scholarly journals Protective Effect of N-Acyl Amino Acids (NAAs) on Cephaloridine (CER) Nephrotoxicity in Rabbits

1993 ◽  
Vol 63 (4) ◽  
pp. 487-494 ◽  
Author(s):  
Yasukuni Hirouchi ◽  
Hideo Naganuma ◽  
Yukinori Kawahara ◽  
Ryuzo Okada ◽  
Akira Kamiya ◽  
...  
Keyword(s):  
Amino Acids ◽  
Protective Effect

PROTECTIVE EFFECT OF POLYPEPTIDE AND AMINO ACIDS ON THE DEVELOPMENT OF THE NERVOUS TISSUE CULTURE IN THE PRESENCE OF CYCLOPHOSPHAMIDE

2017 ◽  
pp. 22-26
Author(s):  
V. B. Dolgo-Saburov ◽  
N. I. Chalisova ◽  
L. V. Lyanginen ◽  
E. S. Zalomaeva
Keyword(s):  
Amino Acids ◽  
Cell Proliferation ◽  
Tissue Culture ◽  
Protective Effect ◽  
Organotypic Culture ◽  
Inhibitory Effect ◽  
Mustard Gas ◽  
Synthesis Inhibitor ◽  
Combined Administration ◽  
The Central Nervous System

In an organotypic culture, an investigation was conducted into combined effects of cyclophosphamide DNA as synthesis inhibitor used to model a resorptive action of mustard gas, and cortexin polypeptide or each of 20 encoded amino acids on the development of cell proliferation in cerebral cortex explants of the rat. The combined administration of cyclophosphamide together with cortexin or with each of the 20 encoded amino acids, except glycine, showed suppression of the cytostatic agent inhibitory effect. Thus, cortexin and amino acids have a protective effect on cell proliferation in the tissue culture of the central nervous system under the action of mustardlike substances.

The protective effect of amino acids on the copper(II)-catalyzed autoxidation of ascorbic acid

2020 ◽  
Vol 16 (6) ◽  
Author(s):  
F. Imer ◽  
E. Aldemir ◽  
H. Kiliç ◽  
I. Sonmezoǧlu ◽  
R. Apak
Keyword(s):  
Amino Acids ◽  
Ascorbic Acid ◽  
Protective Effect

scholarly journals Immunogenicity and Safety of a Chemically Synthesized Divalent Group A Streptococcal Vaccine

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yongxiang Wu ◽  
Suhua Li ◽  
Yanting Luo ◽  
Yunyue Zhao ◽  
Jiarui Wang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Amino Acids ◽  
Survival Rate ◽  
Protective Effect ◽  
Health Problem ◽  
Group A Streptococcus ◽  
Peptide Vaccine ◽  
Effective Vaccine ◽  
Histopathological Analysis ◽  
Group A

Background. Group A streptococcus (GAS) infections and poststreptococcal sequelae remain a health problem worldwide, which necessitates searching for an effective vaccine, while no licensed GAS vaccine is available. We have developed a divalent peptide vaccine composed of 84 amino acids to cover the main GAS serotypes (M1 and M12 streptococci) in China, and herein, we aimed to evaluate immunogenicity and safety of this vaccine.Methods. Mice were immunized with the vaccine. ELISA, indirect bactericidal test, and immunofluorescent assay were used to study immunogenicity. GAS challenge assay was used to test the protective effect. Safety was tested by histopathological analysis.Results. Immunized group mice (n=16) developed higher titer antibody after immunization than nonimmunized group mice (n=16) did. This antibody can deposit on the surface of GAS and promote killing of GAS, resulting in 93.1% decrease of M1 GAS and 89.5% of M12 GAS. When challenged with M1 and M12 streptococci, immunized group mice had a higher survival rate (87.5% and 75%) than nonimmunized group mice (37.5% and 25%). No autoimmune reactions were detected on organs of mice.Conclusion. The results suggest that this vaccine shows fair immunogenicity and safety, which will lead our research on GAS vaccine into clinical trial.

scholarly journals The Protective Effect of Sheep Placental Extract on Concanavalin A-induced Liver Injury in Mice

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 28 ◽  
Author(s):  
Jingwen Liu ◽  
Suting Luo ◽  
Jun Yang ◽  
Fazheng Ren ◽  
Yu Zhao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Amino Acids ◽  
Liver Injury ◽  
Protective Effect ◽  
Concanavalin A ◽  
B Cell Lymphoma ◽  
Therapeutic Effects ◽  
Model Group ◽  
Con A ◽  
Placental Extract

Though the biological effects of human placental extract have been widely studied, it has limited availability and its use poses ethical problems. Thus, domestic animal placental extracts are suggested as alternatives. In this study, the protective effect of sheep placental extract (SPE) on concanavalin A (Con A)-induced liver injury was investigated. BALB/c mice were randomly divided into six groups, including one normal group and five experimental groups, which received different oral doses of SPE (0, 5, 10 and 50 mg/kg) or a mixture of amino acids for 3 days before Con A injection. Compared with Con A-induced model group, the SPE administration significantly decreased serum aminotransaminase activity, alleviated pathological changes, recovered liver antioxidant capacity and prevented the increase of nitric oxide. Secretion of pro-inflammatory cytokines in serum decreased and mRNA expression of hepatic intercellular adhesion molecule-1, interferon-inducible chemokine 10 and inducible nitric oxide synthase were downregulated, while B-cell lymphoma-2 expression increased. The administration of amino acids mixture had no significant effect in most measurements compared with the model group, which indicated proteins and peptides, rather than individual amino acid, were largely responsible for the bioactivity of SPE. The results indicate SPE has potential therapeutic effects against immune-mediated hepatitis.

scholarly journals Use of transglutaminase for improvement of quality of pastry produced by frozen-dough technology

2011 ◽  
Vol 20 (No. 6) ◽  
pp. 215-222 ◽  
Author(s):  
B. Hozová ◽  
J. Jančovičová ◽  
L. Dodok ◽  
V. Buchtová ◽  
L. Staruch
Keyword(s):  
Amino Acids ◽  
Protective Effect ◽  
Sensory Quality ◽  
Microbiological Quality ◽  
The Other ◽  
Sensory Profile ◽  
Total Count ◽  
Frozen Dough ◽  
Ph Values

The improving effect on the quality of final products has been studied of the enzyme transglutaminase added in two concentrations, i.e. 4.5 mg or 7.5 mg/300 g of flour destined for the preparation of pastry dough. Changes of the sensory (sensory profile), nutritional (the contents of amino acids, especially that of lysine), and microbiological quality (total count, yeasts, moulds) were investigated as well as those of aw and pH values of the pastry produced from the freezer-stored dough (–18 ± 2°C). It has been found that the sensory quality is favourably affected by the addition of transglutaminase (TGM) in the amount of 4.5 mg/300 g of flour and on the other hand that the protective effect on lysine increases if the applied TGM concentration is higher (7.5 mg per 300 g of flour). The microbiological quality, the pH and aw values of dough, and the products have satisfied the criteria for the sanitary and hygienic requirements.  

scholarly journals The protective action of some amino-acids against the effect of heat on complement

1953 ◽  
Vol 51 (1) ◽  
pp. 140-144 ◽  
Author(s):  
J. Gordon
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Guinea Pig ◽  
Protective Effect ◽  
Glutamic Acid ◽  
High Molecular Weight ◽  
Aspartic Acid ◽  
Protective Action ◽  
Derivatives Of ◽  
Pig Serum

1. Glycine, alanine, and several isomers of alanine, DL-glutamic acid and DL-aspartic acid, when added to fresh guinea-pig serum and allowed to stand on the bench for half an hour, will protect the complement of this serum from destruction by heating at 55 and 56° C. for half an hour, but most of the complement activity is destroyed by heating at 57° C. and it is completely destroyed at 58° C. after half an hour.2. Derivatives of glycine do not have any protective effect.3. Various substances of high molecular weight, that might be described as ‘protective colloids’ do not have any protective effect.4. How these amino-acids when added to serum alter the heat-lability of the complement is not understood.

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