scholarly journals Anti-stress Effects of Ginkgo biloba and Panax ginseng: a Comparative Study

2003 ◽  
Vol 93 (4) ◽  
pp. 458-464 ◽  
Author(s):  
Deepak Rai ◽  
Gitika Bhatia ◽  
Tuhinadri Sen ◽  
Gautam Palit
2003 ◽  
Vol 75 (3) ◽  
pp. 701-709 ◽  
Author(s):  
D.O. Kennedy ◽  
A.B. Scholey ◽  
L. Drewery ◽  
V.R. Marsh ◽  
B. Moore ◽  
...  
Keyword(s):  

2016 ◽  
Vol 62 (1) ◽  
pp. 42-54 ◽  
Author(s):  
Anna Bogacz ◽  
Monika Karasiewicz ◽  
Karolina Dziekan ◽  
Danuta Procyk ◽  
Małgorzata Górska-Paukszta ◽  
...  

Summary Introduction: Despite widespread use of Panax ginseng and Ginkgo biloba, the data on the safety as well as herb-drug interactions are very limited. Therefore, we postulate that P. ginseng and G. biloba may modulate the activity and content of cytochrome P450 isozymes involved in the biotransformation of diverse xenobiotic substances. Objective: The aim of our study was to determine the influence of herbal remedies on the expression level of CYP enzymes and transcriptional factors. Methods: Male Wistar rats were given standardized Panax ginseng (30 mg/kg p.o.) or standardized Ginkgo biloba (200 mg/kg p.o.) for 3 and 10 days. The expression in liver tissue was analyzed by realtime PCR method. Results: Our results showed a decrease of CYP3A1 (homologue to human CYP3A4) mRNA level after P. ginseng extract treatment. The CYP2C6 (homologue to human CYP2C9) expression was also reduced. Additionally, after 10 days of the treatment with P. ginseng an increase of CYP1A1 (homologue to human CYP1A1) and CYP1A2 (homologue to human CYP1A2) expression was observed. Moreover, G. biloba extract also caused an increase of expression level for CYP1A1, CYP2C6, CYP3A1 and CYP3A2. Conclusion: Our findings suggest that herbal extracts can modulate the expression of transcriptional factors and CYP enzymes involved in xenobiotic metabolism and chemical carcinogenesis.


2003 ◽  
Vol 31 (06) ◽  
pp. 841-855 ◽  
Author(s):  
V. D. Petkov ◽  
S. Belcheva ◽  
V. V. Petkov

The behavioral effects of a standardized extract from Panax ginseng roots (G115), of a standardized extract from Ginkgo biloba leaves (GK501) and of their combination (PHL-00701) (Gincosan®) were examined in experiments on rats with undisturbed memory and on rats with experimentally-impaired memory (by alcohol or by muscarinic- and dopamine-receptor antagonists), using methods for active avoidance (shuttle-box) and passive avoidance (step-down and step-through). On multiple administration G115, GK501 and PHL-00701 exerted favorable effects on learning and memory. These effects varied with the dose and administration schedules, with the rat strain and with the behavioral method. Based on earlier results, we discuss the role of changes in brain biogenic amines induced by the extracts in their mechanism of action. The present results allow for ranking G115, GK501 and their combination PHL-00701 (Gincosan®) among cognition-enhancing (nootropic) drugs.


2014 ◽  
Vol 15 (3) ◽  
Author(s):  
Fernanda Stumpf TONIN ◽  
Fábio BRASIL ◽  
Ellis Marina SZABO ◽  
Roberto PONTAROLO

A esquizofrenia é a mais comum e prevalente psicose, tendo um curso crônico e deteriorativo capaz de impactar na qualidade de vida dos pacientes, familiares e cuidadores. Essa doença afeta as esferas social e ocupacional gerando custos pessoais e financeiros para o paciente e para o sistema de saúde do país. Em termos de tratamento, já existem no mercado diversos fármacos e intervenções disponíveis, sendo usados principalmente antipsicóticos em associação com outras classes de medicamentos (estabilizadores de humor, antidepressivos, benzodiazepínicos). No entanto, além de apresentarem um custo elevado, essas intervenções podem causar diversos sintomas e eventos adversos, o que influencia a adesão e sucesso no tratamento. Nesse contexto, destaca-se o uso de abordagens complementares como as plantas medicinais e a fitoterapia, que tem se mostrado, nas últimas décadas, como uma alternativa viável para auxiliar no tratamento dessa doença. As plantas medicinais são popularmente utilizadas e com isso podem representar um suporte efetivo à terapia medicamentosa de desordens mentais. Este artigo tem como objetivo revisar o uso complementar, bem como a efetividade e segurança de algumas plantas medicinais para o tratamento de sintomas da esquizofrenia. Aparentemente a combinação de plantas medicinais associada à terapia medicamentosa é uma estratégia útil para melhorar a eficácia dos antipsicóticos ou reduzir eventos adversos e custos no tratamento. Foi reportado o uso benéfico de diferentes plantas para o tratamento de sintomas da esquizofrenia incluindo: Erva de São João (Hypericum perforatum) para o tratamento de desordens afetivas e depressão; Valeriana (Valeriana officinalis) para ansiedade e epilepsia; Ginkgo biloba em casos de demência e déficit de memória; Ginseng (Panax ginseng) para pacientes esquizofrênicos com disfunções cognitivas.


2021 ◽  
pp. 90-97
Author(s):  
Yogita Surendra Karandikar ◽  
Namrata Rajendra Pawar ◽  
Uma Anand Bhosale ◽  
Prachi Doiphode

2002 ◽  
Vol 73 (4) ◽  
pp. 893-900 ◽  
Author(s):  
Amitava Das ◽  
Girja Shanker ◽  
Chandishwar Nath ◽  
Raghwendra Pal ◽  
Satyawan Singh ◽  
...  

2007 ◽  
Vol 35 (06) ◽  
pp. 995-1009 ◽  
Author(s):  
Hsin-Fang Chang ◽  
Yun-Ho Lin ◽  
Chia-Chou Chu ◽  
Shu-Ju Wu ◽  
Ya-Hui Tsai ◽  
...  

This study investigated the effects of the combined extracts of Ginkgo biloba, Panax ginseng, and Schizandra chinensis at different doses on hepatic antioxidant status and fibrosis in rats with carbon tetrachloride ( CCl 4)-induced liver injury. Male Sprague-Dawley rats ( n = 8–12 per group) were divided into the control, CCl 4, CCl 4 + silymarin (0.35%), CCl 4 + low-dose herbal extract (0.24% of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract at 1:1:1; LE), and CCl 4 + high-dose herbal extract (1.20% of the same herbal extract; HE) groups. Silymarin or herbal extract was orally given to rats a week before chronic intraperitoneal injection with CCl 4 for 6 weeks. The pathological results showed that herbal extract suppressed hepatic bile duct proliferation, and low-dose herbal extract inhibited liver fibrosis. Hepatic superoxide dismutase (SOD) activity was lower in the CCl 4 group, but there was no difference in the silymarin or herbal extract treated groups compared to the control group. Hepatic catalase activity and the ratio of reduced to oxidized glutathione were significantly higher ( p < 0.05) in the HE group than those in the CCl 4 group. Silymarin and herbal extract reversed the impaired hepatic total antioxidant status ( p < 0.05). Herbal extract partially reduced the elevated hepatic lipid peroxides. Hepatic transforming growth factor-β1 (TGF-β1) level decreased significantly ( p < 0.05) in the LE group. Therefore, high-dose herbal extract improved hepatic antioxidant capacity through enhancing catalase activity and glutathione redox status, whereas low-dose herbal extract inhibited liver fibrosis through decreasing hepatic TGF-β1 level in rats with CCl 4-induced liver injury.


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