenac ◽

Double Hydroxides

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Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

Journal of Nanostructure in Chemistry ◽

10.1007/s40097-021-00391-z ◽

2021 ◽

Author(s):

Lorenzo Lisuzzo ◽

Giuseppe Cavallaro ◽

Stefana Milioto ◽

Giuseppe Lazzara

Keyword(s):

Salicylic Acid ◽

Release Kinetics ◽

Halloysite Nanotubes ◽

Drug Molecules ◽

Sodium Diclofenac ◽

Tunable Release ◽

Feature Based ◽

Kinetics Of ◽

Filling Mechanism

AbstractIn this work, we investigated the effects of the vacuum pumping on both the loading efficiencies and the release kinetics of halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid and sodium diclofenac were selected. For comparison, the loading of the drug molecules was conducted on platy kaolinite to explore the key role of the hollow tubular morphology on the filling mechanism of halloysite. The effects of the pressure conditions used in the loading protocol were interpreted and discussed on the basis of the thermodynamic results provided by Knudsen thermogravimetry, which demonstrated the ethanol confinement inside the halloysite cavity. Several techniques (TEM, FTIR spectroscopy, DLS and $$\zeta$$ ζ -potential experiments) were employed to characterize the drug filled nanoclays. Besides, release kinetics of the drugs were studied and interpreted according to the loading mechanism. This work represents a further step for the development of nanotubular carriers with tunable release feature based on the loading protocol and drug localization into the carrier. Graphic abstract The filling efficiency of halloysite nanotubes is enhanced by the reduction of the pressure conditions used in the loading protocol.

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