Aversive inhibition in adult ADHD and its restoration by mindfulness-based cognitive therapy: A behavioral pilot study

Background: Control over the tendency to make or withhold responses based on contextual Pavlovian information, might play a key role in understanding impulsivity/hyperactivity in ADHD. Here we set out to assess (1) the understudied relation between Pavlovian inhibitory control and hyperactivity/impulsivity in adults with ADHD and (2) whether this inhibition can be enhanced by mindfulness based cognitive therapy (MBCT).Methods: 50 Adult ADHD patients were assessed before and after 8 weeks of treatment as usual (TAU) with (n=24) or without (n=26) MBCT. We employed a sophisticated, well-established Pavlovian-to-instrumental transfer task that quantifies Pavlovian control over instrumental behavior. Results: Task results revealed (1) less aversive Pavlovian inhibition in patients with clinical hyperactivity/impulsivity; and (2) enhanced inhibition after TAU+MBCT compared with TAU. Conclusions: Aversive Pavlovian inhibition plays a role in clinically relevant hyperactivity/impulsivity in adult ADHD and MBCT can be used to enhance this form of inhibition.

Analyzing the Effects of Parameters for Tremor Modulation via Phase-Locked Electrical Stimulation on a Peripheral Nerve

(1) Background: Non-invasive neuromodulation is a promising alternative to medication or deep-brain stimulation treatment for Parkinson’s Disease or essential tremor. In previous work, we developed and tested a wearable system that modulates tremor via the non-invasive, electrical stimulation of peripheral nerves. In this article, we examine the proper range and the effects of various stimulation parameters for phase-locked stimulation. (2) Methods: We recruited nine participants with essential tremor. The subjects performed a bean-transfer task that mimics an eating activity to elicit kinetic tremor while using the wearable stimulation system. We examined the effects of stimulation with a fixed duty cycle, at different stimulation amplitudes and frequencies. The epochs of stimulation were locked to one of four phase positions of ongoing tremor, as measured with an accelerometer. We analyzed stimulation-evoked changes of the frequency and amplitude of tremor. (3) Results: We found that the higher tremor amplitude group experienced a higher rate of tremor power reduction (up to 65%) with a higher amplitude of stimulation when the stimulation was applied at the ±peak of tremor phase. (4) Conclusions: The stimulation parameter can be adjusted to optimize tremor reduction, and this study lays the foundation for future large-scale parameter optimization experiments for personalized peripheral nerve stimulation.

Grab Bar Use Influences Fall Hazard During Bathtub Exit

Objective This study evaluated the hazard (risk of unrecovered balance loss and hazardous fall) and strategies associated with grab bar use, compared to no grab bar use, during unexpected balance loss initiated whilst exiting a bathtub. Background While independent bathing is critical for maintaining self-sufficiency, injurious falls during bathing transfer tasks are common. Grab bars are recommended to support bathing tasks, but no evidence exists regarding fall prevention efficacy. Method Sixty-three adults completed a hazardous bathtub transfer task, experiencing an unpredictable external balance perturbation while stepping from a slippery bathtub to a dry surface. Thirty-two were provided a grab bar, while 31 had no grab bar available. Slips and grab bar use were recorded via four video cameras. Slip occurrence and strategy were identified by two independent video coders. Results Participants who had a grab bar were 75.8% more likely to recover their balance during the task than those who did not have a grab bar. Successful grab bar grasp was associated with balance recovery in all cases. Attempts to stabilize using other environmental elements, or using internal strategies only, were less successful balance recovery strategies. Grab bar presence appeared to cue use of the environment for stability. Proactive grasp and other strategies modified grasping success. Conclusion Grab bars appear to provide effective support for recovery from unexpected balance loss. Grab bar presence may instigate development of fall prevention strategies prior to loss of balance. Application Bathroom designs with grab bars may reduce frequency of fall-related injuries during bathing transfer tasks.

Perceptual metric-guided human image generation

Pose transfer, which synthesizes a new image of a target person in a novel pose, is valuable in several applications. Generative adversarial networks (GAN) based pose transfer is a new way for person re-identification (re-ID). Typical perceptual metrics, like Detection Score (DS) and Inception Score (IS), were employed to assess the visual quality after generation in pose transfer task. Thus, the existing GAN-based methods do not directly benefit from these metrics which are highly associated with human ratings. In this paper, a perceptual metrics guided GAN (PIGGAN) framework is proposed to intrinsically optimize generation processing for pose transfer task. Specifically, a novel and general model-Evaluator that matches well the GAN is designed. Accordingly, a new Sort Loss (SL) is constructed to optimize the perceptual quality. Morevover, PIGGAN is highly flexible and extensible and can incorporate both differentiable and indifferentiable indexes to optimize the attitude migration process. Extensive experiments show that PIGGAN can generate photo-realistic results and quantitatively outperforms state-of-the-art (SOTA) methods.

Effective Connectivity during an Avoidance-Based Pavlovian-to-Instrumental Transfer Task

Pavlovian-to-instrumental transfer (PIT) refers to a phenomenon whereby a classically conditioned stimulus (CS) impacts the motivational salience of instrumental behavior. We examined behavioral response patterns and functional magnetic resonance imaging (fMRI) based effective connectivity during an avoidance-based PIT task. Eleven participants (8 females; Mage = 28.2, SD = 2.8, range = 25–32 years) completed the task. Effective connectivity between a priori brain regions engaged during the task was determined using hemodynamic response function group iterative multiple model estimation (HRF-GIMME). Participants exhibited behavior that was suggestive of specific PIT, a CS previously associated with a reinforcing outcome increased instrumental responding directed at the same outcome. We did not find evidence for general PIT; a CS did not significantly increase instrumental responding towards a different but related outcome. Using HRF-GIMME, we recovered effective connectivity maps among corticostriatal circuits engaged during the task. Group-level paths revealed directional effects from left putamen to right insula and from right putamen to right cingulate. Importantly, a direct effect of specific PIT stimuli on blood–oxygen-level-dependent (BOLD) activity in the left putamen was found. Results provide initial evidence of effective connectivity in key brain regions in an avoidance-based PIT task network. This study adds to the literature studying PIT effects in humans and employing GIMME models to understand how psychological phenomena are supported in the brain.

Differentiating Laparoscopic Skills of Trainees with Computer Vision Based Metrics

Context dependent gaze metrics, derived from eye movements explicitly associated with how a task is being performed, are particularly useful for formative assessment that includes feedback on specific behavioral adjustments for skill acquisitions. In laparoscopic surgery, context dependent gaze metrics are under investigated and commonly derived by either qualitatively inspecting the videos frame by frame or mapping the fixations onto a static surgical task field. This study collected eye-tracking and video data from 13 trainees practicing the peg transfer task. Machine learning algorithms in computer vision were employed to derive metrics of tool speed, fixation rate on (moving or stationary) target objects, and fixation rate on tool-object combination. Preliminary results from a clustering analysis on the measurements from 499 practice trials indicated that the metrics were able to differentiate three skill levels amongst the trainees, suggesting high sensitivity and potential of context dependent gaze metrics for surgical assessment.

Performance-based assessment: Self-efficacy, decision-making, and problem-solving skills in learning science

Performance-based assessment is a purposive-oriented assessment activity in revealing student understanding of unwrapped concepts, skills, and big ideas. This study aimed to determine the effects of performance task assessment on the students' self–efficacy, problem–solving, and decision–making skills in learning science that used the quantitative and correlation methods of research. There were 35 Grade 9 students of the University of San Carlos, Basic Education Department – South Campus in science class as respondents of the study. The assessment was given after the engagement session of the instructional plan to be accomplished after the transfer task session and evaluated using specific rubrics. A modified Albert Bandura's Instrument was used to measure self–efficacy and Mind Tool: Essential Skill for Excellent Career questionnaires for the problem–solving and decision–making skills of the students in learning science. The study's findings indicated that the Performance Assessment developed students' self–efficacy in learning science and had a significant impact on how students think, feel, and behave in the process of learning. Moreover, the assessment conveyed positive influence in developing students' problem–solving and decision–making skills. This assessment encouraged students to apply the scientific processes in evaluating the identified options before deciding the problem's solution.

Commercial Brain Training: Efficacy, Transfer Effects, and the Influence of Personality Traits: A Study Conducted on Healthy Young Adults

In the present study, we investigated the effects of a four-week working memory (WM) and attention training program using commercial brain training (Synaptikon GmbH, Berlin). Sixty young healthy adults were assigned to the experimental and active control training programs. The training was conducted in a naturalistic home-based setting, while the pre- and post-examinations were conducted in a controlled laboratory setting. Transfer effects to an untrained WM task and to an untrained episodic memory task were examined. Furthermore, possible influences of personality, i.e., the five-factor model (FFM) traits and need for cognition (NFC), on training outcomes were examined. Additionally, the direct relationship between improvement in single trained tasks and improvement in the transfer tasks was investigated. Our results showed that both training groups significantly increased performance in the WM task, but only the WM training group increased their performance in the episodic memory transfer task. One of the training tasks, a visuospatial WM task, was particularly associated with improvement in the episodic memory task. Neuroticism and conscientiousness showed differential effects on the improvement in training and transfer tasks. It needs to be further examined whether these effects represent training effects or, for example, retest/practice or motivation effects.

Effective Connectivity During an Avoidance-Based Pavlovian-to-Instrumental Transfer Task

Pavlovian-to-instrumental transfer (PIT) refers to a phenomenon whereby a classically conditioned stimulus (CS) impacts the motivational salience of instrumental behavior. We examined behavioral response patterns and functional magnetic resonance imaging (fMRI) based effective connectivity during an avoidance-based PIT task. Eleven participants (8 females; Mage = 28.2, SD = 2.8, range = 25-32 years) completed the task. Effective connectivity between a priori brain regions engaged during the task was determined using hemodynamic response function group iterative multiple model estimation (HRF-GIMME). Behaviorally, participants exhibited specific PIT, a CS previously associated with a reinforcing outcome increased instrumental responding directed at the same outcome. We did not find evidence for general PIT; a CS did not significantly increase instrumental responding towards a different but related outcome. Using HRF-GIMME, we recovered effective connectivity maps among corticostriatal circuits engaged during the task. Group-level paths revealed directional effects from left putamen to right insula and from right putamen to right cingulate. Importantly, a direct effect of specific PIT stimuli on blood-oxygen-level-dependent (BOLD) activity in the left putamen was found. Results provide initial evidence of effective connectivity in key brain regions in an avoidance-based PIT task network. This study adds to the literature studying PIT effects in humans and employing GIMME models to understand how psychological phenomena are supported in the brain.