Effects of the chorda tympani damage on submandibular glands: scintigraphic changes

2004 ◽  
Vol 118 (2) ◽  
pp. 102-105 ◽  
Author(s):  
C. Yagmur ◽  
M. C. Miman ◽  
E. Karatas ◽  
M. Akarcay ◽  
T. Erdem ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Concentration Ratio ◽  
Chorda Tympani ◽  
Excretion Ratio ◽  
Ear Surgery ◽  
Normal Side ◽  
Submandibular Glands ◽  
Valuable Method

The aim of this study is to compare the scintigraphic results of a denervated submandibular gland with the contralateral normal side in patients with unilateral chorda tympani damage. Sixteen patients (11 women and five men with a mean age of 27) with unilateral proven chorda tympani damage during their previous ear surgery were included in the study. The perfusion ratio (PR), concentration ratio (CR) and stimulated excretion ratio (SER) were calculated scintigraphically and the results from the salivary glands on opposite sides were compared.For submandibular glands, the perfusion ratio (PR), concentration ratio (CR) and stimulated excretion ratio (SER) were found to be 0.65 ± 0.21, 0.70 ± 0.21, 0.79 ± 0.37, respectively. All ratios resulted from statistically decreased radioactivity accumulation on the affected side (p<0.05).Chorda tympani damage negatively affects the function of the ipsilateral submandibular glands despite the absence of atrophy. Dynamic salivary gland scintigraphy is a practical and valuable method of disclosing the decreased capacity of perfusion, concentration and secretion function in unilateral neurological deprivation.

Developmental Changes of Calcium-Stimulated Adenosine Triphosphatase in Rat Submandibular Gland

1976 ◽  
Vol 55 (5) ◽  
pp. 864-867 ◽  
Author(s):  
Shunsuke Furuyama ◽  
Yoshimitsu Son ◽  
Hitoshi Ogawa ◽  
Hiroo Matsubayashi ◽  
Hisashi Takiguchi
Keyword(s):  
Salivary Gland ◽  
Submandibular Gland ◽  
Adenosine Triphosphatase ◽  
Developmental Changes ◽  
Submandibular Glands ◽  
Old Rats ◽  
Rat Submandibular Gland

Developmental changes of Ca2+-stimulated adenosine triphosphatase (ATPase) in rat submandibular glands were determined in the fetus and up to 300-day-old rats, and were discussed in relation to the development of salivary gland functions.

Salivary gland diseases

2018 ◽  
Author(s):  
Max Robinson ◽  
Keith Hunter ◽  
Michael Pemberton ◽  
Philip Sloan
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Neck Region ◽  
Normal Function ◽  
Minor Salivary Glands ◽  
Flow Rates ◽  
Endocrine Disturbances ◽  
Systemic Factors ◽  
Gland Function

The salivary glands consist of three paired major glands—parotid, sub­mandibular, and sublingual—and the countless minor salivary glands found in almost every part of the oral cavity, except the gingiva and anterior regions of the hard palate. The secretion of saliva is essential for the normal function and health of the mouth, and disorders of salivary gland function predispose to oral disease. Functional disorders in salivary secretion may be associated with primary salivary gland disease but in other cases are a consequence of systemic factors, such as medi­cations, endocrine disturbances, and neurological disease, which are discussed in Chapter 10. Developmental anomalies of the salivary glands are rare. Aplasia of one or more major glands and atresia of one or more major salivary gland ducts have been reported. Congenital aplasia of the parotid gland may be associated with other facial abnormalities, e.g. ectodermal dysplasia, mandibulofacial dysostosis, and hemifacial microsomia. Heterotopic salivary tissue has been reported from a variety of sites in the head and neck region, the most frequent being its inclusion at the angle, or within the body, of the mandible, called a Stafne bone cavity. It is usually an incidental radiological finding and appears as a round or oval, well-demarcated radiolucency between the premolar region and angle of the jaw, and is typically located beneath the inferior dental canal. The radiographic appearances are due to a saucer-shaped depression or concavity of varying depth on the lingual aspect of the mandible, which contains salivary tissue in continuity with the submandibular gland. Accessory parotid tissue within the cheek or masseter muscle is rela­tively common and is subject to the same diseases that may affect the main gland. Age changes can be detected in both major and minor salivary glands. Reduction in the weights of submandibular and parotid glands has been reported with increasing age, associated in the submandibular gland with an age-dependent reduction in flow rates. By contrast, sev­eral studies have demonstrated that there is no significant reduction in parotid flow rates in the elderly.

scholarly journals Unusually Large Submandibular Sialoliths: Report of Two Cases

2009 ◽  
Vol 03 (02) ◽  
pp. 135-139 ◽  
Author(s):  
Meryem Toraman Alkurt ◽  
Ilkay Peker
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Histopathological Examination ◽  
Floor Of The Mouth ◽  
Common Diseases ◽  
Wharton’S Duct

ABSTRACTSialoliths are the most common diseases of the salivary glands. They may occur in any of the salivary gland ducts but are most common in Wharton’s duct and the submandibular gland. This report presents clinical and radiographical signs of two unusually large sialoliths. There were painless swellings on the floor of the mouth in both cases. Radiographical examination revealed large irregular radioopaque mass superimposed right canine and premolar areas. After the lesions were removed, histopathological examination was performed and lesions were diagnosed as sialoliths. (Eur J Dent 2009;3:135-139)

Two malignant salivary gland tumours of different type in one patient

1994 ◽  
Vol 108 (9) ◽  
pp. 798-800 ◽  
Author(s):  
A. Hosni ◽  
C. Fisher ◽  
P. Rhŷ-Evans
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Histological Type ◽  
Salivary Gland Tumours ◽  
Adenoid Cystic ◽  
The Right ◽  
Left Parotid Gland

AbstractThe synchronous or metachronous occurrence of two tumours of the salivary glands in one patient is rare. These are mainly benign and of the same histological type. Here we report a 56-year-old man who developed a mucoepidermoid tumour of the left parotid gland four years after diagnosis of adenoid cystic carcinoma of the right submandibular gland. This combination of neoplasms has not to our knowledge been reported before.

scholarly journals Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Sunmi Jo ◽  
Hye-kyung Shim ◽  
Joo Yeon Kim ◽  
Sang Kyun Bae ◽  
Mi Ra Kim
Keyword(s):  
Salivary Gland ◽  
Literature Review ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Diagnostic Methods ◽  
Myeloid Sarcoma ◽  
Histopathologic Evaluation ◽  
High Index Of Suspicion ◽  
Sebaceous Lymphadenoma

Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. A 62-year-old man was initially diagnosed with carcinoma that arose in a sebaceous lymphadenoma in the parotid gland, through a total parotidectomy with neck dissection. After an extensive histopathological review that included immunohistochemistry, a pathologic diagnosis of MS with infiltration into the sebaceous lymphadenoma with concurrent BM involvement was confirmed. MS is difficult to diagnose accurately; herein, we analyzed the clinical presentations and effectiveness of the various diagnostic methods with a review of the literature. There are 17 cases, including our case, reported in 13 studies. Of the cases in which the salivary glands were affected, 10 involved the parotid gland, six involved the submandibular gland, and one involved both. Isolated invasion of the salivary gland was found in one case of parotid gland invasion and three cases of submandibular gland invasion. In 13 cases, the salivary glands were affected by various other lesions. Although there were no incidences of isolated MS, six patients were diagnosed with secondary MS and eight patients with MS with BM involvement, including this case. The diagnosis of MS is difficult given its rarity, and a high index of suspicion and integrated radiologic and careful histopathologic evaluation are required. Most cases of MS infiltrating the salivary gland might be indicated by the possibility of BM involvement. MS with BM involvement predicts poor prognosis and the need for intensive systemic treatment.

Salivary gland protection by amifostine in high-dose radioiodine treatment: results of a double-blind placebo-controlled study.

1998 ◽  
Vol 16 (11) ◽  
pp. 3542-3549 ◽  
Author(s):  
K H Bohuslavizki ◽  
S Klutmann ◽  
W Brenner ◽  
J Mester ◽  
E Henze ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Differentiated Thyroid Cancer ◽  
Controlled Study ◽  
High Dose ◽  
Radioiodine Treatment ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Submandibular Glands

PURPOSE Salivary gland impairment is a well-recognized side effect following high-dose radioiodine treatment (HD-RIT). Since differentiated thyroid cancer has a good prognosis, reduction of long-term side effects is important. Therefore, the effect of amifostine was studied in HD-RIT. PATIENTS AND METHODS Parenchymal function was assessed by quantitative salivary gland scintigraphy performed prospectively in 50 patients with differentiated thyroid cancer before and 3 months after HD-RIT with either 3 GBq iodine ((131)I) (n=21) or 6 GBq (131)I (n=29) in a double-blind, placebo-controlled study. Twenty-five patients were treated with 500 mg/m2 amifostine intravenously before HD-RIT and 25 patients served as controls, who received physiologic saline solution. Xerostomia was graded according to World Health Organization (WHO) criteria. RESULTS Before HD-RIT in 25 control patients, uptake of technetium-99m (99mTc)-pertechnetate was 0.45%+/-0.16% and 0.42%+/-0.16% in parotid and submandibular glands, respectively. Three months after HD-RIT, parenchymal function was significantly (P < .001) reduced by 40.2%+/-14.1% and 39.9%+/-15.3% in parotid and submandibular glands, respectively. Nine control patients developed grade I and two grade II xerostomia. In 25 amifostine-treated patients, uptake of 99mTc-pertechnetate was 0.46%+/-0.16% and 0.43%+/-0.17% in parotid and submandibular glands, respectively. Three months after HD-RIT, parenchymal function of salivary glands was not significantly altered (P=.691) and xerostomia did not occur in any of these patients. CONCLUSION Parenchymal damage in salivary glands caused by HD-RIT can significantly be reduced by amifostine, which may improve the quality of life of patients with differentiated thyroid cancer.

Clock Gene Expression in the Submandibular Glands

2005 ◽  
Vol 84 (12) ◽  
pp. 1193-1197 ◽  
Author(s):  
M. Furukawa ◽  
T. Kawamoto ◽  
M. Noshiro ◽  
K.K. Honda ◽  
M. Sakai ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Clock Gene ◽  
Clock Genes ◽  
Expression Profiles ◽  
Mrna Levels ◽  
Peripheral Tissues ◽  
Submandibular Glands ◽  
Circadian Expression ◽  
Clock Gene Expression

Clock genes, which mediate molecular circadian rhythms, are expressed in a circadian fashion in the suprachiasmatic nucleus and in various peripheral tissues. To establish a molecular basis for circadian regulation in the salivary glands, we examined expression profiles of clock-related genes and salivary gland-characteristic genes. Clock-related genes—including Per1, Per2, Cry1, Bmal1, Dec1, Dec2, Dbp, and Reverbα—showed robust circadian expression rhythms in the submandibular glands in 12:12-hour light-dark conditions. In addition, a robust circadian rhythm was observed in amylase 1 mRNA levels, whereas the expression of other salivary-gland-characteristic genes examined was not rhythmic. The Clock mutation resulted in increased or decreased mRNA levels of Per2, Bmal1, Dec1, Dec2, and Dbp, and in Cry1− /− background, Cry2 disruption also increased or decreased mRNA levels of these clock-related genes and the amylase 1 gene. These findings indicate that the Clock- and Cry-dependent molecular clock system is active in the salivary glands.

Polymorphous adenocarcinoma of the submandibular gland

2021 ◽  
Vol 14 (8) ◽  
pp. e244218
Author(s):  
Shiv Rajan ◽  
Ajay Kumar Singh ◽  
Sumaira Qayoom ◽  
Palavalasa Niranjan ◽  
Deep Chakrabarti
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Major Salivary Gland ◽  
Salivary Gland Tumours ◽  
Polymorphous Adenocarcinoma ◽  
Uncommon Case ◽  
Criteria For Diagnosis ◽  
Rare Malignancy

Polymorphous adenocarcinoma (PA) of the salivary glands is a rare malignancy that predominantly affects the minor salivary glands of the palate. Major salivary gland involvement is rare (<5%). The submandibular gland is a highly unusual location for this tumour. Recently, the WHO has updated the classification of salivary gland tumours in which the PA subtype has been modified. We report a very uncommon case of a classical variant of PA involving the submandibular gland in a 49-year-old woman managed at our institute and discuss the most recent pathological criteria for diagnosis, management strategy and prognosis of PA.

scholarly journals Scoring hypoechogenic areas in one parotid and one submandibular gland increases feasibility of ultrasound in primary Sjögren’s syndrome

2017 ◽  
Vol 77 (4) ◽  
pp. 556-562 ◽  
Author(s):  
Esther Mossel ◽  
Suzanne Arends ◽  
Jolien F van Nimwegen ◽  
Konstantina Delli ◽  
Alja J Stel ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Scoring System ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Submandibular Glands

ObjectiveTo assess whether ultrasonographic scoring of (i) both parotid and submandibular salivary glands and (ii) all individual components of the Hocevar scoring system, is needed for classifying patients as primary Sjögren’s syndrome (pSS).MethodsUltrasound examination of the major salivary glands (sUS) was performed in 204 consecutive patients clinically suspected (n=171) or diagnosed (n=33) with pSS.Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and salivary gland posterior border were scored in left and right parotid and submandibular glands. Logistic regression analyses were performed to assess which glands and sUS components contributed significantly to classification as pSS or non-pSS according to the 2016 American College of Rheumatology-European League Against Rheumatism (ACR-EULAR) criteria.Results116 (57%) patients were classified as pSS, the remaining as non-pSS. Instead of scoring both sides (area under the curve; AUC=0.856, Nagelkerke R2=0.526), multivariate analysis showed that sUS scoring of only right (AUC=0.850; R2=0.518) or left (AUC=0.852; R2=0.511) parotid and submandibular glands is sufficient to predict ACR-EULAR classification. Moreover, all individual components of the Hocevar scoring system significantly predicted classification. Multivariate analysis showed that parenchymal echogenicity and hypoechogenic areas contributed independently to ACR-EULAR classification (AUC=0.857; R2=0.539). Scoring these components in one parotid and one submandibular gland highly predicted ACR-EULAR classification (AUC=0.855; R2=0.539). Scoring only hypoechogenic areas on one side showed almost similar results (AUC=0.846; R2=0.498).ConclusionsUS examination of parotid and submandibular glands on one side is sufficient to predict classification of patients according to the ACR-EULAR criteria. To further increase feasibility of sUS in outpatient clinics worldwide, only hypoechogenic areas can be scored.

Surgery of sialorrhoea

1985 ◽  
Vol 99 (11) ◽  
pp. 1107-1109 ◽  
Author(s):  
S. L. Sellars
Keyword(s):  
Salivary Gland ◽  
Submandibular Gland ◽  
Salivary Flow ◽  
Motor Neurone ◽  
Chorda Tympani ◽  
Chorda Tympani Nerve ◽  
Nerve Section ◽  
Operative Complications ◽  
Severely Handicapped ◽  
Submandibular Gland Excision

SummaryThe drooling that accompanies motor neurone disorders adds to the burden of an individual already severely handicapped socially. Control of this problem can be achieved by a number of measures, such as the surgical repositioning of the salivary gland ducts and by use of medical or surgical means of reducing salivary production.Nineteen patients aged 5 to 9 years, with excessive drooling as a result of perinatal brain damage, have been treated surgically at Groote Schuur Hospital, Cape Town, by bilateral tympanic neurectomies, unilateral chorda tympani nerve section and contralateral submandibular gland excision. In all 19, salivary flow was reduced and the drooling problem significantly improved. No post-operative complications occurred.

Sign in / Sign up

Export Citation Format

Share Document