Exacerbation of acetic acid ulcer induced by non-steroidal anti-inflammatory drugs in rats.

BACKGROUND Diclofenac is a Non-steroid Anti-inflammatory drug (NSAID) derived from non-steroidal phenylacetic acid. Diclofenac is a benzene acetic acid derivative used to treat the pain and swelling associated with rheumatic disorders since 1974. It is one of the most widely used non-steroidal anti-inflammatory Drugs (NSAIDs) in the world. A few reports have demonstrated that non-steroidal anti-inflammatory drugs exerted embryo toxicity and teratogenicity among experimental animals but there is no clear evidence of the effect in humans. OBJECTIVE To perform a systematic review on the effect of Diclofenac exposure during Pregnancy on mother and fetus. METHODS This systematic review was conducted in accordance with the JBI methodology for systematic review of effectiveness evidence. A three-step search strategy used in this review. Databases searched included Pub Med, Medline Scopus, Embase, cinihal, Google, different Universities repositories and Google scholar. Titles and abstracts were then screened by two independent reviewers for assessment against the inclusion criteria for the review. Eligible studies were critically appraised by two independent reviewers at the study level. Appraisal was occurred at the outcome level for methodological quality in the review using standardized critical appraisal instruments from the Joanna Briggs Institute (JBI) for observational studies. The data extracted from the studies include specific details about the populations, study methods, interventions, and outcomes of significance to the review objective indicate the specific details. Statistical pooling was not possible due to outcome and nature of data. So, that the findings were presented in narrative form. RESULTS Three relevant articles (two cohort and a nested case control studies) were identified with a total of 1,490,679 participants. Diclofenac exposure during pregnancy increases the risk of low birth weight on fetus, increased risk of spontaneous abortion and increased risk of maternal vaginal bleeding. CONCLUSIONS Exposures to Diclofenac during pregnancy have adverse embryonic and maternal effect. So pregnant women taking Diclofenac may affect mother and fetus and additional primary RCTs are needed.

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Interaction of indomethacin with calf thymus DNA: a multi-spectroscopic, thermodynamic and molecular modelling approach

MedChemComm ◽

10.1039/c7md00094d ◽

2017 ◽

Vol 8 (6) ◽

pp. 1283-1296 ◽

Cited By ~ 24

Author(s):

Mohammed Amir Husain ◽

Hassan Mubarak Ishqi ◽

Tarique Sarwar ◽

Sayeed Ur Rehman ◽

Mohammad Tabish

Keyword(s):

Acetic Acid ◽

Acid Derivative ◽

Molecular Modelling ◽

Biological Activities ◽

Calf Thymus Dna ◽

Calf Thymus ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Modelling Approach

Indomethacin belongs to the acetic acid derivative class of non-steroidal anti-inflammatory drugs with diverse pharmacological and biological activities.

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CONTENT-ANALYSIS OF THE PHARMACEUTICAL MARKET OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN GROUPS OF ACETIC ACID DERIVATIVES IN THE KYRGYZ REPUBLIC

Avicenna Bulletin ◽

10.25005/2074-0581-2020-22-1-74-81 ◽

2020 ◽

Vol 22 (1) ◽

pp. 74-81

Author(s):

Dinara Ermekova ◽

◽

Isabek Ismailov ◽

Keyword(s):

Acetic Acid ◽

Medical Engineering ◽

Pharmaceutical Market ◽

High Price ◽

Kyrgyz Republic ◽

Foreign Countries ◽

Price Range ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Trade Names

Objective: To segment the pharmaceutical market of non-steroidal anti-inflammatory drugs (NSAIDs) of the derivatives groups of acetic acid in the Kyrgyz Republic. Methods: The database of the State Registry of Medicines registered and approved for Medical use in Kyrgyzstan, the Department of Drugs Security and Medical Engineering of the Ministry of Health of the Kyrgyz Republic is used for analysis. Results: Analysis showed that the leaders of the pharmaceutical market in Kyrgyzstan the number of registered medicines (M) under the trade names are Medical Drugs (MD) with international generic name: diclofenac, ketorolac, indomethacin. It has been established that there are 99 trade names of NSAIDs of the groups of acetic acid derivatives in the Kyrgyz pharmaceutical market. The largest part of the range consists of diclofenac (M01AB05), represented by 62 trade names MD (62.6%), and ketorolac (M01AB15), represented by 20 trade names MD (20.2%). In the pharmaceutical market of Kyrgyzstan are NSAIDs from the groups of acetic acid derivatives from 15 countries, of which 21.1% of MDs are produced by neighboring countries, and 73.3% – in far countries. Conducted studies have revealed that the structure of the range of NSAIDs groups of acetic acid derivatives is dominated by soft medicinal forms, which making up 37.4%. A comparative analysis of the composition of MD by the number of active substances revealed that 92.9% of NSAIDs of the groups of acetic acid derivatives are monodrugs. Based on the analysis of the price segmentation of NSAIDs of the groups of acetic acid derivatives, most of the drugs are in the low-price segment. Conclusions: A sufficient assortment saturation of the pharmaceutical market of Kyrgyzstan NSAIDs groups of acetic acid derivatives has been revealed. The pharmaceutical market of the Kyrgyz Republic is dominated by monocomponent NSAIDs in the form of soft medicinal forms produced in foreign countries. Only 7 MDs from this group are in the high-price range, making the remaining drugs financially available to consumers. Keywords: NSAIDs, indomethacin, diclofenac, etodolac, ketorolac, aceclophenac.

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Analgesic and anti-inflammatory activity of 5,7-diacyl-3-H(alkіl)-6- aryl-5H-[1,2,4]triazol[3,4-b][1,3,4]tіadiazin derivaties

Medical and Clinical Chemistry ◽

10.11603/mcch.2410-681x.2015.v17.i2.4866 ◽

2015 ◽

Vol 17 (2) ◽

Author(s):

O. Ye. Yadlovskyi ◽

А. Ya. Koval ◽

N. M. Seredynska ◽

T. A. Bukhtiarova ◽

T. A. Bershova ◽

...

Keyword(s):

Acetic Acid ◽

Specific Activity ◽

Reference Product ◽

Antinociceptive Effect ◽

Antinociceptive Activity ◽

Hot Plate ◽

Carrageenan Edema ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Derivatives Of

The search for new analgesic and anti-inflammatory drugs, exceeding by efficacy and/or safety the existing analogues is very important and relevant. The nitrogenous heterocycles are promising in this respect, in particular, the compounds containing an imidazole triazol and tіadiazin moiety. The aim of the current study was to investigate the antiexudative and antinociceptive activity of new derivatives of 5,7-diacyl-3-H(alkyl)-6-aryl-5H[1,2,4]triazol[3,4-b] [1,3,4]thiadiazine. The antinociceptive and antiexudative activity studies were carried out on the white nonlinear mice. The experimental evaluation of specific activity was carried out on the models “Hot plate”, acetic acid induced writhing (antinociceptive action) and carrageenan edema (antiexudative action). The substance was used in a single oral rout administration in a dose of 25 mg/kg. Ketorolac was used as a reference product in the dose of 25 mg/kg (models “Hot plate”, acetic acid induced writhing). Diclofenac was used as a reference product in the dose of 25 mg/kg on the model carrageenan edema. The experimental study showed the antinociceptive and antiexudative effects of the derivatives. The antinociceptive activity of 5,7-diacyl-3-H(alkіl)-6-aryl-5H[1,2,4]triazol[3,4-b][1,3,4]tіadiazin derivaties related to the modification structure in the para position of benzene ring. The antiexudative activity is associated with acetyl groups thiadiazine ring. The most promising compound IFT_247 showed a significant antinociceptive effect, which is comparable to an active comparator ketorolac: “Hot plate” +232.46 % and +112.71 %; acetic acid induced writhing -66.67 % and -61.02 %, respectively.

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Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs

Investigational New Drugs ◽

10.1007/s10637-008-9167-7 ◽

2008 ◽

Vol 27 (3) ◽

pp. 280-284 ◽

Cited By ~ 8

Author(s):

L.-C. Steve Wang ◽

Lai-Ming Ching ◽

James W. Paxton ◽

Philip Kestell ◽

Rachel Sutherland ◽

...

Keyword(s):

Acetic Acid ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Vibrational and theoretical studies of non-steroidal anti-inflammatory drugs Ibuprofen [2-(4-isobutylphenyl)propionic acid]; Naproxen [6-methoxy-α-methyl-2-naphthalene acetic acid] and Tolmetin acids [1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid]

Journal of Molecular Structure ◽

10.1016/j.molstruc.2005.08.018 ◽

2006 ◽

Vol 783 (1-3) ◽

pp. 34-51 ◽

Cited By ~ 53

Author(s):

Alicia Jubert ◽

María Leticia Legarto ◽

Néstor E. Massa ◽

Leonor López Tévez ◽

Nora Beatriz Okulik

Keyword(s):

Acetic Acid ◽

Propionic Acid ◽

Naphthalene Acetic Acid ◽

Theoretical Studies ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Phytochemical Screening, Anti-inflammatory and Analgesic Activities of Root Barks from Acacia macrostachya Reichenb. Ex DC. (Fabaceae)

Annual Research & Review in Biology ◽

10.9734/arrb/2020/v35i730249 ◽

2020 ◽

pp. 76-83

Author(s):

Adjaratou C. Coulibaly ◽

W. L. M. Esther B. Kabre ◽

Tata K. Traore ◽

Constantin Achatde ◽

Gilchrist L. Boly ◽

...

Keyword(s):

Acetic Acid ◽

Acute Toxicity ◽

Inflammatory Diseases ◽

Scientific Basis ◽

Phytochemical Screening ◽

Snake Bites ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Traditional Pharmacopoeia ◽

Analgesic Activities

Aims: Acacia macrostachya Reichenb. ex DC. (Fabaceae) is used in traditional medicine for the treatment of many pathologies including diarrhea, malaria with convulsion and fevers, snake bites, vomiting, nausea, dysenteric syndrome and choleriformis, inflammatory diseases and old wounds. The purpose of this study was to carry out the phytochemical screening, to assess the general acute toxicity, the anti-inflammatory and analgesic activities of the dichloromethane extract of A. macrostachya root barks in order to develop new lower-toxic anti-inflammatory drugs. Place and Duration of Study: The work was carried out in the Department of Traditional Pharmacopoeia and Pharmacy (MEPHATRA / PH) of the Institute for Research in Health Sciences (IRSS) and LABIOCA from Université Joseph KI-ZERBO in Ouagadougou between March and June 2020. Methodology: Phytochemical screening was carried out through thin layer chromatography with specific reagents. Acute toxicity assay was carried out according to the "dose adjustment" method from the OECD guideline 423 2001. Analgesic effect was evaluated on the number of abdominal contortions induced by the intraperitoneal injection of acetic acid while the anti-inflammatory activity using the Carrageenan anti-edematous test was determined according to Winter. Results: Phytochemical profile demonstrated the presence of alkaloids, coumarins, polyphenols, tannins, flavonoids, saponosides, triterpenes and sterols. At the dose of 200 mg/kg (bw), the extract inhibited acetic acid-induced pain by 67.08% and carragenaan-induced edema by 74.03%. A. macrostachya dichloromethane extract is slightly toxic with LD50 higher than 5000 mg/kg (bw). Conclusion:The results of this study demonstrated the interest of A. macrostachya in the treatment of inflammatory pathologies and constitute a scientific basis of its traditional uses.

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Analgesic and Anti-inflammatory Activities of Triterpenoid Molecules Isolated from the Leaves of Combretum glutinosum Perr. Ex DC (Combretaceae)

Journal of Advances in Medical and Pharmaceutical Sciences ◽

10.9734/jamps/2018/v19i430096 ◽

2019 ◽

pp. 1-8

Author(s):

Madièye Sene ◽

Daouda Ndiaye ◽

Abdoulaye Gassama ◽

Firmin Sylva Barboza ◽

Mbaye Diagne Mbaye ◽

...

Keyword(s):

Acetic Acid ◽

Medicinal Plant ◽

Acetylsalicylic Acid ◽

Traditional Medicine ◽

Control Group ◽

Paw Oedema ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Rat Paw ◽

Rat Paw Oedema

Combretum glutinosum Perr. Ex DC (COMBRETACEAE) is a traditional medicinal plant, widely distributed in Senegal and Africa. The aim of that study was to investigate the analgesic and anti-inflammatory activities of two triterpenes, betulonic acid (DN7) and cabraleone (DN12), isolated from the leaves of Combretum glutinosum. Experiments were performed in acetic acid-induced contortions in mice and carrageenan rat paw oedema. DN7 (3 mg/kg, per os) and DN12 (3 mg/kg, per os) significantly prevent contortions in mice. The number of contortions is respectively 30±10 and 32±7 versus 72.6±6.64 in control group (p<0.05, n=5). DN7 (3 mg/kg, per os) significantly prevented the increased rat paw oedema (31.84±6.76 vs 92.72±6.05%) (p<0.05, n=5). DN12 (10 mg/kg, per os) induced rat paw oedema prevention similar to that of acetylsalicylic acid (10 mg/kg, per os) administered in the same conditions (29.28±5.88 vs 30.96±7.25%; ns, n=5). The analgesic and anti-inflammatory activities of triterpenes isolated from C. glutinosum leaves are similar to those of non-steroidal anti-inflammatory drugs such acetylsalicylic acid, justifying the use of this plant in traditional medicine to manage pain and inflammation.

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