Intermuscular Adipose Tissue, Muscle Quality and Physical Function Following Weight loss in Overweight Older Women

2016 ◽  
Vol 48 ◽  
pp. 156
Author(s):  
Chad R. Straight ◽  
Rachelle M. Acitelli ◽  
Alison C. Berg ◽  
Mary Ann Johnson ◽  
Ellen M. Evans
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Physical Function ◽  
Older Women ◽  
Muscle Quality ◽  
Intermuscular Adipose Tissue

scholarly journals Muscle Quality Predicts Improvements In Transfer Task Performance After Weight Loss In Older Women

2020 ◽  
Vol 52 (7S) ◽  
pp. 747-747
Author(s):  
Ewan R. Williams ◽  
Isaura M. Castillo-Hernandez ◽  
Chad Straight ◽  
Alison Berg ◽  
Rachelle A. Reed ◽  
...  
Keyword(s):  
Weight Loss ◽  
Older Women ◽  
Task Performance ◽  
Transfer Task ◽  
Muscle Quality

IMPACT OF BODY COMPOSITION ON PHYSICAL PERFORMANCE TASKS IN OLDER OBESE WOMEN UNDERGOING A MODERATE WEIGHT LOSS PROGRAM

2013 ◽  
pp. 1-6
Author(s):  
G.D. MILLER ◽  
S.L. ROBINSON
Keyword(s):  
Weight Loss ◽  
Soft Tissue ◽  
Physical Function ◽  
Soft Tissue Mass ◽  
Energy Restriction ◽  
Muscle Quality ◽  
Obese Women ◽  
Tissue Mass ◽  
Intentional Weight Loss ◽  
Dietary Energy Restriction

Background: Although obesity is a recognized risk factor for impaired physical function in olderadults, there is still debate on whether older obese adults should undergo intentional weight loss due to concern ofloss in lean body mass, including appendicular lean soft tissue mass. This may put them at risk for worseningmuscle strength and mobility. Objectives:Therefore, the purpose of this study was to examine the effect of aweight loss intervention on body composition and physical function in obese older women. Design:Womenwere randomized into either a weight stable (WS) (n=20) or an intensive weight loss (WL) (n=26) group.Setting:The study setting was at a university research facility. Participants:Women (age, 67.8±1.3 yrs; BMI,34.9 (0.7) kg/m2; mean±standard error of the mean) were recruited. Intervention:The WL intervention was for 6months and included moderate dietary energy restriction and aerobic and strength exercise training.Measurements:Variables were obtained at baseline and 6-months and included body weight, dual energy x-rayabsorptiometry (DXA), 6-minute walk distance, stair climb time, and concentric knee extension muscularstrength. Results:Estimated marginal means (SEM) for weight loss at 6-months was -8.5 (0.9)% for WL and +0.7(1.0)% for WS. There was a significant loss of body fat mass, lean body mass, appendicular lean soft tissue mass,relative muscle mass, and skeletal muscle index for WL vs. WS at 6-months. However, improvements for WLvs. WS were seen in 6-minute walk distance and stair climb time, and trends for improved relative strength andleg muscle quality. Change in body fat mass was positively related to improved physical function and musclestrength and quality. Conclusion:These results further support the use of a sound intentional weight loss programincorporating moderate dietary energy restriction and exercise training in older obese women to improve physicalfunction. Although lean soft tissue mass was lost, over the 6-month program there was no deleterious effect onmuscle strength or muscle quality.

Weight loss and exercise differentially affect insulin sensitivity, body composition, cardiorespiratory fitness and muscle strength in older adults with obesity; a randomized controlled trial

2021 ◽  
Author(s):  
Andrea M Brennan ◽  
Robert A Standley ◽  
Steven J Anthony ◽  
Kory E Grench ◽  
Nicole L Helbling ◽  
...  
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Body Composition ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Lean Mass ◽  
Disease Risk ◽  
Controlled Trial ◽  
Statistical Significance ◽  
Intermuscular Adipose Tissue

Abstract Background Aging-related disease risk is exacerbated by obesity and physical inactivity. It is unclear how weight loss and increased activity improve risk in older adults. We aimed to determine the effects of diet-induced weight loss with and without exercise on insulin sensitivity, VO2peak, body composition, and physical function in older obese adults. Methods Physically inactive older (68.6 ± 4.5 years) obese (BMI 37.4 ± 4.9 kg/m 2) adults were randomized to: Health education control (HEC; n=25); Diet-induced weight loss (WL; n=31); or Weight loss and exercise (WLEX; n=28) for 6 months. Insulin sensitivity was measured by hyperinsulinemic euglycemic clamp, body composition by DXA and MRI, strength by isokinetic dynamometry, and VO2peak by graded exercise test. Results WLEX improved (p<0.05) peripheral insulin sensitivity (+75 ± 103%) vs. HEC (+12 ± 67%); WL (+36 ± 47%) vs. HEC did not reach statistical significance. WLEX increased VO2peak (+7 ± 12%) vs. WL (-2 ± 24%), and prevented reductions in strength and lean mass induced by WL (p<0.05). WLEX decreased abdominal adipose tissue (-16 ± 9%) vs. HEC (-3 ± 8%) and intermuscular adipose tissue (-15 ± 13 %) vs. both HEC (+9 ± 15%) and WL (+2 ± 11%) (p<0.01). Conclusions Exercise with weight loss improved insulin sensitivity and VO2peak, decreased ectopic fat, and preserved lean mass and strength. Weight loss alone decreased lean mass and strength. Older adults intending to lose weight should perform regular exercise to promote cardiometabolic and functional benefits, which may not occur with calorie restriction-induced weight loss alone.

scholarly journals Intermuscular adipose tissue and thigh muscle area dynamics during an 18-month randomized weight loss trial

2016 ◽  
Vol 121 (2) ◽  
pp. 518-527 ◽  
Author(s):  
Anat Yaskolka Meir ◽  
Ilan Shelef ◽  
Dan Schwarzfuchs ◽  
Yftach Gepner ◽  
Lilac Tene ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Lifestyle Intervention ◽  
Resting Metabolic Rate ◽  
Thigh Muscle ◽  
Muscle Area ◽  
Intermuscular Adipose Tissue ◽  
Glucose Levels ◽  
Reactive Protein ◽  
Fat Depots

It remains unclear whether intermuscular adipose tissue (IMAT) has any metabolic influence or whether it is merely a marker of abnormalities, as well as what are the effects of specific lifestyle strategies for weight loss on the dynamics of both IMAT and thigh muscle area (TMA). We followed the trajectory of IMAT and TMA during 18-mo lifestyle intervention among 278 sedentary participants with abdominal obesity, using magnetic resonance imaging. We measured the resting metabolic rate (RMR) by an indirect calorimeter. Among 273 eligible participants (47.8 ± 9.3 yr of age), the mean IMAT was 9.6 ± 4.6 cm2. Baseline IMAT levels were directly correlated with waist circumference, abdominal subdepots, C-reactive protein, and leptin and inversely correlated with baseline TMA and creatinine ( P < 0.05 for all). After 18 mo (86.3% adherence), both IMAT (−1.6%) and TMA (−3.3%) significantly decreased ( P < 0.01 vs. baseline). The changes in both IMAT and TMA were similar across the lifestyle intervention groups and directly corresponded with moderate weight loss ( P < 0.001). IMAT change did not remain independently associated with decreased abdominal subdepots or improved cardiometabolic parameters after adjustments for age, sex, and 18-mo weight loss. In similar models, 18-mo TMA loss remained associated with decreased RMR, decreased activity, and with increased fasting glucose levels and IMAT ( P < 0.05 for all). Unlike other fat depots, IMAT may not represent a unique or specific adipose tissue, instead largely reflecting body weight change per se. Moderate weight loss induced a significant decrease in thigh muscle area, suggesting the importance of resistance training to accompany weight loss programs.

Relative Contributions of Adiposity and Muscle Quality to Physical Function in Middle-Aged and Older Women

2014 ◽  
Vol 46 ◽  
pp. 626
Author(s):  
Chad R. Straight ◽  
Anne O. Brady ◽  
Christie L. Ward-Ritacco ◽  
Ellen M. Evans
Keyword(s):  
Physical Function ◽  
Older Women ◽  
Muscle Quality ◽  
Middle Aged

scholarly journals Intermuscular Adipose Tissue Is Muscle Specific and Associated with Poor Functional Performance

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Lori J. Tuttle ◽  
David R. Sinacore ◽  
Michael J. Mueller
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Peripheral Neuropathy ◽  
Physical Function ◽  
Physical Performance ◽  
Gastrocnemius Muscle ◽  
Muscle Volume ◽  
Obese People ◽  
Intermuscular Adipose Tissue ◽  
Healthy Obese

Purpose. People with obesity, diabetes, and peripheral neuropathy have high levels of intermuscular adipose tissue (IMAT) volume which has been inversely related to physical function. We determined if IMAT is muscle specific, if calf IMAT is different between a healthy obese group (HO), a group with diabetes mellitus (D), and a group with diabetes mellitus and peripheral neuropathy (DN), and if IMAT volume or the ratio of IMAT/muscle volume is related to physical function in these groups.Methods. 10 healthy obese people, 11 with type 2 diabetes, 24 with diabetes and peripheral neuropathy, had assessments of muscle morphology, physical function and muscle performance.Results. The gastrocnemius muscle had a higher ratio of IMAT/muscle volume than any other muscle or compartment. There were no differences between groups in calf muscle or IMAT volumes. Calf IMAT was inversely related to physical performance on the 6-minute walk test (r=−0.47) and physical performance test (r=−0.36). IMAT/muscle volume was inversely related to physical performance (PPT,r=−0.44; 6 MWr=−0.48; stair power,r=−0.30).Conclusions. IMAT accumulation varies in calf muscles, is highest in the gastrocnemius muscle, and is associated with poor physical performance.

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